细菌介导的肿瘤治疗研究进展
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摘要
虽然针对肿瘤治疗的化学合成药物、天然提取物、基因工程药物和靶向性药物得到了快速发展,但还达不到治疗肿瘤的效果。一些细菌,尤其是厌氧或兼性厌氧菌可在肿瘤组织内定殖,而且有效抑制肿瘤的生长。随着生物技术的发展,人们改造了一系列厌氧或兼性厌氧菌,降低其毒性的同时,利用肿瘤靶向定殖的能力,使之作为携带治疗分子的载体,为肿瘤治疗提供了新的方向。如果细菌介导肿瘤治疗,以宠物临床应用为目的,做进一步深入研究,可为宠物肿瘤提供更理想的治疗方案。
The tumor drugs have been rapidly developed such as chemosyntheses,herbal medicines,and gene therapy in recently,but we could not reach efficiently treatment of cancer.The tumor was colonized and suppressed by anaerobic or facultative anaerobic bacteria.The researcher reduced toxicity of anaerobic or facultative anaerobic bacteria and carried therapeutic molecules using new biotechnology,which provided a new direction for cancer therapy.If bacteria mediated tumor therapy can be used in pet clinicity,may provide new strategy for tumor therapy for dogs.
The tumor drugs have been rapidly developed such as chemosyntheses,herbal medicines,and gene therapy in recently,but we could not reach efficiently treatment of cancer.The tumor was colonized and suppressed by anaerobic or facultative anaerobic bacteria.The researcher reduced toxicity of anaerobic or facultative anaerobic bacteria and carried therapeutic molecules using new biotechnology,which provided a new direction for cancer therapy.If bacteria mediated tumor therapy can be used in pet clinicity,may provide new strategy for tumor therapy for dogs.
引文
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[30]朱国,师福山,杨杨.2012年—2014年杭州地区宠物犬肿瘤调查[J].动物医学进展,2015,36(11):129-133.
[31]Dang L H,Bettegowda C,Huso D L,et al.Combination bacteriolytic therapy for the treatment of experimental tumors[J].Proc Nati Acad Sci,2001,98(26):15155-15160.
[32]Roberts N J,Zhang L,Janku F,et al.Intratumoral injection of clostridium novyi NT spores induces antitumor responses[J].Sci Trans Med,2014,6(249):1-11.
[33]张红,张迪,金艺鹏,等.细菌治疗犬自发性肿瘤的研究进展[J].畜牧兽医杂志,2016,52(2):66-68.
[2]哈小琴,张尚弟,杨志华,等.肿瘤生物治疗的新技术-靶向基因治疗[J].解放军医药杂志,2014,26(7):24-27.
[3]邹雅如,陈丽华,伍勇.细菌在恶性肿瘤防治中的作用[J].中华临床实验室管理电子杂志,2014,2(3):152-157.
[4]赵文钺,刘璐,刘福囡.双歧杆菌在肿瘤基因靶向治疗的应用[J].解剖科学进展,2015,21(4):405-407.
[5]Nguyen V H,Min J J.Visualization of anticancer Salmonella typhimurium engineered for remote control of therapeutic proteins[J].Meth Mol Biol,2016,1409:135-142.
[6]Jiang S N,Phan T X,Nam T K,et al.Inhibition of tumor growth and metastasis by a combination of Escherichia coli mediated cytolytic therapy and Radiotherapy[J].Mol Thera,2010,18(3):635-642.
[7]Uthman S,Zheng S,Han J,et al.Preparation of engineered salmonella typhimurium drivern hyaluronic acid based microbeads with both chemotactic and biological targeting towards breast cancer cell for enhanced anticancer therapy[J].Adv Health Material,2016,5(2):288-295.
[8]Min J J,Kim H J,Park J H,et al.Noninvasive real-time imaging of tumors and metastases using tumor-targeting light-emitting Escherichia coli[J].Mol Imag Biol,2008,10(1):54-61.
[9]Jiang S N,Park S H,Lee H J,et al.Engineering of bacteria for the visualization of targeted delivery of a cytolytic anticancer agent[J].Mol Thera,2013,21(11):1985-1995.
[10]Phan T X,Nguyen V H,Duong M T,et al.Activation of inflammasome by attenuated Salmonella typhimuriumin bacteria mediated cancer therapy[J].Microbiol Immunol,2015,59(11):664-675.
