维生素D_3与雌性生殖
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摘要
综述了维生素D_3(vitamin D_3,VD_3)的代谢和作用机制、维生素D代谢酶和维生素D受体在雌性生殖系统中的分布、VD_3与雌性生育力、VD_3与雌性激素的关系,可以为推进VD_3影响雌性生殖的分子机制和临床治疗女性生殖相关疾病的研究提供理论依据。
This review summarizes the metabolism and mechanism of vitamin D_3( VD_3),the distribution of vitamin D metabolic enzymes and vitamin D receptor( VDR) in the female reproductive system,VD_3 and female fertility,VD_3 and estrogens,in order to provide a theoretical basis for the advancement of the molecular mechanism of VD_3 effects on female reproduction and the clinical treatment of female reproductive-related diseases.
This review summarizes the metabolism and mechanism of vitamin D_3( VD_3),the distribution of vitamin D metabolic enzymes and vitamin D receptor( VDR) in the female reproductive system,VD_3 and female fertility,VD_3 and estrogens,in order to provide a theoretical basis for the advancement of the molecular mechanism of VD_3 effects on female reproduction and the clinical treatment of female reproductive-related diseases.
引文
[1]JOHNSON J A,GRANDE J P,ROCHE P C,et al.Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3receptor in rat reproductive tissues[J].Histochem Cell Biol,1996,105(1):7-15.
[2]NANDI A,SINHA N,ONG E,et al.Is there a role for vitamin D in human reproduction[J].Horm Mol Biol Clin Investig,2016,25(1):15-28.
[3]SAKAKI T.Recent studies on vitamin D metabolizing enzymes[J].Clin Calcium,2006,16(7):1129-1135.
[4]ZHU J,DELUCA H F.Vitamin D 25-hydroxylase-Four decades of searching,are we there yet?[J].Arch Biochem Biophys,2012,523(1):30-36.
[5]何琳琳,兰飞,徐欢,等.维生素D3与雄性生殖[J].生理科学进展,2015(5):334-340.
[6]NORMAN A W.Minireview:vitamin D receptor:new assignments for an already busy receptor[J].Endocrinology,2006,147(12):5542-5548.
[7]HII C S,FERRANTE A.The Non-Genomic Actions of Vitamin D[J].Nutrients,2016,8(3):135.
[8]LOPES N,SOUSA B,MARTINS D,et al.Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression:a study of VDR,CYP27B1 and CYP24A1 expression in benign and malignant breast lesions[J].BMC Cancer,2010(10):483.
[9]BROZYNA·A A,JZ'WICKI W,JOCHYMSKI C,et al.Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas[J].Oncol Rep,2015,33(2):599-606.
[10]YILDIRIM B,ABBAN G,ERDOGAN B S.Immunohistochemical detection of 1,25-dihydroxyvitamin D receptor in rat vaginal epithelium[J].Fertil Steril,2004,82(6):1602-1608.
[11]YILDIRIM B N,METE G A,ROTA S,et al.Immunohistochemical Detection and Distribution of Cornifin Alpha and Vitamin D Receptor Expression in Vaginal Epithelium Treated with Vitamin D3[J].Journal of the Turkish German Gynecological Association,2007,8(1):33-37.
[12]ZARNANI A H,SHAHBAZI M,SALEK-MOGHADDAM A,et al.Vitamin D3receptor is expressed in the endometrium of cycling mice throughout the estrous cycle[J].Fertil Steril,2010,93(8):2738-2743.
[13]TAVERA-MENDOZA L E,WESTERLING T,LIBBY E,et al.Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells[J].Proc Natl Acad Sci,2017,114(11):2186-2194.
[14]SHAHBAZI M,JEDDI-TEHRANI M,ZAREIE M,et al.Expression profiling of vitamin D receptor in placenta,decidua and ovary of pregnant mice[J].Placenta,2011,32(9):657-664.
[15]KIM T H,LEE H H,PARK J.Immunohistochemical detection of the 1,25-dihydroxy vitamin D receptor in the human vagina[J].Iranian Journal of Reproductive Medicine,2014,12(12):805-810.
