miRNA-378家族研究进展
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摘要
miRNA是一类小分子非编码单链RNA,主要发挥转录后调控作用,通过调控各种基因表达在正常组织和多种肿瘤中发挥细胞增殖、分裂、凋亡和侵袭转移等作用。最近研究发现miR-378家族与肿瘤、心脏疾病和肝脏疾病密切相关,且相关研究越来越多。本文就miRNA-378家族在各型疾病中的功能研究进行综述,为疾病诊断和治疗提供新的方向。
MiRNA is a class of non coding small single strand RNA,which plays the role of post transcriptional regulation and plays an important role in normal tissues and tumors,such as cell proliferation,division,apoptosis,invasion and metastasis. Recent studies have found that the miR-378 family is closely related to tumors,heart diseases and liver diseases,and related research is increasing. This article summarizes the functions of miRNA-378 in various types of tumors and normal tissues,and provides a newdirection for clinical diagnosis and treatment.
MiRNA is a class of non coding small single strand RNA,which plays the role of post transcriptional regulation and plays an important role in normal tissues and tumors,such as cell proliferation,division,apoptosis,invasion and metastasis. Recent studies have found that the miR-378 family is closely related to tumors,heart diseases and liver diseases,and related research is increasing. This article summarizes the functions of miRNA-378 in various types of tumors and normal tissues,and provides a newdirection for clinical diagnosis and treatment.
引文
[1]刘厚辰,屠宇杰,董冠军.长链非编码RNA与风湿性疾病[J]济宁医学院学报,2018,41(5):363-366.DOI:10. 3969/j. issn. 1000-9760. 2018. 05. 015.
[2]陈亚男,郝延磊. MicroRNAs与阿尔茨海默病研究进展[J].济宁医学院学报,2019,42(1):42-46. DOI:10. 3969Jissh. 1000-9760,2019. 01. 010.
[3] Fu XZ,Zhu W,Cai LJ,et al. Improved pre-miRNAs identification through mutual information of pre-miRNA sequences and structures[J]. Front Genet,2019,10:119. DOI:10. 3389/fgene. 2019. 00119.
[4] Jaiswal S,Iquebal MA,Arora V,et al. Development of species specific putative miRNA and its target prediction tool in wheat(Triticum aestivum L.)[J]. Sci Rep,2019,9(1):3790. DOI:10. 1038/s41598-019-40333-y.
[5] Peng J,Xie ZY,Cheng LY,et al. Paired design study by real-time PCR:miR-378 and miR-145 are potent early diagnostic biomarkers of human colorectal cancer[J].BMC Cancer,2015,15:158. DOI:10. 1186/s12885-015-1123-2.
[6] Weng WH,Leung WH,Pang YJ,et al. Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression[J]. Oncol Rep,2016,35(1):107-116. DOI:10. 3892/or. 2015. 4336.
[7] Chen QG,Zhou W,Han T,et al. MiR-378 suppresses prostate cancer cell growth through downregulation of MAPK1 in vitro and in vivo[J]. Tumour Biol,2016,37(2):2095-2103. DOI:10. 1007/s13277-015-3996-8.
[8] Fei BJ,Wu HR. MiR-378 inhibits progression of human gastric cancer MGC-803 cells by targeting MAPK1 in vitro[J]. Oncol Res,2012,20(12):557-564. DOI:10.3727/096504013X13775486749254.
[9] Qiu P,Xu TJ,Lu XD,et al. MicroRNA-378 regulates cell proliferation and migration by repressing RNF31 in pituitary adenoma[J]. Oncol Lett,2018,15(1):789-794. DOI:10. 3892/ol. 2017. 7431.
[10] Zhang ZY,Zhu B,Zhao XW,et al. Regulation of UHRF1by microRNA-378 modulates medulloblastoma cell proliferation and apoptosis[J]. Oncol Rep,2017,38(5):3078-3084. DOI:10. 3892/or. 2017. 5939.
[11] Shi HZ,Wang D,Sun XN,et al. MicroRNA-378 acts as a prognosis marker and inhibits cell migration,invasion and epithelial-mesenchymal transition in human glioma by targeting IRG1[J]. Eur Rev Med Pharmacol Sci,2018,22(12):3837-3846. DOI:10. 26355/eurrev_201806_15268.
[12] Eichner LJ,Perry MC,Dufour CR,et al. MiR-378(*)mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγtranscriptional pathway[J]. Cell Metab,2010,12(4):352-361. DOI:10. 1016/j. cmet. 2010. 09.002.
