宫颈绒毛管状腺癌的诊治
摘要
宫颈绒毛管状腺癌(VGA)是一种少见且特殊类型的宫颈腺癌,其诊断需要做排除性的诊断,易误诊、漏诊。一般认为宫颈腺癌的预后较差,易发生早期转移,对放疗不敏感,而VGA患者发病年龄更年轻,以外生型生长为主,一般无血管淋巴卵巢的转移,预后较好。多数学者提出临床可以进行相对保守的治疗方法。因VGA发病率低,样本量较少,目前暂无确切、标准的治疗方案。对有生育要求的妊娠合并VGA患者,多采取孕期保守治疗,待胎儿成熟再剖宫产加宫颈癌根治性手术,并需根据具体临床分期、孕期等制定个体化治疗策略。通过总结已有文献报道分析总结VGA的诊治情况,为寻找临床最佳的诊治路径打下基础。
引文
[1]Young RH,Scully RE.Villoglandular papillary adenocarcinoma of the uterine cervix:A clinicopathologic analysis of 13 cases[J].Cancer,1989,63(9):1773-1779.
[2]孙岚,吴捷,陆惠娟,等.子宫颈高分化绒毛腺管状腺癌一例[J].中华妇产科杂志,2002,37(2):126.
[3]Muller S,Flores-Staino C,Skyldberg B.Expression of p16INK4a and MIB-1 inrelation to histopathology and HPV types in cervical adenocarcinoma[J].Int J Oncol,2008,32(2):333-340.
[4]刘潇阳.探讨中国妇女宫颈腺癌人乳头瘤病毒感染及组织学特征[D].北京协和医学院,2014.
[5]Jones MW,Kounelis S,Papadaki H,et al.Well differentiated villoglandular adenoearcinoma of the uterine cervix:oncogene/tumor suppressor gene alteration and human papilloma Virusgenotyping[J].Int J Gynecol Pathol,2000,19(2):110-117.
[6]Jones M.Well-differentiated villoglandular adenocarcinoma of the uterine cervix:a clinicopathological study of 24 cases[J].Int J Gynecol Pathol,1993,12(1):1-7.
[7]庄勋,顾晓梅,何爱,等.宫颈癌危险因素的流行病学调查[J].中国妇幼保健,2008,23(28):4053-4056.
[8]朱夏琴,吴鸣,谭先杰,等.宫颈绒毛管状腺癌16例临床分析[J].中华医学杂志,2015,95(7):519-522.
[9]Khunamornpong S,Maleemonkol S.Well-Differentiated villoglandular adenocarcinoma of the uterine cervix:a report of 15 cases including two with lymph node metastasis[J].J Med Assoc Thai,2001,84(6):882-888.
[10]Utsugi K,Shimizu Y.Clinicopathologic features of villoglandular Papillary adenocarcinoma of the uterine cervix[J].Gynecol Oncol,2004,92(1):64-70.
[11]Boumana A,Jurjen GE.Villoglandular papillary adenocarcinoma of the cervix Beware of a wolf in sheep's clothing European[J].Journal of Obstetrics&Gynecology and Reproductive Biology,1999,87(2):183-189.
[12]Macdonald RD,Kirwan J.Villoglandular adenocarcinoma of the cervix:Clarity is needed on the histological definition for this difficult diagnosis B[J].Gynecologic Oncology,2006,100(1):192-199.
[13]Korach JI,Machtinger R.Villoglandular papillary adenocarcinoma of the uterine cervix:a diagnostic challenge[J].Acta Obstet Gynecol Scand,2009,88(3):355-358.
[14]朱伦,施雅,郭庆,等.宫颈绒毛管状腺癌11例临床病理学特征及文献复习[J].临床与实验病理学杂志,2013,29(5):506-510.
[15]Falcón OI,García R.Successful term delivery following conservative management for villoglandular papillary adenocarcinoma of theuterine cervix:A case report[J].Gynecol Oncol,2006,101(1):168-171.
