非高密度脂蛋白胆固醇与血管性认知障碍的相关性
摘要
目的评估非高密度脂蛋白(non-HDL-C)对血管性认知障碍(VCI)的影响。方法筛选2016年9月至2018年3月邯郸市第一医院神经内科收治的脑梗死患者126例,根据简易精神状态量表(MMSE)得分将其分成单纯梗死组(n=57)和认知障碍组(n=69),比较两组性别、吸烟、饮酒、高脂血症等危险因素的发生频率,研究认知障碍患者的非高密度脂蛋白胆固醇(non-HDL-C)水平与MMSE评分之间的关系。结果单纯梗死组年龄显著低于认知障碍组(P=0.02)。认知障碍组患者的non-HDL-C浓度与MMSE分值呈负相关(P=0.031)。结论 non-HDL-C水平可能是VCI患者的潜在临床指标。
引文
1 安晓雷,李传玲,李晓宾,等.脑卒中后早期血管性认知功能障碍发生的危险因素分析[J].中华神经医学杂志,2012;11(11):1106-9.
2 中华医学会神经病学分会痴呆与认知障碍学组写作组.血管性认知障碍诊治指南[J].中华神经科杂志,2011;44(2):142-7.
3 Ma CR,Yin ZX,Zhu PF,et al.Blood cholesterol in late-life and cognitive decline:a longitudinal study of the Chinese elderly[J].Mol Neurodegeneration,2017;12:24.
4 Appleton JP,Scutt P,Sprigg N,et al.Hypercholesterolaemia and vascular dementia[J].Clin Sci,2017;131(14):1561.
5 刘节武,刘晓东,张冠茂,等.冠心病患者中非高密度脂蛋白胆固醇和动脉粥样硬化指数水平分析[J].中国医科大学学报,2014;43(1):84-6.
6 刘慧.非高密度脂蛋白胆固醇与心脑血管病风险研究进展[J].中华临床医师杂志(电子版),2014;8(16):3021-4.
7 王玮婧,金蔚涛,任红卫,等.非高密度脂蛋白与颈动脉粥样硬化程度的相关性研究[J].中华老年心脑血管病杂志,2017;19(9):945-7.
8 中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015;48(4):246-57.
9 中国痴呆与认知障碍指南写作组.2018中国痴呆与认知障碍诊治指南(一):痴呆及其分类诊断标准[J].中华医学杂志,2018;98(13):965-70.
10 Iadecola C.Vascular and metabolic factors in Alzheimer′s diseases and related dementias:introduction[J].Cell Mol Neurobiol,2016;36(2):151-4.
11 Ramos AR,Dib SI,Wright CB.Vascular dementia[J].Curr Translat Geriatr Exp Gerontol Report,2013;2(3):188.
12 Corriveau RA,Bosetti F,Emr M,et al.The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID):a framework for advancing research priorities in the cerebrovascular biology of cognitive decline[J].Cell Mol Neurobiol,2016;36(2):281-8.
13 Hachinski V.Stroke and vascular cognitive impairment a transdisciplinary,translational and transactional approach[J].Stroke,2007;38(4):1396.
14 LI R,Wang TJ,Lyu PY,et al.Effects of plasma lipids and statins on cognitive function[J].Chin Med J,2018;131(4):471-6.
15 Ramjee V,Sperling LS,Jacobson TA.Non-high-density lipoprotein cholesterol versus apolipoprotein B in cardiovascular risk stratification:do the math[J].J Am Coll Cardiol,2011;58(5):457-63.
16 Burns M,Duff K.Cholesterol in Alzheimer′s disease and tauopathy[J].Am N Y Acad Sci,2010;977(1):367-75.
17 Mauch DH,N?gler K,Schumacher S,et al.CNS synaptogenesis promoted by glia-derived cholesterol[J].Science,2001;294(5545):1354-7.
18 G?ritz C,Mauch DH,N?gler K,et al.Role of glia-derived cholesterol in synaptogenesis:new revelations in the synapse-glia affair[J].J Physiol Paris,2002;96(3-4):257-63.
19 Wendell CR,Zonderman AB,Metter EJ,et al.Carotid intimal medial thickness predicts cognitive decline among adults without clinical vascular disease[J].Stroke,2009;40(10):3180-5.
20 Wright CB,Festa JR,Paik MC,et al.White matter hyperintensities and subclinical infarction:associations with psychomotor speed and cognitive flexibility[J].Stroke,2008;39(3):800-5.
21 de Haan EH,Nys GM,van Zandvoort MJ.Cognitive function following stroke and vascular cognitive impairment[J].Curr Opin Neurol,2006;19(6):559-64.
