维生素D_3与雄性生殖
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摘要
维生素D3的经典作用是调节体内钙、磷的代谢平衡和维持骨的健康,有证据显示维生素D3也可调节动物生殖。维生素D代谢酶可合成和降解活性维生素D3及其代谢中间产物,活性维生素D3通过结合至目标组织的维生素D受体(vitamin D receptor,VDR)以发挥其生物学作用。VDR和维生素D代谢酶在雄性生殖系统中表达,表明维生素D3在雄性生殖生物学中起关键作用。本文对维生素D3与雄性生殖的研究进展作一综述,以期为推进维生素D3影响雄性生殖的分子机制和临床治疗男性不育的研究提供理论依据。
The classical effects of vitamin D3 are modulating calcium and phosphorus metabolic balance and maintaining bone health in vivo. It has been shown that vitamin D3 could regulate animal reproduction. Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermediates,and active vitamin D3 exerts its biological effects through binding to vitamin D receptor( VDR).VDR and vitamin D metabolic enzymes expressed in male reproductive system,it suggest that vitamin D3 plays a pivotal role in male reproductive biology. In this review,we mainly focus on the progress of vitamin D3 and male reproduction to provide a theoretical basis for pushing forward the molecular mechanisms research of vitamin D3 effects on male reproduction and clinical therapy for male infertility.
The classical effects of vitamin D3 are modulating calcium and phosphorus metabolic balance and maintaining bone health in vivo. It has been shown that vitamin D3 could regulate animal reproduction. Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermediates,and active vitamin D3 exerts its biological effects through binding to vitamin D receptor( VDR).VDR and vitamin D metabolic enzymes expressed in male reproductive system,it suggest that vitamin D3 plays a pivotal role in male reproductive biology. In this review,we mainly focus on the progress of vitamin D3 and male reproduction to provide a theoretical basis for pushing forward the molecular mechanisms research of vitamin D3 effects on male reproduction and clinical therapy for male infertility.
引文
1 Blomberg Jensen M.Vitamin D and male reproduction.Nat Rev Endocrinol,2014,10:175~186.
2 Anagnostis P,Karras S,Goulis DG.Vitamin D in human reproduction:a narrative review.Int J Clin Pract,2013,67:225 ~235.
3 Corbett ST,Hill O,Nangia AK.Vitamin D receptor found in human sperm.Urology,2006,68:1345~1349.
4 Aquila S,Guido C,Perrotta I,et al.Human sperm anatomy:ultrastructural localization of 1alpha,25-dihydroxyvitamin D receptor and its possible role in the human male gamete.J Anat,2008,213:555~564.
5 Choudhary D,Jansson I,Stoilov I,et al.Expression patterns of mouse and human CYP orthologs(families 1-4)during development and in different adult tissues.Arch Biochem Biophys,2005,436:50~61.
6 Blomberg Jensen M,Nielsen JE,Jorgensen A,et al.Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract.Hum Reprod,2010,25:1303~1311.
7 Mahmoudi AR,Zarnani AH,Jeddi-Tehrani M,et al.Distribution of vitamin D receptor and 1alpha-hydroxylase in male mouse reproductive tract.Reprod Sci,2013,20:426~436.
8 Blomberg Jensen M,Bjerrum PJ,Jessen TE,et al.Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa.Hum Reprod,2011,26:1307~1317.
9 Blomberg Jensen M,Jorgensen A,Nielsen JE,et al.Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality.Int J Androl,2012,35:499~510.
10 朱晨露,李淑湘,魏佳玲,等.男性不育患者血清维生素D的变化及意义.中华男科学杂志,2014,20:751~754.
11 Blomberg Jensen M.Vitamin D metabolism,sex hormones,and male reproductive function.Reproduction,2012,144:135 ~152.
12 Hammoud AO,Meikle AW,Peterson CM,et al.Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters.Asian J Androl,2012,14:855~859.
13 Samplaski MK,Loai Y,Wong K,et al.Testosterone use in the male infertility population:prescribing patterns and effects on semen and hormonal parameters.Fertil Steril,2014,101:64~69.
14 Lee DM,Tajar A,Pye SR,et al.Association of hypogonadism with vitamin D status:the European Male Ageing Study.Eur J Endocrinol,2012,166:77~85.