[11]Neil S F.Engineering the perfect(bacterial)cancer therapy[J].Nat Rev,2010,11(10):785-794.
[12]Harrison L B,Chadha M,Hill R J,et al.Impact of tumor hypoxia and anemia on radiation therapy outcomes[J].Oncologist,2002,7(6):492-508.
[13]Wachsberger P,Burd R,Dicker A P.Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents:exploring mechanisms of interaction[J].Clin Cancer Res,2003,9(6):1957-1971.
[14]Pawelek J M,Low K B,Bermudes D.Bacteria as tumour-targeting vectors[J].Lancet Oncol,2003,4(9):548-556.
[15]蔡惠,郑有礼,王健生.细菌载体在肿瘤治疗中的应用[J].中国现代普通外科进展,2010,13(1):63-67.
[16]Stritzker J,Weibel S,Hill P J,et al.Tumor-specific colonization,tissue distribution,and gene Induction by probiotic Escherichia coli Nissle1917in live mice[J].Int J Med Microbiol,2007,297(3):151-162.
[17]Schultz M,Watzl S,Oelschlaeger T A,et al.Green fluorescent protein for detection of the probiotic microorganism Escherichia coli strain Nissle 1917(EcN)in vivo[J].J Microbiol Meth,2005,61(3):389-398.
[18]Lasaro M A,Salinger N,Zhang J,et al.F1Cfimbriae play an important role in biofilm formation and intestinal colonization by the Escherichia coli commensal strain Nissle 1917[J].Appl Environ Microbiol,2009,75(1):246-251.
[19]Pawelek J M,Low K B,Bermudes D.Tumor-targeted Samonellaas a novel anticancer vector[J].Cancer Res,1997,57(20):4537-4544.
[20]Zheng L M,Luo X,Feng M,et al.Tumor amplified protein expression therapy:Salmonella as a tumor-selective protein delivery vector[J].Oncol Res,2000,12(3):127-135.
[21]Luo X,Li Z,Lin S,et al.Antitumor effect of VNP20009,an attenuated Salmonella,in murine tumor models[J].Oncol Res,2001,12(11):501-508.
[22]Rosenberg S A,Spiess P J,Kleiner D E.Antitumor effects in mice of the intravenous inject ion of attenuated Salmonella typhimurium[J].J Immunother,2002,25(3):218-225.
[23]Jeong J H,Kim K,Lim D,et al.Anti-tumoral effect of the mitochondrial target domain of noxa delivered by an engineered Salmonella typhimurium[J].PLoS One,2014,9(1):1-11.
[24]Hong H,Lim D,Kim G J,et al.Targeted deletion of the ara operon of Salmonella typhimuriumenhances L-arabinose accumulation and drives PBAD-promoted expression of anti-cancer toxins and imaging agent[J].Cell Cycle,2014,13(19):3112-3120.
[25]Wen M,Jung S,Moon K S,et al.Targeting orthotopic glioma in mice with genetically engineered Salmonella typhimurium[J].J Korean Neurosurg Soc,2014,55(3):131-135.
[26]Westphal K,Leschner S,Jablonska J,et al.Containment of tumor colonizing bacteria by host neuthophils[J].Cancer Res,2008,68(8):2952-2960.
[27]Kim J E,Phan T X,Nguyen V H,et al.Salmonella typhimurium suppresses tumor growth via the proinflammatory cytokine interleukin-1β[J].Theranostics,2015,5(12):1328-1342.
[28]闫妮娜.合肥地区犬肿瘤流行病学调查及临床诊断技术的研究[D].安徽合肥:安徽农业大学,2013.
[29]刘春晖,杨蕾,孙艳争,等.北京地区犬肿瘤发生率调查[J].中国兽医杂志,2013,49(1):63-64.
[30]朱国,师福山,杨杨.2012年—2014年杭州地区宠物犬肿瘤调查[J].动物医学进展,2015,36(11):129-133.
[31]Dang L H,Bettegowda C,Huso D L,et al.Combination bacteriolytic therapy for the treatment of experimental tumors[J].Proc Nati Acad Sci,2001,98(26):15155-15160.
[32]Roberts N J,Zhang L,Janku F,et al.Intratumoral injection of clostridium novyi NT spores induces antitumor responses[J].Sci Trans Med,2014,6(249):1-11.
[33]张红,张迪,金艺鹏,等.细菌治疗犬自发性肿瘤的研究进展[J].畜牧兽医杂志,2016,52(2):66-68.