氨甲环酸在全膝关节置换术中的应用进展
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摘要
全膝关节置换术(total knee arthroplasty,TKA)现已普遍运用于治疗终末期膝骨关节病。氨甲环酸(tranexamic acid,TXA)对于控制围手术期全膝关节置换术中的失血情况具有明显的效果。但氨甲环酸在全膝关节置换术中的安全性、给药途径、给药剂量以及给药时机等方面仍没有确切的定论,存在较多争议。故将近年来氨甲环酸在全膝关节置换术中相关研究的进展做一综述。
Total knee arthroplasty(TKA) has been widely used in the treatment of end-stage knee osteoarthrosis. Tranexamic acid(TXA) has a significant effect on the control of blood loss during perioperative total knee arthroplasty. However,the safety,route of administration,dose,and timing of administration of tranexamic acid in total knee arthroplasty remain inconclusive,and there are many controversies. This article reviews the progress of related studies on tranexamic acid in total knee arthroplasty in recent years.
Total knee arthroplasty(TKA) has been widely used in the treatment of end-stage knee osteoarthrosis. Tranexamic acid(TXA) has a significant effect on the control of blood loss during perioperative total knee arthroplasty. However,the safety,route of administration,dose,and timing of administration of tranexamic acid in total knee arthroplasty remain inconclusive,and there are many controversies. This article reviews the progress of related studies on tranexamic acid in total knee arthroplasty in recent years.
引文
[1]杨阳.全膝关节置换术患者出、凝血功能的变化及应对措施[D].石家庄:河北医科大学,2017.
[2] TAN J,CHEN H,LIU Q,et al. A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty[J]. J Surg Res,2013,2(8):880-887.
[3] GEORGIADIS AG,MUH SJ,SLIVERTON CD,et al. A prospective double-blind placebo controlled trial of topic tranexamic acid in total knee arthroplasty[J]. J Arthroplasty,2013,8(1):78-82.
[4] LEE SH,CHO KY,KHURANA S,et al. Less blood loss under concomitant administration of topic tranexamic acid and indirect factor Xa inhibitor following total knee arthroplasty:a prospective randomized controlled trail[J]. Knee Surg Sports Traumatol Arthrosc,2013,11(24):2611-2617.
[5] HYNES MC,CALDER P,ROSENFELD P,et al. The use of the tranexamic acid to reduce bloof loss during total hip arthroplasty:an observational study[J]. Ann R Coll Srug Engl,2005,2(9):99-101.
[6] MACGILLIVRAY RG,TARABICHI SB,HAWARI MF,et al.Tranexamic acid to reduce bloof loss after bilateral total knee arthroplasty:a prospective,randomized double blind study[J]. J Arthroplasty,2011,1(1):24-28.
[7]景鹏举.氨甲环酸在单侧初次全膝关节置换术中的应用分析[D].兰州:兰州大学,2017.
[8] TUTTLE JR,RITTERMAN SA,CASSIDY DB,et al. Cost benefit analysis of topical tranexamic acid in primary total hip and knee arthroplasty[J]. Journal of Arthroplasty,2014,29(8):1512-1515.
[9] SONI A,SAINI R,GULATI A,et al. Comparison between intravenous and intra-articular regimens of tranexamic acid in reducing blood loss during total knee arthroplasty[J]. Journal of Arthroplasty,2014,29(8):1525.
[10] WANG H,SHEN B,ZENG Y. Comparison of topical versus intravenous tranexamic acid in primary total knee arthroplasty:a meta-analysis of randomized controlled and prospective cohort trials[J]. Knee,2014,21(6):987-993.
[11] AHLBERG A,ERIKSSON O,KJELLMAN H. Diffusion of tranexamic acid to the joint[J]. Acta Orthop Scand,1976,47(5):486-488.
[12] SARZAEEM MM,RAZI M,KAZEMIAN G,et al. Comparing efficacy of three methods of tranexamic acid administration in reducing hemoglobin drop following total knee arthroplasty[J].Journal of Arthroplasty,2014,29(8):1521-1524.
