糖化血红蛋白对老年2型糖尿病心功能影响的研究
摘要
目的:观察不同水平糖化血红蛋白(HbA1c)对老年2型糖尿病(T2DM)患者心功能的影响及相关性。方法:随机选取2018-01～2018-06期间在呼伦贝尔市人民医院内分泌科住院老年患者50例为糖尿病组,正常组为我院体检体健的老年患者46例,采集两组所有患者的性别、年龄、体重、吸烟、血压等一般指标。其中糖尿病组50例,正常组46例,所有患者于实验指标测定前1d空腹8～12h,第2d晨起静脉采血,行心脏彩超检查。结果:(1)正常组、糖尿病组、各组间性别、年龄、体重、吸烟比较无统计学差异(P>0.05),正常组、糖尿病组间比较高血压间差异具有统计学意义(P<0.05)。(2)糖尿病组与正常组糖化血红蛋白、空腹血糖、氨基末端B型脑钠肽、左室射血分数、舒张未期左室内径、收缩末期左室内径、舒张末期室间隔厚度之间差异比较均具有统计学意义(P<0.05)。(3)所有患者糖化血红蛋白与NT-proBNP呈现正相关,与LVEF呈负相关。结论:老年糖尿病患者糖化血红蛋白与心功能呈负相关,HbA1c可作为评价糖尿病治疗效果及影响心功能预后的关键性影响因素。
引文
[1]International Diabetes Federation:IDF Diabetes Atlas.8th edition.Brussels,Belgium:International Diabetes Federation;2018
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[2]Rubler S,Dlugash J,Yuceoglu YZ,et al.New type of cardiomyopathy associated with diabetic glomerulosclerosis[J].American Journal of Cardiology,1972;30(6):595-602
[3]Hamby R I,Zoneraich S,Sherman L.Diabetic cardiomyopathy[J].Jama the Journal of the American Medical Association,1974;229(13):1749-1754
[4]贾伟平.中国2型糖尿病防治指南(2017年版)[J].中华医学会糖尿病学分会,2017
[5]Goyal A,Mahaffey K W,Garg J,et al.Prognostic significance of the change in glucose level in the first 24 h after acute myocardial infarction:results from the CARDINAL study[J].European Heart Journal,2006;27(11):1289-97
[6]Khavandi K,Khavandi A,Asghar O,et al.Diabetic cardiomyopathy—a distinct disease?[J].Best Practice & Research Clinical Endocrinology & Metabolism,2009;23(3):10-18