[13] Ji KX,Cui F,Qu D,et al. MiR-378 promotes the cell proliferation of non-small cell lung cancer by inhibiting FOXG1[J]. Eur Rev Med Pharmacol Sci,2018,22(4):1011-1019. DOI:10. 26355/eurrev_201802_14383.
[14] Skrzypek K,Tertil M,Golda S,et al. Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth,vascularization,and metastasis[J]. Antioxid Redox Signal,2013,19(7):644-660.DOI:10. 1089/ars. 2013. 5184.
[15] Chan JK,Kiet TK,Blansit K,et al. MiR-378 as a biomarker for response to anti-angiogenic treatment in ovarian cancer[J]. Gynecol Oncol,2014,133(3):568-574.DOI:10. 1016/j. ygyno. 2014. 03. 564.
[16] Pandey R,Woo HH,Varghese F,et al. Circulating miRNA profiling of women at high risk for ovarian cancer[J]. Transl Oncol,2019,12(5):714-725. DOI:10.1016/j. tranon. 2019. 01. 006.
[17] Elias KM,Fendler W,Stawiski K,et al. Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer[J]. Elife,2017,6:e28932. DOI:10.7554/e Life. 28932.
[18] Sun MY,Ma XN,Tu C,et al. MicroRNA-378 regulates epithelial-mesenchymal transition and metastasis of melanoma by inhibiting FOXN3 expression through the Wnt/β-catenin pathway[J]. Cell Biol Int,2018. DOI:10. 1002/cbin. 11027.
[19] Fang J,Song XW,Tian J,et al. Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes[J].Apoptosis,2012,17(4):410-423. DOI:10. 1007/s10495-011-0683-0.
[20] Templin C,Volkmann J,Emmert MY,et al. Increased proangiogenic activity of mobilized CD34+progenitor cells of patients with acute ST-segment-elevation myocardial infarction:role of differential MicroRNA-378 expression[J]. Arterioscler Thromb Vasc Biol,2017,37(2):341-349. DOI:10. 1161/ATVBAHA. 116. 308695.
[21] Ganesan J,Ramanujam D,Sassi Y,et al. MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors[J]. Circulation,2013,127(21):2097-2106. DOI:10. 1161/CIRCULATIONAHA. 112. 000882.
[22] Yuan J,Liu HB,Gao W,et al. MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress[J]. Theranostics,2018,8(9):2565-2582.DOI:10. 7150/thno. 22878.
[23] Hyun J,Wang S,Kim J,et al. MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression[J]. Nat Commun,2016,7:10993. DOI:10. 1038/ncomms10993.
[24] Zhang TP,Hu JJ,Wang XM,et al. MicroRNA-378 promotes hepatic inflammation and fibrosis via modulation of the NF-ΚB-TNFαpathway[J]. J Hepatol,2019,70(1):87-96. DOI:10. 1016/j. jhep. 2018. 08. 026.
[25] Li P,Lang XF,Xia SG. Elevated expression of microRNA-378 in children with asthma aggravates airway remodeling by promoting the proliferation and apoptosis resistance of airway smooth muscle cells[J]. Exp Ther Med,2019,17(3):1529-1536. DOI:10. 3892/etm.2018. 7141.
[26] Xie L,Yao ZH,Zhang Y,et al. Deep RNA sequencing reveals the dynamic regulation of miRNA,lncRNAs,and mRNAs in osteosarcoma tumorigenesis and pulmonary metastasis[J]. Cell Death Dis,2018,9(7):772. DOI:10. 1038/s41419-018-0813-5.
[27] Wang XL,Zhang T,Wang J,et al. MiR-378b promotes differentiation of keratinocytes through NKX3. 1[J].PLo S One,2015,10(8):e0136049. DOI:10. 1371/journal. pone. 0136049.
[28] Lu YL,Jing W,Feng LS,et al. Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers[J]. J Zhejiang Univ Sci B,2014,15(9):820-829. DOI:10. 1631/jzus. B1400052.
[29] Li C,Gao S,Chen S,et al. Differential expression of microRNAs in luteinising hormone-treated mouse TM3Leydig cells[J]. Andrologia,2018,50(1). DOI:10.1111/and. 12824.
[30] Benyeogor I,Simoneaux T,Wu YH,et al. A unique insight into the MiRNA profile during genital chlamydial infection[J]. BMC Genomics,2019,20(1):143. DOI:10. 1186/s12864-019-5495-6.
