神经递质在中脑导水管周围灰质调节焦虑和抑郁中的作用机制研究
摘要
中脑导水管周围灰质(PAG)是一个具有高度复杂的解剖和功能的脑干核团,参与很多病理生理学过程,包括心血管调控、生殖行为、发声、恐惧、焦虑、抑郁、防御行为以及痛觉调制等。越来越多的动物试验证实了PAG通过多种神经递质在焦虑、抑郁的调节中起重要作用。本文将对PAG参与调节焦虑、抑郁的机制作一综述,探讨其调节机制在人类焦虑和抑郁的治疗中的临床意义和价值。
引文
[1]Mendesgomes J, Amaral VC,Nunesdesouza RL. Ventrolateral periaqueductal gray lesion attenuates nociception but does not change anxiety-like indices or fear-induced antinociception in mice[J]. Behav Brain Res, 2011, 219(2):248-253.
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[3] Back EP,Carobrez AP. Periaqueductal gray glutamatergic,cannabinoid and vanilloid receptor interplay in defensive behavior and aversive memory formation[J]. Neuropharmacology, 2018, 135:399-41 1.
[4] Ho YC,Lin TB,Hsieh MC,et al. Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression[J]. Neuropsychopharmacology, 2018,43(2):302-312.
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[6] Zanos P,Moaddel R,Morris PJ,et al. NMDAR inhibitionindependent antidepressant actions of ketamine metabolites[J]. Nature,2016, 53 3(7604):481-486.
[7] Juhasz G,Hullam G, Eszlari N, et al. Brain galanin system genes interact with life stresses in depression-related phenotypes[J]. Proc Nat Acad Sci U S A, 2014, 111(16):E1666-E1673.
[8] Wang P,Li H,Barde S,et al. Depression-like behavior in rat:Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray[J]. Proc Nat Acad Sci U S A, 2016,113(32):E4726-E4735.
[9] Soares FR,Silote GP,Almeida-Santos AF,et al. Galanin microinjection into the dorsal periaqueductal gray matter produces paradigm-dependent anxiolytic effects[J]. Brain Res Bull, 2016, 121:42-47.
[10] Husum H,Wortwein G, Andersson W,et al. Gene-environment interaction affects substance P and neurokinin A in the entorhinal cortex and periaqueductal grey in a genetic animal model of depression:implications for the pathophysiology of depression[J]. Int J Neuropsychopharmacol, 2008,11(1):93-101.
[11] Brenes JC,Broiz AC,Bassi GS,et al. Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety[J]. Brazilian J Med Biol Res, 2012, 45(4):349-356.
[12] Genaro K, Juliano MA, Prado WA, et al. Effects of angiotensin(5-8)microinfusions into the ventrolateral periaque-ductal gray on defensive behaviors in rats[J]. Behav Brain Res, 2013, 256(11):537-544.
[13] Genaro K,Fabris D,Fachim HA,et al. Angiotensin AT1receptors modulate the anxiogenic effects of angiotensin(5-8)injected into the rat ventrolateral periaqueductal gray[J].Peptides, 2017, 96:8-14.
[14] Lowery-Gionta EG,DiBerto J,Mazzone CM,et al. GABA neurons of the ventral periaqueductal gray area modulate behaviors associated with anxiety and conditioned fear[J].Brain Struct Funet, 2018, 223(8):3787-3799.
[15] Lim LW,Temel Y,Sesia T,et al. Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of rats[J]. Neuroscience,2008,155(1):164-173.
[16] de Paula Soares V,Zangrossi H Jr. Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats[J]. Behav Brain Res, 2009, 197(1):178-185.
[17] Spiacci A Jr,Sergio Tde O,da Silva GS,et al. Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia[J]. Neuroscience, 2015, 307:191-198.
[18] Miguel TT,Nunes-De-Souza RL. Anxiogenic and antinociceptive effects induced by corticotropin-releasing factor(GRF)injections into the periaqueductal gray are modulated by CRF1 receptor in mice[J]. Horm Behav,2011,60(3):292-300.
[19] Sergio Tde O,Spiacci A Jr, Zangrossi H Jr. Effects of dorsalperiaqueductal gray CRFI-and CRF2-receptor stimulation in animal models of panic[J]. Psychoneuroendocrinology,2014, 49(1):321-330.
[20] Litvin Y,Pentkowski NS,Blanchard DC,et al. CRF TYPE1 RECEPTORS IN THE DORSAL PERIAQUEDUCTAL GRAY MODULATE ANXIETY-INDUCED DEFENSIVE BEHAVIORS[J]. Horm Behav, 2007, 52(2):244-251.
[21] Miguel TT,Gomes KS,Nunes-De-Souza RL. Contrasting effects of nitric oxide and corticotropin-releasing factor within the dorsal periaqueductal gray on defensive behavior and nociception in mice[J]. Brazilian J Med Biol Res, 2012, 45(4):299-307.
[22] Ping Z, Xu HS, Li MM, et al. Mechanism of nitric oxide and acid-sensing ion channel 1 a modulation of panic-like behaviour in the dorsal periaqueductal grey of the mouse[J].Behav Brain Res,2018,353:32-3 9.
[23] Netto CF, Guimaraes FS. Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray[J]. Neuropsychopharmacology, 2004, 29(1):101-107.
[24] Estrada VB, Matsubara NK, Gomes MV, et al. Noradrenaline microinjected into the dorsal periaqueductal gray matter causes anxiolytic-like effects in rats tested in the elevated Tmaze[J]. Life Sci, 2016, 152:94-98.
