药用植物茵陈的化学成分及药理研究
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摘要
目的药用植物茵陈的化学成分及药理研究。方法对茵陈化学成分进行分析。之后选取该院2017年1月—2018年1月收治的100例高血压患者,分为观察组和对照组,各50例。对照组常规接受药物治疗,观察组额外给予茵陈进行辅助,对比两组患者治疗有效率、血压变化。结果茵陈的化学成分包括香豆素类、挥发油类、黄酮类等,占比分别为1.95%、1.83%、1.72%、1.77%。观察组患者的治疗有效率为96.00%,对照组为84.00%,差异有统计学意义(χ~2=22.656,P<0.05)。观察组患者血压得到控制,收缩压为131.2 mmHg,舒张压为114.8 mmHg,对照组患者收缩压为136.7 mmHg,舒张压为122.4 mmHg,差异有统计学意义(t=21.098,P<0.05)。结论茵陈的化学成分复杂,有效成分多,药理作用体现在疾病控制和预防上,可应用于后续工作中。
Objective To study the chemical constituents and pharmacology of the medicinal plant Yinchen. Methods The chemical constituents of Yinchen were analyzed. After that, 100 hypertensive patients admitted to our hospital from January 2017 to January 2018 were divided into observation group and control group, 50 cases each. The control group received routine drug treatment, while the observation group was supplemented with Yinchen. The treatment efficiency and blood pressure changes were compared between the two groups. Results The chemical constituents of Yinchen included coumarins, flavonoids and volatile oils, accounting for 1.95%, 1.83%, 1.72% and 1.77% respectively. The effective rate was 96.00% in the observation group and 84.00% in the control group. The difference was statistically significant(χ~2=22.656,P<0.05). In the observation group, the systolic blood pressure was 131.2 mmHg, and the diastolic blood pressure was 114.8 mmHg; in the control group, the data was 136.7 mmHg and 122.4 mmHg. The difference was statistically significant(t=21.098,P<0.05). Conclusion The chemical constituents of Yinchen are complex and there are many active ingredients. Its pharmacological effects are reflected in the control and prevention of disease, and can be applied in the follow-up work.
Objective To study the chemical constituents and pharmacology of the medicinal plant Yinchen. Methods The chemical constituents of Yinchen were analyzed. After that, 100 hypertensive patients admitted to our hospital from January 2017 to January 2018 were divided into observation group and control group, 50 cases each. The control group received routine drug treatment, while the observation group was supplemented with Yinchen. The treatment efficiency and blood pressure changes were compared between the two groups. Results The chemical constituents of Yinchen included coumarins, flavonoids and volatile oils, accounting for 1.95%, 1.83%, 1.72% and 1.77% respectively. The effective rate was 96.00% in the observation group and 84.00% in the control group. The difference was statistically significant(χ~2=22.656,P<0.05). In the observation group, the systolic blood pressure was 131.2 mmHg, and the diastolic blood pressure was 114.8 mmHg; in the control group, the data was 136.7 mmHg and 122.4 mmHg. The difference was statistically significant(t=21.098,P<0.05). Conclusion The chemical constituents of Yinchen are complex and there are many active ingredients. Its pharmacological effects are reflected in the control and prevention of disease, and can be applied in the follow-up work.
引文
[1]廖天录,廖天江,吕麟华.药用植物茵陈的化学成分及药理研究[J].乡村科技,2018(20):40-41.
[2]熊耀坤,胡吉贤,慕泽泾,等.GC-MS结合主成分分析比较茵陈干燥前后挥发油化学成分差异[J].江西中医药,2018,49(3):64-68.
[3]杨磊,刘梦娇,张志国,等.基于计算预测的茵陈蒿汤治疗肝硬化的“成分-靶标-通路”相关性分析[J].中国中药杂志,2018,43(7):1345-1351.
[4]张慧.基于不同极性部位的藏茵陈指纹图谱质量及药理活性研究[D].成都:成都中医药大学,2017.
[5]欧阳文竹,尚展鹏,王文建,等.茵陈提取物中化学成分的UHPLC-LTQ-Orbitrap快速鉴定[J].中国中药杂志,2017,42(3):523-530.
[6]田晓卉,周超,喻长远,等.茵陈配方颗粒中的化学成分分离鉴定[J].中国实验方剂学杂志,2017,23(3):55-59.
[7]曹金凤.茵陈蒿的化学成分研究[A].中国化学会.中国化学会第十一届全国天然有机化学学术会议论文集(第二册)[C].中国化学会:中国化学会,2016:1.
[8]田成旺.藏茵陈的利胆退黄药效物质鉴定及其药物代谢和药理作用研究[D].天津:天津大学,2014.
[9]雷昌,夏新华,黄玛莎,等.二种纯化工艺对茵陈水提液的影响研究[J].中成药,2013,35(12):2626-2630.
[10]曹锦花.茵陈的化学成分和药理作用研究进展[J].沈阳:沈阳药科大学,2013,30(6):489-494.
[2]熊耀坤,胡吉贤,慕泽泾,等.GC-MS结合主成分分析比较茵陈干燥前后挥发油化学成分差异[J].江西中医药,2018,49(3):64-68.
[3]杨磊,刘梦娇,张志国,等.基于计算预测的茵陈蒿汤治疗肝硬化的“成分-靶标-通路”相关性分析[J].中国中药杂志,2018,43(7):1345-1351.
[4]张慧.基于不同极性部位的藏茵陈指纹图谱质量及药理活性研究[D].成都:成都中医药大学,2017.
[5]欧阳文竹,尚展鹏,王文建,等.茵陈提取物中化学成分的UHPLC-LTQ-Orbitrap快速鉴定[J].中国中药杂志,2017,42(3):523-530.
[6]田晓卉,周超,喻长远,等.茵陈配方颗粒中的化学成分分离鉴定[J].中国实验方剂学杂志,2017,23(3):55-59.
[7]曹金凤.茵陈蒿的化学成分研究[A].中国化学会.中国化学会第十一届全国天然有机化学学术会议论文集(第二册)[C].中国化学会:中国化学会,2016:1.
[8]田成旺.藏茵陈的利胆退黄药效物质鉴定及其药物代谢和药理作用研究[D].天津:天津大学,2014.
[9]雷昌,夏新华,黄玛莎,等.二种纯化工艺对茵陈水提液的影响研究[J].中成药,2013,35(12):2626-2630.
[10]曹锦花.茵陈的化学成分和药理作用研究进展[J].沈阳:沈阳药科大学,2013,30(6):489-494.