超声造影监测肾移植术后并发症的应用进展
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摘要
肾移植术后并发症的早期诊断和及时治疗对移植肾存活具有重要意义。CEUS技术提高了对低强度信号及低流速血流的显示能力,结合时间-强度曲线(TIC)各参数,可以更有效地增加移植肾并发症检出的敏感度、特异度及准确率。
The early diagnosis and timely treatment of complications after renal transplantation are important significance to graft survival.CEUS can improve the detection of low intensity signal and low velocity blood flow.Combining with parameters of time-intensity curve(TIC),CEUS can more effectively improve the sensitivity,specificity and accuracy in diagnosis of complications after renal transplantation.
The early diagnosis and timely treatment of complications after renal transplantation are important significance to graft survival.CEUS can improve the detection of low intensity signal and low velocity blood flow.Combining with parameters of time-intensity curve(TIC),CEUS can more effectively improve the sensitivity,specificity and accuracy in diagnosis of complications after renal transplantation.
引文
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[9]Rapoport N,Gao Z,Kennedy A.Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy.J Natl Cancer Inst,2007,99(14):1095-1106.
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[13]Kay DH,Mazonakis M,Geddes C,et al.Ultrasonic microbubble contrast agents and the transplant kidney.Clin Radiol,2009,64(11):1081-1087.
[14]Higgins R,Zehnder D,Chen K,et al.The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation.Nephrol Dial Transplant,2010,25(4):1306-1312.
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[16]Krejci K,Zadrazil J,Tichy T,et al.Sonographic findings in borderline changes and subclinical acute renal allograft rejection.Eur J Radiol,2009,71(2):288-295.
[17]万广生,郑克立,吕明德,等.声学造影与彩色多普勒能量图定量分析诊断移植肾急性排斥反应.中华器官移植杂志,2002,23(3):136-138.
[18]龚渭冰,罗国新,王莎莎.超声造影在移植肾急性排斥反应的初步临床研究.临床超声医学杂志,2008,10(1):7-9.
[19]李国斌.经静脉声学造影对移植肾急性排斥反应的诊断价值.中外医疗,2013,32(6):58-59.
[20]纪丽景,王宝平,罗利红,等.细胞间黏附分子-1靶向微泡超声造影成像评价肾移植后急性排异反应.中华超声影像学杂志,2011,20(12):1070-1073.
[21]王宝平.超声辐射力结合靶向超声微泡评价小鼠肾缺血再灌注损伤的研究.广州:南方医科大学,2012.
[22]刘永生,殷淑君,孙强,等.肾移植术后围手术期出血的诊断与治疗.中国临床实用医学,2010,4(9):96-98.
[23]Xu RX,Li YK,Li T,et al.Real-time 3-dimensional contrastenhanced ultrasound in detecting hemorrhage of blunt renal trauma.Am J Emerg Med,2013,31(10):1427-1431.
[24]邢晋放,杜联芳,李凡,等.SonoVue超声造影在移植肾周血肿临床诊断中的价值.中国组织工程研究与临床康复,2009,13(18):3413-3416.
[25]Seratnahaei A,Shah A,Bodiwala K,et al.Management of transplant renal artery stenosis.Angiology,2011,62(3):219-224.
[26]Su CH,Lian JD,Chang HR,et al.Long-Term outcomes of patients treated with primary stenting for transplant renal artery stenosis:A 10-year case cohort study.World J Surg,2012,36(1):222-228.
[27]张艳.超声造影诊断移植肾动脉狭窄的动物实验及临床研究.广州:南方医科大学,2007.
[28]Grzelak P,Kurnatowska I,Nowicki M,et al.Detection of transplant renal artery stenosis in the early postoperative period with analysis of parenchymal perfusion with ultrasound contrast agent.Ann Transplant,2013,18:187-194.
[29]Fathi T,Samhan M,Gawish A,et al.Renal allograft venous thrombosis is salvageable.Transplant Proc,2007,39(4):1120-1121.
[30]Grzelak P,Kurnatowska I,Sapieha M,et al.Disturbances of kidney graft perfusion as indicators of acute renal vein thrombosis in contrast-enhanced ultrasonography.Transplant Proc,2011,43(8):3018-3020.
[31]Schwenger V,Korosoglou G,Hinkel UP,et al.Real-time contrast-enhanced sonography of renal transplant recipients predicts chronic allograft nephropathy.Am J Transplant,2006,6(3):609-615.
[2]吴恩惠,邓又斌,谢明星,等.中华影像医学.2版.北京:人民卫生出版社,2011:678-679.
[3]Torraco A,Tomasella G,Baldan N,et al.Efficacy of SH U 508A(levovist)in color doppler imaging of pancreatic grafts.Transplant Proc,1998,30(5):1950-1951.
[4]Tsuruoka K,Yasuda T,Koitabashi KA,et al.Evaluation of renal microcirculation by contrast-enhanced ultrasound with sonazoid(TM)as a contrast agent.Int Heart J,2010,51(3):176-182.