15 Wehr E,Pilz S,Boehm BO,et al.Association of vitamin D status with serum androgen levels in men.Clin Endocrinol(Oxf),2010,73:243~248.
16 Nimptsch K,Platz EA,Willett WC,et al.Association between plasma 25-OH vitamin D and testosterone levels in men.Clin Endocrinol(Oxf),2012,77:106~112.
17 Foresta C,Strapazzon G,De Toni L,et al.Bone mineral density and testicular failure:evidence for a role of vitamin D 25-hydroxylase in human testis.J Clin Endocrinol Metab,2011,96:E646~E652.
18 Blomberg Jensen M,Lieben L,Nielsen JE,et al.Characterization of the testicular,epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model:targeting estrogen signalling.Mol Cell Endocrinol,2013,377:93~102.
19 Kinuta K,Tanaka H,Moriwake T,et al.Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads.Endocrinology,2000,141:1317~1324.
20 Erben RG,Soegiarto DW,Weber K,et al.Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.Mol Endocrinol,2002,16:1524~1537.
21 Sun W,Chen L,Zhang W,et al.Active vitamin D deficiency mediated by extracellular calcium and phosphorus results in male infertility in young mice.Am J Physiol Endocrinol Metab,2015,308:E51~E62.
22 Zanatta L,Zamoner A,Zanatta AP,et al.Nongenomic and genomic effects of 1alpha,25(OH)2 vitamin D3in rat testis.Life Sci,2011,89:515~523.
23 Rosso A,Pansera M,Zamoner A,et al.1alpha,25(OH)2 -Vitamin D3stimulates rapid plasma membrane calcium influx via MAPK activation in immature rat Sertoli cells.Biochimie,2012,94:146~154.
24 Blomberg Jensen M,Dissing S.Non-genomic effects of vitamin D in human spermatozoa.Steroids,2012,77:903~909.
25 Weissgerber P,Kriebs U,Tsvilovskyy V,et al.Male fertility depends on Ca2+absorption by TRPV6 in epididymal epithelia.Sci Signal,2011,4:ra27.
26 Saini RK,Kaneko I,Jurutka PW,et al.1,25-dihydroxyvitamin D3regulation of fibroblast growth factor-23 expression in bone cells:evidence for primary and secondary mechanisms modulated by leptin and interleukin-6.Calcif Tissue Int,2013,92:339~353.
27 Chanakul A,Zhang MY,Louw A,et al.FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues.Plo S one,2013,8:e72816.
28 Forster RE,Jurutka PW,Hsieh JC,et al.Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells.Biochem Biophys Res Commun,2011,414:557~562.
29 Zanatta L,Bouraima-Lelong H,Delalande C,et al.Regulation of aromatase expression by 1alpha,25(OH)2 vitamin D3in rat testicular cells.Reprod Fertil Dev,2011,23:725 ~735.
30 Dennis NA,Houghton LA,Jones GT,et al.The level of serum anti-Mullerian hormone correlates with vitamin D status in men and women but not in boys.Am J Physiol Endocrinol Metab,2012,97:2450~2455.
2 Anagnostis P,Karras S,Goulis DG.Vitamin D in human reproduction:a narrative review.Int J Clin Pract,2013,67:225 ~235.
3 Corbett ST,Hill O,Nangia AK.Vitamin D receptor found in human sperm.Urology,2006,68:1345~1349.
4 Aquila S,Guido C,Perrotta I,et al.Human sperm anatomy:ultrastructural localization of 1alpha,25-dihydroxyvitamin D receptor and its possible role in the human male gamete.J Anat,2008,213:555~564.
5 Choudhary D,Jansson I,Stoilov I,et al.Expression patterns of mouse and human CYP orthologs(families 1-4)during development and in different adult tissues.Arch Biochem Biophys,2005,436:50~61.
6 Blomberg Jensen M,Nielsen JE,Jorgensen A,et al.Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract.Hum Reprod,2010,25:1303~1311.
7 Mahmoudi AR,Zarnani AH,Jeddi-Tehrani M,et al.Distribution of vitamin D receptor and 1alpha-hydroxylase in male mouse reproductive tract.Reprod Sci,2013,20:426~436.
