外用重组人碱性成纤维细胞生长因子联合康复新液治疗糜烂型扁平苔藓的临床应用
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摘要
目的探讨外用重组人碱性成纤维细胞生长因子与康复新液联合应用对于糜烂型扁平苔藓的疗效。方法选取我院收治的90例糜烂型扁平苔藓患者作为研究对象,随机分为实验组和对照组,各45例。实验组采用重组人碱性成纤维细胞生长因子与康复新液联合治疗,对照组采用康复新液含漱。观察治疗前后患者客观指标体征和主观症状评分情况,比较两组临床疗效。结果治疗4周后实验组客观指标记分为(0.81±0.35)分、主观症状评分为(0.31±0.27)分,低于对照组的(1.38±0.41)分、(0.76±0.39)分,差异有统计学意义(P<0.05);实验组治疗总有效率为82.22%,高于对照组的64.44%,差异有统计学意义(P=0.035)。结论外用重组人碱性成纤维细胞生长因子联合康复新液联合治疗糜烂型扁平苔藓,治疗效果显著,可有效改善患者临床症状。
Objective To investigate the therapeutic effect of recombiant human basic fibroblast growth factor for external use combined with Kangfuxin solution in the treatment of erosive lichen planus.Methods 90 patients with erosive lichen planus admitted to our hospital were selected as subjects and randomly divided into experimental group and control group,45 cases each.The experimental group was treated with recombiant human basic fibroblast growth factor for external use and Kangfuxin solution,while the control group was gargled with Kangfuxin solution.Objective indicators and subjective symptom scores before and after treatment were observed,and the clinical effects of the two groups were compared.Results After 4 weeks of treatment,the objective index of the experimental group was(0.81±0.35)points and the subjective symptom score was(0.31±0.27)points,which was lower than the control group(1.38 ±0.41) points and(0.76 ±0.39) points,the difference was statistically significant(P <0.05).The total effective rate of the experimental group was 82.22%,which was higher than that of the control group 64.44%,the difference was statistically significant( P=0.035).Conclusion The combination of recombiant human basic fibroblast growth factor for external use and Kangfuxin solution in the treatment of erosive lichen planus has obvious therapeutic effect and can effectively improve the clinical symptoms of patients.
Objective To investigate the therapeutic effect of recombiant human basic fibroblast growth factor for external use combined with Kangfuxin solution in the treatment of erosive lichen planus.Methods 90 patients with erosive lichen planus admitted to our hospital were selected as subjects and randomly divided into experimental group and control group,45 cases each.The experimental group was treated with recombiant human basic fibroblast growth factor for external use and Kangfuxin solution,while the control group was gargled with Kangfuxin solution.Objective indicators and subjective symptom scores before and after treatment were observed,and the clinical effects of the two groups were compared.Results After 4 weeks of treatment,the objective index of the experimental group was(0.81±0.35)points and the subjective symptom score was(0.31±0.27)points,which was lower than the control group(1.38 ±0.41) points and(0.76 ±0.39) points,the difference was statistically significant(P <0.05).The total effective rate of the experimental group was 82.22%,which was higher than that of the control group 64.44%,the difference was statistically significant( P=0.035).Conclusion The combination of recombiant human basic fibroblast growth factor for external use and Kangfuxin solution in the treatment of erosive lichen planus has obvious therapeutic effect and can effectively improve the clinical symptoms of patients.
引文
[1]张桂琴.中西医结合治疗口腔扁平苔藓167例临床治疗观察[J].医学信息,2011,24(01):339.
[2]左雯鑫,李晓宇,陈艳卿,等.口腔扁平苔藓患者口腔健康相关生活质量的初步研究[J].华西口腔医学杂志,2012,30(1):40-44.
[3]陈谦明.口腔黏膜病学[M].3版.北京:人民卫生出版社,2008:101-102.
[4]周刚,刘宏伟,林梅,等.口腔扁平苔藓(萎缩型,糜烂型)疗效评价标准(试行)[J].中华口腔医学杂志,2005,40(2):92-93.
[5]渠晓黎,赵桂秋,高昂,等.那他霉素联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗真菌性角膜溃疡的疗效[J].国际眼科杂志,2013,13(07):1322-1325.
[6]潘德标,叶冠雄,吴成军,等.重组人碱性成纤维细胞生长因子与磺胺嘧啶银霜联合应用对慢性难愈性创面愈合过程的修复效应[J].温州医科大学学报,2014,44(04):294-296.
[7]Hoegh A,Lindholt JS.Basic seience review.Vacular dis-tensibility as a predictive tool in the management of small asymptomaticabdominal aortic aneurysms[J].Vasc EndowascularSurg,2013,43(4):333-338.
[8]汤雁利,李罡,李启艳.康复新药理作用的研究进展[J].西北药学杂志,2014,29(01):103-106.
[9]周晓丽,张晓辉.康复新液治疗糜烂型扁平苔藓疗效观察[J].四川医学,2013,34(12):1913-1914.
[2]左雯鑫,李晓宇,陈艳卿,等.口腔扁平苔藓患者口腔健康相关生活质量的初步研究[J].华西口腔医学杂志,2012,30(1):40-44.
[3]陈谦明.口腔黏膜病学[M].3版.北京:人民卫生出版社,2008:101-102.
[4]周刚,刘宏伟,林梅,等.口腔扁平苔藓(萎缩型,糜烂型)疗效评价标准(试行)[J].中华口腔医学杂志,2005,40(2):92-93.
[5]渠晓黎,赵桂秋,高昂,等.那他霉素联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗真菌性角膜溃疡的疗效[J].国际眼科杂志,2013,13(07):1322-1325.
[6]潘德标,叶冠雄,吴成军,等.重组人碱性成纤维细胞生长因子与磺胺嘧啶银霜联合应用对慢性难愈性创面愈合过程的修复效应[J].温州医科大学学报,2014,44(04):294-296.
[7]Hoegh A,Lindholt JS.Basic seience review.Vacular dis-tensibility as a predictive tool in the management of small asymptomaticabdominal aortic aneurysms[J].Vasc EndowascularSurg,2013,43(4):333-338.
[8]汤雁利,李罡,李启艳.康复新药理作用的研究进展[J].西北药学杂志,2014,29(01):103-106.
[9]周晓丽,张晓辉.康复新液治疗糜烂型扁平苔藓疗效观察[J].四川医学,2013,34(12):1913-1914.