基于数据挖掘方法对溃疡性结肠炎灌肠方用药及配伍规律分析
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摘要
目的:分析期刊文献中治疗溃疡性结肠炎(UC)的灌肠处方用药及配伍规律,为临床治疗UC提供参考。方法:筛选期刊文献中治疗UC的灌肠方剂,进行信息标准化处理,应用数据挖掘技术中的频数与频繁项集对筛选的方剂进行分析。结果:共筛选了117个处方,组成药味数在10味以下的方剂占总方剂数82.05%。方中以清热燥湿药和凉血止血药使用频率最高,方中出现频率最高的10味药为白及、黄连、地榆、黄柏、苦参、白头翁、五倍子、败酱草、甘草、黄芪等,最常使用的药对为白头翁配黄连,频数34次;其次为白及配地榆,黄柏配黄连,白及配黄连,地榆配苦参、白及配苦参,白头翁配地榆,白及配黄柏,白及配白头翁,地榆配黄连。结论:期刊文献中治疗UC的灌肠处方用药精当,标本兼治,针对UC的基本病机,能为中医药临床治疗UC组方选药提供一定的借鉴与参考。
Objective: To analyze the compatibility law of the herbs used in CNKI enema recipes treating ulcerative colitis( UC) to provide the reference for its clinical treatment. Methods: The CNKI enema recipes treating UC were enrolled and processed with information standardization. The data mining method was used to analyze the compatibility law of the herbs. Results: Totally 117 prescriptions were studied. The result showed that those with less than 10 herbs occupied 82. 05% of the total prescriptions. The herbs mainly included those for clearing heat and removing dampness and cooling blood and stopping bleed which were the most frequently used. The most frequently used herbs were Baiji,Huanglian,Diyu,Huangbai,Kusheng,Baitouweng,Wubeizi,Baijiangcao,Gancao and Huangqi. Meanwhile,the most often used pairs were Baitouweng with Huanglian,Baiji with Diyu, Huangbai with Huanglian,Baiji with Huanglian,Diyu with Kusheng,Baiji with Kusheng,Baitouweng with Diyu,Baiji with Huangbai,Baiji with Baitouweng and Diyu with Huanglian. Conclusion: The herbs in CNKI enema recipes for UC were selected carefully according to the basic pathogenesis of UC which could treat both Biao and Ben and provide a reference for UC treatment nowadays.
Objective: To analyze the compatibility law of the herbs used in CNKI enema recipes treating ulcerative colitis( UC) to provide the reference for its clinical treatment. Methods: The CNKI enema recipes treating UC were enrolled and processed with information standardization. The data mining method was used to analyze the compatibility law of the herbs. Results: Totally 117 prescriptions were studied. The result showed that those with less than 10 herbs occupied 82. 05% of the total prescriptions. The herbs mainly included those for clearing heat and removing dampness and cooling blood and stopping bleed which were the most frequently used. The most frequently used herbs were Baiji,Huanglian,Diyu,Huangbai,Kusheng,Baitouweng,Wubeizi,Baijiangcao,Gancao and Huangqi. Meanwhile,the most often used pairs were Baitouweng with Huanglian,Baiji with Diyu, Huangbai with Huanglian,Baiji with Huanglian,Diyu with Kusheng,Baiji with Kusheng,Baitouweng with Diyu,Baiji with Huangbai,Baiji with Baitouweng and Diyu with Huanglian. Conclusion: The herbs in CNKI enema recipes for UC were selected carefully according to the basic pathogenesis of UC which could treat both Biao and Ben and provide a reference for UC treatment nowadays.
引文
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[3]宋立人.现代中药大辞典[M].北京:人民卫生出版社,2001.
[4]耿志国,郑世玲.白芨对盐酸引起的大鼠胃粘膜损伤的保护作用[J].中草药,1990,21(2):24-27.
[5]仇树林,王晓,李兵,等.白芨胶载重组人表皮生长因子对创面表皮细胞DNA含量及周期的影响[J].中国组织工程研究与临床康复,2007,11(1):63-66.
[6]陈德利,施伟民.中药白芨促进角质形成细胞的游走[J].中华皮肤科杂志,1999,32(3):161-163.
[7]王蒨,李东华,李继坤,等.白及胶对体外培养兔胆管成纤维细胞形态及活性的影响[J].河北中医,2007,29(8):752-753.
[8]刘如玉,陈守涛.黄连等8种中药对常引起医院内感染的条件致病菌体外抗菌活性检测[J].福建中医学院学报,2004,14(2):26-27.
[9]粱莹.黄柏抑菌效果的实验研究[J].现代医药卫生,2005,21(20):2746.
[10]上川浩.黄柏提取物的抗溃疡效果[J].国外医学·中医中药分册,1994,16(1):29.
[11]南云生,孔祥德,牛序菊,等.地榆炮制初探[J].中成药,1990,12(4):15.
[12]吴开云,黄雪芳,彭宣宪.冰片、虎杖、地榆抑菌作用的实验研究[J].江西医学院学报,1996,2(25):53-55.
[13]王玉,成心莲,何新华,等.复方三黄酊与复方地榆酊联合治疗创伤感染的临床疗效探讨[J].滨州医学院学报,1997,20(5):433-434.
[14]傅乃武,郭蓉,刘福成,等.诃子鞣质和五倍子鞣酸抑制体内亚硝胺生成和对抗活性氧的作用[J].中草药,1992,23(11):585.
[15]岳晓红.五倍子水提取物对牙龈卟啉菌内毒素诱导人单核细胞CD14表达改变的影响[J].牙体牙髓牙周病学杂志,2004,19(4):500