维吾尔医综合治疗银屑病患者的血清差异性代谢组分
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摘要
目的:分析维吾尔医综合治疗银屑病患者的血清差异性代谢组分。方法:选取2014年4月至2015年10月维吾尔医综合治疗的银屑病患者和通过体检确定健康志愿者血清,利用~1H-NMR技术结合正交偏最小二乘法,分析检测健康志愿者、银屑病患者血清差异性代谢组分。结果:与健康志愿者比较,银屑病患者血清极低密度脂蛋白(VLDL)、低密度脂蛋白(LDL)、不饱和脂类、糖蛋白、酪氨酸、组氨酸及丙酮含量降低,乳酸、肌酸、甲酸、乙酸及苯丙氨酸水平升高,且差异有统计学意义(P <0. 05)。结论:通过维吾尔医综合治疗,银屑病患者血清仍存在氨基酸、脂类及其一些小分子化合代谢紊乱。
Objective: To analyze serum differential metabolic components in Uyghur medical treatment in patients with psoriasis.Methods: The serum of psoriasis patients and healthy volunteers from Hospital of Xinjiang Traditional Uyghur Medicine from April2014 to October 2015 were selected. The differential metabolic components of serum from healthy volunteers and patients with psoriasis were analyzed by 1 H-NMR technique combined with orthogonal partial least squares method. Results: Compared with healthy volunteers group,VLDL,LDL,unsaturated lipid,glycoprotein,tyrosine,histidine,acetone of serum in psoriasis patients group were decreased and serum lactic acid,creatine,formic acid,acetic acid,phenylalanine were increased. The difference was statistically significant( P < 0. 05). Conclusion: Psoriasis patients still have amino acid,lipid and some small molecules metabolic disorder by combined treatment of Uyghur Medicine.
Objective: To analyze serum differential metabolic components in Uyghur medical treatment in patients with psoriasis.Methods: The serum of psoriasis patients and healthy volunteers from Hospital of Xinjiang Traditional Uyghur Medicine from April2014 to October 2015 were selected. The differential metabolic components of serum from healthy volunteers and patients with psoriasis were analyzed by 1 H-NMR technique combined with orthogonal partial least squares method. Results: Compared with healthy volunteers group,VLDL,LDL,unsaturated lipid,glycoprotein,tyrosine,histidine,acetone of serum in psoriasis patients group were decreased and serum lactic acid,creatine,formic acid,acetic acid,phenylalanine were increased. The difference was statistically significant( P < 0. 05). Conclusion: Psoriasis patients still have amino acid,lipid and some small molecules metabolic disorder by combined treatment of Uyghur Medicine.
引文
[1]伊沙克江·马合穆德.中国医学百科全书—维吾尔医学[M].上海:上海科学技术出版社,2005:141.
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[3]哈力旦·铁力木,阿不都热西提·吾布力卡斯木,努尔比亚·艾沙,等.维吾尔医治疗70例咸味黏液质型银屑病的经验[J].中国民族医药杂志,2017,23(6):27-28.
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[5]斯拉甫·艾白,买尼沙·买买提,吐尔逊·吾甫尔,等.维药新药治疗寻常型银屑病临床研究指导原则(草案)[J].中国中医药信息杂志,2015,22(1):133-136.
[6]斯拉甫·艾白,玉苏甫·买提努尔,吐尔洪·艾买尔,等.维吾尔医优势病种规范化诊治关键技术的研究与应用[J].中国民族医药杂志,2016,22(6):28-32.
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[9]Coban M,Tasli L,Turgut S,et al. Association of Adipokines,Insulin Resistance,Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris[J]. Ann Dermatol,2016,28(1):74-79.
[10]Singh S,Bhansali A. Randomized placebo control study of insulin sensitizers(Metformin and Pioglitazone)in psoriasis patients with metabolic syndrome(Topical Treatment Cohort)[J]. BMC Dermatol,2016,16(1):12.
[11]Asha K,Singal A,Sharma SB,et al. Dyslipidaemia&oxidative stress in patients of psoriasis:Emerging cardiovascular risk factors[J]. Indian J Med Res,2017,146(6):708-713.
[12]Salihbegovic EM,Hadzigrahic N,Suljagic E,et al. Psoriasis and dyslipidemia[J]. Mater Sociomed,2015,27(1):15-17.
[13]G9nül M,Tatar,Canpolat F,et al. Evaluation of abdominal fat index by ultrasonography and its relationship with psoriasis and metabolic syndrome[J]. Postepy Dermatol Alergol,2017,34(5):453-456.
