超声靶向微泡破坏技术评价心肌缺血再灌注损伤的研究进展
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摘要
心肌缺血再灌注损伤是指原缺血心肌恢复血供后发生更为严重的损伤,再灌注损伤减弱了再灌注给机体带来的益处。心肌缺血再灌注损伤在靶向超声分子显像技术中有多种研究,包括超声靶向破坏微泡技术对心肌缺血再灌注的评价与介导靶向治疗,其中携IL-8单克隆抗体的超声靶向微泡破坏技术可明显减轻再灌注后炎症反应引起的损伤,减轻心肌坏死程度。
Myocardial ischemia-reperfusion injury refers to more severe injury occurred after recovery from previous myocardial ischemia,which reduces the benefit induced by reperfusion. Effects of targeted ultrasound molecular imaging technology on myocardial ischemia-reperfusion injury has been researched a lot,including evaluation for myocardial ischemia-reperfusion by ultrasound-targeted microbubble destruction as well as mediating targeted therapy,among which,IL-8 monoclonal antibody based ultrasound-targeted microbubble destruction could significantly reduce the injury caused by inflammation after reperfusion injury,and reduce myocardial necrosis.
Myocardial ischemia-reperfusion injury refers to more severe injury occurred after recovery from previous myocardial ischemia,which reduces the benefit induced by reperfusion. Effects of targeted ultrasound molecular imaging technology on myocardial ischemia-reperfusion injury has been researched a lot,including evaluation for myocardial ischemia-reperfusion by ultrasound-targeted microbubble destruction as well as mediating targeted therapy,among which,IL-8 monoclonal antibody based ultrasound-targeted microbubble destruction could significantly reduce the injury caused by inflammation after reperfusion injury,and reduce myocardial necrosis.
引文
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[14]Lindner JR,Song J,Christiansen J,et al.Ultrasound assessment of inflammmion and renal tissue injury witll microbubbles targeted to P-selectin[J].Circulation,2001,104(17):2107-2112.
[15]Linder JR.Contrast ultrasound molecular imaging of inflammation in cardiovascular disease[J].Cardiovasc Res,2009,84(2):182-189.
[16]Frangogiannis NG,Smith CW,Entman ML.The inflammatory response in myocardial infarctionl[J].Cardiovasc Res,2002,53(1):31-47.
[17]Yan Y,Liao Y,Yang L,et al.Late-phase detection of recent myocardial ischaemia using ultrasound molecular imaging targeted to intercellular adhesion molecule-1[J].Cardiovasc Res,2011,89(1):175-183.
[18]尚艳文,唐红,韦馨,等.抗细胞间黏附分子-1靶向液态氟碳微球对大鼠缺血再灌注损伤心肌的靶向结合和抗炎作用的研究[J].中国修复重建外科杂志,2013,27(3):340-344
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[22]Blankenberg S,Barbaux S,Tiret L.Adhesion molecules and atherosclerosis[J].Atherosclerosis,2003,170(2):191-203.
[23]Timmers L,Pasterkamp G,de Hoog VC,et al.The innate immune response in reperfused myocardium[J].Cardiovasc Res,2012,94(2):276-283.
[24]Zhang M,Chen L.Status of cytokines in ischemia reperfusion induced heart injury[J].Cardiovasc Hematol Disord Drug Tragets,2008,8(3):161-172.
[25]Romson JL,Hook BG,Kumkel SL,et al.Reduction of the exten of ischemic myocardial injury by meutrophil depletion in the dog[J].Circulation,1983,675(5):1016-1023.
[26]凌智瑜,王志刚,冉海涛,等.超声微泡造影剂介导VEGf基因治疗大鼠心肌缺血的实验性研究[J].中国超声医学杂志,2002,18(7):502-504.
[27]蔡丽萍,方平,王捍平等.靶向超声介导VEGF_(165)c DNA基因及抗ICAM-1单克隆抗体治疗大鼠心肌缺血的对比性研究[J].中华超声影像学杂志,2010,19(4):336-339.
[2]Anderson CR,Hu X,Zhang H,et al.Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent[J].Invest Radiol,201l,46(4):215-224.
[3]Deshpande N,Ren Y,Foygel K,et al.Tumor angiogenic marker expression levels during tumor growth:longitudinal assessment with molecularly targeted microbubbles and US imaging[J].Radiology,2011,258(3):804-811.
[4]Klibanov Al.Preparation of targeted microbubbles:ultrasound contrast agents for molecular imaging[J].Med Biol Eng Comput,2009,47(8):875-882.
