硫普罗宁联合拉米夫定治疗肺结核合并慢性乙型肝炎的效果及其对肝功能、T淋巴细胞免疫应答的影响
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摘要
目的探讨硫普罗宁联合拉米夫定(LAM)治疗肺结核合并慢性乙型肝炎(CHB)的效果及其对肝功能、T淋巴细胞免疫应答的影响。方法将106例肺结核合并CHB患者随机分为对照组(LAM治疗)和观察组(硫普罗宁+LAM治疗),每组53例。比较两组的治疗效果、肝功能、细胞免疫功能及不良反应发生情况。结果观察组愈显率、治疗总有效率、ALT、AST、TBIL、CD4+、CD8+水平及CD4~+/CD8~+均显著优于对照组(P<0.05)。结论肺结核合并CHB治疗中应用硫普罗宁联合LAM,有助于改善患者的肝功能及免疫功能,提高临床疗效。
Objective To investigate the effect of tiopronin combined with lamivudine(LAM) on tuberculosis complicated with chronic hepatitis B(CHB) and its influence on liver function and T lymphocyte immune response. Methods A total of106 patients with tuberculosis complicated with CHB were randomly divided into control group(LAM therapy) and observation group(tiopronin +LAM therapy), with 53 cases in each group. The therapeutic effects, liver function, cellular immune function and adverse reactions were compared between the two groups. Results The markedly effective rate, total therapeutic efficiency, ALT, AST, TBIL, CD4~+, CD8~+levels and CD4~+/CD8~+in the observation group were significantly better than those in the control group(P<0.05). Conclusion Tiopronin combined with LAM in the treatment of pulmonary tuberculosis complicated with CHB can help improve the liver function, immune function of patients and improve the clinical efficacy.
Objective To investigate the effect of tiopronin combined with lamivudine(LAM) on tuberculosis complicated with chronic hepatitis B(CHB) and its influence on liver function and T lymphocyte immune response. Methods A total of106 patients with tuberculosis complicated with CHB were randomly divided into control group(LAM therapy) and observation group(tiopronin +LAM therapy), with 53 cases in each group. The therapeutic effects, liver function, cellular immune function and adverse reactions were compared between the two groups. Results The markedly effective rate, total therapeutic efficiency, ALT, AST, TBIL, CD4~+, CD8~+levels and CD4~+/CD8~+in the observation group were significantly better than those in the control group(P<0.05). Conclusion Tiopronin combined with LAM in the treatment of pulmonary tuberculosis complicated with CHB can help improve the liver function, immune function of patients and improve the clinical efficacy.
引文
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[2]陈美玲,周蓉,周俊霞.目标管理在慢性乙型肝炎合并肺结核患者中的应用体会[J].肝脏,2016,21(8):709-711.
[3]许东,赵满芝,孙登顺,等.87例肺结核合并慢性乙型肝炎患者抗结核治疗的回顾性分析[J].中西医结合肝病杂志,2013,23(2):112-113.
[4]孙丽梅,苏海涛,王海荣.不同治疗方案对合并乙型肝炎肺结核患者肝功能的影响及疗效分析[J].药物不良反应杂志,2015,17(5):330.
[5]丁佩佩,甄沛林,何纲,等.核苷类抗病毒药物对慢性重型乙型肝炎的近期疗效分析[J].中国热带医学,2012,12(12):1513-1515.
[6]冯悦静,陈裕,闫振富.硫普罗宁治疗抗结核药物所致肝损害35例疗效观察[J].中西医结合肝病杂志,2013,23(1):56-57.
[7]刘慧敏,张绪清,郭艳,等.核苷(酸)类似物抗病毒治疗对早期乙型肝炎病毒相关性慢加急性肝衰竭患者预后的影响[J].第三军医大学学报,2017,39(24):2412-2417.