金核壳结构复合纳米颗粒在生物医学中的应用
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摘要
核壳结构纳米材料是一种新型复合材料。贵金属金纳米核壳材料同时具有核和壳的性质,以及独特的光学、电学、催化性能和良好的生物相容性,因此在生物、化学、医学等领域具有巨大的应用价值。基于文献分析,综述了金及其核壳结构纳米复合颗粒在生物及医学上的应用,包括蛋白质、DNA、细菌和病毒的检测,以及肿瘤热疗、生物成像、生物传感、药物传递与释放等。并对完善制备技术以便更好地应用于临床进行了展望。
Au nanocomposites,as a new core-shell structure,have the advantage of both the core and shell structure, which endows them with excellent optical, electrical and catalytic properties as well as with good compatibility. Au nanocomposites are, therefore, widely used in the fields of biology, medicine and chemistry. Basing on literature analysis, the present article mainly reviewed the application of the core-shell Au in biology and medicine, including the detection of protein, DNA, bacterial and virus, as well as tumor hyperthermia, bioimaging, biosensor, drug delivery and release. And an outlook was also provided in this review to improve the preparation technology for better clinical application.
Au nanocomposites,as a new core-shell structure,have the advantage of both the core and shell structure, which endows them with excellent optical, electrical and catalytic properties as well as with good compatibility. Au nanocomposites are, therefore, widely used in the fields of biology, medicine and chemistry. Basing on literature analysis, the present article mainly reviewed the application of the core-shell Au in biology and medicine, including the detection of protein, DNA, bacterial and virus, as well as tumor hyperthermia, bioimaging, biosensor, drug delivery and release. And an outlook was also provided in this review to improve the preparation technology for better clinical application.
引文
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[18]颜浩,高志云,张桂云,等.HIV-1新发感染快速检测方法的建立与初步评价[J].中国艾滋病性病,2014,20(6):394-397.YAN H,GAO Z Y,ZHANG G Y,et al.Establishment and preliminary evaluation of a rapid detection method for HIV-1 new infection[J].Chinese journal of Aids&STD,2014,20(6):394-397.
[19]LAL S,CLARE S E,HALAS N J.Nanoshell-enabled photothermal cancer therapy:Impending clinical impact[J].Accounts Chem Res,2008,41(12):1842-1851.
[20]梁重实.Au@Si O2纳米复合材料的制备及其在肝癌光热治疗中的应用研究[D].上海:华东师范大学,2011:17-19.LIANG C S.Preparation of Au@Si O2 nanocomposite and its application in photothermal therapy of hepatocellular carcinoma[D].Shanghai:East China Normal University,2011:17-19.
[21]许娟,陈智栋,孙毅,等.Au改性Ti O2纳米复合物对人结肠癌细胞的光催化杀伤作用[J].化学学报,2008,66(10):1163-1167.XU J,CHEN Z D,SUN Y,et al.Photocatalytic killing effect of Au modified Ti O2 nanocomposite on human colon cancer cells[J].Acta chem sin,2008,66(10):1163-1167.
[22]WU Y N,CHEN D H,SHI X Y,et al.Cancer-cellspecificy to toxicity of non-oxidized iron elements niron core-gold shell NPs[J].Nanomedicine nanotechnology biology&medicine,2011,7(4):420-427.
[23]LAL S,CLARE S E,HALAS N J.Nanoshell-enabled photothermal cancer therapy:Impending clinical impact[J].Accounts Chem Res,2008,41(12):1842-1851.
[24]ZHOU T,WU B Y,XING D.Bio-modified Fe3O4core/Au shell nanoparticles for targeting and multimodal imaging of cancer cells[J].J Mater Chem,2012,22(2),470-477.
[25]GOBIN A M,LEE M H,HALAS N J,et al.Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy[J].Nano Lett,2007,7(7):1929-1934.
[26]LIN C J,LEE C H,HSIEH J T,et al.Synthesis of fluorescent metallic nanoclusters toward biomedical application:recent progress and present challenges[J].Journal of medical&biological engineering,2009,29(6):276-283.
[27]LIN S Y,CHEN N T,SUM S P,et al.Ligand exchanged photoluminescent gold quantum dots functionalized with leading peptides for nuclear targeting and intracellular imaging[J].Chem Commun,2008,39:4762-4764.
