细菌在恶性肿瘤防治中的作用
|
摘要
不同细菌与各种肿瘤之间的关系正成为目前科研关注的热点。正常组织中存在某些特定细菌可能促使恶性肿瘤的形成,而某些肿瘤组织的继发性细菌感染又与肿瘤消退相关。尽管仅有少量细菌可促进肿瘤的发生发展,但大多数情况下,细菌对实体肿瘤是有抑制作用的,并可运用于肿瘤靶向细菌疗法,以发挥抗癌作用。
Associations between different bacteria and various tumours have becoming the focus of current research. The presence of bacteria within healthy tissues may be tumourigenesis, while there may be a correlation between spontaneous bacterial infection and tumour regression. Though a few bacteria are playing a causative role in tumor, mostly bacteria inhibit solid tumours, and can be utilized in tumour-specific bacterial therapy for cancer treatment.
Associations between different bacteria and various tumours have becoming the focus of current research. The presence of bacteria within healthy tissues may be tumourigenesis, while there may be a correlation between spontaneous bacterial infection and tumour regression. Though a few bacteria are playing a causative role in tumor, mostly bacteria inhibit solid tumours, and can be utilized in tumour-specific bacterial therapy for cancer treatment.
引文
1 Polk DB,Peek RM Jr.Helicobacter pylori:gastric cancer and beyond[J].Nat Rev Cancer,2010,10(6):403-414.
2 Hoption Cann SA,van Netten JP,van Netten C.Dr William Coley and tumour regression:a place in history or in the future[J].Postgrad Med J,2003,79(938):672-680.
3 Grivennikov SI,Greten FR,Karin M.Immunity,inflammation,and cancer[J].Cell,2010,140(6):883-899.
4 Coussens LM,Werb Z.Inflammation and cancer[J].Nature,2002,420(6917):860-867.
5 Karin M,Greten FR.NF-κB:linking inflammation and immunity to cancer development and progression.Nat Rev Immunol,2005,5(10):749-759.
6 Goodwin AC,Destefano CE,Wu S,et al.Polyamine catabolism contributes to enterotoxigenic.Bacteroides fragilis-induced colon tumorigenesis[J].Proc Natl Acad Sci U S A,2011,108(37):15345-15359.
7 Waris G,Ahsan H.Reactive oxygen species:role in the development of cancer and various chronic conditions[J].J Carcinog,2006,5:14.
8 Buti L,Spooner E,Van der Veen AG,et al.Helicobacterpylori cytotoxin-associated gene A(Cag A)subverts the apoptosis-stimulating protein of p53(ASPP2)tumor suppressor pathway of the host[J].Proc Natl Acad Sci U S A,2011,108(22):9238-9243.
9 Preuss I,Hildebrand D,Orth JH,et al.Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways[J].Cell Microbiol,2010,12(8):1174-1185.
10 Jinadasa RN,Bloom SE,Weiss RS,et al.Cytolethal distending toxin:a conserved bacterial genotoxin that blocks cell cycle progression,leading to apoptosis of a broad range of mammalian cell lineages[J].Microbiology,2011,157(Pt 7):1851-1875.
11 Abdulamir AS,Hafidh RR,Abu Bakar F.The association of Streptococcus bovis/gallolyticus with colorectal tumors:the nature and the underlying mechanisms of its etiological role[J].J Exp Clin Cancer Res,2011,30:11.
12 Sears CL.Enterotoxigenic Bacteroides fragilis:a rogue among symbiotes[J].Clin Microbiol Rev,2009,22(2):349-369.
13 Rhee KJ,Wu S,Wu X,et al.Induction of persistent colitis by a human commensal,enterotoxigenic Bacteroides fragilis,in wild-type C57BL/6 mice[J].Infect Immun,2009,77(4):1708-1718.
14 Buc E,Dubois D,Sauvanet P,et al.High prevalence of mucosaassociated E.Coli producing cyclomodulin and genotoxin in colon cancer[J].PLo S One,2013,8(2):e56964.
