宫颈绒毛管状腺癌的临床分析
摘要
目的探讨宫颈绒毛管状腺癌(VGA)的临床病理特点、治疗效果及预后。方法回顾性分析该科2011年8月至2016年5月收治的17例宫颈VGA患者的临床病理资料,对患者的年龄、首诊症状、病灶大体形态、高危人类乳头瘤病毒(HPV)感染情况、国际妇产科协会分期、手术方式等情况进行总结分析。结果 15例行广泛性子宫切除术加双侧盆腔淋巴结切除术,其中11例行双侧附件切除术,4例行双侧卵巢移位术;1例行广泛性子宫切除术,1例行全子宫切术。12例患者行术后辅助治疗。14例患者获术后随访,随访时间3~36个月,均存活,未见复发和转移。结论宫颈VGA整体预后较好,以外生型肿瘤多见,规范的妇科检查及高危HPV检测有利于该疾病的早期发现,无高危因素的患者可考虑保守手术治疗,但无随访条件的患者仍建议行广泛性子宫切除术加盆腔淋巴结切除术。
引文
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[4]Lataifeh IM,Al-Hussaini M,Uzan C,et al.Villoglandular papillary adenocarcinoma of the cervix:a series of 28 cases including two with lymph node metastasis[J].Int J Gynecol Cancer,2013,23(5):900-905.
[5]王蓉蓉,吴亮,黄卡特,等.宫颈绒毛管状腺癌2例并文献复习[J].浙江实用医学,2010,15(4):299-301.
[6]Jones MW,Kounelis S,Papadaki H,et al.Well-differentiated villoglandular adenocarcinoma of the uterine cervix:Oncogene/tumor suppressor gene alterations and human papillomavirus genotyping[J].Int J Gynecol Pathol,2000,19(2):110-117.
[7]Yamazawa K,Matsui H,Seki K,et al.Human papillomavirus-positive well-differentiated villoglandular adenocarcinoma of the uterine cervix:A case report and review of the literature[J].Gynecol Oncol,2000,77(3):473-477.
[8]游燕,郭丽娜.宫颈绒毛腺管状腺癌的临床病理[J].协和医学杂志,2012,3(1):61-67.
[9]陈仕高,黄琳,杨明东,等.宫颈绒毛状腺癌临床病理分析[J].华西医学,2016,31(6):1069-1072.
[10]于晶功,姜丹,王亚萍.宫颈微偏腺癌12例临床病理分析[J].当代医学,2016,22(23):3-5.
[11]刘鹏飞,郭朋,吴鸣,等.宫颈绒毛管状腺癌38例临床病理分析[J].现代妇产科进展,2015,24(10):739-742.
[12]喻金梅,安云婷,邹美燕.宫颈绒毛管状腺癌3例临床病理特点及文献复习[J].实用癌症杂志,2015(1):151-152.
[13]任雪,张馨遥,杨长滨,等.宫颈绒毛管状腺癌临床分析[J].中国妇幼保健,2014,29(9):1466-1468.
[14]Bouman A,Oosterhuis GJ,Naudin ten Cate L,et al.Villoglandular papillary adenocarcinoma of the cervix.Beware of a wolf in sheep′s clothing[J].Eur J Obstet Gynecol Reprod Biol,1999,87(2):183-189.
[15]Kim HJ,Sung JH,Lee E,et al.Prognostic factors influencing decisions about surgical treatment of villoglandular adenocarcinoma of the uterine cervix[J].Int J Gynecol Cancer,2014,24(7):1299-1305.
[16]朱伦,施雅,郭庆,等.宫颈绒毛管状腺癌11例临床病理学特征及文献复习[J].临床与实验病理学杂志,2013,29(5):506-510.
[2]孙岚,吴捷,陆惠娟.子宫颈高分化绒毛腺管状腺癌1例[J].中华妇产科杂志,2002,37(2):126.
[3]冯彩霞,郭红燕,孔东丽.宫颈绒毛管状腺癌的诊治[J].实用妇产科杂志,2016,32(7):495-499.
[4]Lataifeh IM,Al-Hussaini M,Uzan C,et al.Villoglandular papillary adenocarcinoma of the cervix:a series of 28 cases including two with lymph node metastasis[J].Int J Gynecol Cancer,2013,23(5):900-905.
[5]王蓉蓉,吴亮,黄卡特,等.宫颈绒毛管状腺癌2例并文献复习[J].浙江实用医学,2010,15(4):299-301.
[6]Jones MW,Kounelis S,Papadaki H,et al.Well-differentiated villoglandular adenocarcinoma of the uterine cervix:Oncogene/tumor suppressor gene alterations and human papillomavirus genotyping[J].Int J Gynecol Pathol,2000,19(2):110-117.
[7]Yamazawa K,Matsui H,Seki K,et al.Human papillomavirus-positive well-differentiated villoglandular adenocarcinoma of the uterine cervix:A case report and review of the literature[J].Gynecol Oncol,2000,77(3):473-477.
[8]游燕,郭丽娜.宫颈绒毛腺管状腺癌的临床病理[J].协和医学杂志,2012,3(1):61-67.
[9]陈仕高,黄琳,杨明东,等.宫颈绒毛状腺癌临床病理分析[J].华西医学,2016,31(6):1069-1072.
[10]于晶功,姜丹,王亚萍.宫颈微偏腺癌12例临床病理分析[J].当代医学,2016,22(23):3-5.
[11]刘鹏飞,郭朋,吴鸣,等.宫颈绒毛管状腺癌38例临床病理分析[J].现代妇产科进展,2015,24(10):739-742.
[12]喻金梅,安云婷,邹美燕.宫颈绒毛管状腺癌3例临床病理特点及文献复习[J].实用癌症杂志,2015(1):151-152.
[13]任雪,张馨遥,杨长滨,等.宫颈绒毛管状腺癌临床分析[J].中国妇幼保健,2014,29(9):1466-1468.
[14]Bouman A,Oosterhuis GJ,Naudin ten Cate L,et al.Villoglandular papillary adenocarcinoma of the cervix.Beware of a wolf in sheep′s clothing[J].Eur J Obstet Gynecol Reprod Biol,1999,87(2):183-189.
[15]Kim HJ,Sung JH,Lee E,et al.Prognostic factors influencing decisions about surgical treatment of villoglandular adenocarcinoma of the uterine cervix[J].Int J Gynecol Cancer,2014,24(7):1299-1305.
[16]朱伦,施雅,郭庆,等.宫颈绒毛管状腺癌11例临床病理学特征及文献复习[J].临床与实验病理学杂志,2013,29(5):506-510.