人类组织血型抗原在小儿轮状病毒感染中的研究进展
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摘要
轮状病毒(RV)是引起婴幼儿病毒性腹泻的主要病原体之一,RV感染宿主细胞主要依赖于病毒识别细胞表面的特异性受体并与其发生结合,因此,受体是病毒感染细胞的重要因素。近年研究发现,组织血型抗原(HBGAs)可以作为RV的结合受体被病毒蛋白VP8识别。该领域的研究不仅部分揭示HBGAs在RV感染、进化中的重要作用,也提示了不同个体对RV易感性的差异,而且对于探索RV感染的发病机制、流行病学规律和防治措施具有重要意义。文章分析RV感染与HBGAs的相关性以进一步探讨最佳疫苗的研发。
Rotavirus(RV) is one of the major pathogens responsible for acute viral gastro-enteritis in children. The infection of RV is dependent upon the recognition of the host cell specific receptors and attachment. Thus, receptors are the important factors of infection. Recent studies have suggested that a genetic factor might play a role in the susceptibility of hosts to RV infection. Histo-blood group antigens have recently been discovered as receptors binding to RV, which are important for the study of evolution. Thus it will be also crucial for the pathogenesis and epidemiology and prevention and treatment for RV. In this article, we will review the correlation of the RV infection and histo-blood group antigens and further discuss the development of optimal vaccine.
Rotavirus(RV) is one of the major pathogens responsible for acute viral gastro-enteritis in children. The infection of RV is dependent upon the recognition of the host cell specific receptors and attachment. Thus, receptors are the important factors of infection. Recent studies have suggested that a genetic factor might play a role in the susceptibility of hosts to RV infection. Histo-blood group antigens have recently been discovered as receptors binding to RV, which are important for the study of evolution. Thus it will be also crucial for the pathogenesis and epidemiology and prevention and treatment for RV. In this article, we will review the correlation of the RV infection and histo-blood group antigens and further discuss the development of optimal vaccine.
引文
[1]Armah GE,Steele AD,Binka FN,et al.Changing patterns of rotavirus genotypes in ghana:emergence of human rotavirus G9 as a major cause of diarrhea in children[J].J Clin Microbiol,2003,41(6):2317-2322.
[2]Yolken RH,Willoughby R,Wee SB,et al.Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses[J].J Clin Invest,1987,79(1):148-154.
[3]Ciarlet M,Estes MK.Human and most animal rotavirus strains do not require the presence of sialic acid on the cell surface for efficient infectivity[J].J Gen Virol,1999,80(Pt 4):943-948.
[4]Ciarlet M,Ludert JE,Iturriza-Gómara M,et al.Initial interaction of rotavirus strains with N-acetylneuraminic(sialic)acid residues on the cell surface correlates with VP4genotype,not species of origin[J].J Virol,2002,76(8):4087-4095.
[5]Fukudome K,Yoshie O,Konno T.Comparison of human,simian,and bovine rotaviruses for requirement of sialic acid in hemagglutination and cell adsorption[J].Virology,1989,172(1):196-205.
[6]Kuhlenschmidt TB,Hanafin WP,Gelberg HB,et al.Sialic acid dependence and independence of group A rotaviruses[J].Adv Exp Med Biol,1999,473:309-317.
[7]Huang P,Xia M,Tan M,et al.Spike protein VP8*of human rotavirus recognizes histo-blood group antigens in a type-specific manner[J].J Virol,2012,86(9):4833-4843.
[8]Clausen H,Hakomori S.ABH and related histo-blood group antigens;immunochemical differences in carrier isotypes and their distribution[J].Vox Sang,1989,56(1):1-20.
[9]Hakomori S.Antigen structure and genetic basis of histo-blood groups A,B and O:their changes associated with human cancer[J].Biochim Biophys Acta,1999,1473(1):247-266.
[10]Henry S,Oriol R,Samuelsson B.Lewis histo-blood group system and associated secretory phenotypes[J].Vox Sang,1995,69(3):166-182.
[11]Henry SM.Review:phenol typing for Lewis and secretor histo-blood group antigens[J].Immunohematology,1996,12(2):51-61.
[12]Le Pendu J.Histo-blood group antigen and human milk oligosaccharides:genetic polymorphism and risk of infectious diseases[J].Adv Exp Med Biol,2004,554:135-143.
