摘要
改进氨甲环酸片(薄膜衣片)红外分光光度法鉴别。样品前处理方式中过滤的步骤以高转速离心(10000 r·min~(-1),离心20 min)替代,以避免辅料等在过滤过程中堵塞滤膜或滤器的滤孔,造成过滤困难、耗时长;低温放置样品溶液以促进结晶的析出,利于晶体的获得,便于红外检测。改进后的方法得到的结晶明显、量大、效率高;该方法简便、高效,适用于氨甲环酸片的批量处理。
To improve IR identification of Tranexamic Acid tablets( film-coated tablets),filtration was replaced by centrifugation by high speed( 10000 r·min~(-1) for 20 min) in the pre-process,which could reduce the interference of inactive ingredient as difficult filtration and time consuming for blockage. Sample solution was stored in low temperature for crystallization which could be easily tested by IR. More crystals were efficiently acquired by the improved method. The method was simple and efficient,which could be applied in batch process of Tranexamic Acid tablets.
引文
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