遗传性结直肠肿瘤研究进展
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摘要
结直肠肿瘤疾病,属于我国发病率较高的消化系统恶性肿瘤,病死率高,占据所有恶性肿瘤的前几名。当前,这一疾病呈上升趋势发展。遗传性结直肠肿瘤主要分为:遗传性非息肉病性结直肠肿瘤和遗传性结肠肿瘤。因为遗传性结直肠肿瘤的发病机制比较复杂、特殊,临床病理特点明显,所以及早诊治是关键,从而改善患者的预后。针对于此,研究对结直肠肿瘤遗传学模式进行分析,对结直肠肿瘤发生相关基因改变情况进行研究,对遗传学结直肠肿瘤研究进展加以探析,从根本上控制遗传性结直肠肿瘤的发病率,改善遗传性结直肠肿瘤患者的预后。
Colorectal cancer is one of the most common malignant tumors of digestive system in China. It has a high mortality rate and occupies the top of all malignant tumors. At present, the disease is on the rise. Hereditary colorectal tumors are mainly divided into hereditary non-polyposis colorectal tumors and hereditary colon tumors. Because the pathogenesis of hereditary colorectal tumors is complex and special, and the clinical and pathological characteristics are obvious, early diagnosis and treatment is the key to improve the prognosis of patients. In view of this, the study analyzed the genetic model of colorectal cancer, studied the genetic changes related to colorectal cancer, and explored the research progress of genetic colorectal cancer to fundamentally control the incidence of hereditary colorectal cancer and improve the prognosis of patients with hereditary colorectal cancer.
Colorectal cancer is one of the most common malignant tumors of digestive system in China. It has a high mortality rate and occupies the top of all malignant tumors. At present, the disease is on the rise. Hereditary colorectal tumors are mainly divided into hereditary non-polyposis colorectal tumors and hereditary colon tumors. Because the pathogenesis of hereditary colorectal tumors is complex and special, and the clinical and pathological characteristics are obvious, early diagnosis and treatment is the key to improve the prognosis of patients. In view of this, the study analyzed the genetic model of colorectal cancer, studied the genetic changes related to colorectal cancer, and explored the research progress of genetic colorectal cancer to fundamentally control the incidence of hereditary colorectal cancer and improve the prognosis of patients with hereditary colorectal cancer.
引文
[1]鲁有望,王昆华.结直肠癌原发与配对转移肿瘤遗传异质性研究进展[J].遗传,2017,39(6):482-490.
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[5]刘宝华.慢性便秘与结直肠肿瘤的相关性[J].中华胃肠外科杂志,2017,20(3):255-257.
[6]姜烈君,陆晓旭,黄华艺.遗传性结直肠癌基因检测及其在临床上的应用规范化问题[J].分子诊断与治疗杂志,2016,8(2):135-141.
[7]韦青,王晰程,沈琳.遗传性消化道肿瘤现状及二代测序应用前景[J].中国医学前沿杂志(电子版),2016,8(3):31-36.
[8]房静远,时永全,陈萦晅,等.中国结直肠癌预防共识意见(2016年,上海)[J].胃肠病学,2016,21(11):668-686.
[9]黄尔炯,洪万东,黄智铭.胃底腺息肉与结直肠肿瘤关系的病例对照研究[J].中华消化内镜杂志,2015,32(12):825-827.
[10]张国飞.腹腔镜手术治疗结直肠肿瘤的效果分析[J].微创医学,2015,10(2):217-218.
[11]梁永辉,温钦,磨鹏诗,等.腹腔镜联合结肠镜治疗结直肠肿瘤的临床疗效观察[J].临床医学,2015,35(9):13-14.
[12]汤小伟,姜泊.结直肠肿瘤内镜早期诊断的新进展[J].中华消化杂志,2015,35(3):157-160.
[2]季午阳,吴斌.家族性结直肠癌X型研究进展[J].中华结直肠疾病电子杂志,2017,6(4):320-323.
[3]赵春梅,王旭东,申娴娟,等.长链非编码RNA在结直肠癌中的研究进展[J].临床检验杂志,2017,35(5):366-369.
[4]田林. Lynch综合征相关结直肠癌患者临床特征[J].岭南现代临床外科,2017,17(4):414-416.
[5]刘宝华.慢性便秘与结直肠肿瘤的相关性[J].中华胃肠外科杂志,2017,20(3):255-257.
[6]姜烈君,陆晓旭,黄华艺.遗传性结直肠癌基因检测及其在临床上的应用规范化问题[J].分子诊断与治疗杂志,2016,8(2):135-141.
[7]韦青,王晰程,沈琳.遗传性消化道肿瘤现状及二代测序应用前景[J].中国医学前沿杂志(电子版),2016,8(3):31-36.
[8]房静远,时永全,陈萦晅,等.中国结直肠癌预防共识意见(2016年,上海)[J].胃肠病学,2016,21(11):668-686.
[9]黄尔炯,洪万东,黄智铭.胃底腺息肉与结直肠肿瘤关系的病例对照研究[J].中华消化内镜杂志,2015,32(12):825-827.
[10]张国飞.腹腔镜手术治疗结直肠肿瘤的效果分析[J].微创医学,2015,10(2):217-218.
[11]梁永辉,温钦,磨鹏诗,等.腹腔镜联合结肠镜治疗结直肠肿瘤的临床疗效观察[J].临床医学,2015,35(9):13-14.
[12]汤小伟,姜泊.结直肠肿瘤内镜早期诊断的新进展[J].中华消化杂志,2015,35(3):157-160.