[13]Marionneau S,Cailleau-Thomas A,Rocher J,et al.ABH and Lewis histo-blood group antigens,a model for the meaning of oligosaccharide diversity in the face of a changing world[J].Biochimie,2001,83(7):565-573.
[14]曾玫,王晓红,朱启镕.诺如病毒及其受体人类组织血型抗原的研究进展[J].临床儿科杂志,2007,25(12):1036-1039.
[15]Imbert-Marcille BM,BarbéL,DupéM,et al.A FUT2gene common polymorphism determines resistance to rotavirus A of the P[8]genotype[J].J Infect Dis,2014,209(8):1227-1230.
[16]Nordgren J,Sharma S,Bucardo F,et al.Both lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner[J].Clin Infect Dis,2014,59(11):1567-1573.
[17]Bj?rk S,Breimer ME,Hansson GC,et al.Structures of blood group glycosphingolipids of human small intestine.A relation between the expression of fucolipids of epithelial cells and the ABO,Le and Se phenotype of the donor[J].J Biol Chem,1987,262(14):6758-6765.
[18]Karlsson KA,Larson G.Molecular characterization of cell surface antigens of fetal tissue.Detailed analysis of glycosphingolipids of meconium of a human O Le(a--b+)secretor[J].J Biol Chem,1981,256(7):3512-3524.
[19]Van Trang N,Vu HT,Le NT,et al.Association between norovirus and rotavirus infection and histo-blood group antigen types in Vietnamese children[J].J Clin Microbiol,2014,52(5):1366-1374.
[20]Miura T,Sano D,Suenaga A,et al.Histo-blood group antigen-like substances of human entericbacteria as specificy adsorbents for human noroviruses[J].J Virol,2013,87(17):9441-9451.
[21]Jones MK,Watanabe M,Zhu S,et al.Enteric bacteria promote human and mouse norovirus infection of B cells[J].Science,2014,346(6210):755-759.
[22]Hu L,Crawford SE,Czako R,et al.Cell attachment protein VP8*of a human rotavirus specifically interacts with A-type histo-blood group antigen[J].Nature,2012,485(7397):256-259.
[23]B?hm R,Fleming FE,Maggioni A,et al.Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion[J]Nat Commun,2015,6:5907.
[24]Haselhorst T,Fleming FE,Dyason JC,et al.Sialic acid dependence in rotavirus host cell invasion[J].Nat Chem Biol,2009,5(2):91-93.
[25]Isa P,Arias CF,Lopez S.Role of sialic acids in rotavirus infection[J].Glycoconj J,2006,23(1-2):27-37.
[26]Blanchard H,Yu X,Coulson BS,et al.Insight into host cell carbohydrtate-recognition by human and porcine rotavirus from crystal structure of the virion spike associated carbohydrate-binding domain(VP8*)[J].J Mol Biol,2007,367(4):1215-1226.
[27]Madhi SA,Cunliffe NA,Steele D,et al.Effect of human rotavirus vaccine on severe diarrhea in African infants[J].N Engl J Med,2010,362(4):289-298.
[28]Armah GE,Sow SO,Breiman RF,et al.Effecicy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing ountries in sub-Saharan Africa:a randomised,double-blind,placebo-controlled trial[J].Lancet,2010,376(9741):606-614.
[2]Yolken RH,Willoughby R,Wee SB,et al.Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses[J].J Clin Invest,1987,79(1):148-154.
[3]Ciarlet M,Estes MK.Human and most animal rotavirus strains do not require the presence of sialic acid on the cell surface for efficient infectivity[J].J Gen Virol,1999,80(Pt 4):943-948.
[4]Ciarlet M,Ludert JE,Iturriza-Gómara M,et al.Initial interaction of rotavirus strains with N-acetylneuraminic(sialic)acid residues on the cell surface correlates with VP4genotype,not species of origin[J].J Virol,2002,76(8):4087-4095.
[5]Fukudome K,Yoshie O,Konno T.Comparison of human,simian,and bovine rotaviruses for requirement of sialic acid in hemagglutination and cell adsorption[J].Virology,1989,172(1):196-205.
[6]Kuhlenschmidt TB,Hanafin WP,Gelberg HB,et al.Sialic acid dependence and independence of group A rotaviruses[J].Adv Exp Med Biol,1999,473:309-317.