[16]张纯,朱伟杰,徐建平.维生素D受体蛋白及其m RNA在人输卵管黏膜上皮的表达[J].暨南大学学报(自然科学与医学版),2009,30(2):170-175.
[17]RANJZAD F,MAHBAN A,SHEMIRANI A I,et al.Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome[J].J Assist Reprod Genet,2011,28(3):225-232.
[18]SAYEGH L,GEL-H F,NASSAR A H.Vitamin D in endometriosis:a causative or confounding factor[J].Metabolism,2014,63(1):32-41.
[19]POSPECHOVA K,ROZEHNAL V,STEJSKALOVA L,et al.Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma Be Wo and JEG-3 cell lines[J].Mol Cell Endocrinol,2009,299(2):178-187.
[20]ZHALEHJOO N,SHAKIBA Y,PANJEHPOUR M.Alterations of Vitamin D Receptor(VDR)Expression Profile in Normal and Malignant Breast Tissues[J].Clin Lab,2016,62(8):1461-1468.
[21]KINUTA K,TANAKA H,MORIWAKE T,et al.Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads[J].Endocrinology,2000,141(4):1317-1324.
[22]YOSHIZAWA T,HANDA Y,UEMATSU Y,et al.Mice lacking the vitamin D receptor exhibit impaired bone formation,uterine hypoplasia and growth retardation after weaning[J].Nat Genet,1997,16(4):391-396.
[23]PANDA D K,MIAO D,TREMBLAY M L,et al.Targeted ablation of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme:evidence for skeletal,reproductive,and immune dysfunction[J].Proc Natl Acad Sci,2001,98(13):7498-7503.
[24]HALLORAN B P,DELUCA H F.Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat[J].J Nutr,1980,110(8):1573-1580.
[25]KWIECINKSI G G,PETRIE G I,DELUCA H F.1,25-Dihydroxyvitamin D3restores fertility of vitamin D-deficient female rats[J].Am J Physiol,1989,256(1):483-487.
[26]NICHOLAS C,DAVIS J,FISHER T,et al.Maternal Vitamin D Deficiency Programs Reproductive Dysfunction in Female Mice Offspring Through Adverse Effects on the Neuroendocrine Axis[J].Endocrinology,2016,157(4):1535-1545.
[27]HALLORAN B P,DELUCA H F.Vitamin D deficiency and reproduction in rats[J].Science,1979,204(4388):73-74.
[28]JOHNSON L E,DELUCA H F.Vitamin D receptor null mutant mice fed high levels of calcium are fertile[J].J Nutr,2001,131(6):1787-1791.
[29]KIELY M E,ZHANG J Y,KINSELLA M,et al.Vitamin D status is associated with uteroplacental dysfunction indicated by pre-eclampsia and small-for-gestational-age birth in a large prospective pregnancy cohort in Ireland with low vitamin D status[J].American Journal of Clinical Nutrition,2016,104(2):354-361.
[30]LEPSCH J,ESHRIQUI I,FARIAS D R,et al.Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy[J].Metabolism,2017,70:85-97.
[31]TABATABAEI N,AUGER N,HERBA C M,et al.Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated with Increased Risk of Preterm Birth in Ethnic Minority Women in Canada[J].J Nutr,2017,147(6):1145-1151.
[32]NEVILLE G,MARTYN F,KILBANE M,et al.Vitamin D status and fertility outcomes during winter among couples undergoing in vitro fertilization/intracytoplasmic sperm injection[J].Int J Gynaecol Obstet,2016,135(2):172-176.
[33]WOLSK H M,HARSHFIELD B J,LARANJO N,et al.Vitamin D supplementation in pregnancy,prenatal 25(OH)D levels,race,and subsequent asthma or recurrent wheeze in offspring:Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial[J].J Allergy Clin Immunol,2017,140(5):1423-1429.
[34]EGGEMOENR,JENUM A K,MDALA I,et al.Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn:a longitudinal multiethnic population-based study[J].Br J Nutr,2017,117(7):985-993.
[35]OZKAN S,JINDAL S,GREENSEID K,et al.Replete vitamin D stores predict reproductive success following in vitro fertilization[J].Fertil Steril,2010,94(4):1314-1319.
[36]RUDICK B J,INGLES S A,CHUNG K,et al.Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles[J].Fertil Steril,2014,101(2):447-452.
