DNA纳米材料的应用研究进展
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摘要
DNA作为生物遗传信息的储存分子,因其具有纳米尺寸、分子识别和可操控性等特点还可以作为一种优良的纳米材料。本文介绍了DNA的材料学性质,DNA作为纳米材料近年来在纳米自组装、分子检测和药物输送载体上的应用研究进展,并展望了DNA纳米材料未来的应用前景和发展方向。
DNA is a biomolecule for storing genetic information,while it can also be used as functional nanomaterial due to its unique properties such as nano-scale size,molecular recognition capacity,controllable manipulation capability,etc.In this review,we introduced the special properties of DNA as an excellent nanomaterial and reviewed the research and application progress of using DNA as nanomaterial in self-assembly,molecular detection and drug delivery.We further discussed the prospect and directions of using DNA as nanomaterial in the future.
DNA is a biomolecule for storing genetic information,while it can also be used as functional nanomaterial due to its unique properties such as nano-scale size,molecular recognition capacity,controllable manipulation capability,etc.In this review,we introduced the special properties of DNA as an excellent nanomaterial and reviewed the research and application progress of using DNA as nanomaterial in self-assembly,molecular detection and drug delivery.We further discussed the prospect and directions of using DNA as nanomaterial in the future.
引文
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[2]Jong Bum Lee,Michael John Campolongo,Jason Samuel Kahn,et al.DNA-Based Nanostructures for Molecular Sensing[J].Nanoscale,2010,2(2):188～197.
[3]Rahul Chhabra,Jaswinder Sharma,Yan Liu,et al.DNA Self-Assem-bly for Nanomedicine[J].Advanced Drug Delivery Reviews,2010,62(6):617～625.
[4]Alan Saghatelian,Nicolas H V lcker,Kevin M Guckian,et al.DNA-Based Photonic Logic Gates:And,Nand,and Inhibit[J].Journal ofthe American Chemical Society,2003,125(2):346～347.
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[6]Philippe Cluzel,Anne Lebrun,Christoph Heller,et al.DNA-an Ex-tensible Molecule[J].Science,1996,271(5250):792～794.
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[8]Sung Yong Park,Abigail Kr Lytton-Jean,Byeongdu Lee,et al.DNA-Programmable Nanoparticle Crystallization[J].Nature,2008,451(7178):553～556.
[9]Alexander J Mastroianni,Shelley A Claridge and A Paul Alivisatos.Pyramidal and Chiral Groupings of Gold Nanocrystals Assembled U-sing DNA Scaffolds[J].Journal of the American Chemical Society,2009,131(24):8 455～8 459.
[10]Kinneret Keren,Rotem S Berman,Evgeny Buchstab,et al.DNA-Templated Carbon Nanotube Field-Effect Transistor[J].Science,2003,302(5649):1 380～1 382.
[11]Berea Ar Williams,Kyle Lund,Yan Liu,et al.Self-Assembled Pep-tide Nanoarrays:An Approach to Studying Protein Protein Interac-tions[J].Angewandte Chemie,2007,119(17):3 111～3 114.
[12]Sherri Rinker,Yonggang Ke,Yan Liu,et al.Self-Assembled DNANanostructures for Distance-Dependent Multivalent Ligand ProteinBinding[J].Nature Nanotechnology,2008,3(7):418～422.
[13]Kentaro Numajiri,Takahiro Yamazaki,Mayumi Kimura,et al.Dis-crete and Active Enzyme Nanoarrays on DNA Origami Scaffolds Pu-rified by Affinity Tag Separation[J].Journal of the American Chem-ical Society,2010,132(29):9 937～9 939.
[14]Ofer I Wilner,Yossi Weizmann,Ron Gill,et al.Enzyme CascadesActivated on Topologically Programmed DNA Scaffolds[J].NatureNanotechnology,2009,4(4):249～254.
[15]Christof M Niemeyer,Takeshi Sano,Cassandra L Smith,et al.Oligo-nucleotide-Directed Self-Assembly of Proteins:Semisynthetic DNA-Streptavidin Hybrid Molecules as Connectors for the Generation ofMacroscopic Arrays and the Construction of Supramolecular Biocon-jugates[J].Nucleic Acids Research,1994,22(25):5 530～5 539.
[16]Christof M Niemeyer,Joerg Koehler and Chris Wuerdemann.DNA‐Directed Assembly of Bienzymic Complexes from in Vivo Biotiny-lated Nad(P)H:Fmn Oxidoreductase and Luciferase[J].Chem-BioChem,2002,3(2/3):242～245.