8 Blomberg Jensen M,Bjerrum PJ,Jessen TE,et al.Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa.Hum Reprod,2011,26:1307~1317.
9 Blomberg Jensen M,Jorgensen A,Nielsen JE,et al.Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality.Int J Androl,2012,35:499~510.
10 朱晨露,李淑湘,魏佳玲,等.男性不育患者血清维生素D的变化及意义.中华男科学杂志,2014,20:751~754.
11 Blomberg Jensen M.Vitamin D metabolism,sex hormones,and male reproductive function.Reproduction,2012,144:135 ~152.
12 Hammoud AO,Meikle AW,Peterson CM,et al.Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters.Asian J Androl,2012,14:855~859.
13 Samplaski MK,Loai Y,Wong K,et al.Testosterone use in the male infertility population:prescribing patterns and effects on semen and hormonal parameters.Fertil Steril,2014,101:64~69.
14 Lee DM,Tajar A,Pye SR,et al.Association of hypogonadism with vitamin D status:the European Male Ageing Study.Eur J Endocrinol,2012,166:77~85.
15 Wehr E,Pilz S,Boehm BO,et al.Association of vitamin D status with serum androgen levels in men.Clin Endocrinol(Oxf),2010,73:243~248.
16 Nimptsch K,Platz EA,Willett WC,et al.Association between plasma 25-OH vitamin D and testosterone levels in men.Clin Endocrinol(Oxf),2012,77:106~112.
17 Foresta C,Strapazzon G,De Toni L,et al.Bone mineral density and testicular failure:evidence for a role of vitamin D 25-hydroxylase in human testis.J Clin Endocrinol Metab,2011,96:E646~E652.
18 Blomberg Jensen M,Lieben L,Nielsen JE,et al.Characterization of the testicular,epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model:targeting estrogen signalling.Mol Cell Endocrinol,2013,377:93~102.
19 Kinuta K,Tanaka H,Moriwake T,et al.Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads.Endocrinology,2000,141:1317~1324.
20 Erben RG,Soegiarto DW,Weber K,et al.Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.Mol Endocrinol,2002,16:1524~1537.
21 Sun W,Chen L,Zhang W,et al.Active vitamin D deficiency mediated by extracellular calcium and phosphorus results in male infertility in young mice.Am J Physiol Endocrinol Metab,2015,308:E51~E62.
22 Zanatta L,Zamoner A,Zanatta AP,et al.Nongenomic and genomic effects of 1alpha,25(OH)2 vitamin D3in rat testis.Life Sci,2011,89:515~523.
23 Rosso A,Pansera M,Zamoner A,et al.1alpha,25(OH)2 -Vitamin D3stimulates rapid plasma membrane calcium influx via MAPK activation in immature rat Sertoli cells.Biochimie,2012,94:146~154.
24 Blomberg Jensen M,Dissing S.Non-genomic effects of vitamin D in human spermatozoa.Steroids,2012,77:903~909.
25 Weissgerber P,Kriebs U,Tsvilovskyy V,et al.Male fertility depends on Ca2+absorption by TRPV6 in epididymal epithelia.Sci Signal,2011,4:ra27.
26 Saini RK,Kaneko I,Jurutka PW,et al.1,25-dihydroxyvitamin D3regulation of fibroblast growth factor-23 expression in bone cells:evidence for primary and secondary mechanisms modulated by leptin and interleukin-6.Calcif Tissue Int,2013,92:339~353.
27 Chanakul A,Zhang MY,Louw A,et al.FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues.Plo S one,2013,8:e72816.
28 Forster RE,Jurutka PW,Hsieh JC,et al.Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells.Biochem Biophys Res Commun,2011,414:557~562.
29 Zanatta L,Bouraima-Lelong H,Delalande C,et al.Regulation of aromatase expression by 1alpha,25(OH)2 vitamin D3in rat testicular cells.Reprod Fertil Dev,2011,23:725 ~735.
30 Dennis NA,Houghton LA,Jones GT,et al.The level of serum anti-Mullerian hormone correlates with vitamin D status in men and women but not in boys.Am J Physiol Endocrinol Metab,2012,97:2450~2455.