15 Cuevas Rammos G,Petit CR,Marcq I,et al.Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells[J].Proc Natl Acad Sci U S A,2010,107(25):11537-11542.
16 Cougnoux A1,Dalmasso G,Martinez R,et al.Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescenceassociated secretory phenotype[J].Gut,2014,Epub ahead of print
17 Uronis JM,Muhlbauer M,Herfarth HH,et al.Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility[J].PLo S One,2009,4(6):e6026.
18 Kitajima S,Morimoto M,Sagara E,et al.Dextran sodium sulfateinduced colitis in germ-free IQI/Jic mice[J].Exp Anim,2001,50(5):387-395.
19 Shen XJ,Rawls JF,Randall T,et al.Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas[J].Gut Microbes,2010,1(3):138-147.
20 Yoshimoto S,Loo TM,Atarashi K,et al.Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome[J].Nature,2013,499(7456):97-101.
21 Kurkivuori J,Salaspuro V,Kaihovaara P,et al.Acetaldehyde production from ethanol by oral streptococci[J].Oral Oncol,2007,43(2):181-186.
22 Mager DL,Haffajee AD,Devlin PM,et al.The salivary microbiota as a diagnostic indicator of oral cancer:a descriptive,non-randomized study of cancer-free and oral squamous cell carcinoma subjects[J].J Translational Med,2005,3:27.
23 Farrell JJ,Zhang L,Zhou H,et al.Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer[J].Gut,2012,61(4):582-588.
24 Engberts MK,Verbruggen BS,Boon ME,et al.Candida and dysbacteriosis:a cytologic,population-based study of 100,605asymptomatic women concerning cervical carcinogenesis[J].Cancer,2007,111(5):269-274.
25 汪万英,赵芳芳,何杰,等.p53、p16和细菌L型DNA在卵巢肿瘤中的表达及意义[J].中国微生态学杂志,2005,17(5):359-361.
26 Wei MQ,Ellem KA,Dunn P,et al.Facultative or obligate anaerobic bacteria have the potential for multimodality therapy of solid tumours[J].Eur J Cancer,2007,43(3):490-496.
27 Baban CK,Cronin M,O'Hanlon D,et al.Bacteria as vectors for gene therapy of cancer[J].Bioeng Bugs,2010,1(6):385-394.
28 Cronin M,Akin AR,Collins SA,et al.High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting[J].PLo S One,2012,7(1):e30940.
29 周易明,刘常星,邬剑华,等.减毒鼠伤寒沙门氏菌作为肿瘤基因治疗载体的低毒性和靶向性研究[J].复旦学报(医学版),2008,35(3):336-341.
30 Leschner S,Westphal K,Dietrich N,et al.Tumor invasion of Salmonella enterica serovar typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha[J].PLo S One,2009,4(8):e6692.
31 Leschner S,Deyneko IV,Lienenklaus S,et al.Identification of tumorspecific Salmonella Typhimurium promoters and their regulatory logic[J].Nucleic Acids Res,2012,40(7):2984-2994.
32 Gravekamp C,Paterson Y.Harnessing Listeria monocytogenes to target tumors[J].Cancer Biol Ther,2010,9(4):257-265.
33 Saccheri F,Pozzi C,Avogadri F,et al.Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity[J].Sci Transl Med,2010,2(44):44ra57.
34 Srikanth CV,Wall DM,Maldonado Contreras A,et al.Salmonella pathogenesis and processing of secreted effectors by caspase-3[J].Science,2010,330(6002):390-393.
35 dos Santos SA,de Andrade Júnior DR,de Andrade DR.TNF-αproduction and apoptosis in hepatocytes after Listeria monocytogenes and Salmonella Typhimurium invasion[J].Rev Inst Med Trop Sao Paulo,2011,53(2):107-112.
