血清TPS、B7H4水平与结直肠癌患者肿瘤发生发展的关系
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摘要
目的探讨结直肠癌患者血清组织多肽特异性抗原(TPS)、负性共刺激分子(B7H4)的变化及其意义。方法选取2016年1月至2017年8月我院确诊的结直肠癌患者100例(肿瘤组)、同期健康体检对象100例(对照组),检测两组的血清TPS、B7H4水平,并将肿瘤组按照是否发生淋巴结转移、TNM分期、病理学分化程度、有无远处转移进行分层分析。结果肿瘤组患者的TPS、B7H4水平显著的高于对照组,差异具有统计学意义(P<0.05);在不同TNM分期、不同分化程度的结直肠癌患者血清TPS水平比较,差异具有统计学意义(P<0.05);在不同TNM分期、是否发生淋巴结转移、是否发生远处转移的结直肠癌患者血清B7H4水平比较,差异具有统计学意义(P<0.05)。结论结直肠癌患者血清TPS、B7H4较健康人群显著的升高,并且与肿瘤的发生发展关系密切。
Objective To investigate the changes and significance of serum tissue polypeptide specific antigen(TPS) and negative costimulatory molecule(B7H4) in patients with colorectal cancer. Methods A total of 100 patients with colorectal cancer diagnosed in our hospital from January 2016 to August 2017(tumor group) and 100 healthy subjects during the same period(control group) were selected. Serum TPS and B7H4 levels were measured in both groups. The stratified analysis was performed within tumor group according to whether lymph node metastasis,TNM staging,pathological differentiation,and distant metastasis occurred.Results The levels of TPS and B7H4 in the tumor group were significantly higher than those in the control group(P<0.05). The difference in serum TPS levels in patients with colorectal cancer with different TNM stages and different degrees of differentiation were statistically significant(P<0.05);The serum B7H4 levels in patients with colorectal cancer with different TNM staging,lymph node metastasis and distant metastasis were statistically significant(P<0.05). Conclusion Serum TPS and B7H4 in patients with colorectal cancer are significantly higher than those in healthy people,and are closely related to the occurrence and development of tumors.
Objective To investigate the changes and significance of serum tissue polypeptide specific antigen(TPS) and negative costimulatory molecule(B7H4) in patients with colorectal cancer. Methods A total of 100 patients with colorectal cancer diagnosed in our hospital from January 2016 to August 2017(tumor group) and 100 healthy subjects during the same period(control group) were selected. Serum TPS and B7H4 levels were measured in both groups. The stratified analysis was performed within tumor group according to whether lymph node metastasis,TNM staging,pathological differentiation,and distant metastasis occurred.Results The levels of TPS and B7H4 in the tumor group were significantly higher than those in the control group(P<0.05). The difference in serum TPS levels in patients with colorectal cancer with different TNM stages and different degrees of differentiation were statistically significant(P<0.05);The serum B7H4 levels in patients with colorectal cancer with different TNM staging,lymph node metastasis and distant metastasis were statistically significant(P<0.05). Conclusion Serum TPS and B7H4 in patients with colorectal cancer are significantly higher than those in healthy people,and are closely related to the occurrence and development of tumors.
引文
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[15]陈颖,何杨,莫骏. B7家族成员B7-H6在肿瘤免疫中的研究进展[J].中华微生物学和免疫学杂志,2015,35(12):932-934.
[2]鲍乐锋,姚鑫,金正贤,等.腹腔镜辅助与开腹结直肠癌根治术临床疗效对比分析[J].湖南师范大学学报(医学版),2017,14(6):64-66.
[3]薛刚,周均,曹永宽,等.血清结肠癌特异性抗原-2检测在结直肠癌随访和预后判断中的应用[J].重庆医科大学学报,2014,39(3):354-357.
[4]陈辰,裴红蕾.肿瘤放射治疗对共刺激分子影响的机制[J].中华实验外科杂志,2016,33(1):272-274.
[5]贺文财.老年原发性肝癌患者外周血肿瘤标志物的改变及临床意义[J].中国肿瘤临床与康复,2017,24(10):1176-1178.
[6]操燕红.3种肿瘤特异性抗原联合检测对胃癌诊断的应用价值分析[J].黑龙江医药科学,2015,38(5):115-116.
[7]于月,耿敬姝.结直肠癌免疫治疗生物标志物的研究进展[J].癌症进展,2017,15(9):998-1002.
[8]Cho WK,Choi DH,Park HC,et al. Elevated CEA is associated with worse survival in recurrent rectal cancer[J]. Oncotarget,2017,8(62):90-93.
[9]Probst CP,Becerra AZ,Aquina CT,et al. Watch and Wait?-Elevat￣ed Pretreatment CEA Is Associated with Decreased Pathological Complete Response in Rectal Cancer[J]. J Gastrointest Surg,2016,20(1):43-52.
[10]丁雪峰,刘飞,韩璐,等.外周血清中肿瘤标志物TPS、B7H4、CEA、OPN在结直肠癌中的检测及临床应用[J].中国卫生标准管理,2015,6(15):169-170.
[11]仵菲斐,克晓燕.新型共刺激分子B7-H6的研究现状[J].中国实验血液学杂志,2016,24(1):295-298.
[12]王利飞,崔澂,刘翠莲,等.协同共刺激分子B7-H4参与肿瘤免疫逃逸的研究进展[J].中国免疫学杂志,2015,31(1):139-141.
[13]陈承晓,张琪惠,李春梅,等.人肝癌相关抗原Cdc25C特异性多肽抗体的制备及其应用[J].山东医药,2016,56(13):1-3.
[14]徐悦蓉,杨安钢,温伟红.负性共刺激分子阻断抗体用于肿瘤治疗的研究进展[J].细胞与分子免疫学杂志,2015,31(1):125-128.
[15]陈颖,何杨,莫骏. B7家族成员B7-H6在肿瘤免疫中的研究进展[J].中华微生物学和免疫学杂志,2015,35(12):932-934.