[13] MANNUCCI PM. Hemostatic drugs[J]. New England Journal of Medicine,1998,339(4):245-253.
[14] MANIAR RN,KUMAR G,SINGHI T,et al. Most effective regimen of tranexamic acid in knee arthroplasty:a prospective randomized controlled study in 240 patients[J]. Clinical Orthopaedics&Related Research,2012,470(9):2605-2612.
[15] AGUILERA X,HINAREJOS P,LEAL J,et al. Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty:a multicenter,randomized,controlled trial[J]. Archives of Orthopaedic&Trauma Surgery,2015,135(7):1017-1025.
[16] WONG J,ABRISHAMI A,EL BH,et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty:a randomized,controlled trial[J]. Journal of Bone&Joint Surgery-american Volume,2010,92(15):2503-2513.
[17] MELVIN JS,STRYKER LS,SIERRA RJ. Tranexamic acid in hip and knee arthroplasty[J]. J Am Acad Orthop Surg,2015,23(12):732-740.
[18]刘江俊,刘忠强,田少奇,等.氨甲环酸对减少单侧全膝关节置换术后出血的疗效观察[J].中国矫形外科杂志,2014,23(22):2144-2148.
[19] AGRAWAL Y,PATRI S,CHHATRALA H,et al. Demographic parameters related to 30-day readmission of patients with pulmonary embolism:Analysis of 650,819 hospitalizations[J].International Journal of Cardiology,2016,221(2):152-154.
[20]王坤,李海燕,苏晴晴,等.人工全膝关节置换术后深静脉血栓形成相关危险因素及护理的研究进展[J].中西医结合护理(中英文),2017,3(11):198-201.
[21]席少华,周朝波,赵桂林.氨甲环酸在全膝关节置换术中局部应用和静脉应用的止血效果比较[J].实用药物与临床,2015,18(4):481-484.
[22] ZHANG Y,FU X,LIU WX,et al. Safety and efficacy of intraarticular injection of tranexamic acid in total knee arthroplasty[J]. Orthopedics,2014,37(9):e775-782.
[23] SHEN PF,HOU WL,CHEN JB,et al. Effectiveness and safety of tranexamic acid for total knee arthroplasty:A Prospective Randomized Controlled Trial[J]. Medical Science Monitor International Medical Journal of Experimental&Clinical Research,2015,21(5):576-581.
[24] POERAN J,RASUL R,SUZUKI S,et al. Tranexamic acid use and postoper ative outcomes in patients undergoing total hip or knee arthroplasty in the United States:retrospective analysis of effectiveness and safety[J]. Br Med J,2014,349(8):4829.
[25]蒋华,颜宇,马红兵,等.静脉与关节腔内使用氨甲环酸对全膝关节置换术失血量的影响比较[J].中国药业,2015,24(12):44-46.
[2] TAN J,CHEN H,LIU Q,et al. A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty[J]. J Surg Res,2013,2(8):880-887.
[3] GEORGIADIS AG,MUH SJ,SLIVERTON CD,et al. A prospective double-blind placebo controlled trial of topic tranexamic acid in total knee arthroplasty[J]. J Arthroplasty,2013,8(1):78-82.
[4] LEE SH,CHO KY,KHURANA S,et al. Less blood loss under concomitant administration of topic tranexamic acid and indirect factor Xa inhibitor following total knee arthroplasty:a prospective randomized controlled trail[J]. Knee Surg Sports Traumatol Arthrosc,2013,11(24):2611-2617.
[5] HYNES MC,CALDER P,ROSENFELD P,et al. The use of the tranexamic acid to reduce bloof loss during total hip arthroplasty:an observational study[J]. Ann R Coll Srug Engl,2005,2(9):99-101.
[6] MACGILLIVRAY RG,TARABICHI SB,HAWARI MF,et al.Tranexamic acid to reduce bloof loss after bilateral total knee arthroplasty:a prospective,randomized double blind study[J]. J Arthroplasty,2011,1(1):24-28.