[7]Huang P,Xia M,Tan M,et al.Spike protein VP8*of human rotavirus recognizes histo-blood group antigens in a type-specific manner[J].J Virol,2012,86(9):4833-4843.
[8]Clausen H,Hakomori S.ABH and related histo-blood group antigens;immunochemical differences in carrier isotypes and their distribution[J].Vox Sang,1989,56(1):1-20.
[9]Hakomori S.Antigen structure and genetic basis of histo-blood groups A,B and O:their changes associated with human cancer[J].Biochim Biophys Acta,1999,1473(1):247-266.
[10]Henry S,Oriol R,Samuelsson B.Lewis histo-blood group system and associated secretory phenotypes[J].Vox Sang,1995,69(3):166-182.
[11]Henry SM.Review:phenol typing for Lewis and secretor histo-blood group antigens[J].Immunohematology,1996,12(2):51-61.
[12]Le Pendu J.Histo-blood group antigen and human milk oligosaccharides:genetic polymorphism and risk of infectious diseases[J].Adv Exp Med Biol,2004,554:135-143.
[13]Marionneau S,Cailleau-Thomas A,Rocher J,et al.ABH and Lewis histo-blood group antigens,a model for the meaning of oligosaccharide diversity in the face of a changing world[J].Biochimie,2001,83(7):565-573.
[14]曾玫,王晓红,朱启镕.诺如病毒及其受体人类组织血型抗原的研究进展[J].临床儿科杂志,2007,25(12):1036-1039.
[15]Imbert-Marcille BM,BarbéL,DupéM,et al.A FUT2gene common polymorphism determines resistance to rotavirus A of the P[8]genotype[J].J Infect Dis,2014,209(8):1227-1230.
[16]Nordgren J,Sharma S,Bucardo F,et al.Both lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner[J].Clin Infect Dis,2014,59(11):1567-1573.
[17]Bj?rk S,Breimer ME,Hansson GC,et al.Structures of blood group glycosphingolipids of human small intestine.A relation between the expression of fucolipids of epithelial cells and the ABO,Le and Se phenotype of the donor[J].J Biol Chem,1987,262(14):6758-6765.
[18]Karlsson KA,Larson G.Molecular characterization of cell surface antigens of fetal tissue.Detailed analysis of glycosphingolipids of meconium of a human O Le(a--b+)secretor[J].J Biol Chem,1981,256(7):3512-3524.
[19]Van Trang N,Vu HT,Le NT,et al.Association between norovirus and rotavirus infection and histo-blood group antigen types in Vietnamese children[J].J Clin Microbiol,2014,52(5):1366-1374.
[20]Miura T,Sano D,Suenaga A,et al.Histo-blood group antigen-like substances of human entericbacteria as specificy adsorbents for human noroviruses[J].J Virol,2013,87(17):9441-9451.
[21]Jones MK,Watanabe M,Zhu S,et al.Enteric bacteria promote human and mouse norovirus infection of B cells[J].Science,2014,346(6210):755-759.
[22]Hu L,Crawford SE,Czako R,et al.Cell attachment protein VP8*of a human rotavirus specifically interacts with A-type histo-blood group antigen[J].Nature,2012,485(7397):256-259.
[23]B?hm R,Fleming FE,Maggioni A,et al.Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion[J]Nat Commun,2015,6:5907.
[24]Haselhorst T,Fleming FE,Dyason JC,et al.Sialic acid dependence in rotavirus host cell invasion[J].Nat Chem Biol,2009,5(2):91-93.
[25]Isa P,Arias CF,Lopez S.Role of sialic acids in rotavirus infection[J].Glycoconj J,2006,23(1-2):27-37.
[26]Blanchard H,Yu X,Coulson BS,et al.Insight into host cell carbohydrtate-recognition by human and porcine rotavirus from crystal structure of the virion spike associated carbohydrate-binding domain(VP8*)[J].J Mol Biol,2007,367(4):1215-1226.
[27]Madhi SA,Cunliffe NA,Steele D,et al.Effect of human rotavirus vaccine on severe diarrhea in African infants[J].N Engl J Med,2010,362(4):289-298.
[28]Armah GE,Sow SO,Breiman RF,et al.Effecicy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing ountries in sub-Saharan Africa:a randomised,double-blind,placebo-controlled trial[J].Lancet,2010,376(9741):606-614.