补肾化瘀法治疗宫环导致经期延长的疗效及对血液流变学的影响
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摘要
目的探讨补肾化瘀法治疗宫环导致经期延长的疗效及对血液流变学的影响。方法将198例宫环导致经期延长患者分为研究组和对照组。对照组采用吲哚美辛治疗,研究组采用自拟补肾化瘀方治疗。对比2组的疗效,检测2组患者治疗前后血液流变学水平(全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原、血细胞比容),记录2组患者治疗第1个月后和第3个月后月经周期的经期时间,记录2组治疗过程中不良反应发生情况。结果研究组总有效率明显高于对照组(P <0. 05); 2组治疗后全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原、血细胞比容均明显降低(P均<0. 05),且研究组治疗后的全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原、血细胞比容均明显低于对照组(P均<0. 05); 2组治疗后经期时间明显缩短(P均<0. 05),研究组治疗3个月后的经期时间明显短于对照组(P <0. 05); 2组治疗过程中均无不良反应发生。结论补肾化瘀法治疗宫环导致经期延长疗效确切,能有效改善血液流变学水平。
Objective It is to investigate the effect of the method of invigorating the kidney and removing blood stasis on the prolongation of menstrual cycle induced by uterine ring and its effect on hemorheology. Methods 198 patients with menostaxis induced by uterine ring were divided into study group and control group. The control group was treated with indomethacin. On the basis of the control group,the study group was treated with self-made Bushen Huayu decoction. The curative effects of the two groups were compared. The levels of indexes of hemorheology including whole blood high-viscosity,whole blood low-cut viscosity,plasma viscosity,fibrinogen,and hematocrit before and after treatment were measured in the two groups,the menstrual period of the patients in the two groups after the first and the third month of treatment was recorded. The incidence of adverse reactions during the treatments was recorded. Results The total effective rate of the study group was higher than that of the control group(P < 0. 05). After treatment,the whole blood high-viscosity,whole blood low-cut viscosity,plasma viscosity,fibrinogen,and hematocrit were significantly decreased in the two groups(P < 0. 05),the whole blood high-viscosity,whole blood low-cut viscosity,plasma viscosity,fibrinogen and hematocrit were lower in the study group than those in the control group(P < 0. 05). The menstrual period was significantly decreased after treatment in the two groups(P < 0. 05),the menstrual period of the study group was shorter than that of the control group after 3 months of treatment(P < 0. 05). No adverse reactions occurred during the treatment. Conclusion The method of invigorating the kidney and removing blood stasis which can effectively improve the level of hemorheology has clear curative effect on prolongation of menstrual period induced by uterine ring.
Objective It is to investigate the effect of the method of invigorating the kidney and removing blood stasis on the prolongation of menstrual cycle induced by uterine ring and its effect on hemorheology. Methods 198 patients with menostaxis induced by uterine ring were divided into study group and control group. The control group was treated with indomethacin. On the basis of the control group,the study group was treated with self-made Bushen Huayu decoction. The curative effects of the two groups were compared. The levels of indexes of hemorheology including whole blood high-viscosity,whole blood low-cut viscosity,plasma viscosity,fibrinogen,and hematocrit before and after treatment were measured in the two groups,the menstrual period of the patients in the two groups after the first and the third month of treatment was recorded. The incidence of adverse reactions during the treatments was recorded. Results The total effective rate of the study group was higher than that of the control group(P < 0. 05). After treatment,the whole blood high-viscosity,whole blood low-cut viscosity,plasma viscosity,fibrinogen,and hematocrit were significantly decreased in the two groups(P < 0. 05),the whole blood high-viscosity,whole blood low-cut viscosity,plasma viscosity,fibrinogen and hematocrit were lower in the study group than those in the control group(P < 0. 05). The menstrual period was significantly decreased after treatment in the two groups(P < 0. 05),the menstrual period of the study group was shorter than that of the control group after 3 months of treatment(P < 0. 05). No adverse reactions occurred during the treatment. Conclusion The method of invigorating the kidney and removing blood stasis which can effectively improve the level of hemorheology has clear curative effect on prolongation of menstrual period induced by uterine ring.
引文
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[21]龚梅芳,李发香,段莎莉.血瘀证患者的血液流变学及体外血栓形成分析[J].湖北中医药大学学报,2000,2(1):25-26
[2]师伟,刘瑞芬,胡瑞华.中医药防治IUD出血不良反应的思路与方法研究[J].山东中医药大学学报,2006,30(5):350-351
[3]魏学勤.化瘀补肾法治疗放环后月经失调68例[J].辽宁中医杂志,1996,23(9):415
[4]国家中医药管理局.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:243-245
[5]卢秀霞,贾晓,袁萍,等.放置与未放置IUD子宫异常出血患者的子宫内膜病理变化对比分析[J].中国妇幼健康研究,2017,28(3):323-325
[6]王莉.宫内节育器作用机制的研究现状[J].西部中医药,2003,16(1):6-9
[7]师伟,刘瑞芬,徐丽,等.吲哚美辛治疗置IUD后出血者子宫内膜形态学变化观察[J].中国计划生育学杂志,2010,18(6):335
[8]苏玉萍,闫宏宇.经期延长的中医辨证分型与性激素的关系[J].中国医药导报,2007,4(34):61-62
[9]陈桂梅,惠春丽,惠永红.放置宫内节育器后月经不调辨证心得[J].西部中医药,2004,17(9):34-35
[10]汪文来,鞠大宏,刘梅洁,等.续断有效成分药理学研究进展[J].中国医药导刊,2015,10(10):1059-1060
[11]王娟娟,秦雪梅,高晓霞,等.杜仲化学成分、药理活性和质量控制现状研究进展[J].中草药,2017,48(15):3228-3237
[12]张芳,郭盛,钱大玮,等.枸杞子中多类型小分子化学物质研究开发现状及前景分析[J].中药材,2016,39(12):2917-2921
[13]魏祥燕,王国娟,王桦影,等.女贞子药理作用研究进展[J].上海中医药杂志,2017,9(8):106-108
[14]黄兴,王哲,王保和.仙鹤草药理作用及临床应用研究进展[J].山东中医杂志,2017,12(2):172-176
[15]李海峰,肖凌云,张菊,等.茜草化学成分及其药理作用研究进展[J].中药材,2016,39(6):1433-1436
[16]陈红宇,沈洪.地榆活性成分及抗炎作用研究进展[J].中医药导报,2017,20(17):110-113
[17]叶招浇,阎澜,李洪娇,等.中药地榆的药理作用及临床应用研究进展[J].药学服务与研究,2015,15(1):47-50
[18]张来宾,吕洁丽,陈红丽,等.当归中苯酞类成分及其药理作用研究进展[J].中国中药杂志,2016,41(2):167-176
[19]杜旌畅,谢晓芳,熊亮,等.川芎挥发油的化学成分与药理活性研究进展[J].中国中药杂志,2016,41(23):4328-4333
[20]王玉红,程霞,陈光辉.地黄化学成分研究及治疗心血管疾病的临床应用[J].中西医结合心脑血管病杂志,2009,7(12):1450-1452
[21]龚梅芳,李发香,段莎莉.血瘀证患者的血液流变学及体外血栓形成分析[J].湖北中医药大学学报,2000,2(1):25-26