[37]PAFFONI A,FERRARI S,VIGANP,et al.Vitamin D deficiency and infertility:insights from in vitro fertilization cycles[J].J Clin Endocrinol Metab,2014,99(11):2372-2376.
[38]FARZADI L,KHAYATZADEH B H,GHOJAZADEH M,et al.Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes[J].Iran J Reprod Med,2015,13(6):361-366.
[39]LV S S,WANG J Y,WANG X Q,et al.Serum vitamin D status and in vitro fertilization outcomes:a systematic review and meta-analysis[J].Arch Gynecol Obstet,2016,293(6):1339-1345.
[40]文娅,王华伟,速存梅,等.抗苗勒管激素在生殖内分泌诊断中的临床价值及应用前景[J].现代妇产科进展,2016,25(11):874-876.
[41]POTASHNIK G,LUNENFELD E,LEVITAS E,et al.The relationship between endogenous oestradiol and vitamin D3metabolites in serum and follicular fluid during ovarian stimulation for in-vitro fertilization and embryo transfer[J].Hum Reprod,1992,7(10):1357-1360.
[42]MERHI Z,DOSWELL A,KREBS K,et al.Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells[J].J Clin Endocrinol Metab,2014,99(6):1137-1145.
[43]朱建林.维生素D3的雌性性腺毒性及其机制的研究[D].福州:福建医科大学,2009.
[44]THANGAMANI S,KIM M,SON Y,et al.Cutting edge:progesterone directly upregulates vitamin d receptor gene expression for efficient regulation of T cells by calcitriol[J].Journal of Immunology,2015,194(3):883-886.
[45]KIM C H.A functional relay from progesterone to vitamin D in the immune system[J].DNA Cell Biol,2015,34(6):379-382.
[46]HONG S H,LEE J E,KIM H S,et al.Effect of vitamin D3on production of progesterone in porcine granulosa cells by regulation of steroidogenic enzymes[J].J Biomed Res,2016,30(3):203-208.
[47]XU J,HENNEBOLD J D,SEIFER D B.Direct vitamin D3actions on rhesus macaque follicles in three-dimensional culture:assessment of follicle survival,growth,steroid,and antimüllerian hormone production[J].Fertil Steril,2016,106(7):1815-1820.
[48]DENNIS N A,HOUGHTON L A,JONES G T,et al.The level of serum anti-Müllerian hormone correlates with vitamin D status in men and women but not in boys[J].J Clin Endocrinol Metab,2012,97(7):2450-2455.
[49]CHANG E M,KIM Y S,WON H J,et al.Association between sex steroids,ovarian reserve,and vitamin D levels in healthy nonobese women[J].J Clin Endocrinol Metab,2014,99(7):2526-2532.
[2]NANDI A,SINHA N,ONG E,et al.Is there a role for vitamin D in human reproduction[J].Horm Mol Biol Clin Investig,2016,25(1):15-28.
[3]SAKAKI T.Recent studies on vitamin D metabolizing enzymes[J].Clin Calcium,2006,16(7):1129-1135.
[4]ZHU J,DELUCA H F.Vitamin D 25-hydroxylase-Four decades of searching,are we there yet?[J].Arch Biochem Biophys,2012,523(1):30-36.
[5]何琳琳,兰飞,徐欢,等.维生素D3与雄性生殖[J].生理科学进展,2015(5):334-340.
[6]NORMAN A W.Minireview:vitamin D receptor:new assignments for an already busy receptor[J].Endocrinology,2006,147(12):5542-5548.
[7]HII C S,FERRANTE A.The Non-Genomic Actions of Vitamin D[J].Nutrients,2016,8(3):135.
[8]LOPES N,SOUSA B,MARTINS D,et al.Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression:a study of VDR,CYP27B1 and CYP24A1 expression in benign and malignant breast lesions[J].BMC Cancer,2010(10):483.
[9]BROZYNA·A A,JZ'WICKI W,JOCHYMSKI C,et al.Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas[J].Oncol Rep,2015,33(2):599-606.
