维生素A棕榈酸酯联合妥布霉素修复角膜上皮损伤
|
摘要
目的:探讨维生素A棕榈酸酯眼用凝胶联合妥布霉素眼液对角膜上皮损伤疾病的临床疗效。方法:选取2015-05/2016-03来我院就诊的角膜上皮缺损患者80例100眼作为研究对象,随机分为治疗组和对照组。治疗组采用维生素A棕榈酸酯眼用凝胶联合妥布霉素眼液治疗,对照组患眼仅应用妥布霉素眼液治疗。比较两组治疗2、4wk后的疗效。结果:治疗组痊愈率为80%,有效率为94%。对照组痊愈率为70%,有效率为78%,两组患者之间有效率差异有统计学(P<0. 05)。SⅠt以及BUT结果显示与对照组比较,治疗组的时间显著延长(P<0. 01)。治疗组的患者治疗2wk后的症状体征评分明显低于对照组(P<0. 01),但治疗4wk后,两组的症状体征评分差异无统计学意义(P>0. 05)。结论:维生素A棕榈酸酯眼用凝胶联合妥布霉素眼液能够明显改善眼干症状,且能够有效缩短角膜上皮的愈合时间,是一种治疗角膜上皮损伤的有效方法。
AIM: To investigate the clinical effect of vitamin A Palm itate Eye Gel com bined w ith Tobram ycin Eye Drops on corneal epithelial injury.METHODS: Totally 80 patients( 100 eyes) with corneal epithelial injury who came to our hospital from May 2015 to March 2016 were randomly divided into treatment group( 50 eyes) and control group( 50 eyes). The treatment group was treated with vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops,while the control group was treated with Tobramycin Eye Drops only. The curative effect of two groups was compared after 2 wk and 4 wk of treatment.RESULTS: The cure rate was 80% and the effective rate was 94% in the treatment group. The cure rate was 70%and the effective rate was 78% in the control group. There was significant difference in the effective rate between the two groups( P<0.05). The results of SⅠt and BUT test showed that the time of treatment group was significantly longer than that of control group( P<0.01). The score of symptoms and signs in the treatment group was significantly lower than that in the control group after 2 wk of treatment( P < 0. 01),but there was no significant between treatment groups and control grouop after 4 wk of treatment( P>0.05).CONCLUSION: Vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops can significantly improve dry eye symptoms and effectively shorten the healing time of corneal epithelium. It is an effective method to treat corneal epithelial injury.
AIM: To investigate the clinical effect of vitamin A Palm itate Eye Gel com bined w ith Tobram ycin Eye Drops on corneal epithelial injury.METHODS: Totally 80 patients( 100 eyes) with corneal epithelial injury who came to our hospital from May 2015 to March 2016 were randomly divided into treatment group( 50 eyes) and control group( 50 eyes). The treatment group was treated with vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops,while the control group was treated with Tobramycin Eye Drops only. The curative effect of two groups was compared after 2 wk and 4 wk of treatment.RESULTS: The cure rate was 80% and the effective rate was 94% in the treatment group. The cure rate was 70%and the effective rate was 78% in the control group. There was significant difference in the effective rate between the two groups( P<0.05). The results of SⅠt and BUT test showed that the time of treatment group was significantly longer than that of control group( P<0.01). The score of symptoms and signs in the treatment group was significantly lower than that in the control group after 2 wk of treatment( P < 0. 01),but there was no significant between treatment groups and control grouop after 4 wk of treatment( P>0.05).CONCLUSION: Vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops can significantly improve dry eye symptoms and effectively shorten the healing time of corneal epithelium. It is an effective method to treat corneal epithelial injury.