[28]封宾.金包覆核壳结构纳米复合材料的制备及性能研究[D].北京:北京交通大学,2010:13-17.FENG B.Preparation and properties of gold coated core shell nanocomposites[D].Beijing:Beijing Jiaotong University,2010:13-17.
[29]LAKSHMANAN S B,ZOU X,HOSSU M,et al.Local field enhanced Au/Cu S nanocomposites as efficient photothermal transducer agents for cancer treatment[J].Journal of biomedical nanotechnology,2012,8(6):883-890.
[30]MAXWELL D J,TAYLOR J R,NIE S M.Self-assembled nanoparticle probes for recognition and detection of biomolecules[J].J Am Chem Soc,2002,124(32):9606-9612.
[31]李春梅.金纳米与磁纳米颗粒及其复合物的生物传感和细胞成像研究[D].重庆:西南大学,2013:1-109.LI C M.Biosensing and cell imaging of gold nanoparticles and magnetic nanoparticles and their composites[D].Chongqing:Southwestern University,2013:1-109.
[32]张伟.基于Au/Ce O2-CS复合纳米材料修饰的过氧化氢生物传感器研究[D].重庆:重庆医科大学,2012:34-37.ZHANG W.Hydrogen peroxide biosensor based on Au/Ce O2-CS composite nanomaterial modified[D].Chongqing:Medical University of Chongqing,2012:34-37.
[33]GHOSH R,HURI C,PARIA S.Core/shell nanoparticles:Classes,properties,synthesis mechanisms,characterization and applications[J].Chem rev,2011,112(324):2373-2433.
[34]SERSHEN S,WEST J.Implantable,polymeric systems for modulated drug delivery[J].Advanced drug delivery review,2002,54(9):1225-1235.
[35]JIN Y,GAO X.Spectrally tunable leakage-free gold nanocontainers[J].J Am Chem Soc,2009,131(49):17774-17776.
[36]XING Z M,LIU Z G,ZU Y G,et al.Synthesis of camptothecin-loaded gold nanomaterial[J].Appl surf sci,2010,256(12):3917-3920.
[37]DHAR S,DANIEL W L,GILJOHANN D A,et al.Lippard poly-valent oligonucleotide gold nanoparticle conjugates as delivery ve-hicles for platinum(IV)warheads[J].J Am Chem Soc,2010,131(41):14652-14653.
[38]LIU H Y,DONG C,LI L L,et al.Multifunctional gold Nanoshells on silica nanorattles:A platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity[J].Angewandte chemie,2011,50(4):891-895.
[39]KAYAL S,RAMANUJAN R V.Anti-cancer drug loaded iron-gold core-shell nanoparticles(Fe@Au)for magnetic drug targeting[J].Journal of nanoscience&nanotechnology,2010,10(9):5527-5539.
[40]CHAO X,GUO L,ZHAO Y,et al.PEG-modified gold mag nanoparticles(PGMNs)combined with the magnetic field for local drug delivery[J].Journal of drug targeting,2011,19(3):161-170.
[2]LIU X Y,LIU M H,LUO Y C,et al.Strong metal-support interactions between gold nanoparticles and Zn O nanorods in CO oxidation[J].J Am Chem Soc,2012,134:10251-10258.
[3]张莹,燕宁宁,朱忠其,等.Ag-Ti O2光催化剂的制备、性能及机理研究[J].功能材料,2013,44(2):172-176.ZHANG Y,YAN N N,ZHU Z Q,et al.Study on preparation,properties and mechanism of Ag-Ti O2photocatalyst[J].Functional materials,2013,44(2):172-176.
[4]辛铁军,张和鹏,马明亮,等.Fe3O4@Ti O2核壳磁性纳米材料的制备及表征[J].功能材料,2014,45(1):72-77.XIN T J,ZHANG H P,MA M L,et al.Preparation and characterization of core shell magnetic nanomaterials Fe3O4@Ti O2[J].Functional materials,2014,45(1):72-77.
[5]刘贵高.核壳结构纳米颗粒的制备与表征及其性能研究[D].天津:天津大学,2012:13-25.LIU G G.Preparation,characterization and properties of core shell structured nanoparticles[J].Tianjin:Tianjin University,2012:13-25.
[6]郭小华,马建琪,葛红光.核壳结构纳米Zn O@Au的制备、表征和光催化性能研究[J].人工晶体学报,2014,43(4):967-971.GUO X H,MA J Q,GE H G.Preparation,characterization and the research of photocatalytic properties of Zn O@Au nanoparticles with core-shell structure[J].J synth cryst,2014,43(4):967-971.
