RhoC与肿瘤血管生成关系的研究进展
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摘要
肿瘤血管生成是目前肿瘤治疗方面的研究热点。随着研究的不断深入,以RhoC为代表的Rho酶家族逐渐被发现与肿瘤血管生成存在密切关系。对RhoC与肿瘤血管生成关系进行研究,将有助于肿瘤血管生成新靶点的发现。
Tumor angiogenesis is the research focus in the field of tumor therapy. In further reasearthes, the Rho enzyme family represented by RhoC gradually presents to be related with tumor angiogenesis. The discussion and exploration of the relationship between RhoC and tumor angiogenesis will contribute to the discovery of new targets for tumor angiogenesis.
Tumor angiogenesis is the research focus in the field of tumor therapy. In further reasearthes, the Rho enzyme family represented by RhoC gradually presents to be related with tumor angiogenesis. The discussion and exploration of the relationship between RhoC and tumor angiogenesis will contribute to the discovery of new targets for tumor angiogenesis.
引文
[1]Xie S,Zhu M,Lv G,et al.The role of Rho C in the proliferation and apoptosis of hepatocellular carcinoma cells[J].Med Oncol,2012,29(3):1802-9.
[2]Zhao ZH,Tian Y,Yang JP,et al.Rho C,vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma[J].World J Gastroenterol,2015,21(3):905-12.
[3]Wrighton KH.Cytoskeleton:Rho C invades cofilin’s space[J].Nat Rev Mol Cell Biol,2011,12(6):346-7.
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[8]陈伟浩,徐衍盛,欧阳昀,等.Ras同源物基因家族成员B对肾透明细胞癌细胞生长及迁移能力的影响[J].转化医学杂志,2017,6(2):80-3,87.[Chen WH,Xu YS,Ouyang Y,et al.The effect of Ras homolog gene family member B on cell growth activity and migration of renal clear cell carcinoma[J].Zhuan Hua Yi Xue Za Zhi,2017,6(2):80-3,87.]
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[13]Hoeppner LH,Sinha S,Wang Y,et al.Rho C maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells[J].J Cell Sci,2015,128(19):3556-68.
[14]Wu Y,Tao Y,Chen Y,et al.Rho C regulates the proliferation of gastric cancer cells through interaction with IQGAP1[J].Plo S One,2012,7(11):e48917.
[15]Xie S,Zhu M,Lv G,et al.Overexpression of Ras homologous C(Rho C)induces malignant transformation of hepatocytes in vitro and in nude mouse xenografts[J].Plo S One,2013,8(1):e54493.
[16]Islam M,Sharma S,Teknos TN.Rho C Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3[J].PLo S One,2014,9(2):e88527.
[17]袁耀东,鲁峰,高建华.细胞外基质在调控血管生成中的研究进展[J].中华实验外科杂志,2014,31(6):1385-6.[Yuan YD,Lu F,Gao JH.Research progress of extracellular matrix in the regulation of angiogenesis[J].Zhonghua Shi Yan Wai Ke Za Zhi,2014,31(6):1385-6.]
[18]Griner EM,Dancik GM,Costello JC,et al.Rho C Is an Unexpected Target of Rho GDI2 in Prevention of Lung Colonization of Bladder Cancer[J].Mol Cancer Res,2015,13(3):483-92.
[19]Chang GH,Lay AJ,Ting KK,et al.ARHGAP18:an endogenous inhibitor of angiogenesis,limiting tip formation and stabilizing junctions[J].Small GTPases,2014,5(3):1-15.
[20]Rong C,Yuan C,Youyi Z,et al.Rho C mediates invasion and migration of Ca Ski cells through the Rho-associated serinethreonine protein kinase 1 signaling pathway[J].Int J Gynecol Cancer,2014,24(2):184-91.
[21]Linda J,Michael FO.Rho-associated coiled-coil containing kinases(ROCK):structure,regulation,and functions[J].Small GTPases,2014,5:e29846.
[22]Chong LD,Traynor-Kaplan A,Bokoch GM,et al.The small GTPbinding protein Rho regulates a phosphatidylinositol 4-phosphate5-kinase in mammalian cells[J].Cell,1994,79(3):507-13.
[23]靖旭,孙金隆,张晓芸,等.Jasplakinolide通过稳定细胞骨架调控内皮细胞功能[J].中国药理学通报,2013,29(8):1079-83.[Jing X,Sun JL,Zhang XY,et al.Jasplakinolide affects the functions of HUVECs via actin stabilization[J].Zhongguo Yao Li Xue Tong Bao,2013,29(8):1079-83.]
