调制磁性纳米颗粒提高磁热性能的研究
|
摘要
磁性纳米颗粒具有独特的磁学性质,即在外加交变磁场下因产生磁滞释放热量,使其在生物医学领域,特别是肿瘤磁热疗,获得了广泛应用.到目前为止,磁性纳米颗粒介导的磁热疗成为一种治疗癌症的有效手段,已进入临床三期实验.因此,针对磁性纳米颗粒本身,优化设计尺寸、形貌、组分和表面修饰来提高其磁热性能,进而减小临床应用中的颗粒浓度来最小化毒副作用的研究,对肿瘤治疗及生物医药研究具有十分重要的意义.本综述详述如何优化调制磁性纳米颗粒以提高其磁热性能,为高效、低毒的磁性纳米颗粒的设计提供了指导性的研究方向.
The application of magnetic nanoparticles in the biomedical field has widely utilized in recent years especially in magnetic-mediated hyperthermia for cancer treatment because of their unique magnetic properties,that is, the hysteresis loss induces heat under an alternating magnetic field. So far, the magnetic-mediated hyperthermia as a kind of effective means for the treatment of cancer, has entered the third phase of clinical trial.Therefore, in view of the magnetic nanoparticles itself, it has great significance to optimize size, morphology,composition and surface modification to improve their magnetic hyperthermia performance. So it can reduce the concentration of magnetic nanoparticles in clinical practice and minimize the side effects in tumor treatment. This review described in detail that how to optimize the modulation of magnetic nanoparticles to improve magnetic hyperthermia performances.
The application of magnetic nanoparticles in the biomedical field has widely utilized in recent years especially in magnetic-mediated hyperthermia for cancer treatment because of their unique magnetic properties,that is, the hysteresis loss induces heat under an alternating magnetic field. So far, the magnetic-mediated hyperthermia as a kind of effective means for the treatment of cancer, has entered the third phase of clinical trial.Therefore, in view of the magnetic nanoparticles itself, it has great significance to optimize size, morphology,composition and surface modification to improve their magnetic hyperthermia performance. So it can reduce the concentration of magnetic nanoparticles in clinical practice and minimize the side effects in tumor treatment. This review described in detail that how to optimize the modulation of magnetic nanoparticles to improve magnetic hyperthermia performances.
引文
[1]Miller M M,Prinz G A,Cheng S F,et al.Detection of a micronsized magnetic sphere using a ring-shaped anisotropic magnetoresistance-based sensor:a model for a magnetoresistancebased biosensor.Applied Physics Letters,2002,81(12):2211-2213
[2]Jain T K,Morales M A,Sahoo S K,et al.Iron oxide nanoparticles for sustained delivery of anticancer agents.Molecular Pharmaceutics,2005,2(3):194-205
[3]Gilchrist R K,Medal R,Shorey W D,et al.Selective inductive heating of lymph nodes.Annals of Surgery,1957,146(4):596-606
[4]Eppink B,Krawczyk P M,Stap J,et al.Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies.International Journal of Hyperthermia,2012,28(6):509-517
[5]Riedinger A,Guardia P,Curcio A,et al.Subnanometer local temperature probing and remotely vontrolled drug release based on azo-functionalized iron oxide nanoparticles.Nano Letters,2013,13(6):2399-2406
[6]Gian F B M D.Hyperthermia in cancer treatment:a primer.New York:Springer US,2006
[7]Yang K,Zhang S,Zhang G,et al.Graphene in mice:ultrahigh in vivo tumor uptake and efficient photothermal therapy.Nano Letters,2010,10(9):3318-3323
[8]O'neal D P,Hirsch L R,Halas N J,et al.Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles.Cancer Letters,2004,209(2):171-176
[9]Roti J L R.Cellular responses to hyperthermia(40-46℃):cell killing and molecular events.International Journal of Hyperthermia,2008,24(1):3-15
[10]Kida Y,Ishiguri H,Ichimi K,et al.Hyperthermia of metastatic brain tumor with implant heating system:a preliminary clinical results.No Shinkei Geka Neurological Surgery,1990,18(6):521-526
[11]Deger S,Taymoorian K,Boehmer D,et al.Thermoradiotherapy using interstitial self-regulating thermoseeds:an intermediate analysis of a phase II trial.European Urology,2004,45(5):574-580