36 Ganai S,Arenas RB,Sauer JP,et al.In tumors Salmonella migrate away from vasculature toward the transition zone and induce apoptosis[J].Cancer Gene Ther,2011,18(7):457-466.
37 Zhao M,Suetsugu A,Ma H,et al.Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetentmice[J].Cell Cycle,2012,11(1):187-193.
38 Nagakura C,Hayashi K,Zhao M,et al.Efficacy of a geneticallymodified Salmonella typhimurium in an orthotopic human pancreatic cancer in nudemice[J].Anticancer Res,2009,29(6):1873-1878.
39 Momiyama M,Zhao M,Kimura H,et al.Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model[J].Cell Cycle,2012,11(3):628-632.
40 Hayashi K,Zhao M,Yamauchi K,et al.Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium[J].Cell Cycle,2009,8(6):870-875.
41 Shao C,Yang B,Zhao L,et al.Tumor suppressor gene RBM5delivered by attenuated Salmonella inhibits lung adenocarcinoma through diverseapoptotic signaling pathways[J].World J Surg Oncol,2013,11:123.
42 Jellbauer S,Panthel K,Hetrodt JH,et al.CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposesagainst a murine melanoma[J].PLo S One,2012,7 (4):e34214.
43 Sorenson BS,Banton KL,Augustin LB,et al.Antioxidant oils and Salmonella enterica Typhimurium reduce tumor in an experimental model of hepaticmetastasis[J].Onco Targets Ther,2011,4:59-69.
44 Jiang Z,Zhao P,Zhou Z,et al.Using attenuated Salmonella typhi as tumor targeting vector for MDR1 si RNA delivery[J].Cance Gene Ther,2007,6(4):555-560.
45 Jeong J H,Kim K,Lim effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium[J].PLo S One,2014,9(1):e80050.
46 Fraillery D,Baud D,Pang SY,et al.Salmonella enterica serovar Typhi Ty21a expressing human papillomavirus type 16 L1 as a potential live vaccineagainst cervical cancer and typhoid fever[J].Clin Vaccine Immunol,2007,14(10):1285-1295.
47 Jia Y,Yin Y,Duan F,et al.Prophylactic and therapeutic efficacy of an attenuated Listeria monocytogenes-based vaccine delivering HPV16E7 in a mouse model Int[J].J Mol Med,2012,30(6):1335-1342.
48 Maciag PC,Radulovic S,Rothman J.The first clinical use of a liveattenuated Listeria monocytogenes vaccine:a Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix[J].Vaccine,2009,27(30):3975-83.
49 Pijkeren J P,Morrissey D,Monk I R,eta l.Anovel Listeia monocytogenes-based DNA delivery system for cancer gene therapy[J].Hum Gene Ther,2010,21(4):405-416.
2 Hoption Cann SA,van Netten JP,van Netten C.Dr William Coley and tumour regression:a place in history or in the future[J].Postgrad Med J,2003,79(938):672-680.
3 Grivennikov SI,Greten FR,Karin M.Immunity,inflammation,and cancer[J].Cell,2010,140(6):883-899.
4 Coussens LM,Werb Z.Inflammation and cancer[J].Nature,2002,420(6917):860-867.
5 Karin M,Greten FR.NF-κB:linking inflammation and immunity to cancer development and progression.Nat Rev Immunol,2005,5(10):749-759.
6 Goodwin AC,Destefano CE,Wu S,et al.Polyamine catabolism contributes to enterotoxigenic.Bacteroides fragilis-induced colon tumorigenesis[J].Proc Natl Acad Sci U S A,2011,108(37):15345-15359.
7 Waris G,Ahsan H.Reactive oxygen species:role in the development of cancer and various chronic conditions[J].J Carcinog,2006,5:14.
8 Buti L,Spooner E,Van der Veen AG,et al.Helicobacterpylori cytotoxin-associated gene A(Cag A)subverts the apoptosis-stimulating protein of p53(ASPP2)tumor suppressor pathway of the host[J].Proc Natl Acad Sci U S A,2011,108(22):9238-9243.
