微米平瘿散治疗亚急性甲状腺炎临床观察
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摘要
目的验证微米平瘿散治疗亚急性甲状腺炎的临床疗效,为亚急性甲状腺炎的临床治疗提供新的方法。方法 72例亚急性甲状腺炎患者随机分为2组,2组病例均服用吲哚美辛25 mg,每日3次。试验组同时使用微米平瘿散外敷甲状腺体表部位,每日1次,时间在8 h以上,疗程为2周。比较2组患者治疗1周及2周后的中医症状积分,血清FT3、FT4、TSH,血沉数据,治疗2周后患者起效时间、疗效、糖皮质激素使用率。结果治疗1周后2组血清FT3、FT4、TSH及血沉比较差异无统计学意义(P> 0. 05);中医症状积分比较差异有统计学意义(P <0. 05),试验组中医症状积分低于对照组。治疗2周后,2组血清FT3、FT4、TSH比较差异有统计学意义(P <0. 05),试验组疗效优于对照组;血沉比较差异无统计学意义(P>0. 05); 2组中医症状积分比较差异有统计学意义(P <0. 05),试验组低于对照组; 2组总体疗效比较差异有统计学意义(P <0. 05),试验组总有效率、痊愈率及显效率高于对照组。2组治疗起效时间比较差异有统计学意义(P <0. 05),试验组起效更快;激素使用情况比较差异有统计学意义(P <0. 05)。试验组糖皮质激素使用率低于对照组。结论微米平瘿散外敷联合吲哚美辛的方案在缩短起效时间,改善患者症状,改善血清FT3、FT4、TSH水平,提高疗效,减少糖皮质激素使用率方面优于单纯西药治疗,验证了微米平瘿散治疗亚急性甲状腺的临床疗效。
Objective To verify the clinical efficacy of Weimi Pingying powder in the treatment of subacute thyroiditis,so as to provide a new method for the clinical treatment of subacute thyroiditis. Methods 72 patients with subacute thyroiditis were randomly divided into 2 groups. Both two groups of patients took indomethacin 25 mg 1 day 3 times. In the experimental group,Weimi Pingying powder was applied to the surface of the thyroid gland,one times on one day,the time is more than 8 hours,and the course of treatment is two weeks. Data on TCM symptom scores,serum FT3,FT4,TSH and ESR from two groups of patients after one and two weeks of treatment were collected,and the differences between the two groups was compared. After 2 weeks of treatment,the onset time and efficacy of two groups of patients and compare their differences was evaluated. The usage rate of glucocorticoids was observed and compared between the two groups. Result One week after treatment,there was no statistically significant difference in serum FT3,FT4,TSH and ESR between the two groups( P > 0. 05).There was statistically significant difference in TCM symptom score between the two groups( P < 0. 05). The TCM symptom score of the experimental group was lower than that of the control group. Two weeks after treatment,there were statistically significant differences in serum FT3,FT4,TSH between the two groups( P < 0. 05). The curative effect of the experimental group was better than that of the control group,and there was no statistically significant difference in ESR between the two groups( P > 0. 05). There was statistically significant difference in TCM symptom score between the two groups( P < 0. 05). The score of TCM symptoms in the experimental group was lower than that in the control group. The difference between the two groups of curative effects was statistically significant( P < 0. 05). The total effective rate,cure rate and effective rate in the experimental group were higher than those in the control group. There was a statistically significant difference in onset time between the two groups( P < 0. 05). The experimental group had a faster onset time. There was a statistically significant difference in the use of hormones( P < 0. 05). The use rate of glucocorticoid use in the experimental group was lower than that in the control group. Conclusion External application of Weimi Pingying powder combined with indomethacin is superior to western medicine in shortening the onset time,improving symptoms,improving serum FT3,FT4,TSH levels,improving curative effect,reducing the usage rate of glucocorticoids. The clinical efficacy of micron Weimi Pingying powder in the treatment of subacute thyroid is verified.