[17]Tsu Ju Fu and Nadrian C Seeman.DNA Double-Crossover Molecules[J].Biochemistry,1993,32(13):3 211～3 220.
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[19]Erik Winfree,Furong Liu,Lisa A Wenzler,et al.Design and Self-Assembly of Two-Dimensional DNA Crystals[J].Nature,1998,394(6693):539～544.
[20]Yu He,Yi Chen,Haipeng Liu,et al.Self-Assembly of HexagonalDNA Two-Dimensional(2d)Arrays[J].Journal of the AmericanChemical Society,2005,127(35):12 202～12 203.
[21]Hao Yan,Sung Ha Park,Gleb Finkelstein,et al.DNA-TemplatedSelf-Assembly of Protein Arrays and Highly Conductive Nanowires[J].Science,2003,301(5641):1 882～1 884.
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[23]Jaswinder Sharma,Rahul Chhabra,Yan Liu,et al.DNA-TemplatedSelf-Assembly of Two-Dimensional and Periodical Gold NanoparticleArrays[J].Angewandte Chemie International Edition,2005,45(5):730～735.
[24]Yu He,Tao Ye,Min Su,et al.Hierarchical Self-Assembly of DNAinto Symmetric Supramolecular Polyhedra[J].Nature,2008,452(7184):198～201.
[25]Paul Wk Rothemund.Folding DNA to Create Nanoscale Shapes andPatterns[J].Nature,2006,440(7082):297～302.
[26]Ebbe S Andersen,Mingdong Dong,Morten M Nielsen,et al.DNA O-rigami Design of Dolphin-Shaped Structures with Flexible Tails[J].ACS nano,2008,2(6):1 213～1 218.
[27]Qian Lulu,Wang Ying,Zhang Zhao,et al.Analogic China Map Con-structed by DNA[J].Chinese Science Bulletin,2006,51(24):2973～2 976.
[28]Ebbe S Andersen,Mingdong Dong,Morten M Nielsen,et al.Self-As-sembly of a Nanoscale DNA Box with a Controllable Lid[J].Na-ture,2009,459(7243):73～76.
[29]Han Dongran,Pal Suchetan,Jeanette Nangreave,et al.DNA Origamiwith Complex Curvatures in Three-Dimensional Space[J].Science,2011,332(6027):342～346.
[30]Niels V Voigt,Thomas Torring,Alexandru Rotaru,et al.Single-Mol-ecule Chemical Reactions on DNA Origami[J].Nature Nanotechn-ology,2010,5(3):200～203.
[31]Yonggang Ke,Stuart Lindsay,Yung Chang,et al.Self-AssembledWater-Soluble Nucleic Acid Probe Tiles for Label-Free Rna Hybrid-ization Assays[J].Science,2008,319(5860):180～183.
[32]Jaswinder Sharma,Ke Yonggang,Lin Chenxiang,et al.DNA-Tile-Directed Self-Assembly of Quantum Dots into Two-DimensionalNanopatterns[J].Angewandte Chemie,2008,47(28):5 157～5 159.
[33]Yonggang Ke,Jaswinder Sharma,Minghui Liu,et al.Scaffolded DNAOrigami of a DNA Tetrahedron Molecular Container[J].Nano Let-ters,2009,9(6):2 445～2 447.
[34]Albert M Hung,Christine M Micheel,Luisa D Bozano,et al.Large-Area Spatially Ordered Arrays of Gold Nanoparticles Directed byLithographically Confined DNA Origami[J].Nature Nanotechnolo-gy,2009,5(2):121～126.
[35]Jaswinder Sharma,Rahul Chhabra,Anchi Cheng,et al.Control ofSelf-Assembly of DNA Tubules through Integration of Gold Nanopar-ticles[J].Science,2009,323(5910):112～116.
[36]Robert Elghanian,James J Storhoff,Robert C Mucic,et al.SelectiveColorimetric Detection of Polynucleotides Based on the Distance-De-pendent Optical Properties of Gold Nanoparticles[J].Science,1997,277(5329):1 078～1 081.
[37]Jwa-Min Nam,Savka I Stoeva and Chad A Mirkin.Bio-Bar-Code-Based DNA Detection with PCR-Like Sensitivity[J].Journal of theAmerican Chemical Society,2004,126(19):5 932～5 933.
[38]Jaw-Min Nam,C.Shad Thaxton and Chad A Mirkin.Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins[J].Science,2003,301(5641):1 884～1 886.
