对青春期前ALL女童化疗初期AMH及INHB水平变化的初步研究
摘要
目的了解青春期前急性淋巴细胞白血病(ALL)女童化疗初期抗苗勒管激素(AMH)和抑制素B(INHB)的动态变化及探讨CCCG-ALL-2015方案对卵巢功能的影响。方法回顾收集2015年7月至2016年2月在本院血液科化疗的初发的均采用了CCCGALL-2015化疗方案的急性淋巴细胞白血病标危组21名女童。在化疗过程中选取化疗前、化疗3个月、化疗6个月的血清标本,测定AMH、INHB水平,比较化疗过程中AMH、INHB水平变化情况。结果本实验随访了ALL标危组女性患儿21名,化疗3个月AMH水平低于化疗前AMH水平,有显著的统计学意义(P=0.023)。化疗半年AMH水平比化疗前AMH水平要低,经比较,差异有统计学意义(P=0.045)。而化疗3个月AMH水平与化疗6个月AMH水平比较无统计学差异(P=0.388)。对21名患儿INHB的检测结果发现,比较了化疗前与化疗3个月、与化疗半年、化疗3个月与化疗6个月INHB水平各组之间无统计学差异(P均>0.05)。结论应用CCCG-ALL-2015方案对患者实施化疗初期就会影响ALL女童AMH的水平导致水平显著降低,严重影响患者的卵巢功能,因此要对此项指标进行重视。
引文
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[7]Falcone T,Bedaiwy M A.Fertility preservation and pregnancy outcome after malignancy[J].CurrOpinObstetGynecol,2005,17(1):21-26.
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