血清骨桥蛋白、胃癌相关抗原和组织多肽特异性抗原诊断胃癌的临床价值
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摘要
目的探讨血清骨桥蛋白(OPN)、胃癌相关抗原(MG7-Ag)和组织多肽特异性抗原(TPS)对诊断胃癌的临床价值。方法选择胃癌病例86例、癌前病变病例45例、胃良性病变病例48例与健康对照50例,采用ELISA法检测血清OPN、MG7-Ag与TPS。结果胃癌组血清OPN、MG7-Ag和TPS水平及阳性率均高于其他3组,差异均有统计学意义(P<0.01)。胃癌TNMⅢ/Ⅳ期病例、低分化胃癌病例及淋巴结转移的病例血清中OPN、MG7-Ag与TPS的水平分别高于Ⅰ/Ⅱ期、高/中分化及无淋巴结转移的病例(P均<0.05)。OPN、MG7-Ag、TPS之间均呈显著的正相关关系(P均<0.05)。结论 OPN、MG7-Ag与TPS在胃癌患者体内呈高表达,检测OPN、MG7-Ag、TPS对胃癌的早期诊断具有重要的意义。
Objective To study the clinical value of serum levels of OPN,MG7-Ag and TPS in the diagnosis of gastric cancer. Methods 86 cases of gastric cancer,45 cases of precancerous lesions,48 cases of benign gastric diseases cases and 50 healthy controls were selected. Enzyme linked immunosorbent assay( ELISA) was adopted to detect serum levels of OPN,MG7-Ag and TPS. Results The serum levels and positive rate of OPN,MG7-Ag and TPS in gastric cancer groups were both higher than those of the other 3 groups,there had statistical difference( P < 0. 01). The levels of OPN,MG7-Ag and TPS in gastric cancer cases with TNM Ⅲ/Ⅳ phase,low-differentiation and lymphatic metastasis were all higher than those of gastric cancer cases with TNM Ⅰ/Ⅱ,middle/high-differentiation and without lymphatic metastasis( all P < 0. 05). There were obvious positive correlation among OPN,MG7-Ag and TPS( all P < 0. 05). Conclusion The levels of OPN,MG7-Ag and TPS all presented high expression in gastric cancer cases,and the detection of OPN,MG7-Ag and TPS had important significance to early diagnose of gastric cancer.
Objective To study the clinical value of serum levels of OPN,MG7-Ag and TPS in the diagnosis of gastric cancer. Methods 86 cases of gastric cancer,45 cases of precancerous lesions,48 cases of benign gastric diseases cases and 50 healthy controls were selected. Enzyme linked immunosorbent assay( ELISA) was adopted to detect serum levels of OPN,MG7-Ag and TPS. Results The serum levels and positive rate of OPN,MG7-Ag and TPS in gastric cancer groups were both higher than those of the other 3 groups,there had statistical difference( P < 0. 01). The levels of OPN,MG7-Ag and TPS in gastric cancer cases with TNM Ⅲ/Ⅳ phase,low-differentiation and lymphatic metastasis were all higher than those of gastric cancer cases with TNM Ⅰ/Ⅱ,middle/high-differentiation and without lymphatic metastasis( all P < 0. 05). There were obvious positive correlation among OPN,MG7-Ag and TPS( all P < 0. 05). Conclusion The levels of OPN,MG7-Ag and TPS all presented high expression in gastric cancer cases,and the detection of OPN,MG7-Ag and TPS had important significance to early diagnose of gastric cancer.
引文
[1]涂铭,李林.胃癌防治知识对胃癌患者早期诊断的影响[J].实用癌症杂志,2014,29(8):972-974.
[2]焦艳.肿瘤标志物对胃癌诊断及预后的评估价值[J].实用癌症杂志,2013,28(6):614-616.
[3]薛雯娟,康艳.肿瘤标志物在胃癌早期诊断中的应用价值[J].实用癌症杂志,2016,31(3):393-395.