[12]Kossatz S,Grandke J,Couleaud P,et al.Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery.Breast Cancer Research,2015,17(1):66-67
[13]Johannsen M,Gneveckow U,Wust P,et al.Thermotherapy using magnetic nanoparticles in patients with locally recurrent prostate cancer:initial results of a phase I study.European Urology Supplements,2006,5(2):131-131
[14]Pham Thanh P,Nam P H,Manh D H,et al.Studies of the magnetic properties and specific absorption of Mn0.3Zn0.7Fe2O4nanoparticles.Journal of Electronic Materials,2015,44(1):287-294
[15]Ma M,Wu Y,Zhou H,et al.Size dependence of specific power absorption of Fe3O4particles in AC magnetic field.Journal of Magnetism and Magnetic Materials,2004,268(1-2):33-39
[16]Lee J H,Jang J T,Choi J S,et al.Exchange-coupled magnetic nanoparticles for efficient heat induction.Nature Nanotechnology,2011,6(7):418-422
[17]Mehdaoui B,Meffre A,Carrey J,et al.Optimal size of nanoparticles for magnetic hyperthermia:a combined theoretical and experimental study.Advanced Functional Materials,2011,21(23):4573-4581
[18]Hosono T,Takahashi H,Sato Y,et al.Magnetite nanoparticles for magnetic fluid hyperthermia using modified oxidation method.Japan:Water Dynamics.2007:134-136
[19]Lartigue L,Innocenti C,Kalaivani T,et al.Water-dispersible sugar-coated iron oxide nanoparticles.An evaluation of their relaxometric and magnetic hyperthermia properties.Journal of the American Chemical Society,2011,133(27):10459-10472
[20]Jeun M,Lee S,Kang J K,et al.Physical limits of pure superparamagnetic Fe3O4nanoparticles for a local hyperthermia agent in nanomedicine.Applied Physics Letters,2012,100(9):092406(1-5)
[21]Mohapatra J,Zeng F,Elkins K,et al.Size-dependent magnetic and inductive heating properties of Fe3O4nanoparticles:scaling laws across the superparamagnetic size.Physical Chemistry Chemical Physics,2018,20(18):12879-12887
[22]Nemati Z,Alonso J,Martinez L M,et al.Enhanced magnetic hyperthermia in iron oxide nano-octopods:size and anisotropy effects.Journal of Physical Chemistry C,2016,120(15):8370-8379
[23]Noh S H,Na W,Jang J T,et al.Nanoscale magnetism control via surface and exchange anisotropy for optimized ferrimagnetic hysteresis.Nano Letters,2012,12(7):3716-3721
[24]Guardia P,Di Corato R,Lartigue L,et al.Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment.Acs Nano,2012,6(4):3080-3091
[25]Yang Y,Liu X L,Yi J B,et al.Stable vortex magnetite nanorings colloid:micromagnetic simulation and experimental demonstration.Journal of Applied Physics,2012,111(4):044303(1-10)
[26]Wachowiak A,Wiebe J,Bode M,et al.Direct observation of internal spin structure of magnetic vortex cores.Science,2002,298(5593):577-580
[27]吴建鹏,刘晓丽,张欢,等.涡旋磁纳米颗粒--崭新的生物医用磁性纳米平台.生物化学与生物物理进展,2015,42(7):593-605Wu J P,Liu X L,Zhang H,et al.Progress in Biochemistry and Biophysics,2015,42(7):593-605
[28]Liu X L,Yang Y,Ng C T,et al.Magnetic vortex nanorings:a new class of hyperthermia agent for highly efficient in vivo regression of tumors.Advanced Materials,2015,27(11):1938-1940
[29]Yang Y,Liu X,Lv Y,et al.Orientation mediated enhancement on magnetic hyperthermia of Fe3O4nanodisc.Advanced Functional Materials,2015,25(5):812-820
[30]Hergt R,Hiergeist R,Zeisberger M,et al.Magnetic properties of bacterial magnetosomes as potential diagnostic and therapeutic tools.Journal of Magnetism and Magnetic Materials,2005,293(1):80-86
[31]Mehdaoui B,Tan R P,Meffre A,et al.Increase of magnetic hyperthermia efficiency due to dipolar interactions in lowanisotropy magnetic nanoparticles:theoretical and experimental results.Physical Review B,2013,87(17):174419(1-10)
[32]Lee J H,Huh Y M,Jun Y W,et al.Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging.Nature Medicine,2007,13(1):95-99
[33]Noh S H,Moon S H,Shin T H,et al.Recent advances of magnetothermal capabilities of nanoparticles:from design principles to biomedical applications.Nano Today,2017,13(1):61-76