引文
1 Kim EC, Ryu HW, Lee HJ,et al. Bevacizumab eye drops delay corneal epithelial wound healing and increase the stromal response to epithelial injury in rats. Clin Exp Ophthalmol 2013; 41(7):694-701
2 Xiang J, Le Li Y, et al.In vivo confocal microscopy of early corneal epithelial recovery in patients with chemical injury. Eye(Lond)2015; 29(12):1570-1578
3 He W,Guo X, Feng M,et al. In vitro and in vivo studies on ocular vitamin A palmitate cationic liposomal in situ gels. Int J Pharm 2013; 458(2):305-314
4 Qiu XD,Gong L,Chen MJ. Research on effects of vitamin A palmitate on repair of mechanical corneal epithelial defects and conjunctival goblet cells in rabbits. Zhonghua Yan Ke Za Zhi 2010; 46(2):151-160
5 Feng Y, Feng G,Peng S,et al. The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and BreakUp Time. J Ophthalmol 2015; 2015:420302
6李健,蒋琤,赵昌峰.小牛血去蛋白提取物眼凝胶治疗角膜上皮缺损的临床疗效.江苏医药2013:39(19):2288-2290
7 Lab be A,Liang Q,Wang Z,et al. Corneal nerve structure and function in patients with non-sjogren dry eye:clinical correlations. Invest Ophthahalmol Vis Sci 2013;54(8):5144-5150
8王一宁.重组人表皮生长因子促进外伤性角膜上皮缺损修复的临床观察.中国现代药物应用2012;6(22):28-29
9徐君.重组牛碱性成纤维细胞生长因子眼凝胶辅助治疗外伤性角膜上皮缺损63例效果观察.山东医药2012;52(27):80-81
10 Kim SW,Seo KY,Rhim T,et al. Effect of retinoic acid on epithelial differentiation and mucin expression in primary human corneal limbal epithelial cells. Curr Eye Res 2012;37(1):33-42
11邱晓頔,龚岚,陈敏洁.维生素A棕榈酸酯对兔机械性角膜上皮损伤愈合及结膜杯状细胞的作用研究.中华眼科杂志2010;46(2);151-160
12 Floyd AM,Zhou X,Evans C,et al. Mucin deficiency causes functional and structural changes of the ocular surface. PLoS One 2012; 7(12):e50704
13 Bauskar A,Mack WJ,Mauris J, et al. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS One 2015; 10(9):e0138958
14 Mizoguchi S,Iwanishi H,Arita R, et al. Ocular surface inflammation impairs structure and function of meibomian gland. Exp Eye Res 2017;163:78-84
15 Cabalag MS, Wasiak J, Syed Q, et al. Early and late complications of ocular burn injuries. J Plast Reconstr Aesthet Surg 2015; 68(3):356-361
16 King-Smith PE,Reuter KS,Braun RJ, et al. Tear film breakup and structure studied by simultaneous video recording of fluorescence and tear film lipid layer images. Invest Ophthalmol Vis Sci 2013; 54(7):4900-4909
17 Hattori M,Shimizu K,Katsumura K,et al. Effects of all-trans retinoic acid nanoparticles on corneal epithelial wound healing. Graefes Arch Clin Exp Ophthalmol 2012; 250(4):557-563
18 Rosasco M,Segall A. Determination of the Chemical Stability of Various Formulations of Tobramycin Eye-Drops by HPLC Method and Data Analysis by R-GUI Stability Software. J Applied Pharmaceutical Sci2015; 5(12):8-13
2 Xiang J, Le Li Y, et al.In vivo confocal microscopy of early corneal epithelial recovery in patients with chemical injury. Eye(Lond)2015; 29(12):1570-1578
3 He W,Guo X, Feng M,et al. In vitro and in vivo studies on ocular vitamin A palmitate cationic liposomal in situ gels. Int J Pharm 2013; 458(2):305-314
4 Qiu XD,Gong L,Chen MJ. Research on effects of vitamin A palmitate on repair of mechanical corneal epithelial defects and conjunctival goblet cells in rabbits. Zhonghua Yan Ke Za Zhi 2010; 46(2):151-160
5 Feng Y, Feng G,Peng S,et al. The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and BreakUp Time. J Ophthalmol 2015; 2015:420302
6李健,蒋琤,赵昌峰.小牛血去蛋白提取物眼凝胶治疗角膜上皮缺损的临床疗效.江苏医药2013:39(19):2288-2290
7 Lab be A,Liang Q,Wang Z,et al. Corneal nerve structure and function in patients with non-sjogren dry eye:clinical correlations. Invest Ophthahalmol Vis Sci 2013;54(8):5144-5150
8王一宁.重组人表皮生长因子促进外伤性角膜上皮缺损修复的临床观察.中国现代药物应用2012;6(22):28-29
9徐君.重组牛碱性成纤维细胞生长因子眼凝胶辅助治疗外伤性角膜上皮缺损63例效果观察.山东医药2012;52(27):80-81
10 Kim SW,Seo KY,Rhim T,et al. Effect of retinoic acid on epithelial differentiation and mucin expression in primary human corneal limbal epithelial cells. Curr Eye Res 2012;37(1):33-42
11邱晓頔,龚岚,陈敏洁.维生素A棕榈酸酯对兔机械性角膜上皮损伤愈合及结膜杯状细胞的作用研究.中华眼科杂志2010;46(2);151-160
12 Floyd AM,Zhou X,Evans C,et al. Mucin deficiency causes functional and structural changes of the ocular surface. PLoS One 2012; 7(12):e50704
13 Bauskar A,Mack WJ,Mauris J, et al. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS One 2015; 10(9):e0138958
14 Mizoguchi S,Iwanishi H,Arita R, et al. Ocular surface inflammation impairs structure and function of meibomian gland. Exp Eye Res 2017;163:78-84
15 Cabalag MS, Wasiak J, Syed Q, et al. Early and late complications of ocular burn injuries. J Plast Reconstr Aesthet Surg 2015; 68(3):356-361
16 King-Smith PE,Reuter KS,Braun RJ, et al. Tear film breakup and structure studied by simultaneous video recording of fluorescence and tear film lipid layer images. Invest Ophthalmol Vis Sci 2013; 54(7):4900-4909
17 Hattori M,Shimizu K,Katsumura K,et al. Effects of all-trans retinoic acid nanoparticles on corneal epithelial wound healing. Graefes Arch Clin Exp Ophthalmol 2012; 250(4):557-563
18 Rosasco M,Segall A. Determination of the Chemical Stability of Various Formulations of Tobramycin Eye-Drops by HPLC Method and Data Analysis by R-GUI Stability Software. J Applied Pharmaceutical Sci2015; 5(12):8-13