补肾活血汤治疗精索静脉曲张性不育症的临床疗效及对附睾功能、精子活力的影响
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摘要
目的研究补肾活血汤治疗精索静脉曲张性不育症的临床疗效及对附睾功能、精子活力的影响。方法选择2016年8月～2018年7月期间在本院接受诊治的98例精索静脉曲张的男性不育症患者,参照随机数表法将患者分为对照组49例和研究组49例。对照组患者给予迈之灵加五子衍宗丸治疗;研究组患者给予补肾活血汤治疗。治疗12周后对患者的临床疗效进行评价,比较两组患者治疗前后精液质量(包括精液量、精子密度、精子活率、前向运动精子)、性激素、精浆中性α-糖苷酶变化情况。治疗结束后随访3个月,观察患者配偶受孕情况。结果治疗后研究组患者临床总有效率87.76%,对照组患者临床总有效率69.39%;研究组患者精液质量、性激素、中性α-糖苷酶水平均优于对照组(P<0.05)。结论补肾活血汤治疗精索静脉曲张性不育临床疗效显著,能够提高患者的精液质量、提高睾酮水平和精浆中性α-糖苷酶水平,改善精索静脉曲张患者生育能力,值得临床推广。
Objective To study the clinical efficacy of Bushen Huoxue decoction in the treatment of varicocele infertility and its influence on epididymis function and sperm vitality. Methods A total of 98 patients with varicocele infertility who were treated in our hospital from August 2016 to July 2018 were selected. The patients were randomly divided into control group of 49 cases and study group of 49 cases. The patients in the control group were treated with Maizhiling plus Wuzi Yanzong pill; the patients in the study group were treated with Bushen Huoxue decoction. After 12 weeks of treatment, the clinical efficacy of the patients was evaluated. The semen quality(including semen volume, sperm density, sperm motility, forward-moving sperm), sex hormones, and seminal plasma neutral α-glucosidase in the two groups were compared before and after treatment. After the end of treatment, the patients were followed up for 3 months to observe the pregnancy of the patients' spouse. Results After treatment, the total effective rate of the study group was87.76%, and the total effective rate of the control group was 69.39%. The semen quality, sex hormone and neutral α-glucosidase levels in the study group were better than those in the control group(P<0.05). Conclusion Bushen Huoxue decoction has a significant clinical effect in treating varicocele infertility. It can improve the semen quality, improve testosterone level and seminal plasma neutral α-glucosidase level, and improve the fertility of patients with varicocele.It is worthy of clinical promotion.
Objective To study the clinical efficacy of Bushen Huoxue decoction in the treatment of varicocele infertility and its influence on epididymis function and sperm vitality. Methods A total of 98 patients with varicocele infertility who were treated in our hospital from August 2016 to July 2018 were selected. The patients were randomly divided into control group of 49 cases and study group of 49 cases. The patients in the control group were treated with Maizhiling plus Wuzi Yanzong pill; the patients in the study group were treated with Bushen Huoxue decoction. After 12 weeks of treatment, the clinical efficacy of the patients was evaluated. The semen quality(including semen volume, sperm density, sperm motility, forward-moving sperm), sex hormones, and seminal plasma neutral α-glucosidase in the two groups were compared before and after treatment. After the end of treatment, the patients were followed up for 3 months to observe the pregnancy of the patients' spouse. Results After treatment, the total effective rate of the study group was87.76%, and the total effective rate of the control group was 69.39%. The semen quality, sex hormone and neutral α-glucosidase levels in the study group were better than those in the control group(P<0.05). Conclusion Bushen Huoxue decoction has a significant clinical effect in treating varicocele infertility. It can improve the semen quality, improve testosterone level and seminal plasma neutral α-glucosidase level, and improve the fertility of patients with varicocele.It is worthy of clinical promotion.
引文
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[4]赵小东,刘琳,马鹏程,等.显微镜下精索静脉结扎术治疗男性不育伴精索静脉曲张患者的疗效比较[J].国际泌尿系统杂志,2018,38(5):798-800.