[34]Jang J T,Nah H,Lee J H,et al.Critical enhancements of MRIcontrast and hyperthermic effects by dopant-controlled magnetic nanoparticles.Angewandte Chemie-International Edition,2009,48(7):1234-1238
[35]Chen R,Christiansen M G,Anikeeva P.Maximizing hysteretic losses in magnetic ferrite nanoparticles via model-driven synthesis and materials optimization.Acs Nano,2013,7(10):8990-9000
[36]Jang J T,Lee J,Seon J,et al.Giant magnetic heat induction of magnesium-doped gamma-Fe2O3superparamagnetic nanoparticles for completely killing tumors.Advanced Materials,2018,30(6):1704362(1-8)
[37]Yu J,Chen F,Gao W,et al.Iron carbide nanoparticles:an innovative nanoplatform for biomedical applications.Nanoscale Horizons,2017,2(2):81-88
[38]Thomas L A,Dekker L,Kallumadil M,et al.Carboxylic acidstabilised iron oxide nanoparticles for use in magnetic hyperthermia.Journal of Materials Chemistry,2009,19(36):6529-6535
[39]Liu X L,Fan H M,Yi J B,et al.Optimization of surface coating on Fe3O4nanoparticles for high performance magnetic hyperthermia agents.Journal of Materials Chemistry,2012,22(17):8235-8244
[40]Hergt R,Dutz S,Zeisberger M.Validity limits of the Néel relaxation model of magnetic nanoparticles for hyperthermia.Nanotechnology,2010,21(1):015706(1-5)
[2]Jain T K,Morales M A,Sahoo S K,et al.Iron oxide nanoparticles for sustained delivery of anticancer agents.Molecular Pharmaceutics,2005,2(3):194-205
[3]Gilchrist R K,Medal R,Shorey W D,et al.Selective inductive heating of lymph nodes.Annals of Surgery,1957,146(4):596-606
[4]Eppink B,Krawczyk P M,Stap J,et al.Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies.International Journal of Hyperthermia,2012,28(6):509-517
[5]Riedinger A,Guardia P,Curcio A,et al.Subnanometer local temperature probing and remotely vontrolled drug release based on azo-functionalized iron oxide nanoparticles.Nano Letters,2013,13(6):2399-2406
[6]Gian F B M D.Hyperthermia in cancer treatment:a primer.New York:Springer US,2006
[7]Yang K,Zhang S,Zhang G,et al.Graphene in mice:ultrahigh in vivo tumor uptake and efficient photothermal therapy.Nano Letters,2010,10(9):3318-3323
[8]O'neal D P,Hirsch L R,Halas N J,et al.Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles.Cancer Letters,2004,209(2):171-176
[9]Roti J L R.Cellular responses to hyperthermia(40-46℃):cell killing and molecular events.International Journal of Hyperthermia,2008,24(1):3-15
[10]Kida Y,Ishiguri H,Ichimi K,et al.Hyperthermia of metastatic brain tumor with implant heating system:a preliminary clinical results.No Shinkei Geka Neurological Surgery,1990,18(6):521-526
[11]Deger S,Taymoorian K,Boehmer D,et al.Thermoradiotherapy using interstitial self-regulating thermoseeds:an intermediate analysis of a phase II trial.European Urology,2004,45(5):574-580
[12]Kossatz S,Grandke J,Couleaud P,et al.Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery.Breast Cancer Research,2015,17(1):66-67
[13]Johannsen M,Gneveckow U,Wust P,et al.Thermotherapy using magnetic nanoparticles in patients with locally recurrent prostate cancer:initial results of a phase I study.European Urology Supplements,2006,5(2):131-131
[14]Pham Thanh P,Nam P H,Manh D H,et al.Studies of the magnetic properties and specific absorption of Mn0.3Zn0.7Fe2O4nanoparticles.Journal of Electronic Materials,2015,44(1):287-294
[15]Ma M,Wu Y,Zhou H,et al.Size dependence of specific power absorption of Fe3O4particles in AC magnetic field.Journal of Magnetism and Magnetic Materials,2004,268(1-2):33-39
[16]Lee J H,Jang J T,Choi J S,et al.Exchange-coupled magnetic nanoparticles for efficient heat induction.Nature Nanotechnology,2011,6(7):418-422
[17]Mehdaoui B,Meffre A,Carrey J,et al.Optimal size of nanoparticles for magnetic hyperthermia:a combined theoretical and experimental study.Advanced Functional Materials,2011,21(23):4573-4581
[18]Hosono T,Takahashi H,Sato Y,et al.Magnetite nanoparticles for magnetic fluid hyperthermia using modified oxidation method.Japan:Water Dynamics.2007:134-136