[39]Takeshi Sano,Cassandra L Smith and Charles R Cantor.Immuno-PCR:Very Sensitive Antigen Detection by Means of Specific Anti-body-DNA Conjugates[J].Science,1992,258(5079):120～122.
[40]Christof M Niemeyer,Michael Adler and Ron Wacker.Immuno-PCR:High Sensitivity Detection of Proteins by Nucleic Acid Ampli-fication[J].Trends in Biotechnology,2005,23(4):208～216.
[41]Simon Fredriksson,Mats Gullberg,Jonas Jarvius,et al.Protein De-tection Using Proximity-Dependent DNA Ligation Assays[J].NatureBiotechnology,2002,20(5):473～477.
[42]Ola S derberg,Mats Gullberg,Malin Jarvius,et al.Direct Observa-tion of Individual Endogenous Protein Complexes in Situ by Proximi-ty Ligation[J].Nature Methods,2006,3(12):995～1 000.
[43]Yougen Li,Yolanda D Tseng,Sang Y Kwon,et al.Controlled Assem-bly of Dendrimer-Like DNA[J].Nature Materials,2003,3(1):38～42.
[44]Jong B Lee,Young H Roh,Soong Ho Um,et al.MultifunctionalNanoarchitectures from DNA-Based Abc Monomers[J].NatureNanotechnology,2009,4(7):430～436.
[45]Robby A Petros and Joseph M Desimone.Strategies in the Design ofNanoparticles for Therapeutic Applications[J].Nature Reviews DrugDiscovery,2010,9(8):615～627.
[46]Wim H De Jong and Paul Ja Borm.Drug Delivery and Nanoparti-cles:Applications and Hazards[J].International Journal of Nano-medicine,2008,3(2):133～149.
[47]Hak Soo Choi,Wenhao Liu,Fangbing Liu,et al.Design Considera-tions for Tumour-Targeted Nanoparticles[J].Nature Nanotechnolo-gy,2009,5(1):42～47.
[48]Hyukjin Lee,Abigail Kr Lytton-Jean,Yi Chen,et al.MolecularlySelf-Assembled Nucleic Acid Nanoparticles for Targeted in Vivo Sir-na Delivery[J].Nature Nanotechnology,2012,7(6):389～393.
[49]Young Hoon Roh,Jong Bum Lee,Pichamon Kiatwuthinon,et al.DNAsomes:Multifunctional DNA‐Based Nanocarriers[J].Small,2011,7(1):74～78.
[2]Jong Bum Lee,Michael John Campolongo,Jason Samuel Kahn,et al.DNA-Based Nanostructures for Molecular Sensing[J].Nanoscale,2010,2(2):188～197.
[3]Rahul Chhabra,Jaswinder Sharma,Yan Liu,et al.DNA Self-Assem-bly for Nanomedicine[J].Advanced Drug Delivery Reviews,2010,62(6):617～625.
[4]Alan Saghatelian,Nicolas H V lcker,Kevin M Guckian,et al.DNA-Based Photonic Logic Gates:And,Nand,and Inhibit[J].Journal ofthe American Chemical Society,2003,125(2):346～347.
[5]Tim Liedl,Thomas L Sobey and Friedrich C Simmel.DNA-BasedNanodevices[J].Nano Today,2007,2(2):36～41.
[6]Philippe Cluzel,Anne Lebrun,Christoph Heller,et al.DNA-an Ex-tensible Molecule[J].Science,1996,271(5250):792～794.
[7]Steven B Smith,Yujia Cui and Carlos Bustamante.Overstretching B-DNA:The Elastic Response of Individual Double-Stranded and Sin-gle-Stranded DNA Molecules[J].Science,1996,271(5250):795～799.
[8]Sung Yong Park,Abigail Kr Lytton-Jean,Byeongdu Lee,et al.DNA-Programmable Nanoparticle Crystallization[J].Nature,2008,451(7178):553～556.
[9]Alexander J Mastroianni,Shelley A Claridge and A Paul Alivisatos.Pyramidal and Chiral Groupings of Gold Nanocrystals Assembled U-sing DNA Scaffolds[J].Journal of the American Chemical Society,2009,131(24):8 455～8 459.
[10]Kinneret Keren,Rotem S Berman,Evgeny Buchstab,et al.DNA-Templated Carbon Nanotube Field-Effect Transistor[J].Science,2003,302(5649):1 380～1 382.
[11]Berea Ar Williams,Kyle Lund,Yan Liu,et al.Self-Assembled Pep-tide Nanoarrays:An Approach to Studying Protein Protein Interac-tions[J].Angewandte Chemie,2007,119(17):3 111～3 114.