[24]赵良平,张庆华,王薇娜,等.R h o C过表达对人脐静脉内皮细胞体外迁移及血管生成能力的影响[J].肿瘤防治研究,2008,35(11):766-9.[Zhao LP,Zhang QH,Wang WN,et al.Overexpression of Rho C Affects Human Umbilical Vein Endothelial Cell Migration and Angiogenesis in Vitro[J].Zhong Liu Fang Zhi Yan Jiu,2008,35(11):766-9.]
[25]赵良平,张庆华,石晓燕,等.RNAi沉默Rho C基因对人脐静脉内皮细胞体外生物学行为的影响[J].中华实验外科杂志,2012,29(9):1713-5.[Zhao LP,Zhang QH,Shi XY,et al.Influence of RNA interference-induced Rho C gene silencing on behaviors of human umbilical vein endothelial cells[J].Zhonghua Shi Yan Wai Ke Za Zhi,2012,29(9):1713-5.]
[26]李忠义,缪起龙,沈周俊.细胞外基质与膀胱肿瘤转移[J].国际泌尿系统杂志,2012,32(3):363-7.[Li ZY,Miao QL,Shen ZJ.Extracellular Matrix and Bladder Tumor Metastasis[J].Guo Ji Mi Niao Xi Tong Za Zhi,2012,32(3):363-7.]
[27]Martín-Villar E,Borda-d’Agua B,Carrasco-Ramirez P,et al.Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability[J].Oncogene,2015,34(34):4531-44.
[28]Loboda A,Jozkowicz A,Dulak J.HO-1/CO system in tumor growth,angiogenesis and metabolism-Targeting HO-1 as an antitumor therapy[J].Vascular pharmacology,2015,74:11-22.
[2]Zhao ZH,Tian Y,Yang JP,et al.Rho C,vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma[J].World J Gastroenterol,2015,21(3):905-12.
[3]Wrighton KH.Cytoskeleton:Rho C invades cofilin’s space[J].Nat Rev Mol Cell Biol,2011,12(6):346-7.
[4]Murali A,Rajalingam K.Small Rho GTPases in the control of cell shape and mobility[J].Cell Mol Life Sci,2014,71(9):1703-21.
[5]Ridley AJ.Rho GTPase signalling in cell migration[J].Curr Opin Cell Biol,2015,36:103-12.
[6]Li X,Wang R,Xun X,et al.The Rho GTPase Family Genes in Bivalvia Genomes:Sequence,Evolution and Expression Analysis[J].Plo S One,2015,10(12):e0143932.
[7]Ridley AJ.Rho A,Rho B and Rho C have different roles in cancer cell migration[J].J Micros,2013,251(3):242-9.
[8]陈伟浩,徐衍盛,欧阳昀,等.Ras同源物基因家族成员B对肾透明细胞癌细胞生长及迁移能力的影响[J].转化医学杂志,2017,6(2):80-3,87.[Chen WH,Xu YS,Ouyang Y,et al.The effect of Ras homolog gene family member B on cell growth activity and migration of renal clear cell carcinoma[J].Zhuan Hua Yi Xue Za Zhi,2017,6(2):80-3,87.]
[9]Vallenius T.Actin stress fibre subtypes in mesenchymal-migrating cells[J].Open Biol,2013,3(6):130001.
[10]陈真,许贤林.黏着斑激酶和踝蛋白在黏着斑合成代谢中的作用[J].中国医药生物技术,2015,10(4):303-5.[Chen Z,Xu XL.The role of focal adhesion kinase and ankle protein in mucosal anabolism[J].Zhongguo Yi Yao Sheng Wu Ji Shu,2015,10(4):303-5.]
[11]欧阳锡武,陶一明,王志明.基质硬度对PKN3表达及肝细胞癌侵袭转移的影响[J].中国普通外科杂志,2016,25(10):1455-60.[Ouyang XW,Tao YM,Wang ZM.Influence of matrix stiffness on PKN3 expression and invasion/metastasis in hepatocellular carcinoma[J].Zhongguo Pu Tong Wai Ke Za Zhi,2016,25(10):1455-60.]
[12]Kaushal N,Durmaz YY,Bao L,et al.“Smart”Nanoparticles Enhance the Cytoplasmic Delivery of Anti-Rho C Silencing RNA and Inhibit the Migration and Invasion of Aggressive Breast Cancer Cells[J].Mol Pharm,2015,12(7):2406-17.
