RNPC1、S100A6蛋白在肺腺癌中的表达及与临床病理特征的关系
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摘要
目的探讨RNPC1、S100A6蛋白在肺腺癌中的表达及与临床病理特征的关系。方法选取2015年1月至2018年3月我院保存的肺腺癌组织标本81例,同时选取癌旁组织作为对照,采用免疫组化染色法检测RNPC1、S100A6蛋白表达。结果肺腺癌组织RNPC1和S100A6蛋白阳性表达率分别为70.37%和81.49%,明显高于癌旁组织,差异有统计学意义(P<0.05);RNPC1表达与肺腺癌患者吸烟、TNM分期、分化程度和淋巴结转移有关(P<0.05);S100A6蛋白表达与肺腺癌患者吸烟、TNM分期和淋巴结转移有关(P<0.05);RNPC1与S100A6蛋白表达呈正相关(rs=0.595,P<0.05)。结论肺腺癌组织中RNPC1和S100A6蛋白表达上调,与患者病理特征有关,可能在肺腺癌发生发展中有一定作用。
Objective To investigate the expression of RNPC1 protein and S100 A6 protein in lung adenocarcinoma and its relationship with clinicopathological features.Methods 81 specimens of lung adenocarcinoma tissue preserved in our hospital from January 2015 to March 2018 were selected,and the para cancerous tissue was selected as the control,the expression of RNPC1 protein and S100 A6 protein were detected by immunohistochemical staining.Results The positive expression rates of RNPC1 and S100 A6 protein in lung adenocarcinoma were 70.37%and 81.49%respectively,which were significantly higher than those in para cancerous tissues,and the difference was statistically significant(P<0.05);The expression of RNPC1 protein were associated with smoking,TNM staging,degree of differentiation and lymph node metastasis(P<0.05);The expression of S100 A6 protein were associated with smoking,TNM staging and lymph node metastasis(P<0.05);RNPC1 protein was a positively correlated with S100 A6 protein expression(rs=0.595,P<0.05).Conclusion The expression of RNPC1 protein and S100 A6 protein in lung adenocarcinoma are up regulated,which is related to the pathological features of the patients,and may play a role in the development of lung adenocarcinoma.
Objective To investigate the expression of RNPC1 protein and S100 A6 protein in lung adenocarcinoma and its relationship with clinicopathological features.Methods 81 specimens of lung adenocarcinoma tissue preserved in our hospital from January 2015 to March 2018 were selected,and the para cancerous tissue was selected as the control,the expression of RNPC1 protein and S100 A6 protein were detected by immunohistochemical staining.Results The positive expression rates of RNPC1 and S100 A6 protein in lung adenocarcinoma were 70.37%and 81.49%respectively,which were significantly higher than those in para cancerous tissues,and the difference was statistically significant(P<0.05);The expression of RNPC1 protein were associated with smoking,TNM staging,degree of differentiation and lymph node metastasis(P<0.05);The expression of S100 A6 protein were associated with smoking,TNM staging and lymph node metastasis(P<0.05);RNPC1 protein was a positively correlated with S100 A6 protein expression(rs=0.595,P<0.05).Conclusion The expression of RNPC1 protein and S100 A6 protein in lung adenocarcinoma are up regulated,which is related to the pathological features of the patients,and may play a role in the development of lung adenocarcinoma.
引文
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[2]Chen Y,Huang T.Prognostic factors of patients with pathologic stage I lung adenocarcinoma[J].Journal of Thoracic Disease,2018,10(9):1115.
[3]李春莲,周旭婕,娄培培,等.RNA结合蛋白38通过增加人表皮生长因子受体2的表达诱导乳腺癌BT474细胞对曲妥珠单抗的敏感性[J].中华肿瘤杂志,2016,38(3):172.
[4]郎红娟,姜华,金发光,等.肿瘤相关基因S100A6在肺腺癌组织中的表达及临床意义[J].中华肺部疾病杂志(电子版),2015,8(5):574.
[5]郑福利,张颖,赵亚宁,等.S100A6siRNA对卵巢癌细胞生物学行为的影响[J].中国妇幼健康研究,2014,25(1):48.
[6]李爱芳,谷月,李雪茹,等.S100A6促宫颈癌细胞增殖、迁移及其可能机制研究[J].中国生物工程杂志,2017,37(2):8.
[7]Hung J,Yeh Y,Wu Y,et al.Prognostic Factors in Completely Resected Node-Negative Lung Adenocarcinoma of 3cm or Smaller[J].Journal of Thoracic Oncology,2017,12(12):1824.
[8]Yang Y,Mao Y,Yang L,et al.Prognostic factors in curatively resected pathological stage I lung adenocarcinoma[J].Journal of Thoracic Disease,2017,9(12):5267.
[9]Hong S R,Hur J,Moon Y W,et al.Predictive factors for treatment response using dual-energy computed tomography in patients with advanced lung adenocarcinoma[J].European Journal of Radiology,2018,101(5):118.
[10]Huang C,Chen B,Chou W,et al.Factors associated with the prognosis and long-term survival of patients with metastatic lung adenocarcinoma:a retrospective analysis[J].Journal of Thoracic Disease,2018,10(4):2070.
[11]张亚琛,梁迪,靳晶,等.非小细胞肺癌相关lncRNA的研究进展[J].中国肺癌杂志,2018,21(1):43.
[12]施华球,谢瑞莲.小细胞肺癌脑转移患者血清S100β蛋白表达水平及临床意义[J].中国老年学杂志,2016,36(24):6165.
[13]刘艳茹,章锐锋,应可净.长链非编码RNA与肺癌的关系研究进展[J].浙江大学学报(医学版),2014,43(5):607.
[14]刘相良,袁铭成,纪伟,等.长链非编码RNA在肺癌发生发展中作用的研究进展[J].吉林大学学报(医学版),2017,43(2):450.
[15]南岩东,姜华,金发光,等.S100A6基因干扰对A549肺腺癌细胞生物学行为的影响[J].国际肿瘤学杂志,2016,43(3):161.