9 Preuss I,Hildebrand D,Orth JH,et al.Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways[J].Cell Microbiol,2010,12(8):1174-1185.
10 Jinadasa RN,Bloom SE,Weiss RS,et al.Cytolethal distending toxin:a conserved bacterial genotoxin that blocks cell cycle progression,leading to apoptosis of a broad range of mammalian cell lineages[J].Microbiology,2011,157(Pt 7):1851-1875.
11 Abdulamir AS,Hafidh RR,Abu Bakar F.The association of Streptococcus bovis/gallolyticus with colorectal tumors:the nature and the underlying mechanisms of its etiological role[J].J Exp Clin Cancer Res,2011,30:11.
12 Sears CL.Enterotoxigenic Bacteroides fragilis:a rogue among symbiotes[J].Clin Microbiol Rev,2009,22(2):349-369.
13 Rhee KJ,Wu S,Wu X,et al.Induction of persistent colitis by a human commensal,enterotoxigenic Bacteroides fragilis,in wild-type C57BL/6 mice[J].Infect Immun,2009,77(4):1708-1718.
14 Buc E,Dubois D,Sauvanet P,et al.High prevalence of mucosaassociated E.Coli producing cyclomodulin and genotoxin in colon cancer[J].PLo S One,2013,8(2):e56964.
15 Cuevas Rammos G,Petit CR,Marcq I,et al.Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells[J].Proc Natl Acad Sci U S A,2010,107(25):11537-11542.
16 Cougnoux A1,Dalmasso G,Martinez R,et al.Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescenceassociated secretory phenotype[J].Gut,2014,Epub ahead of print
17 Uronis JM,Muhlbauer M,Herfarth HH,et al.Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility[J].PLo S One,2009,4(6):e6026.
18 Kitajima S,Morimoto M,Sagara E,et al.Dextran sodium sulfateinduced colitis in germ-free IQI/Jic mice[J].Exp Anim,2001,50(5):387-395.
19 Shen XJ,Rawls JF,Randall T,et al.Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas[J].Gut Microbes,2010,1(3):138-147.
20 Yoshimoto S,Loo TM,Atarashi K,et al.Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome[J].Nature,2013,499(7456):97-101.
21 Kurkivuori J,Salaspuro V,Kaihovaara P,et al.Acetaldehyde production from ethanol by oral streptococci[J].Oral Oncol,2007,43(2):181-186.
22 Mager DL,Haffajee AD,Devlin PM,et al.The salivary microbiota as a diagnostic indicator of oral cancer:a descriptive,non-randomized study of cancer-free and oral squamous cell carcinoma subjects[J].J Translational Med,2005,3:27.
23 Farrell JJ,Zhang L,Zhou H,et al.Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer[J].Gut,2012,61(4):582-588.
24 Engberts MK,Verbruggen BS,Boon ME,et al.Candida and dysbacteriosis:a cytologic,population-based study of 100,605asymptomatic women concerning cervical carcinogenesis[J].Cancer,2007,111(5):269-274.
25 汪万英,赵芳芳,何杰,等.p53、p16和细菌L型DNA在卵巢肿瘤中的表达及意义[J].中国微生态学杂志,2005,17(5):359-361.
26 Wei MQ,Ellem KA,Dunn P,et al.Facultative or obligate anaerobic bacteria have the potential for multimodality therapy of solid tumours[J].Eur J Cancer,2007,43(3):490-496.
27 Baban CK,Cronin M,O'Hanlon D,et al.Bacteria as vectors for gene therapy of cancer[J].Bioeng Bugs,2010,1(6):385-394.
28 Cronin M,Akin AR,Collins SA,et al.High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting[J].PLo S One,2012,7(1):e30940.
29 周易明,刘常星,邬剑华,等.减毒鼠伤寒沙门氏菌作为肿瘤基因治疗载体的低毒性和靶向性研究[J].复旦学报(医学版),2008,35(3):336-341.