[5]Hyvelin JM,Tardy I,Bettinger T,et al.Ultrasound molecular imaging of transient acute myocardial ischemia with a clinically translatable Pand E-selectin targeted contrast agent:correlation with the expression of selectins[J].Invest Radiol,2014,49(4):224-235.
[6]Thomas R,Cheng Y,Yan J,et al.Upregulation of coronary endothelial P-selectin in a monkey heart ischemia reperfusion model[J].J Mol Histol,2010,41(4-5):277-287.
[7]靳康,阚红卫.P-选择素对心肌缺血再灌注损伤的介导作用[J].中国临床药理学与治疗学,2010,15(2):238-240.
[8]刘珍,阚红卫,杨雁,等.大鼠心肌缺血再灌注损伤中Cyslt2r的促进作用[J].安徽医药,2014,18(4):606-609.
[9]Lindner JR,Coggins MP,Kaul S,et al.Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin-and complement-mediated adherence to activated leukocytes[J].Circulation,2000,101(6):668-675.
[10]Kaufmann BA,Lewis C,Xie A,et al.Detection of recent myocardial ischaemia by molecular imaging of P-selectin with targeted contrast echocardiography[J].Eur Heart J,2007,28(16):2011-2017.
[11]纪丽景,杨莉,燕翼,等.P选择素靶向超声分子成像评价小鼠心肌缺血再灌注损伤[J].中华医学杂志,2009,89(24):1698-1701.
[12]Klibanov AL.Ultrasound molecular imaging with targeted microbubble contrast agents[J].J Nucl Cardiol,2007,14(6):876-884.
[13]Kaufmann BA,Lewis C,Xie A,et al.Detection of recent myocardial ischaemia by molecular imaging of P-selectin targeted contrast echocardiography[J].Eur Heart J,2007,28(16):2011-2017.
[14]Lindner JR,Song J,Christiansen J,et al.Ultrasound assessment of inflammmion and renal tissue injury witll microbubbles targeted to P-selectin[J].Circulation,2001,104(17):2107-2112.
[15]Linder JR.Contrast ultrasound molecular imaging of inflammation in cardiovascular disease[J].Cardiovasc Res,2009,84(2):182-189.
[16]Frangogiannis NG,Smith CW,Entman ML.The inflammatory response in myocardial infarctionl[J].Cardiovasc Res,2002,53(1):31-47.
[17]Yan Y,Liao Y,Yang L,et al.Late-phase detection of recent myocardial ischaemia using ultrasound molecular imaging targeted to intercellular adhesion molecule-1[J].Cardiovasc Res,2011,89(1):175-183.
[18]尚艳文,唐红,韦馨,等.抗细胞间黏附分子-1靶向液态氟碳微球对大鼠缺血再灌注损伤心肌的靶向结合和抗炎作用的研究[J].中国修复重建外科杂志,2013,27(3):340-344
[19]Weller GE,Lu E,Csikari MM,et al.Ultrasound imaging of acute cardiac transplant rejection with microbubbles targeted to intercellular adhesion molecule-1[J].Circulation,2003,108(2):218-224.
[20]Weller GE,Villanueva FS,Tom EM,et al.Targeted ultrasound contrast agents:In vitro assessment of endothelial dysfunction and multitargeting to ICAM-1 and sialyl Lewisx[J].Bioteclnol Bioeng,2005,92(6):780-788.
[21]Simpson PJ,Todd RF,Mickelson JK,et al.Sustained limitation of myocardial reperfusion injury by a monoclonal antibody that alters leukocyte function[J].Circulation,1990,81(1):226-237.
[22]Blankenberg S,Barbaux S,Tiret L.Adhesion molecules and atherosclerosis[J].Atherosclerosis,2003,170(2):191-203.
[23]Timmers L,Pasterkamp G,de Hoog VC,et al.The innate immune response in reperfused myocardium[J].Cardiovasc Res,2012,94(2):276-283.
[24]Zhang M,Chen L.Status of cytokines in ischemia reperfusion induced heart injury[J].Cardiovasc Hematol Disord Drug Tragets,2008,8(3):161-172.
[25]Romson JL,Hook BG,Kumkel SL,et al.Reduction of the exten of ischemic myocardial injury by meutrophil depletion in the dog[J].Circulation,1983,675(5):1016-1023.
[26]凌智瑜,王志刚,冉海涛,等.超声微泡造影剂介导VEGf基因治疗大鼠心肌缺血的实验性研究[J].中国超声医学杂志,2002,18(7):502-504.
[27]蔡丽萍,方平,王捍平等.靶向超声介导VEGF_(165)c DNA基因及抗ICAM-1单克隆抗体治疗大鼠心肌缺血的对比性研究[J].中华超声影像学杂志,2010,19(4):336-339.