[10]YILDIRIM B,ABBAN G,ERDOGAN B S.Immunohistochemical detection of 1,25-dihydroxyvitamin D receptor in rat vaginal epithelium[J].Fertil Steril,2004,82(6):1602-1608.
[11]YILDIRIM B N,METE G A,ROTA S,et al.Immunohistochemical Detection and Distribution of Cornifin Alpha and Vitamin D Receptor Expression in Vaginal Epithelium Treated with Vitamin D3[J].Journal of the Turkish German Gynecological Association,2007,8(1):33-37.
[12]ZARNANI A H,SHAHBAZI M,SALEK-MOGHADDAM A,et al.Vitamin D3receptor is expressed in the endometrium of cycling mice throughout the estrous cycle[J].Fertil Steril,2010,93(8):2738-2743.
[13]TAVERA-MENDOZA L E,WESTERLING T,LIBBY E,et al.Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells[J].Proc Natl Acad Sci,2017,114(11):2186-2194.
[14]SHAHBAZI M,JEDDI-TEHRANI M,ZAREIE M,et al.Expression profiling of vitamin D receptor in placenta,decidua and ovary of pregnant mice[J].Placenta,2011,32(9):657-664.
[15]KIM T H,LEE H H,PARK J.Immunohistochemical detection of the 1,25-dihydroxy vitamin D receptor in the human vagina[J].Iranian Journal of Reproductive Medicine,2014,12(12):805-810.
[16]张纯,朱伟杰,徐建平.维生素D受体蛋白及其m RNA在人输卵管黏膜上皮的表达[J].暨南大学学报(自然科学与医学版),2009,30(2):170-175.
[17]RANJZAD F,MAHBAN A,SHEMIRANI A I,et al.Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome[J].J Assist Reprod Genet,2011,28(3):225-232.
[18]SAYEGH L,GEL-H F,NASSAR A H.Vitamin D in endometriosis:a causative or confounding factor[J].Metabolism,2014,63(1):32-41.
[19]POSPECHOVA K,ROZEHNAL V,STEJSKALOVA L,et al.Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma Be Wo and JEG-3 cell lines[J].Mol Cell Endocrinol,2009,299(2):178-187.
[20]ZHALEHJOO N,SHAKIBA Y,PANJEHPOUR M.Alterations of Vitamin D Receptor(VDR)Expression Profile in Normal and Malignant Breast Tissues[J].Clin Lab,2016,62(8):1461-1468.
[21]KINUTA K,TANAKA H,MORIWAKE T,et al.Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads[J].Endocrinology,2000,141(4):1317-1324.
[22]YOSHIZAWA T,HANDA Y,UEMATSU Y,et al.Mice lacking the vitamin D receptor exhibit impaired bone formation,uterine hypoplasia and growth retardation after weaning[J].Nat Genet,1997,16(4):391-396.
[23]PANDA D K,MIAO D,TREMBLAY M L,et al.Targeted ablation of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme:evidence for skeletal,reproductive,and immune dysfunction[J].Proc Natl Acad Sci,2001,98(13):7498-7503.
[24]HALLORAN B P,DELUCA H F.Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat[J].J Nutr,1980,110(8):1573-1580.
[25]KWIECINKSI G G,PETRIE G I,DELUCA H F.1,25-Dihydroxyvitamin D3restores fertility of vitamin D-deficient female rats[J].Am J Physiol,1989,256(1):483-487.
[26]NICHOLAS C,DAVIS J,FISHER T,et al.Maternal Vitamin D Deficiency Programs Reproductive Dysfunction in Female Mice Offspring Through Adverse Effects on the Neuroendocrine Axis[J].Endocrinology,2016,157(4):1535-1545.
[27]HALLORAN B P,DELUCA H F.Vitamin D deficiency and reproduction in rats[J].Science,1979,204(4388):73-74.
[28]JOHNSON L E,DELUCA H F.Vitamin D receptor null mutant mice fed high levels of calcium are fertile[J].J Nutr,2001,131(6):1787-1791.
[29]KIELY M E,ZHANG J Y,KINSELLA M,et al.Vitamin D status is associated with uteroplacental dysfunction indicated by pre-eclampsia and small-for-gestational-age birth in a large prospective pregnancy cohort in Ireland with low vitamin D status[J].American Journal of Clinical Nutrition,2016,104(2):354-361.