[5]周盛,齐青,何婉媛,等.超声造影定量分析在移植肾急性排异中的应用研究.中华超声影像学杂志,2014,23(7):605-608.
[6]Ignee A,Straub B,Brix D,et al.The value of contrast enhanced ultrasound(CEUS)in the characterisation of patients with renal masses.Clin Hemorheol Microcirc,2010,46(4):275-290.
[7]Siracusano S,Bertolotto M,Ciciliato S,et al.The current role of contrast-enhanced ultrasound(CEUS)imaging in the evaluation of renal pathology.World J Urol,2011,29(5):633-638.
[8]Deshpande N,Needles A,Willmann JK.Molecular ultrasound imaging:Current status and future directions.Clin Radiol,2010,65(7,SI):567-581.
[9]Rapoport N,Gao Z,Kennedy A.Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy.J Natl Cancer Inst,2007,99(14):1095-1106.
[10]Zheng SG,Xu HX,Chen HR.Nano/microparticles and ultrasound contrast agents.World J Radiol,2013,5(12):468-471.
[11]Lum AF,Borden MA,Dayton PA,et al.Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles.J Control Release,2006,111(1/2):128-134.
[12]Enhesari A,Mardpour S,Makki Z,et al.Early ultrasound assessment of renal transplantation as the valuable biomarker of long lasting graft survival:A cross-sectional study.Iran J Radiol,2014,11(1):e11492.
[13]Kay DH,Mazonakis M,Geddes C,et al.Ultrasonic microbubble contrast agents and the transplant kidney.Clin Radiol,2009,64(11):1081-1087.
[14]Higgins R,Zehnder D,Chen K,et al.The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation.Nephrol Dial Transplant,2010,25(4):1306-1312.
[15]Ikegami M,Akiyama T.Effect of ultrasound contrast medium in color Doppler of blood flow in transplant kidneys.Nihon Rinsho,1998,56(4):1035-1039.
[16]Krejci K,Zadrazil J,Tichy T,et al.Sonographic findings in borderline changes and subclinical acute renal allograft rejection.Eur J Radiol,2009,71(2):288-295.
[17]万广生,郑克立,吕明德,等.声学造影与彩色多普勒能量图定量分析诊断移植肾急性排斥反应.中华器官移植杂志,2002,23(3):136-138.
[18]龚渭冰,罗国新,王莎莎.超声造影在移植肾急性排斥反应的初步临床研究.临床超声医学杂志,2008,10(1):7-9.
[19]李国斌.经静脉声学造影对移植肾急性排斥反应的诊断价值.中外医疗,2013,32(6):58-59.
[20]纪丽景,王宝平,罗利红,等.细胞间黏附分子-1靶向微泡超声造影成像评价肾移植后急性排异反应.中华超声影像学杂志,2011,20(12):1070-1073.
[21]王宝平.超声辐射力结合靶向超声微泡评价小鼠肾缺血再灌注损伤的研究.广州:南方医科大学,2012.
[22]刘永生,殷淑君,孙强,等.肾移植术后围手术期出血的诊断与治疗.中国临床实用医学,2010,4(9):96-98.
[23]Xu RX,Li YK,Li T,et al.Real-time 3-dimensional contrastenhanced ultrasound in detecting hemorrhage of blunt renal trauma.Am J Emerg Med,2013,31(10):1427-1431.
[24]邢晋放,杜联芳,李凡,等.SonoVue超声造影在移植肾周血肿临床诊断中的价值.中国组织工程研究与临床康复,2009,13(18):3413-3416.
[25]Seratnahaei A,Shah A,Bodiwala K,et al.Management of transplant renal artery stenosis.Angiology,2011,62(3):219-224.
[26]Su CH,Lian JD,Chang HR,et al.Long-Term outcomes of patients treated with primary stenting for transplant renal artery stenosis:A 10-year case cohort study.World J Surg,2012,36(1):222-228.
[27]张艳.超声造影诊断移植肾动脉狭窄的动物实验及临床研究.广州:南方医科大学,2007.
[28]Grzelak P,Kurnatowska I,Nowicki M,et al.Detection of transplant renal artery stenosis in the early postoperative period with analysis of parenchymal perfusion with ultrasound contrast agent.Ann Transplant,2013,18:187-194.
[29]Fathi T,Samhan M,Gawish A,et al.Renal allograft venous thrombosis is salvageable.Transplant Proc,2007,39(4):1120-1121.
[30]Grzelak P,Kurnatowska I,Sapieha M,et al.Disturbances of kidney graft perfusion as indicators of acute renal vein thrombosis in contrast-enhanced ultrasonography.Transplant Proc,2011,43(8):3018-3020.
[31]Schwenger V,Korosoglou G,Hinkel UP,et al.Real-time contrast-enhanced sonography of renal transplant recipients predicts chronic allograft nephropathy.Am J Transplant,2006,6(3):609-615.