[31] Ma CB,Zhang WY,Wu QW,et al. Identification of a microRNA signature associated with survivability in cervical squamous cell carcinoma[J]. PLo S One,2018,13(3):e0193625. DOI:10. 1371/journal. pone. 0193625.
[32] Tan DM,Zhou C,Han S,et al. MicroRNA-378 enhances migration and invasion in cervical cancer by directly targeting autophagy-related protein 12[J]. Mol Med Rep,2018,17(5):6319-6326. DOI:10. 3892/mmr. 2018.8645.
[33] Nunez Lopez YO,Victoria B,Golusinski P,et al. Characteristic miRNA expression signature and random forest survival analysis identify potential cancer-driving miRNAs in a broad range of head and neck squamous cell carcinoma subtypes[J]. Rep Pract Oncol Radiother,2018,23(1):6-20. DOI:10. 1016/j. rpor. 2017. 10.003.
[34] Chaudhry MA,Omaruddin RA,Brumbaugh CD,et al. Identification of radiation-induced microRNA transcriptome by next-generation massively parallel sequencing[J]. J Radiat Res,2013,54(5):808-822. DOI:10.1093/jrr/rrt014.
[35] Kurowska W,Kuca-Warnawin E,Radzikowska A,et al.Monocyte-related biomarkers of rheumatoid arthritis development in undifferentiated arthritis patients-a pilot study[J]. Reumatologia,2018,56(1):10-16. DOI:10.5114/reum. 2018. 74742.
[36] Valmiki S,Ahuja V,Paul J. MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients[J]. World J Gastroenterol,2017,23(29):5324-5332. DOI:10. 3748/wjg. v23. i29. 5324.
[37] Husby S,Ralfkiaer U,Garde C,et al. MiR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator[J]. Blood,2015,125(17):2669-2677. DOI:10. 1182/blood-2014-06-584193.
[38] Min QH,Chen XM,Zou YQ,et al. Differential expression of urinary exosomal microRNAs in Ig A nephropathy[J].J Clin Lab Anal,2018,32(2):DOI:10. 1002/jcla.22226.
[39] Lin J,Wang Y,Zou YQ,et al. Differential miRNA expression in pleural effusions derived from extracellular vesicles of patients with lung cancer,pulmonary tuberculosis,or pneumonia[J]. Tumor Biol,2016,37(12):15835-15845. DOI:10. 1007/s13277-016-5410-6.
[40] Latchana N,Di Vincenzo MJ,Regan K,et al. Alterations in patient plasma microRNA expression profiles following resection of metastatic melanoma[J]. J Surg Oncol,2018,118(3):501-509. DOI:10. 1002/jso. 25163.
[41] Tsai YC,Kuo PL,Kuo MC,et al. The interaction of mir-378i-skp2 regulates cell senescence in diabetic nephropathy[J]. J Clin Med,2018,7(12):E468. DOI:10.3390/jcm7120468.
[2]陈亚男,郝延磊. MicroRNAs与阿尔茨海默病研究进展[J].济宁医学院学报,2019,42(1):42-46. DOI:10. 3969Jissh. 1000-9760,2019. 01. 010.
[3] Fu XZ,Zhu W,Cai LJ,et al. Improved pre-miRNAs identification through mutual information of pre-miRNA sequences and structures[J]. Front Genet,2019,10:119. DOI:10. 3389/fgene. 2019. 00119.
[4] Jaiswal S,Iquebal MA,Arora V,et al. Development of species specific putative miRNA and its target prediction tool in wheat(Triticum aestivum L.)[J]. Sci Rep,2019,9(1):3790. DOI:10. 1038/s41598-019-40333-y.
[5] Peng J,Xie ZY,Cheng LY,et al. Paired design study by real-time PCR:miR-378 and miR-145 are potent early diagnostic biomarkers of human colorectal cancer[J].BMC Cancer,2015,15:158. DOI:10. 1186/s12885-015-1123-2.
[6] Weng WH,Leung WH,Pang YJ,et al. Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression[J]. Oncol Rep,2016,35(1):107-116. DOI:10. 3892/or. 2015. 4336.
[7] Chen QG,Zhou W,Han T,et al. MiR-378 suppresses prostate cancer cell growth through downregulation of MAPK1 in vitro and in vivo[J]. Tumour Biol,2016,37(2):2095-2103. DOI:10. 1007/s13277-015-3996-8.
