氨甲环酸片红外分光光度法鉴别的改进
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摘要
改进氨甲环酸片(薄膜衣片)红外分光光度法鉴别。样品前处理方式中过滤的步骤以高转速离心(10000 r·min~(-1),离心20 min)替代,以避免辅料等在过滤过程中堵塞滤膜或滤器的滤孔,造成过滤困难、耗时长;低温放置样品溶液以促进结晶的析出,利于晶体的获得,便于红外检测。改进后的方法得到的结晶明显、量大、效率高;该方法简便、高效,适用于氨甲环酸片的批量处理。
To improve IR identification of Tranexamic Acid tablets( film-coated tablets),filtration was replaced by centrifugation by high speed( 10000 r·min~(-1) for 20 min) in the pre-process,which could reduce the interference of inactive ingredient as difficult filtration and time consuming for blockage. Sample solution was stored in low temperature for crystallization which could be easily tested by IR. More crystals were efficiently acquired by the improved method. The method was simple and efficient,which could be applied in batch process of Tranexamic Acid tablets.
To improve IR identification of Tranexamic Acid tablets( film-coated tablets),filtration was replaced by centrifugation by high speed( 10000 r·min~(-1) for 20 min) in the pre-process,which could reduce the interference of inactive ingredient as difficult filtration and time consuming for blockage. Sample solution was stored in low temperature for crystallization which could be easily tested by IR. More crystals were efficiently acquired by the improved method. The method was simple and efficient,which could be applied in batch process of Tranexamic Acid tablets.
引文
[1]方艳艳.氨甲环酸的检测方法及其药理活性的研究进展[J].医药,2015(25):194-195.
[2]王强,王霞,汤玉兰,等.氨甲环酸制剂开发的研究进展[J].中国药业,2014(23):1-4.
[3]王强,胡伟,徐芳辉,等.氨甲环酸-一种治疗黄褐斑的重要辅助药物[J].中南药学,2014(12):889-895.
[4]胡焰,李健和,王霞,等.氨甲环酸治疗月经过多的研究进展[J].中国新药与临床杂志,2014(33):105-110.
[5]国家药典委员会编.中华人民共和国药典(二部)[S]. 2015年版.北京:中国医药科技出版社,2015:1144-1145.
[6]张平,张婷.有机化学《过滤及重结晶》实验综述报告[J].科技视界,2015(22):51,87.
[2]王强,王霞,汤玉兰,等.氨甲环酸制剂开发的研究进展[J].中国药业,2014(23):1-4.
[3]王强,胡伟,徐芳辉,等.氨甲环酸-一种治疗黄褐斑的重要辅助药物[J].中南药学,2014(12):889-895.
[4]胡焰,李健和,王霞,等.氨甲环酸治疗月经过多的研究进展[J].中国新药与临床杂志,2014(33):105-110.
[5]国家药典委员会编.中华人民共和国药典(二部)[S]. 2015年版.北京:中国医药科技出版社,2015:1144-1145.
[6]张平,张婷.有机化学《过滤及重结晶》实验综述报告[J].科技视界,2015(22):51,87.