[13]Hoeppner LH,Sinha S,Wang Y,et al.Rho C maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells[J].J Cell Sci,2015,128(19):3556-68.
[14]Wu Y,Tao Y,Chen Y,et al.Rho C regulates the proliferation of gastric cancer cells through interaction with IQGAP1[J].Plo S One,2012,7(11):e48917.
[15]Xie S,Zhu M,Lv G,et al.Overexpression of Ras homologous C(Rho C)induces malignant transformation of hepatocytes in vitro and in nude mouse xenografts[J].Plo S One,2013,8(1):e54493.
[16]Islam M,Sharma S,Teknos TN.Rho C Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3[J].PLo S One,2014,9(2):e88527.
[17]袁耀东,鲁峰,高建华.细胞外基质在调控血管生成中的研究进展[J].中华实验外科杂志,2014,31(6):1385-6.[Yuan YD,Lu F,Gao JH.Research progress of extracellular matrix in the regulation of angiogenesis[J].Zhonghua Shi Yan Wai Ke Za Zhi,2014,31(6):1385-6.]
[18]Griner EM,Dancik GM,Costello JC,et al.Rho C Is an Unexpected Target of Rho GDI2 in Prevention of Lung Colonization of Bladder Cancer[J].Mol Cancer Res,2015,13(3):483-92.
[19]Chang GH,Lay AJ,Ting KK,et al.ARHGAP18:an endogenous inhibitor of angiogenesis,limiting tip formation and stabilizing junctions[J].Small GTPases,2014,5(3):1-15.
[20]Rong C,Yuan C,Youyi Z,et al.Rho C mediates invasion and migration of Ca Ski cells through the Rho-associated serinethreonine protein kinase 1 signaling pathway[J].Int J Gynecol Cancer,2014,24(2):184-91.
[21]Linda J,Michael FO.Rho-associated coiled-coil containing kinases(ROCK):structure,regulation,and functions[J].Small GTPases,2014,5:e29846.
[22]Chong LD,Traynor-Kaplan A,Bokoch GM,et al.The small GTPbinding protein Rho regulates a phosphatidylinositol 4-phosphate5-kinase in mammalian cells[J].Cell,1994,79(3):507-13.
[23]靖旭,孙金隆,张晓芸,等.Jasplakinolide通过稳定细胞骨架调控内皮细胞功能[J].中国药理学通报,2013,29(8):1079-83.[Jing X,Sun JL,Zhang XY,et al.Jasplakinolide affects the functions of HUVECs via actin stabilization[J].Zhongguo Yao Li Xue Tong Bao,2013,29(8):1079-83.]
[24]赵良平,张庆华,王薇娜,等.R h o C过表达对人脐静脉内皮细胞体外迁移及血管生成能力的影响[J].肿瘤防治研究,2008,35(11):766-9.[Zhao LP,Zhang QH,Wang WN,et al.Overexpression of Rho C Affects Human Umbilical Vein Endothelial Cell Migration and Angiogenesis in Vitro[J].Zhong Liu Fang Zhi Yan Jiu,2008,35(11):766-9.]
[25]赵良平,张庆华,石晓燕,等.RNAi沉默Rho C基因对人脐静脉内皮细胞体外生物学行为的影响[J].中华实验外科杂志,2012,29(9):1713-5.[Zhao LP,Zhang QH,Shi XY,et al.Influence of RNA interference-induced Rho C gene silencing on behaviors of human umbilical vein endothelial cells[J].Zhonghua Shi Yan Wai Ke Za Zhi,2012,29(9):1713-5.]
[26]李忠义,缪起龙,沈周俊.细胞外基质与膀胱肿瘤转移[J].国际泌尿系统杂志,2012,32(3):363-7.[Li ZY,Miao QL,Shen ZJ.Extracellular Matrix and Bladder Tumor Metastasis[J].Guo Ji Mi Niao Xi Tong Za Zhi,2012,32(3):363-7.]
[27]Martín-Villar E,Borda-d’Agua B,Carrasco-Ramirez P,et al.Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability[J].Oncogene,2015,34(34):4531-44.
[28]Loboda A,Jozkowicz A,Dulak J.HO-1/CO system in tumor growth,angiogenesis and metabolism-Targeting HO-1 as an antitumor therapy[J].Vascular pharmacology,2015,74:11-22.