[5]世界卫生组织.人类精液及精子-宫颈黏液相互作用实验室检验手册[M].北京:人民卫生出版社,2001:51-52.
[6]周永昌,郭万学.超声医学[M].北京:科学技术文献出版社,2002:952-954.
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[8]鞠建,宋倩,解吕中.高频彩色多普勒超声在精索静脉曲张性不孕不育症患者预后评估中的应用[J].检验医学,2016,31(9):61-62.
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[10]国家药品监督管理局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:292-318.
[11]夏烨,陈向锋,童国庆.生精片联合经脐单孔腹腔镜精索静脉高位结扎术对精索静脉曲张不育症患者术后精液质量及受孕率的影响[J].中医药信息,2018,35(4):94-98.
[12]张华锋,赵佳.保留动脉显微手术联合麒麟丸治疗双侧精索静脉曲张致少弱精子症[J].中华男科学杂志,2016,22(10):902-905.
[13]赵亮宇,田汝辉,黄煜华,等.精索静脉曲张与精索脉管解剖的相关性[J].中华医学杂志,2017,97(16):1244-1247.
[14]苏宏伟,李婷,樊勇,等.不同手术方式对精索静脉曲张患者精液质量和配偶受孕率影响[J].河北医学,2017,23(3):380-384.
[15]史秋华,李沙沙,王磊.精索静脉高位结扎术联合抗氧化剂治疗对精索静脉曲张不育症患者精液质量的影响[J].中国性科学,2016,25(5):110-112.
[16]倪良玉,孙志兴,黄健,等.精索静脉曲张性不育症的病因病机探讨和治疗对策[J].云南中医中药杂志,2017,38(5):38-40.
[2]邓新喜,黄发荣.显微镜精索静脉结扎术对性功能改善的疗效观察[J].江西医药,2017,52(1):52-54.
[3]方跃坤,崔云,郑军状,等.中医药治疗精索静脉曲张不育症的研究进展[J].浙江中医杂志,2017,52(1):71-73.
[4]赵小东,刘琳,马鹏程,等.显微镜下精索静脉结扎术治疗男性不育伴精索静脉曲张患者的疗效比较[J].国际泌尿系统杂志,2018,38(5):798-800.
[5]世界卫生组织.人类精液及精子-宫颈黏液相互作用实验室检验手册[M].北京:人民卫生出版社,2001:51-52.
[6]周永昌,郭万学.超声医学[M].北京:科学技术文献出版社,2002:952-954.
[7]李敏,李凤华.精索静脉曲张的超声诊断研究现状及展望[J].中国男科学杂志,2011,25(1):64-68.
[8]鞠建,宋倩,解吕中.高频彩色多普勒超声在精索静脉曲张性不孕不育症患者预后评估中的应用[J].检验医学,2016,31(9):61-62.
[9]国家技术监督局.中医临床诊疗术语·证候部分[M].北京:中国标准出版社,1997:15.
[10]国家药品监督管理局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:292-318.
[11]夏烨,陈向锋,童国庆.生精片联合经脐单孔腹腔镜精索静脉高位结扎术对精索静脉曲张不育症患者术后精液质量及受孕率的影响[J].中医药信息,2018,35(4):94-98.
[12]张华锋,赵佳.保留动脉显微手术联合麒麟丸治疗双侧精索静脉曲张致少弱精子症[J].中华男科学杂志,2016,22(10):902-905.
[13]赵亮宇,田汝辉,黄煜华,等.精索静脉曲张与精索脉管解剖的相关性[J].中华医学杂志,2017,97(16):1244-1247.
[14]苏宏伟,李婷,樊勇,等.不同手术方式对精索静脉曲张患者精液质量和配偶受孕率影响[J].河北医学,2017,23(3):380-384.
[15]史秋华,李沙沙,王磊.精索静脉高位结扎术联合抗氧化剂治疗对精索静脉曲张不育症患者精液质量的影响[J].中国性科学,2016,25(5):110-112.
[16]倪良玉,孙志兴,黄健,等.精索静脉曲张性不育症的病因病机探讨和治疗对策[J].云南中医中药杂志,2017,38(5):38-40.