22 Kivipelto M,Helkala EL,H?nninen T,et al.Midlife vascular risk factors and late-life mild cognitive impairment:a population-based study[J].Neurology,2001;56(12):1683-9.
23 Pallebage-Gamarallage M,Lam V,Takechi R,et al.Restoration of dietary-fat induced blood-brain barrier dysfunction by anti-inflammatory lipid-modulating agents[J].Lipids Health Dis,2012;11(1):1-11.
24 Freeman LR,Granholm ACE.Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet[J].J Cerebral Blood Flow Metab,2012;32(4):643.
25 Davidson TL,Monnot A,Neal AU,et al.The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats[J].Physiol Behav,2012;107:26-33.
26 Kaffashian S,Dugravot A,Nabi H,et al.Predictive utility of the Framingham general cardiovascular disease risk profile for cognitive function:evidence from the Whitehall Ⅱ study[J].Eur Heart J,2011;32(18):2326.
27 Kivipelto M,Helkala EL,H?nninen T,et al.Midlife vascular risk factors and late-life mild cognitive impairment:a population-based study[J].Neurology,2001;56(12):1683-9.
28 Whitmer RA,Sidney S,Selby J,et al.Midlife cardiovascular risk factors and risk of dementia in late life[J].Neurology,2005;64(2):277-81.
29 Wu J,Zhang Q,Yang H,et al.Association between non-high-density-lipoprotein-cholesterol levels and the prevalence of asymptomatic intracranial arterial stenosis[J].PLos One,2013;8(5):e65229.
30 Frontini MG,Srinivasan SR,Xu JH,et al.Utility of non-high-density lipoprotein cholesterol versus other lipoprotein measures in detecting subclinical atherosclerosis in young adults (The Bogalusa Heart Study)[J].Am J Cardiol,2007;100(1):64-8.
31 Expert Dyslipidemia Panel of the International Atherosclerosis Society Panel members.An international atherosclerosis society position paper:global recommendations for the management of dyslipidemia—full report[J].J Clin Lipidol,2014;8:29-60.
32 Jacobson TA,Ito MK,Maki KC,et al.National lipid association recommendations for patient-centered management of dyslipidemia:part 1--full report[J].J Clin Lipidol,1900;9(2):129-69.
33 Hui M,Lin H,Yu H,et al.Relationship between non-high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults[J].Lipids in Health Dis,2017;16(1):55.
34 涂秋云,杨霞,丁斌蓉,等.缺血性脑卒中后血管性认知障碍的流行病学调查[J].中国老年学杂志,2011;31(18):3576-9.
35 徐晓云,黄蕾,胡晖,等.脑血管病危险因素与脑梗死后认知障碍相关性的研究[J].中华物理与康复杂志,2003;25(7):422-5.
2 中华医学会神经病学分会痴呆与认知障碍学组写作组.血管性认知障碍诊治指南[J].中华神经科杂志,2011;44(2):142-7.
3 Ma CR,Yin ZX,Zhu PF,et al.Blood cholesterol in late-life and cognitive decline:a longitudinal study of the Chinese elderly[J].Mol Neurodegeneration,2017;12:24.
4 Appleton JP,Scutt P,Sprigg N,et al.Hypercholesterolaemia and vascular dementia[J].Clin Sci,2017;131(14):1561.
5 刘节武,刘晓东,张冠茂,等.冠心病患者中非高密度脂蛋白胆固醇和动脉粥样硬化指数水平分析[J].中国医科大学学报,2014;43(1):84-6.
6 刘慧.非高密度脂蛋白胆固醇与心脑血管病风险研究进展[J].中华临床医师杂志(电子版),2014;8(16):3021-4.
7 王玮婧,金蔚涛,任红卫,等.非高密度脂蛋白与颈动脉粥样硬化程度的相关性研究[J].中华老年心脑血管病杂志,2017;19(9):945-7.
8 中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015;48(4):246-57.
9 中国痴呆与认知障碍指南写作组.2018中国痴呆与认知障碍诊治指南(一):痴呆及其分类诊断标准[J].中华医学杂志,2018;98(13):965-70.
10 Iadecola C.Vascular and metabolic factors in Alzheimer′s diseases and related dementias:introduction[J].Cell Mol Neurobiol,2016;36(2):151-4.
11 Ramos AR,Dib SI,Wright CB.Vascular dementia[J].Curr Translat Geriatr Exp Gerontol Report,2013;2(3):188.
12 Corriveau RA,Bosetti F,Emr M,et al.The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID):a framework for advancing research priorities in the cerebrovascular biology of cognitive decline[J].Cell Mol Neurobiol,2016;36(2):281-8.