[4]Fock KM,Talley N,Moayyedi P,et al.Asia-Pacificconsensus guidelines on gastric cancer prevention[J].J Gastroenterol Hepatol,2008,23(3):351-365.
[5]Ceausu M,Hostiuc S,Sajin M,et al.Gestational lung adenocarcinoma:case report[J].Int J Surg Pathol,2014,22(7):663-666.
[6]陈佳佳,吴荣.5种肿瘤标志物在胃癌患者血清中的表达及其临床意义[J].中国医科大学学报,2011,40(8):752-754,759.
[7]张忠,王旭光,李敏,等.联合检测血清骨桥蛋白和MG7抗原在胃癌诊断中的应用[J].中国老年学杂志,2013,33(2):254-256.
[8]Cao DX,Li ZJ,Jiang XO,et al.Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers[J].World J Gastroenterol,2012,18(30):3923-3930.
[9]Coppola D,Szabo M,Boulware D,et al.Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies[J].Clin Cancer Res,2004,10(1):184-190.
[10]项文坤,洪和平.血清骨桥蛋白、胃癌相关抗原和组织多肽特异性抗原联合检测对胃癌诊断的敏感性和特异性[J].中国基层医药,2015,22(19):2919-2922.
[11]王木生,曹辉琼,周冬根,等.联合检测血清OPN、MG7-Ag、TPS对胃癌的诊断价值[J].山东医药,2011,51(25):76-77.
[12]陈建婷,梁树辉,岳晚霞,等.1A6/DRIM表达及血清MG7-Ag含量在胃癌早期诊断中的价值[J].现代肿瘤医学,2014,22(8):1888-1890.
[13]Sliwowska I,Kipczynski Z,Grodecka-Gazdecka S.Diagnostic value of measuring serum CA15-3,TPA,and TPS in women with breast cancer[J].Postepy Hig Med Dosw,2006,60(3):295-299.
[2]焦艳.肿瘤标志物对胃癌诊断及预后的评估价值[J].实用癌症杂志,2013,28(6):614-616.
[3]薛雯娟,康艳.肿瘤标志物在胃癌早期诊断中的应用价值[J].实用癌症杂志,2016,31(3):393-395.
[4]Fock KM,Talley N,Moayyedi P,et al.Asia-Pacificconsensus guidelines on gastric cancer prevention[J].J Gastroenterol Hepatol,2008,23(3):351-365.
[5]Ceausu M,Hostiuc S,Sajin M,et al.Gestational lung adenocarcinoma:case report[J].Int J Surg Pathol,2014,22(7):663-666.
[6]陈佳佳,吴荣.5种肿瘤标志物在胃癌患者血清中的表达及其临床意义[J].中国医科大学学报,2011,40(8):752-754,759.
[7]张忠,王旭光,李敏,等.联合检测血清骨桥蛋白和MG7抗原在胃癌诊断中的应用[J].中国老年学杂志,2013,33(2):254-256.
[8]Cao DX,Li ZJ,Jiang XO,et al.Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers[J].World J Gastroenterol,2012,18(30):3923-3930.
[9]Coppola D,Szabo M,Boulware D,et al.Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies[J].Clin Cancer Res,2004,10(1):184-190.
[10]项文坤,洪和平.血清骨桥蛋白、胃癌相关抗原和组织多肽特异性抗原联合检测对胃癌诊断的敏感性和特异性[J].中国基层医药,2015,22(19):2919-2922.
[11]王木生,曹辉琼,周冬根,等.联合检测血清OPN、MG7-Ag、TPS对胃癌的诊断价值[J].山东医药,2011,51(25):76-77.
[12]陈建婷,梁树辉,岳晚霞,等.1A6/DRIM表达及血清MG7-Ag含量在胃癌早期诊断中的价值[J].现代肿瘤医学,2014,22(8):1888-1890.
[13]Sliwowska I,Kipczynski Z,Grodecka-Gazdecka S.Diagnostic value of measuring serum CA15-3,TPA,and TPS in women with breast cancer[J].Postepy Hig Med Dosw,2006,60(3):295-299.