[16]Novotny DB,Ferlisi P.Villoglandular adenocarcinoma of the cervix:cytol-ogic presentation[J].Diagn Cytopathol,1997,17(5):383-387.
[17]王凤华,张培海,张建平,等.宫颈绒毛管状腺癌1例报道并文献复习[J].现代妇产科进展,2013,22(7):608.
[18]戴珍珍,钟国平,丛玲华,等.宫颈绒毛管状腺癌3例并文献复习[J].浙江医学,2010,32(12):1836-1837.
[19]邰海燕,尤志学.宫颈高分化绒毛管状腺癌1例及文献复习[J].现代妇产科进展,2009,18(2):155-156.
[20]闻强,邵株燕,方素华.宫颈腺癌321例卵巢转移情况的临床分析[J].现代妇产科进展,2015,7(7):501-503.
[21]Khunamornpong S,Siriaunkgul S,Suprasert P.Well-differentiated villoglandular adeno-carcinoma of the uterine cervix:cytomorphologic observation of fivecases[J].Diagn Cyto-pathol,2002,26(1):10-14.
[22]Nagai N,Hirata E.Villoglandular papillary adenocarcinoma of the uterine cervix res-ponding to neoadjuvant chemotherapy with docetaxel and cisplatin:a case report[J].Int J Gynecol Cancer,2005,15(6):1187-1190.
[23]Kim HJ,Sung JH,Lee E.Prognostic factors influencing decisions about surgical treatment of villoglandular adenocarcinoma of the uterine cervix[J].Int J i Gynecol i Cancer,2014,24(7):1299-1305.
[24]Dede MI,Deveci G.Villoglandular papillary Adenocarcinoma of the uterine cervix in a pregnant woman:a case report and review of literature[J].Tohoku J Exp Med,2004,202(4):305-310.
[25]Zagouri F,Sergentanis TN,Chrysikos D,et al.Platinum derivatives during pregnancy in cervical cancer:a systematic review and meta—analysis[J].Obstet Gynecol,2013,121(1):337-343.
[26]Hurteau JA,Rodriguez GC,Kay HH,et al.Villoglandular adenocarcinoma of the cervix:a case report[J].Obstetrics and Gynecology,1995,85(2):906-908.
[27]莫秀兰,凌奕,陈华,等.妊娠合并宫颈绒毛管状腺癌一例报道并文献复习[J].中国优生与遗传杂志,2007,15(7):60-61.
[2]孙岚,吴捷,陆惠娟,等.子宫颈高分化绒毛腺管状腺癌一例[J].中华妇产科杂志,2002,37(2):126.
[3]Muller S,Flores-Staino C,Skyldberg B.Expression of p16INK4a and MIB-1 inrelation to histopathology and HPV types in cervical adenocarcinoma[J].Int J Oncol,2008,32(2):333-340.
[4]刘潇阳.探讨中国妇女宫颈腺癌人乳头瘤病毒感染及组织学特征[D].北京协和医学院,2014.
[5]Jones MW,Kounelis S,Papadaki H,et al.Well differentiated villoglandular adenoearcinoma of the uterine cervix:oncogene/tumor suppressor gene alteration and human papilloma Virusgenotyping[J].Int J Gynecol Pathol,2000,19(2):110-117.
[6]Jones M.Well-differentiated villoglandular adenocarcinoma of the uterine cervix:a clinicopathological study of 24 cases[J].Int J Gynecol Pathol,1993,12(1):1-7.
[7]庄勋,顾晓梅,何爱,等.宫颈癌危险因素的流行病学调查[J].中国妇幼保健,2008,23(28):4053-4056.
[8]朱夏琴,吴鸣,谭先杰,等.宫颈绒毛管状腺癌16例临床分析[J].中华医学杂志,2015,95(7):519-522.