13 Hachinski V.Stroke and vascular cognitive impairment a transdisciplinary,translational and transactional approach[J].Stroke,2007;38(4):1396.
14 LI R,Wang TJ,Lyu PY,et al.Effects of plasma lipids and statins on cognitive function[J].Chin Med J,2018;131(4):471-6.
15 Ramjee V,Sperling LS,Jacobson TA.Non-high-density lipoprotein cholesterol versus apolipoprotein B in cardiovascular risk stratification:do the math[J].J Am Coll Cardiol,2011;58(5):457-63.
16 Burns M,Duff K.Cholesterol in Alzheimer′s disease and tauopathy[J].Am N Y Acad Sci,2010;977(1):367-75.
17 Mauch DH,N?gler K,Schumacher S,et al.CNS synaptogenesis promoted by glia-derived cholesterol[J].Science,2001;294(5545):1354-7.
18 G?ritz C,Mauch DH,N?gler K,et al.Role of glia-derived cholesterol in synaptogenesis:new revelations in the synapse-glia affair[J].J Physiol Paris,2002;96(3-4):257-63.
19 Wendell CR,Zonderman AB,Metter EJ,et al.Carotid intimal medial thickness predicts cognitive decline among adults without clinical vascular disease[J].Stroke,2009;40(10):3180-5.
20 Wright CB,Festa JR,Paik MC,et al.White matter hyperintensities and subclinical infarction:associations with psychomotor speed and cognitive flexibility[J].Stroke,2008;39(3):800-5.
21 de Haan EH,Nys GM,van Zandvoort MJ.Cognitive function following stroke and vascular cognitive impairment[J].Curr Opin Neurol,2006;19(6):559-64.
22 Kivipelto M,Helkala EL,H?nninen T,et al.Midlife vascular risk factors and late-life mild cognitive impairment:a population-based study[J].Neurology,2001;56(12):1683-9.
23 Pallebage-Gamarallage M,Lam V,Takechi R,et al.Restoration of dietary-fat induced blood-brain barrier dysfunction by anti-inflammatory lipid-modulating agents[J].Lipids Health Dis,2012;11(1):1-11.
24 Freeman LR,Granholm ACE.Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet[J].J Cerebral Blood Flow Metab,2012;32(4):643.
25 Davidson TL,Monnot A,Neal AU,et al.The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats[J].Physiol Behav,2012;107:26-33.
26 Kaffashian S,Dugravot A,Nabi H,et al.Predictive utility of the Framingham general cardiovascular disease risk profile for cognitive function:evidence from the Whitehall Ⅱ study[J].Eur Heart J,2011;32(18):2326.
27 Kivipelto M,Helkala EL,H?nninen T,et al.Midlife vascular risk factors and late-life mild cognitive impairment:a population-based study[J].Neurology,2001;56(12):1683-9.
28 Whitmer RA,Sidney S,Selby J,et al.Midlife cardiovascular risk factors and risk of dementia in late life[J].Neurology,2005;64(2):277-81.
29 Wu J,Zhang Q,Yang H,et al.Association between non-high-density-lipoprotein-cholesterol levels and the prevalence of asymptomatic intracranial arterial stenosis[J].PLos One,2013;8(5):e65229.
30 Frontini MG,Srinivasan SR,Xu JH,et al.Utility of non-high-density lipoprotein cholesterol versus other lipoprotein measures in detecting subclinical atherosclerosis in young adults (The Bogalusa Heart Study)[J].Am J Cardiol,2007;100(1):64-8.
31 Expert Dyslipidemia Panel of the International Atherosclerosis Society Panel members.An international atherosclerosis society position paper:global recommendations for the management of dyslipidemia—full report[J].J Clin Lipidol,2014;8:29-60.
32 Jacobson TA,Ito MK,Maki KC,et al.National lipid association recommendations for patient-centered management of dyslipidemia:part 1--full report[J].J Clin Lipidol,1900;9(2):129-69.
33 Hui M,Lin H,Yu H,et al.Relationship between non-high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults[J].Lipids in Health Dis,2017;16(1):55.
34 涂秋云,杨霞,丁斌蓉,等.缺血性脑卒中后血管性认知障碍的流行病学调查[J].中国老年学杂志,2011;31(18):3576-9.
35 徐晓云,黄蕾,胡晖,等.脑血管病危险因素与脑梗死后认知障碍相关性的研究[J].中华物理与康复杂志,2003;25(7):422-5.