[12]Sherri Rinker,Yonggang Ke,Yan Liu,et al.Self-Assembled DNANanostructures for Distance-Dependent Multivalent Ligand ProteinBinding[J].Nature Nanotechnology,2008,3(7):418～422.
[13]Kentaro Numajiri,Takahiro Yamazaki,Mayumi Kimura,et al.Dis-crete and Active Enzyme Nanoarrays on DNA Origami Scaffolds Pu-rified by Affinity Tag Separation[J].Journal of the American Chem-ical Society,2010,132(29):9 937～9 939.
[14]Ofer I Wilner,Yossi Weizmann,Ron Gill,et al.Enzyme CascadesActivated on Topologically Programmed DNA Scaffolds[J].NatureNanotechnology,2009,4(4):249～254.
[15]Christof M Niemeyer,Takeshi Sano,Cassandra L Smith,et al.Oligo-nucleotide-Directed Self-Assembly of Proteins:Semisynthetic DNA-Streptavidin Hybrid Molecules as Connectors for the Generation ofMacroscopic Arrays and the Construction of Supramolecular Biocon-jugates[J].Nucleic Acids Research,1994,22(25):5 530～5 539.
[16]Christof M Niemeyer,Joerg Koehler and Chris Wuerdemann.DNA‐Directed Assembly of Bienzymic Complexes from in Vivo Biotiny-lated Nad(P)H:Fmn Oxidoreductase and Luciferase[J].Chem-BioChem,2002,3(2/3):242～245.
[17]Tsu Ju Fu and Nadrian C Seeman.DNA Double-Crossover Molecules[J].Biochemistry,1993,32(13):3 211～3 220.
[18]Thomas H Labean,Hao Yan,Jens Kopatsch,et al.Construction,A-nalysis,Ligation,and Self-Assembly of DNA Triple Crossover Com-plexes[J].Journal of the American Chemical Society,2000,122(9):1 848～1 860.
[19]Erik Winfree,Furong Liu,Lisa A Wenzler,et al.Design and Self-Assembly of Two-Dimensional DNA Crystals[J].Nature,1998,394(6693):539～544.
[20]Yu He,Yi Chen,Haipeng Liu,et al.Self-Assembly of HexagonalDNA Two-Dimensional(2d)Arrays[J].Journal of the AmericanChemical Society,2005,127(35):12 202～12 203.
[21]Hao Yan,Sung Ha Park,Gleb Finkelstein,et al.DNA-TemplatedSelf-Assembly of Protein Arrays and Highly Conductive Nanowires[J].Science,2003,301(5641):1 882～1 884.
[22]Chuan Zhang,Min Su,Yu He,et al.Conformational Flexibility Facil-itates Self-Assembly of Complex DNA Nanostructures[J].Proceed-ings of the National Academy of Sciences,2008,105(31):10 665～10 669.
[23]Jaswinder Sharma,Rahul Chhabra,Yan Liu,et al.DNA-TemplatedSelf-Assembly of Two-Dimensional and Periodical Gold NanoparticleArrays[J].Angewandte Chemie International Edition,2005,45(5):730～735.
[24]Yu He,Tao Ye,Min Su,et al.Hierarchical Self-Assembly of DNAinto Symmetric Supramolecular Polyhedra[J].Nature,2008,452(7184):198～201.
[25]Paul Wk Rothemund.Folding DNA to Create Nanoscale Shapes andPatterns[J].Nature,2006,440(7082):297～302.
[26]Ebbe S Andersen,Mingdong Dong,Morten M Nielsen,et al.DNA O-rigami Design of Dolphin-Shaped Structures with Flexible Tails[J].ACS nano,2008,2(6):1 213～1 218.
[27]Qian Lulu,Wang Ying,Zhang Zhao,et al.Analogic China Map Con-structed by DNA[J].Chinese Science Bulletin,2006,51(24):2973～2 976.
[28]Ebbe S Andersen,Mingdong Dong,Morten M Nielsen,et al.Self-As-sembly of a Nanoscale DNA Box with a Controllable Lid[J].Na-ture,2009,459(7243):73～76.
[29]Han Dongran,Pal Suchetan,Jeanette Nangreave,et al.DNA Origamiwith Complex Curvatures in Three-Dimensional Space[J].Science,2011,332(6027):342～346.