[7]景鹏举.氨甲环酸在单侧初次全膝关节置换术中的应用分析[D].兰州:兰州大学,2017.
[8] TUTTLE JR,RITTERMAN SA,CASSIDY DB,et al. Cost benefit analysis of topical tranexamic acid in primary total hip and knee arthroplasty[J]. Journal of Arthroplasty,2014,29(8):1512-1515.
[9] SONI A,SAINI R,GULATI A,et al. Comparison between intravenous and intra-articular regimens of tranexamic acid in reducing blood loss during total knee arthroplasty[J]. Journal of Arthroplasty,2014,29(8):1525.
[10] WANG H,SHEN B,ZENG Y. Comparison of topical versus intravenous tranexamic acid in primary total knee arthroplasty:a meta-analysis of randomized controlled and prospective cohort trials[J]. Knee,2014,21(6):987-993.
[11] AHLBERG A,ERIKSSON O,KJELLMAN H. Diffusion of tranexamic acid to the joint[J]. Acta Orthop Scand,1976,47(5):486-488.
[12] SARZAEEM MM,RAZI M,KAZEMIAN G,et al. Comparing efficacy of three methods of tranexamic acid administration in reducing hemoglobin drop following total knee arthroplasty[J].Journal of Arthroplasty,2014,29(8):1521-1524.
[13] MANNUCCI PM. Hemostatic drugs[J]. New England Journal of Medicine,1998,339(4):245-253.
[14] MANIAR RN,KUMAR G,SINGHI T,et al. Most effective regimen of tranexamic acid in knee arthroplasty:a prospective randomized controlled study in 240 patients[J]. Clinical Orthopaedics&Related Research,2012,470(9):2605-2612.
[15] AGUILERA X,HINAREJOS P,LEAL J,et al. Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty:a multicenter,randomized,controlled trial[J]. Archives of Orthopaedic&Trauma Surgery,2015,135(7):1017-1025.
[16] WONG J,ABRISHAMI A,EL BH,et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty:a randomized,controlled trial[J]. Journal of Bone&Joint Surgery-american Volume,2010,92(15):2503-2513.
[17] MELVIN JS,STRYKER LS,SIERRA RJ. Tranexamic acid in hip and knee arthroplasty[J]. J Am Acad Orthop Surg,2015,23(12):732-740.
[18]刘江俊,刘忠强,田少奇,等.氨甲环酸对减少单侧全膝关节置换术后出血的疗效观察[J].中国矫形外科杂志,2014,23(22):2144-2148.
[19] AGRAWAL Y,PATRI S,CHHATRALA H,et al. Demographic parameters related to 30-day readmission of patients with pulmonary embolism:Analysis of 650,819 hospitalizations[J].International Journal of Cardiology,2016,221(2):152-154.
[20]王坤,李海燕,苏晴晴,等.人工全膝关节置换术后深静脉血栓形成相关危险因素及护理的研究进展[J].中西医结合护理(中英文),2017,3(11):198-201.
[21]席少华,周朝波,赵桂林.氨甲环酸在全膝关节置换术中局部应用和静脉应用的止血效果比较[J].实用药物与临床,2015,18(4):481-484.
[22] ZHANG Y,FU X,LIU WX,et al. Safety and efficacy of intraarticular injection of tranexamic acid in total knee arthroplasty[J]. Orthopedics,2014,37(9):e775-782.
[23] SHEN PF,HOU WL,CHEN JB,et al. Effectiveness and safety of tranexamic acid for total knee arthroplasty:A Prospective Randomized Controlled Trial[J]. Medical Science Monitor International Medical Journal of Experimental&Clinical Research,2015,21(5):576-581.
[24] POERAN J,RASUL R,SUZUKI S,et al. Tranexamic acid use and postoper ative outcomes in patients undergoing total hip or knee arthroplasty in the United States:retrospective analysis of effectiveness and safety[J]. Br Med J,2014,349(8):4829.
[25]蒋华,颜宇,马红兵,等.静脉与关节腔内使用氨甲环酸对全膝关节置换术失血量的影响比较[J].中国药业,2015,24(12):44-46.