[19]Lartigue L,Innocenti C,Kalaivani T,et al.Water-dispersible sugar-coated iron oxide nanoparticles.An evaluation of their relaxometric and magnetic hyperthermia properties.Journal of the American Chemical Society,2011,133(27):10459-10472
[20]Jeun M,Lee S,Kang J K,et al.Physical limits of pure superparamagnetic Fe3O4nanoparticles for a local hyperthermia agent in nanomedicine.Applied Physics Letters,2012,100(9):092406(1-5)
[21]Mohapatra J,Zeng F,Elkins K,et al.Size-dependent magnetic and inductive heating properties of Fe3O4nanoparticles:scaling laws across the superparamagnetic size.Physical Chemistry Chemical Physics,2018,20(18):12879-12887
[22]Nemati Z,Alonso J,Martinez L M,et al.Enhanced magnetic hyperthermia in iron oxide nano-octopods:size and anisotropy effects.Journal of Physical Chemistry C,2016,120(15):8370-8379
[23]Noh S H,Na W,Jang J T,et al.Nanoscale magnetism control via surface and exchange anisotropy for optimized ferrimagnetic hysteresis.Nano Letters,2012,12(7):3716-3721
[24]Guardia P,Di Corato R,Lartigue L,et al.Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment.Acs Nano,2012,6(4):3080-3091
[25]Yang Y,Liu X L,Yi J B,et al.Stable vortex magnetite nanorings colloid:micromagnetic simulation and experimental demonstration.Journal of Applied Physics,2012,111(4):044303(1-10)
[26]Wachowiak A,Wiebe J,Bode M,et al.Direct observation of internal spin structure of magnetic vortex cores.Science,2002,298(5593):577-580
[27]吴建鹏,刘晓丽,张欢,等.涡旋磁纳米颗粒--崭新的生物医用磁性纳米平台.生物化学与生物物理进展,2015,42(7):593-605Wu J P,Liu X L,Zhang H,et al.Progress in Biochemistry and Biophysics,2015,42(7):593-605
[28]Liu X L,Yang Y,Ng C T,et al.Magnetic vortex nanorings:a new class of hyperthermia agent for highly efficient in vivo regression of tumors.Advanced Materials,2015,27(11):1938-1940
[29]Yang Y,Liu X,Lv Y,et al.Orientation mediated enhancement on magnetic hyperthermia of Fe3O4nanodisc.Advanced Functional Materials,2015,25(5):812-820
[30]Hergt R,Hiergeist R,Zeisberger M,et al.Magnetic properties of bacterial magnetosomes as potential diagnostic and therapeutic tools.Journal of Magnetism and Magnetic Materials,2005,293(1):80-86
[31]Mehdaoui B,Tan R P,Meffre A,et al.Increase of magnetic hyperthermia efficiency due to dipolar interactions in lowanisotropy magnetic nanoparticles:theoretical and experimental results.Physical Review B,2013,87(17):174419(1-10)
[32]Lee J H,Huh Y M,Jun Y W,et al.Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging.Nature Medicine,2007,13(1):95-99
[33]Noh S H,Moon S H,Shin T H,et al.Recent advances of magnetothermal capabilities of nanoparticles:from design principles to biomedical applications.Nano Today,2017,13(1):61-76
[34]Jang J T,Nah H,Lee J H,et al.Critical enhancements of MRIcontrast and hyperthermic effects by dopant-controlled magnetic nanoparticles.Angewandte Chemie-International Edition,2009,48(7):1234-1238
[35]Chen R,Christiansen M G,Anikeeva P.Maximizing hysteretic losses in magnetic ferrite nanoparticles via model-driven synthesis and materials optimization.Acs Nano,2013,7(10):8990-9000
[36]Jang J T,Lee J,Seon J,et al.Giant magnetic heat induction of magnesium-doped gamma-Fe2O3superparamagnetic nanoparticles for completely killing tumors.Advanced Materials,2018,30(6):1704362(1-8)
[37]Yu J,Chen F,Gao W,et al.Iron carbide nanoparticles:an innovative nanoplatform for biomedical applications.Nanoscale Horizons,2017,2(2):81-88
[38]Thomas L A,Dekker L,Kallumadil M,et al.Carboxylic acidstabilised iron oxide nanoparticles for use in magnetic hyperthermia.Journal of Materials Chemistry,2009,19(36):6529-6535
[39]Liu X L,Fan H M,Yi J B,et al.Optimization of surface coating on Fe3O4nanoparticles for high performance magnetic hyperthermia agents.Journal of Materials Chemistry,2012,22(17):8235-8244
[40]Hergt R,Dutz S,Zeisberger M.Validity limits of the Néel relaxation model of magnetic nanoparticles for hyperthermia.Nanotechnology,2010,21(1):015706(1-5)