Objective To verify the clinical efficacy of Weimi Pingying powder in the treatment of subacute thyroiditis,so as to provide a new method for the clinical treatment of subacute thyroiditis. Methods 72 patients with subacute thyroiditis were randomly divided into 2 groups. Both two groups of patients took indomethacin 25 mg 1 day 3 times. In the experimental group,Weimi Pingying powder was applied to the surface of the thyroid gland,one times on one day,the time is more than 8 hours,and the course of treatment is two weeks. Data on TCM symptom scores,serum FT3,FT4,TSH and ESR from two groups of patients after one and two weeks of treatment were collected,and the differences between the two groups was compared. After 2 weeks of treatment,the onset time and efficacy of two groups of patients and compare their differences was evaluated. The usage rate of glucocorticoids was observed and compared between the two groups. Result One week after treatment,there was no statistically significant difference in serum FT3,FT4,TSH and ESR between the two groups( P > 0. 05).There was statistically significant difference in TCM symptom score between the two groups( P < 0. 05). The TCM symptom score of the experimental group was lower than that of the control group. Two weeks after treatment,there were statistically significant differences in serum FT3,FT4,TSH between the two groups( P < 0. 05). The curative effect of the experimental group was better than that of the control group,and there was no statistically significant difference in ESR between the two groups( P > 0. 05). There was statistically significant difference in TCM symptom score between the two groups( P < 0. 05). The score of TCM symptoms in the experimental group was lower than that in the control group. The difference between the two groups of curative effects was statistically significant( P < 0. 05). The total effective rate,cure rate and effective rate in the experimental group were higher than those in the control group. There was a statistically significant difference in onset time between the two groups( P < 0. 05). The experimental group had a faster onset time. There was a statistically significant difference in the use of hormones( P < 0. 05). The use rate of glucocorticoid use in the experimental group was lower than that in the control group. Conclusion External application of Weimi Pingying powder combined with indomethacin is superior to western medicine in shortening the onset time,improving symptoms,improving serum FT3,FT4,TSH levels,improving curative effect,reducing the usage rate of glucocorticoids. The clinical efficacy of micron Weimi Pingying powder in the treatment of subacute thyroid is verified.
引文
[1] ENGKAKUL P,MAHACHOKLERTWATTANA P,POOMTHAVORN P. Eponym:De Quervain thyroiditis[J]. Eur J Pediatr,2011,170(4):427-431.
[2]欧阳常林.强的松联合诺松治疗亚急性甲状腺炎临床分析[J].中国医药导报,2010,7(22):115-116
[3] VOLPE R. The management of subacute(De Quervain’s)thyroiditis[J].Thyroid,1993,3(3):253-255.
[4] LUOTOLA K,MANTULA P,SALMI J,et al. Allele 2 of interleukin1receptor antagonist gene increases the risk of thyroid peroxidaseantibodies in subacute thyroiditis[J]. APMIS,2001,109(6):454-460.
[5]张进,李继红.亚急性甲状腺炎的诊断与鉴别诊断[J].中国当代医药,2010,17(14):135-136.
[6]黎克江,雷永红,刘新华.小剂量糖皮质激素联合消炎痛用于亚急性甲状腺炎治疗效果的分析[J].河北医药,2014,36(1):65-67
[7]巴颖,周焱,杜建玲,等.亚急性甲状腺炎误诊手术35例分析[J].中国实用内科杂志,2007,27(7):542.
[8]周卫惠,唐爱华.加用夏枯草消瘿散外敷治疗亚急性甲状腺炎疗效观察[J].广西中医药,2008,31(5):15-16
[9]纪放,王旭.王旭教授治疗亚急性甲状腺炎经验总结[J].吉林中医药,2012,32(1):18-19
[2]欧阳常林.强的松联合诺松治疗亚急性甲状腺炎临床分析[J].中国医药导报,2010,7(22):115-116
[3] VOLPE R. The management of subacute(De Quervain’s)thyroiditis[J].Thyroid,1993,3(3):253-255.
[4] LUOTOLA K,MANTULA P,SALMI J,et al. Allele 2 of interleukin1receptor antagonist gene increases the risk of thyroid peroxidaseantibodies in subacute thyroiditis[J]. APMIS,2001,109(6):454-460.
[5]张进,李继红.亚急性甲状腺炎的诊断与鉴别诊断[J].中国当代医药,2010,17(14):135-136.
[6]黎克江,雷永红,刘新华.小剂量糖皮质激素联合消炎痛用于亚急性甲状腺炎治疗效果的分析[J].河北医药,2014,36(1):65-67
[7]巴颖,周焱,杜建玲,等.亚急性甲状腺炎误诊手术35例分析[J].中国实用内科杂志,2007,27(7):542.
[8]周卫惠,唐爱华.加用夏枯草消瘿散外敷治疗亚急性甲状腺炎疗效观察[J].广西中医药,2008,31(5):15-16
[9]纪放,王旭.王旭教授治疗亚急性甲状腺炎经验总结[J].吉林中医药,2012,32(1):18-19