[7]VAN RIE J,THIELEMANS W.Cellulose-gold nanoparticle hybrid materials.[J].Nanoscale,2017,9(25):8525.
[8]ELLIS E,ZHANG K,LIN Q Y,et al.Biocompatible p Hresponsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy[J].Journal of materials chemistry B,2017,5:4421-4425.
[9]ZANELLA R,SANDOVAL A,SANTIAGO P,et al.New preparation method of gold nanoparticles on Si O2[J].J phys chem.B,2006,110(4917):8559-8565.
[10]陈少鹏.Si O2/Au纳米复合材料的制备及其光学性质研究[D].长春:东北师范大学,2012:16-18.CHEN S P.Preparation and the research of optical properties of Si O2/Au Nanocomposites[D].Changchun:Northeast Normal University,2012:16-18.
[11]罗永丰.基于金银核壳纳米自组装膜的制备与生化分析中的应用[D].长沙:长沙理工大学,2013:26-34.LUO Y F.Preparation and application in biochemical analysis of gold silver core shell nano on self-assembled monolayers[D].Changsha:Changsha University of Science and Technology,2013:26-34.
[12]DU L W,JIANG H,LIU X H,et al.Biosynthesis of gold nanoparticles assisted by Escherichia Coli DH5a and its application on direct electro chemistry of hemoglobin[J].Electrochem commun,2007,9(5):1165-1170.
[13]李光照.金纳米粒子传感器用于检测和金属离子及核壳纳米材料制备[D].南京:南京大学,2011:25-34.LI G Z.Gold nanoparticles sensor is used for detection and preparation of metal ions and core-shell nanomaterials[D].Nanjing:Nanjing University,2011:25-34.
[14]习东,宁琴,卢强华,等.Fe3O4(核)/Au(壳)纳米颗粒探针的制备及其在检测乙型肝炎病毒DNA中的应用[J].中华检验医学杂志,2006,29(4):391-395.XI D,NING Q,LU Q H,et al.Preparation of Fe3O4(core)/Au(shell)nanoparticle probe and its application in detection of hepatitis B virus DNA[J].Chin J lab medi,2006,29(4):391-395.
[15]赵媛.基于纳米材料光学性质的DNA超灵敏检测方法的建立[D].无锡:江南大学,2013:35-38.ZHAO Y.Establishment of ultrasensitive detection method for DNA based on optical properties of nanomaterials[D].Wuxi:Jiangnan University,2013:35-38.
[16]杨文胜,高明远,白玉白,等.纳米材料与生物技术[M].北京:化学工业出版社,2005:154-166.YANG W S,GAO M Y,BAI Y B,et al.Nanomaterials and Biotechnology[M].Beijing:Chemical Industry Press,2005:154-166.
[17]李岩,李宏基,韩立强,等.斑点免疫金渗滤法检测抗乳铁蛋白多克隆抗体特异性研究[J].化学与生物工程,2008,25(2):32-34.LI Y,LI H J,HAN L Q,et al.Specificity of dot immunogold filtration assay for detection of polyclonal antibodies against lactoferrin[J].Chem Bio Eng,2008,25(2):32-34.
[18]颜浩,高志云,张桂云,等.HIV-1新发感染快速检测方法的建立与初步评价[J].中国艾滋病性病,2014,20(6):394-397.YAN H,GAO Z Y,ZHANG G Y,et al.Establishment and preliminary evaluation of a rapid detection method for HIV-1 new infection[J].Chinese journal of Aids&STD,2014,20(6):394-397.
[19]LAL S,CLARE S E,HALAS N J.Nanoshell-enabled photothermal cancer therapy:Impending clinical impact[J].Accounts Chem Res,2008,41(12):1842-1851.
[20]梁重实.Au@Si O2纳米复合材料的制备及其在肝癌光热治疗中的应用研究[D].上海:华东师范大学,2011:17-19.LIANG C S.Preparation of Au@Si O2 nanocomposite and its application in photothermal therapy of hepatocellular carcinoma[D].Shanghai:East China Normal University,2011:17-19.
[21]许娟,陈智栋,孙毅,等.Au改性Ti O2纳米复合物对人结肠癌细胞的光催化杀伤作用[J].化学学报,2008,66(10):1163-1167.XU J,CHEN Z D,SUN Y,et al.Photocatalytic killing effect of Au modified Ti O2 nanocomposite on human colon cancer cells[J].Acta chem sin,2008,66(10):1163-1167.
