摘要
全膝关节置换术(total knee arthroplasty,TKA)现已普遍运用于治疗终末期膝骨关节病。氨甲环酸(tranexamic acid,TXA)对于控制围手术期全膝关节置换术中的失血情况具有明显的效果。但氨甲环酸在全膝关节置换术中的安全性、给药途径、给药剂量以及给药时机等方面仍没有确切的定论,存在较多争议。故将近年来氨甲环酸在全膝关节置换术中相关研究的进展做一综述。
Total knee arthroplasty(TKA) has been widely used in the treatment of end-stage knee osteoarthrosis. Tranexamic acid(TXA) has a significant effect on the control of blood loss during perioperative total knee arthroplasty. However,the safety,route of administration,dose,and timing of administration of tranexamic acid in total knee arthroplasty remain inconclusive,and there are many controversies. This article reviews the progress of related studies on tranexamic acid in total knee arthroplasty in recent years.
引文
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