[8] Fei BJ,Wu HR. MiR-378 inhibits progression of human gastric cancer MGC-803 cells by targeting MAPK1 in vitro[J]. Oncol Res,2012,20(12):557-564. DOI:10.3727/096504013X13775486749254.
[9] Qiu P,Xu TJ,Lu XD,et al. MicroRNA-378 regulates cell proliferation and migration by repressing RNF31 in pituitary adenoma[J]. Oncol Lett,2018,15(1):789-794. DOI:10. 3892/ol. 2017. 7431.
[10] Zhang ZY,Zhu B,Zhao XW,et al. Regulation of UHRF1by microRNA-378 modulates medulloblastoma cell proliferation and apoptosis[J]. Oncol Rep,2017,38(5):3078-3084. DOI:10. 3892/or. 2017. 5939.
[11] Shi HZ,Wang D,Sun XN,et al. MicroRNA-378 acts as a prognosis marker and inhibits cell migration,invasion and epithelial-mesenchymal transition in human glioma by targeting IRG1[J]. Eur Rev Med Pharmacol Sci,2018,22(12):3837-3846. DOI:10. 26355/eurrev_201806_15268.
[12] Eichner LJ,Perry MC,Dufour CR,et al. MiR-378(*)mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγtranscriptional pathway[J]. Cell Metab,2010,12(4):352-361. DOI:10. 1016/j. cmet. 2010. 09.002.
[13] Ji KX,Cui F,Qu D,et al. MiR-378 promotes the cell proliferation of non-small cell lung cancer by inhibiting FOXG1[J]. Eur Rev Med Pharmacol Sci,2018,22(4):1011-1019. DOI:10. 26355/eurrev_201802_14383.
[14] Skrzypek K,Tertil M,Golda S,et al. Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth,vascularization,and metastasis[J]. Antioxid Redox Signal,2013,19(7):644-660.DOI:10. 1089/ars. 2013. 5184.
[15] Chan JK,Kiet TK,Blansit K,et al. MiR-378 as a biomarker for response to anti-angiogenic treatment in ovarian cancer[J]. Gynecol Oncol,2014,133(3):568-574.DOI:10. 1016/j. ygyno. 2014. 03. 564.
[16] Pandey R,Woo HH,Varghese F,et al. Circulating miRNA profiling of women at high risk for ovarian cancer[J]. Transl Oncol,2019,12(5):714-725. DOI:10.1016/j. tranon. 2019. 01. 006.
[17] Elias KM,Fendler W,Stawiski K,et al. Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer[J]. Elife,2017,6:e28932. DOI:10.7554/e Life. 28932.
[18] Sun MY,Ma XN,Tu C,et al. MicroRNA-378 regulates epithelial-mesenchymal transition and metastasis of melanoma by inhibiting FOXN3 expression through the Wnt/β-catenin pathway[J]. Cell Biol Int,2018. DOI:10. 1002/cbin. 11027.
[19] Fang J,Song XW,Tian J,et al. Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes[J].Apoptosis,2012,17(4):410-423. DOI:10. 1007/s10495-011-0683-0.
[20] Templin C,Volkmann J,Emmert MY,et al. Increased proangiogenic activity of mobilized CD34+progenitor cells of patients with acute ST-segment-elevation myocardial infarction:role of differential MicroRNA-378 expression[J]. Arterioscler Thromb Vasc Biol,2017,37(2):341-349. DOI:10. 1161/ATVBAHA. 116. 308695.
[21] Ganesan J,Ramanujam D,Sassi Y,et al. MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors[J]. Circulation,2013,127(21):2097-2106. DOI:10. 1161/CIRCULATIONAHA. 112. 000882.
[22] Yuan J,Liu HB,Gao W,et al. MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress[J]. Theranostics,2018,8(9):2565-2582.DOI:10. 7150/thno. 22878.
[23] Hyun J,Wang S,Kim J,et al. MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression[J]. Nat Commun,2016,7:10993. DOI:10. 1038/ncomms10993.
[24] Zhang TP,Hu JJ,Wang XM,et al. MicroRNA-378 promotes hepatic inflammation and fibrosis via modulation of the NF-ΚB-TNFαpathway[J]. J Hepatol,2019,70(1):87-96. DOI:10. 1016/j. jhep. 2018. 08. 026.