[30]Niels V Voigt,Thomas Torring,Alexandru Rotaru,et al.Single-Mol-ecule Chemical Reactions on DNA Origami[J].Nature Nanotechn-ology,2010,5(3):200～203.
[31]Yonggang Ke,Stuart Lindsay,Yung Chang,et al.Self-AssembledWater-Soluble Nucleic Acid Probe Tiles for Label-Free Rna Hybrid-ization Assays[J].Science,2008,319(5860):180～183.
[32]Jaswinder Sharma,Ke Yonggang,Lin Chenxiang,et al.DNA-Tile-Directed Self-Assembly of Quantum Dots into Two-DimensionalNanopatterns[J].Angewandte Chemie,2008,47(28):5 157～5 159.
[33]Yonggang Ke,Jaswinder Sharma,Minghui Liu,et al.Scaffolded DNAOrigami of a DNA Tetrahedron Molecular Container[J].Nano Let-ters,2009,9(6):2 445～2 447.
[34]Albert M Hung,Christine M Micheel,Luisa D Bozano,et al.Large-Area Spatially Ordered Arrays of Gold Nanoparticles Directed byLithographically Confined DNA Origami[J].Nature Nanotechnolo-gy,2009,5(2):121～126.
[35]Jaswinder Sharma,Rahul Chhabra,Anchi Cheng,et al.Control ofSelf-Assembly of DNA Tubules through Integration of Gold Nanopar-ticles[J].Science,2009,323(5910):112～116.
[36]Robert Elghanian,James J Storhoff,Robert C Mucic,et al.SelectiveColorimetric Detection of Polynucleotides Based on the Distance-De-pendent Optical Properties of Gold Nanoparticles[J].Science,1997,277(5329):1 078～1 081.
[37]Jwa-Min Nam,Savka I Stoeva and Chad A Mirkin.Bio-Bar-Code-Based DNA Detection with PCR-Like Sensitivity[J].Journal of theAmerican Chemical Society,2004,126(19):5 932～5 933.
[38]Jaw-Min Nam,C.Shad Thaxton and Chad A Mirkin.Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins[J].Science,2003,301(5641):1 884～1 886.
[39]Takeshi Sano,Cassandra L Smith and Charles R Cantor.Immuno-PCR:Very Sensitive Antigen Detection by Means of Specific Anti-body-DNA Conjugates[J].Science,1992,258(5079):120～122.
[40]Christof M Niemeyer,Michael Adler and Ron Wacker.Immuno-PCR:High Sensitivity Detection of Proteins by Nucleic Acid Ampli-fication[J].Trends in Biotechnology,2005,23(4):208～216.
[41]Simon Fredriksson,Mats Gullberg,Jonas Jarvius,et al.Protein De-tection Using Proximity-Dependent DNA Ligation Assays[J].NatureBiotechnology,2002,20(5):473～477.
[42]Ola S derberg,Mats Gullberg,Malin Jarvius,et al.Direct Observa-tion of Individual Endogenous Protein Complexes in Situ by Proximi-ty Ligation[J].Nature Methods,2006,3(12):995～1 000.
[43]Yougen Li,Yolanda D Tseng,Sang Y Kwon,et al.Controlled Assem-bly of Dendrimer-Like DNA[J].Nature Materials,2003,3(1):38～42.
[44]Jong B Lee,Young H Roh,Soong Ho Um,et al.MultifunctionalNanoarchitectures from DNA-Based Abc Monomers[J].NatureNanotechnology,2009,4(7):430～436.
[45]Robby A Petros and Joseph M Desimone.Strategies in the Design ofNanoparticles for Therapeutic Applications[J].Nature Reviews DrugDiscovery,2010,9(8):615～627.
[46]Wim H De Jong and Paul Ja Borm.Drug Delivery and Nanoparti-cles:Applications and Hazards[J].International Journal of Nano-medicine,2008,3(2):133～149.
[47]Hak Soo Choi,Wenhao Liu,Fangbing Liu,et al.Design Considera-tions for Tumour-Targeted Nanoparticles[J].Nature Nanotechnolo-gy,2009,5(1):42～47.
[48]Hyukjin Lee,Abigail Kr Lytton-Jean,Yi Chen,et al.MolecularlySelf-Assembled Nucleic Acid Nanoparticles for Targeted in Vivo Sir-na Delivery[J].Nature Nanotechnology,2012,7(6):389～393.
[49]Young Hoon Roh,Jong Bum Lee,Pichamon Kiatwuthinon,et al.DNAsomes:Multifunctional DNA‐Based Nanocarriers[J].Small,2011,7(1):74～78.