[30]LEPSCH J,ESHRIQUI I,FARIAS D R,et al.Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy[J].Metabolism,2017,70:85-97.
[31]TABATABAEI N,AUGER N,HERBA C M,et al.Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated with Increased Risk of Preterm Birth in Ethnic Minority Women in Canada[J].J Nutr,2017,147(6):1145-1151.
[32]NEVILLE G,MARTYN F,KILBANE M,et al.Vitamin D status and fertility outcomes during winter among couples undergoing in vitro fertilization/intracytoplasmic sperm injection[J].Int J Gynaecol Obstet,2016,135(2):172-176.
[33]WOLSK H M,HARSHFIELD B J,LARANJO N,et al.Vitamin D supplementation in pregnancy,prenatal 25(OH)D levels,race,and subsequent asthma or recurrent wheeze in offspring:Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial[J].J Allergy Clin Immunol,2017,140(5):1423-1429.
[34]EGGEMOENR,JENUM A K,MDALA I,et al.Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn:a longitudinal multiethnic population-based study[J].Br J Nutr,2017,117(7):985-993.
[35]OZKAN S,JINDAL S,GREENSEID K,et al.Replete vitamin D stores predict reproductive success following in vitro fertilization[J].Fertil Steril,2010,94(4):1314-1319.
[36]RUDICK B J,INGLES S A,CHUNG K,et al.Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles[J].Fertil Steril,2014,101(2):447-452.
[37]PAFFONI A,FERRARI S,VIGANP,et al.Vitamin D deficiency and infertility:insights from in vitro fertilization cycles[J].J Clin Endocrinol Metab,2014,99(11):2372-2376.
[38]FARZADI L,KHAYATZADEH B H,GHOJAZADEH M,et al.Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes[J].Iran J Reprod Med,2015,13(6):361-366.
[39]LV S S,WANG J Y,WANG X Q,et al.Serum vitamin D status and in vitro fertilization outcomes:a systematic review and meta-analysis[J].Arch Gynecol Obstet,2016,293(6):1339-1345.
[40]文娅,王华伟,速存梅,等.抗苗勒管激素在生殖内分泌诊断中的临床价值及应用前景[J].现代妇产科进展,2016,25(11):874-876.
[41]POTASHNIK G,LUNENFELD E,LEVITAS E,et al.The relationship between endogenous oestradiol and vitamin D3metabolites in serum and follicular fluid during ovarian stimulation for in-vitro fertilization and embryo transfer[J].Hum Reprod,1992,7(10):1357-1360.
[42]MERHI Z,DOSWELL A,KREBS K,et al.Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells[J].J Clin Endocrinol Metab,2014,99(6):1137-1145.
[43]朱建林.维生素D3的雌性性腺毒性及其机制的研究[D].福州:福建医科大学,2009.
[44]THANGAMANI S,KIM M,SON Y,et al.Cutting edge:progesterone directly upregulates vitamin d receptor gene expression for efficient regulation of T cells by calcitriol[J].Journal of Immunology,2015,194(3):883-886.
[45]KIM C H.A functional relay from progesterone to vitamin D in the immune system[J].DNA Cell Biol,2015,34(6):379-382.
[46]HONG S H,LEE J E,KIM H S,et al.Effect of vitamin D3on production of progesterone in porcine granulosa cells by regulation of steroidogenic enzymes[J].J Biomed Res,2016,30(3):203-208.
[47]XU J,HENNEBOLD J D,SEIFER D B.Direct vitamin D3actions on rhesus macaque follicles in three-dimensional culture:assessment of follicle survival,growth,steroid,and antimüllerian hormone production[J].Fertil Steril,2016,106(7):1815-1820.
[48]DENNIS N A,HOUGHTON L A,JONES G T,et al.The level of serum anti-Müllerian hormone correlates with vitamin D status in men and women but not in boys[J].J Clin Endocrinol Metab,2012,97(7):2450-2455.
[49]CHANG E M,KIM Y S,WON H J,et al.Association between sex steroids,ovarian reserve,and vitamin D levels in healthy nonobese women[J].J Clin Endocrinol Metab,2014,99(7):2526-2532.