30 Leschner S,Westphal K,Dietrich N,et al.Tumor invasion of Salmonella enterica serovar typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha[J].PLo S One,2009,4(8):e6692.
31 Leschner S,Deyneko IV,Lienenklaus S,et al.Identification of tumorspecific Salmonella Typhimurium promoters and their regulatory logic[J].Nucleic Acids Res,2012,40(7):2984-2994.
32 Gravekamp C,Paterson Y.Harnessing Listeria monocytogenes to target tumors[J].Cancer Biol Ther,2010,9(4):257-265.
33 Saccheri F,Pozzi C,Avogadri F,et al.Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity[J].Sci Transl Med,2010,2(44):44ra57.
34 Srikanth CV,Wall DM,Maldonado Contreras A,et al.Salmonella pathogenesis and processing of secreted effectors by caspase-3[J].Science,2010,330(6002):390-393.
35 dos Santos SA,de Andrade Júnior DR,de Andrade DR.TNF-αproduction and apoptosis in hepatocytes after Listeria monocytogenes and Salmonella Typhimurium invasion[J].Rev Inst Med Trop Sao Paulo,2011,53(2):107-112.
36 Ganai S,Arenas RB,Sauer JP,et al.In tumors Salmonella migrate away from vasculature toward the transition zone and induce apoptosis[J].Cancer Gene Ther,2011,18(7):457-466.
37 Zhao M,Suetsugu A,Ma H,et al.Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetentmice[J].Cell Cycle,2012,11(1):187-193.
38 Nagakura C,Hayashi K,Zhao M,et al.Efficacy of a geneticallymodified Salmonella typhimurium in an orthotopic human pancreatic cancer in nudemice[J].Anticancer Res,2009,29(6):1873-1878.
39 Momiyama M,Zhao M,Kimura H,et al.Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model[J].Cell Cycle,2012,11(3):628-632.
40 Hayashi K,Zhao M,Yamauchi K,et al.Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium[J].Cell Cycle,2009,8(6):870-875.
41 Shao C,Yang B,Zhao L,et al.Tumor suppressor gene RBM5delivered by attenuated Salmonella inhibits lung adenocarcinoma through diverseapoptotic signaling pathways[J].World J Surg Oncol,2013,11:123.
42 Jellbauer S,Panthel K,Hetrodt JH,et al.CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposesagainst a murine melanoma[J].PLo S One,2012,7 (4):e34214.
43 Sorenson BS,Banton KL,Augustin LB,et al.Antioxidant oils and Salmonella enterica Typhimurium reduce tumor in an experimental model of hepaticmetastasis[J].Onco Targets Ther,2011,4:59-69.
44 Jiang Z,Zhao P,Zhou Z,et al.Using attenuated Salmonella typhi as tumor targeting vector for MDR1 si RNA delivery[J].Cance Gene Ther,2007,6(4):555-560.
45 Jeong J H,Kim K,Lim effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium[J].PLo S One,2014,9(1):e80050.
46 Fraillery D,Baud D,Pang SY,et al.Salmonella enterica serovar Typhi Ty21a expressing human papillomavirus type 16 L1 as a potential live vaccineagainst cervical cancer and typhoid fever[J].Clin Vaccine Immunol,2007,14(10):1285-1295.
47 Jia Y,Yin Y,Duan F,et al.Prophylactic and therapeutic efficacy of an attenuated Listeria monocytogenes-based vaccine delivering HPV16E7 in a mouse model Int[J].J Mol Med,2012,30(6):1335-1342.
48 Maciag PC,Radulovic S,Rothman J.The first clinical use of a liveattenuated Listeria monocytogenes vaccine:a Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix[J].Vaccine,2009,27(30):3975-83.
49 Pijkeren J P,Morrissey D,Monk I R,eta l.Anovel Listeia monocytogenes-based DNA delivery system for cancer gene therapy[J].Hum Gene Ther,2010,21(4):405-416.