[25] Pelosi GG,Resstel LL,Soares VP,et al. Anxiolytic-like effect of noradrenaline microinjection into the dorsal periaqueductal gray of rats[J]. Behav Pharmacol, 2009, 20(3):252-259.
[2] Benarroch EE. Periaqueductal gray:an interface for behavioral control[J]. Neurology, 2012, 78(3):210-217.
[3] Back EP,Carobrez AP. Periaqueductal gray glutamatergic,cannabinoid and vanilloid receptor interplay in defensive behavior and aversive memory formation[J]. Neuropharmacology, 2018, 135:399-41 1.
[4] Ho YC,Lin TB,Hsieh MC,et al. Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression[J]. Neuropsychopharmacology, 2018,43(2):302-312.
[5] Chou D,Peng HY,Lin TB,et al.(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray[J]. Neuropharmacology,2018,139:1-12.
[6] Zanos P,Moaddel R,Morris PJ,et al. NMDAR inhibitionindependent antidepressant actions of ketamine metabolites[J]. Nature,2016, 53 3(7604):481-486.
[7] Juhasz G,Hullam G, Eszlari N, et al. Brain galanin system genes interact with life stresses in depression-related phenotypes[J]. Proc Nat Acad Sci U S A, 2014, 111(16):E1666-E1673.
[8] Wang P,Li H,Barde S,et al. Depression-like behavior in rat:Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray[J]. Proc Nat Acad Sci U S A, 2016,113(32):E4726-E4735.
[9] Soares FR,Silote GP,Almeida-Santos AF,et al. Galanin microinjection into the dorsal periaqueductal gray matter produces paradigm-dependent anxiolytic effects[J]. Brain Res Bull, 2016, 121:42-47.
[10] Husum H,Wortwein G, Andersson W,et al. Gene-environment interaction affects substance P and neurokinin A in the entorhinal cortex and periaqueductal grey in a genetic animal model of depression:implications for the pathophysiology of depression[J]. Int J Neuropsychopharmacol, 2008,11(1):93-101.
[11] Brenes JC,Broiz AC,Bassi GS,et al. Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety[J]. Brazilian J Med Biol Res, 2012, 45(4):349-356.
[12] Genaro K, Juliano MA, Prado WA, et al. Effects of angiotensin(5-8)microinfusions into the ventrolateral periaque-ductal gray on defensive behaviors in rats[J]. Behav Brain Res, 2013, 256(11):537-544.
[13] Genaro K,Fabris D,Fachim HA,et al. Angiotensin AT1receptors modulate the anxiogenic effects of angiotensin(5-8)injected into the rat ventrolateral periaqueductal gray[J].Peptides, 2017, 96:8-14.
[14] Lowery-Gionta EG,DiBerto J,Mazzone CM,et al. GABA neurons of the ventral periaqueductal gray area modulate behaviors associated with anxiety and conditioned fear[J].Brain Struct Funet, 2018, 223(8):3787-3799.
[15] Lim LW,Temel Y,Sesia T,et al. Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of rats[J]. Neuroscience,2008,155(1):164-173.
[16] de Paula Soares V,Zangrossi H Jr. Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats[J]. Behav Brain Res, 2009, 197(1):178-185.
[17] Spiacci A Jr,Sergio Tde O,da Silva GS,et al. Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia[J]. Neuroscience, 2015, 307:191-198.
[18] Miguel TT,Nunes-De-Souza RL. Anxiogenic and antinociceptive effects induced by corticotropin-releasing factor(GRF)injections into the periaqueductal gray are modulated by CRF1 receptor in mice[J]. Horm Behav,2011,60(3):292-300.
[19] Sergio Tde O,Spiacci A Jr, Zangrossi H Jr. Effects of dorsalperiaqueductal gray CRFI-and CRF2-receptor stimulation in animal models of panic[J]. Psychoneuroendocrinology,2014, 49(1):321-330.
[20] Litvin Y,Pentkowski NS,Blanchard DC,et al. CRF TYPE1 RECEPTORS IN THE DORSAL PERIAQUEDUCTAL GRAY MODULATE ANXIETY-INDUCED DEFENSIVE BEHAVIORS[J]. Horm Behav, 2007, 52(2):244-251.
[21] Miguel TT,Gomes KS,Nunes-De-Souza RL. Contrasting effects of nitric oxide and corticotropin-releasing factor within the dorsal periaqueductal gray on defensive behavior and nociception in mice[J]. Brazilian J Med Biol Res, 2012, 45(4):299-307.
[22] Ping Z, Xu HS, Li MM, et al. Mechanism of nitric oxide and acid-sensing ion channel 1 a modulation of panic-like behaviour in the dorsal periaqueductal grey of the mouse[J].Behav Brain Res,2018,353:32-3 9.
[23] Netto CF, Guimaraes FS. Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray[J]. Neuropsychopharmacology, 2004, 29(1):101-107.
[24] Estrada VB, Matsubara NK, Gomes MV, et al. Noradrenaline microinjected into the dorsal periaqueductal gray matter causes anxiolytic-like effects in rats tested in the elevated Tmaze[J]. Life Sci, 2016, 152:94-98.
[25] Pelosi GG,Resstel LL,Soares VP,et al. Anxiolytic-like effect of noradrenaline microinjection into the dorsal periaqueductal gray of rats[J]. Behav Pharmacol, 2009, 20(3):252-259.