DNA纳米自组装技术研究进展及应用
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摘要
本文总结了DNA纳米自组装技术在近20年来的研究,归纳了DNA纳米结构的优势及三种组装技术的原理和发展历程。阐述该技术在纳米材料制造、药物靶向递送、DNA计算等方面的应用。最后,探讨了DNA纳米技术的发展前景,并对其相关应用进行展望。
This paper summarized the research of DNA nano-assembly technology in recent 20 years, and summarized the advantages of DNA nano-structure and the principle and development process of three kinds of assembly technology. And then it elaborated the application of this technology in nano-material manufacturing, drug targeted delivery, DNA calculation. Finally, the paper discussed the development prospect of DNA nanotechnology and prospected its related applications.
This paper summarized the research of DNA nano-assembly technology in recent 20 years, and summarized the advantages of DNA nano-structure and the principle and development process of three kinds of assembly technology. And then it elaborated the application of this technology in nano-material manufacturing, drug targeted delivery, DNA calculation. Finally, the paper discussed the development prospect of DNA nanotechnology and prospected its related applications.
引文
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[2]Winfree E,Liu F,Wenzler L A,et.al.Design and selfassembly of two-dimensional DNA crystals[J].Nature,1998,394(6693):539.
[3]Yan H,Park S H,Ginkelstein G,etal.Science,2003,301:1882-1884.
[4]Han DR,Pal S,Nangreave J,et al.DNA Origami with Complex Curvaturesin Three-Dimensional Space.Science,2011,Vol.332(6027):342-346.
[5]Yin P,Hariadi R F,Sahu S,et al.Programming DNA tube circumferences.Science,2008,321:824–826.
[6]Wei B,Dai M,Yin P.Complex shapes self-assembled from single-stranded DNAtiles.Nature,2012,485:623–626.
[7]Han X,Li Y,Deng Z.DNA-wrapped single-walled carbon nanotubes as rigid templates for assembling linear gold nanoparticle arrays[J].Adv Mater,2007,19(11):1518-1522.
[8]Yang Jing,Zhang Cheng,XU Jin.Molecular Logic Computing Model Based on Self-assembly of DNA Nanoparticles[J].Chinese Science Bulletin,2011,56(33):3566-3571.
[9]Jiang Q,Song C,Nangreave J,et al.DNA origami as a carrier for circumvention of drug resistance.[J].Journal of the American Chemical Society,2012,134(32):13396.