[25] Li P,Lang XF,Xia SG. Elevated expression of microRNA-378 in children with asthma aggravates airway remodeling by promoting the proliferation and apoptosis resistance of airway smooth muscle cells[J]. Exp Ther Med,2019,17(3):1529-1536. DOI:10. 3892/etm.2018. 7141.
[26] Xie L,Yao ZH,Zhang Y,et al. Deep RNA sequencing reveals the dynamic regulation of miRNA,lncRNAs,and mRNAs in osteosarcoma tumorigenesis and pulmonary metastasis[J]. Cell Death Dis,2018,9(7):772. DOI:10. 1038/s41419-018-0813-5.
[27] Wang XL,Zhang T,Wang J,et al. MiR-378b promotes differentiation of keratinocytes through NKX3. 1[J].PLo S One,2015,10(8):e0136049. DOI:10. 1371/journal. pone. 0136049.
[28] Lu YL,Jing W,Feng LS,et al. Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers[J]. J Zhejiang Univ Sci B,2014,15(9):820-829. DOI:10. 1631/jzus. B1400052.
[29] Li C,Gao S,Chen S,et al. Differential expression of microRNAs in luteinising hormone-treated mouse TM3Leydig cells[J]. Andrologia,2018,50(1). DOI:10.1111/and. 12824.
[30] Benyeogor I,Simoneaux T,Wu YH,et al. A unique insight into the MiRNA profile during genital chlamydial infection[J]. BMC Genomics,2019,20(1):143. DOI:10. 1186/s12864-019-5495-6.
[31] Ma CB,Zhang WY,Wu QW,et al. Identification of a microRNA signature associated with survivability in cervical squamous cell carcinoma[J]. PLo S One,2018,13(3):e0193625. DOI:10. 1371/journal. pone. 0193625.
[32] Tan DM,Zhou C,Han S,et al. MicroRNA-378 enhances migration and invasion in cervical cancer by directly targeting autophagy-related protein 12[J]. Mol Med Rep,2018,17(5):6319-6326. DOI:10. 3892/mmr. 2018.8645.
[33] Nunez Lopez YO,Victoria B,Golusinski P,et al. Characteristic miRNA expression signature and random forest survival analysis identify potential cancer-driving miRNAs in a broad range of head and neck squamous cell carcinoma subtypes[J]. Rep Pract Oncol Radiother,2018,23(1):6-20. DOI:10. 1016/j. rpor. 2017. 10.003.
[34] Chaudhry MA,Omaruddin RA,Brumbaugh CD,et al. Identification of radiation-induced microRNA transcriptome by next-generation massively parallel sequencing[J]. J Radiat Res,2013,54(5):808-822. DOI:10.1093/jrr/rrt014.
[35] Kurowska W,Kuca-Warnawin E,Radzikowska A,et al.Monocyte-related biomarkers of rheumatoid arthritis development in undifferentiated arthritis patients-a pilot study[J]. Reumatologia,2018,56(1):10-16. DOI:10.5114/reum. 2018. 74742.
[36] Valmiki S,Ahuja V,Paul J. MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients[J]. World J Gastroenterol,2017,23(29):5324-5332. DOI:10. 3748/wjg. v23. i29. 5324.
[37] Husby S,Ralfkiaer U,Garde C,et al. MiR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator[J]. Blood,2015,125(17):2669-2677. DOI:10. 1182/blood-2014-06-584193.
[38] Min QH,Chen XM,Zou YQ,et al. Differential expression of urinary exosomal microRNAs in Ig A nephropathy[J].J Clin Lab Anal,2018,32(2):DOI:10. 1002/jcla.22226.
[39] Lin J,Wang Y,Zou YQ,et al. Differential miRNA expression in pleural effusions derived from extracellular vesicles of patients with lung cancer,pulmonary tuberculosis,or pneumonia[J]. Tumor Biol,2016,37(12):15835-15845. DOI:10. 1007/s13277-016-5410-6.
[40] Latchana N,Di Vincenzo MJ,Regan K,et al. Alterations in patient plasma microRNA expression profiles following resection of metastatic melanoma[J]. J Surg Oncol,2018,118(3):501-509. DOI:10. 1002/jso. 25163.
[41] Tsai YC,Kuo PL,Kuo MC,et al. The interaction of mir-378i-skp2 regulates cell senescence in diabetic nephropathy[J]. J Clin Med,2018,7(12):E468. DOI:10.3390/jcm7120468.