[14]Stefanadi EC,Dimitrakakis G,Antoniou CK,et al. Metabolic syndrome and the skin:a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients[J]. Diabetol Metab Syndr,2018,10:9.
[15]何源.银屑灵治疗寻常型银屑病血清及尿液代谢组学的初步研究[D].广州:广州中医药大学,2016:1-44.
[16]]王晓华,李炳源.银屑病患者血浆16种氨基酸检测及其临床意义[J].中国全科医学杂志,1999,2(2):113-115.
[17]刘英.基于代谢组学方法探讨寻常型银屑病的生物标志物并研究药物对标志物的作用[D].广州:暨南大学,2017:1-88.
[18]刘英,李沙沙,吴晓松,等.基于核磁共振的寻常型银屑病患者血浆代谢组学研究[J].第二军医大学学报,2017,38(1):74-80.
[19]贾小芳,陈军,马芳,等.糖蛋白质组学方法研究人类免疫缺陷病毒感染相关糖蛋白[J].中华传染病杂志,2011,29(4):193-198.
[2]巴哈古丽·力提甫.维吾尔医治疗银屑病100例的临床观察[J].世界最新医学信息文摘:连续型电子期刊,2016,16(90):85.
[3]哈力旦·铁力木,阿不都热西提·吾布力卡斯木,努尔比亚·艾沙,等.维吾尔医治疗70例咸味黏液质型银屑病的经验[J].中国民族医药杂志,2017,23(6):27-28.
[4]迪里木拉提·吐尔逊.维吾尔医治疗银屑病的经验[J].新疆维吾尔医学专科学校学报(维文版),2017,27(3):67-70.
[5]斯拉甫·艾白,买尼沙·买买提,吐尔逊·吾甫尔,等.维药新药治疗寻常型银屑病临床研究指导原则(草案)[J].中国中医药信息杂志,2015,22(1):133-136.
[6]斯拉甫·艾白,玉苏甫·买提努尔,吐尔洪·艾买尔,等.维吾尔医优势病种规范化诊治关键技术的研究与应用[J].中国民族医药杂志,2016,22(6):28-32.
[7]Phan C,Sigal ML,Lhafa M,et al. Metabolic comorbidities and hypertension in psoriasis patients in France. Comparisons with French national databases[J]. Ann Dermatol Venereol,2016,143(4):264-274.
[8]Paschoal RS,Silva DA,Cardili RN,et al. Metabolic syndrome,C-reactive protein and cardiovascular risk in psoriasis patients:a cross-sectional study[J]. An Bras Dermatol,2018,93(2):222-228.
[9]Coban M,Tasli L,Turgut S,et al. Association of Adipokines,Insulin Resistance,Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris[J]. Ann Dermatol,2016,28(1):74-79.
[10]Singh S,Bhansali A. Randomized placebo control study of insulin sensitizers(Metformin and Pioglitazone)in psoriasis patients with metabolic syndrome(Topical Treatment Cohort)[J]. BMC Dermatol,2016,16(1):12.
[11]Asha K,Singal A,Sharma SB,et al. Dyslipidaemia&oxidative stress in patients of psoriasis:Emerging cardiovascular risk factors[J]. Indian J Med Res,2017,146(6):708-713.
[12]Salihbegovic EM,Hadzigrahic N,Suljagic E,et al. Psoriasis and dyslipidemia[J]. Mater Sociomed,2015,27(1):15-17.
[13]G9nül M,Tatar,Canpolat F,et al. Evaluation of abdominal fat index by ultrasonography and its relationship with psoriasis and metabolic syndrome[J]. Postepy Dermatol Alergol,2017,34(5):453-456.
[14]Stefanadi EC,Dimitrakakis G,Antoniou CK,et al. Metabolic syndrome and the skin:a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients[J]. Diabetol Metab Syndr,2018,10:9.
[15]何源.银屑灵治疗寻常型银屑病血清及尿液代谢组学的初步研究[D].广州:广州中医药大学,2016:1-44.
[16]]王晓华,李炳源.银屑病患者血浆16种氨基酸检测及其临床意义[J].中国全科医学杂志,1999,2(2):113-115.
[17]刘英.基于代谢组学方法探讨寻常型银屑病的生物标志物并研究药物对标志物的作用[D].广州:暨南大学,2017:1-88.
[18]刘英,李沙沙,吴晓松,等.基于核磁共振的寻常型银屑病患者血浆代谢组学研究[J].第二军医大学学报,2017,38(1):74-80.
[19]贾小芳,陈军,马芳,等.糖蛋白质组学方法研究人类免疫缺陷病毒感染相关糖蛋白[J].中华传染病杂志,2011,29(4):193-198.