[22]WU Y N,CHEN D H,SHI X Y,et al.Cancer-cellspecificy to toxicity of non-oxidized iron elements niron core-gold shell NPs[J].Nanomedicine nanotechnology biology&medicine,2011,7(4):420-427.
[23]LAL S,CLARE S E,HALAS N J.Nanoshell-enabled photothermal cancer therapy:Impending clinical impact[J].Accounts Chem Res,2008,41(12):1842-1851.
[24]ZHOU T,WU B Y,XING D.Bio-modified Fe3O4core/Au shell nanoparticles for targeting and multimodal imaging of cancer cells[J].J Mater Chem,2012,22(2),470-477.
[25]GOBIN A M,LEE M H,HALAS N J,et al.Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy[J].Nano Lett,2007,7(7):1929-1934.
[26]LIN C J,LEE C H,HSIEH J T,et al.Synthesis of fluorescent metallic nanoclusters toward biomedical application:recent progress and present challenges[J].Journal of medical&biological engineering,2009,29(6):276-283.
[27]LIN S Y,CHEN N T,SUM S P,et al.Ligand exchanged photoluminescent gold quantum dots functionalized with leading peptides for nuclear targeting and intracellular imaging[J].Chem Commun,2008,39:4762-4764.
[28]封宾.金包覆核壳结构纳米复合材料的制备及性能研究[D].北京:北京交通大学,2010:13-17.FENG B.Preparation and properties of gold coated core shell nanocomposites[D].Beijing:Beijing Jiaotong University,2010:13-17.
[29]LAKSHMANAN S B,ZOU X,HOSSU M,et al.Local field enhanced Au/Cu S nanocomposites as efficient photothermal transducer agents for cancer treatment[J].Journal of biomedical nanotechnology,2012,8(6):883-890.
[30]MAXWELL D J,TAYLOR J R,NIE S M.Self-assembled nanoparticle probes for recognition and detection of biomolecules[J].J Am Chem Soc,2002,124(32):9606-9612.
[31]李春梅.金纳米与磁纳米颗粒及其复合物的生物传感和细胞成像研究[D].重庆:西南大学,2013:1-109.LI C M.Biosensing and cell imaging of gold nanoparticles and magnetic nanoparticles and their composites[D].Chongqing:Southwestern University,2013:1-109.
[32]张伟.基于Au/Ce O2-CS复合纳米材料修饰的过氧化氢生物传感器研究[D].重庆:重庆医科大学,2012:34-37.ZHANG W.Hydrogen peroxide biosensor based on Au/Ce O2-CS composite nanomaterial modified[D].Chongqing:Medical University of Chongqing,2012:34-37.
[33]GHOSH R,HURI C,PARIA S.Core/shell nanoparticles:Classes,properties,synthesis mechanisms,characterization and applications[J].Chem rev,2011,112(324):2373-2433.
[34]SERSHEN S,WEST J.Implantable,polymeric systems for modulated drug delivery[J].Advanced drug delivery review,2002,54(9):1225-1235.
[35]JIN Y,GAO X.Spectrally tunable leakage-free gold nanocontainers[J].J Am Chem Soc,2009,131(49):17774-17776.
[36]XING Z M,LIU Z G,ZU Y G,et al.Synthesis of camptothecin-loaded gold nanomaterial[J].Appl surf sci,2010,256(12):3917-3920.
[37]DHAR S,DANIEL W L,GILJOHANN D A,et al.Lippard poly-valent oligonucleotide gold nanoparticle conjugates as delivery ve-hicles for platinum(IV)warheads[J].J Am Chem Soc,2010,131(41):14652-14653.
[38]LIU H Y,DONG C,LI L L,et al.Multifunctional gold Nanoshells on silica nanorattles:A platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity[J].Angewandte chemie,2011,50(4):891-895.
[39]KAYAL S,RAMANUJAN R V.Anti-cancer drug loaded iron-gold core-shell nanoparticles(Fe@Au)for magnetic drug targeting[J].Journal of nanoscience&nanotechnology,2010,10(9):5527-5539.
[40]CHAO X,GUO L,ZHAO Y,et al.PEG-modified gold mag nanoparticles(PGMNs)combined with the magnetic field for local drug delivery[J].Journal of drug targeting,2011,19(3):161-170.