[9]Khunamornpong S,Maleemonkol S.Well-Differentiated villoglandular adenocarcinoma of the uterine cervix:a report of 15 cases including two with lymph node metastasis[J].J Med Assoc Thai,2001,84(6):882-888.
[10]Utsugi K,Shimizu Y.Clinicopathologic features of villoglandular Papillary adenocarcinoma of the uterine cervix[J].Gynecol Oncol,2004,92(1):64-70.
[11]Boumana A,Jurjen GE.Villoglandular papillary adenocarcinoma of the cervix Beware of a wolf in sheep's clothing European[J].Journal of Obstetrics&Gynecology and Reproductive Biology,1999,87(2):183-189.
[12]Macdonald RD,Kirwan J.Villoglandular adenocarcinoma of the cervix:Clarity is needed on the histological definition for this difficult diagnosis B[J].Gynecologic Oncology,2006,100(1):192-199.
[13]Korach JI,Machtinger R.Villoglandular papillary adenocarcinoma of the uterine cervix:a diagnostic challenge[J].Acta Obstet Gynecol Scand,2009,88(3):355-358.
[14]朱伦,施雅,郭庆,等.宫颈绒毛管状腺癌11例临床病理学特征及文献复习[J].临床与实验病理学杂志,2013,29(5):506-510.
[15]Falcón OI,García R.Successful term delivery following conservative management for villoglandular papillary adenocarcinoma of theuterine cervix:A case report[J].Gynecol Oncol,2006,101(1):168-171.
[16]Novotny DB,Ferlisi P.Villoglandular adenocarcinoma of the cervix:cytol-ogic presentation[J].Diagn Cytopathol,1997,17(5):383-387.
[17]王凤华,张培海,张建平,等.宫颈绒毛管状腺癌1例报道并文献复习[J].现代妇产科进展,2013,22(7):608.
[18]戴珍珍,钟国平,丛玲华,等.宫颈绒毛管状腺癌3例并文献复习[J].浙江医学,2010,32(12):1836-1837.
[19]邰海燕,尤志学.宫颈高分化绒毛管状腺癌1例及文献复习[J].现代妇产科进展,2009,18(2):155-156.
[20]闻强,邵株燕,方素华.宫颈腺癌321例卵巢转移情况的临床分析[J].现代妇产科进展,2015,7(7):501-503.
[21]Khunamornpong S,Siriaunkgul S,Suprasert P.Well-differentiated villoglandular adeno-carcinoma of the uterine cervix:cytomorphologic observation of fivecases[J].Diagn Cyto-pathol,2002,26(1):10-14.
[22]Nagai N,Hirata E.Villoglandular papillary adenocarcinoma of the uterine cervix res-ponding to neoadjuvant chemotherapy with docetaxel and cisplatin:a case report[J].Int J Gynecol Cancer,2005,15(6):1187-1190.
[23]Kim HJ,Sung JH,Lee E.Prognostic factors influencing decisions about surgical treatment of villoglandular adenocarcinoma of the uterine cervix[J].Int J i Gynecol i Cancer,2014,24(7):1299-1305.
[24]Dede MI,Deveci G.Villoglandular papillary Adenocarcinoma of the uterine cervix in a pregnant woman:a case report and review of literature[J].Tohoku J Exp Med,2004,202(4):305-310.
[25]Zagouri F,Sergentanis TN,Chrysikos D,et al.Platinum derivatives during pregnancy in cervical cancer:a systematic review and meta—analysis[J].Obstet Gynecol,2013,121(1):337-343.
[26]Hurteau JA,Rodriguez GC,Kay HH,et al.Villoglandular adenocarcinoma of the cervix:a case report[J].Obstetrics and Gynecology,1995,85(2):906-908.
[27]莫秀兰,凌奕,陈华,等.妊娠合并宫颈绒毛管状腺癌一例报道并文献复习[J].中国优生与遗传杂志,2007,15(7):60-61.