维生素D受体基因型FokⅠ-ff与中国人群结核易感性的Meta分析
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摘要
目的应用Meta分析综合分析维生素D受体FokⅠ-ff基因型与结核易感性的关系。方法采用软件Rev Man 5.1.1,选用随机效应模型(M-H)法对纳入的10项针对中国人群的病例对照研究进行数据分析,并绘制漏斗图评价发表偏倚。结果共收录病例2892例,对照3355例,合并效应值RR为1.74(95%CI:1.20~2.52);未发现上述文献有显著的发表偏倚存在。结论中国人群FokⅠff基因型是结核的易感因子。
Objective To analyze the association between FokⅠ-ff genotype of vitamin D receptor and the tuberculosis susceptibility in the Chinese population by means of meta-analysis. Methods Mantel-Haenszel(MH) method was applied in the data analysis for the included 10 case-control studies by using Rev Man 5.5.1 software,and funnel plot was used to estimate the publication bias. Results The cumulative cases and controls were 2892 and 3355,respectively.The consoladition effect value RR was 1.74(95%CI:1.20-2.52).Significant publication bias was not found in the above literature. Conclusion FokⅠ-ff genotype of vitamin D receptor should be associated with susceptibility of tuberculosis among Chinese population.
Objective To analyze the association between FokⅠ-ff genotype of vitamin D receptor and the tuberculosis susceptibility in the Chinese population by means of meta-analysis. Methods Mantel-Haenszel(MH) method was applied in the data analysis for the included 10 case-control studies by using Rev Man 5.5.1 software,and funnel plot was used to estimate the publication bias. Results The cumulative cases and controls were 2892 and 3355,respectively.The consoladition effect value RR was 1.74(95%CI:1.20-2.52).Significant publication bias was not found in the above literature. Conclusion FokⅠ-ff genotype of vitamin D receptor should be associated with susceptibility of tuberculosis among Chinese population.
引文
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[16]冯福民,郭梅,郝金奇,等.维生素D受体基因多态性与汉族人肺结核发病的关系[J].山东医药,2009,49(45):4-6.
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[18]苏倩,向颖,胡代玉,等.VDR基因多态性、环境因素与重庆地区肺结核病的联系及交互作用研究[J].局解手术学杂志,2012,21(4):361-364.
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[22]Roth DE,Soto G,Arenas F,et al.Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis[J].J Infect Dis,2004,190(5):920-927.
[23]杨本付,韩长磊.维生素D受体基因多态性与肺结核关系的Meta分析[J].中国热带医学,2006,6(8):1347-1349.
[24]Lewis SJ,Baker I,Davey Smith G.Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk[J].Int J Tuberc Lung Dis,9(10):1174-1177.
[2]Dubaniewicz A.HLA-DR antigens in patients with pulmonary tuberculosis in northern Poland.Preliminary report[J].Arch Immunol Ther Exp(Warsz),2000,48(1):47-50.
[3]Goldfeld AE,Delgado JC,Thim S,et al.Association of an HLA-DQ allele with clinical tuberculosis[J].JAMA,1998,279(3):226-228.
[4]Selvaraj P,Raeetha AM,Uma H,et al.Influence of HLADR and-DO phenotypes on tuberculin reactive status in pulmonary tuberculosis patients[J].Tuber Lung Dis,1996,77(4):369-373.
[5]罗会元.人类遗传学[M].第3版.北京:人民卫生出版社,1999:749-750.
[6]中华医学会结核病学分会.中国结核病分类法[J].中华结核和呼吸杂志,1998,21(12):716.
[7]Ledwina T,Gnot S.Testing for Hardy-Weinberg equilibrium[J].Biomertics,1980,36(1):161-165.
[8]刘玮,张翠英,吴晓明,等.维生素D受体多态性与肺结核易患性的病例对照研究[J].中华流行病学杂志,2003,24(5):389-392.
[9]陈雪融,冯玉麟,唐晓燕,等.维生素D受体基因多态性对中国藏族结合患者排菌情况的影响[J].中国呼吸与危重症监护杂志,2006,5(1):42-45.
[10]焦伟伟,李兆娜,孙琳,等.维生素D受体基因多态性与中国汉族儿童结核病易感性的研究[J].中国实用儿科杂志,2009,24(4):264-266.
[11]向颖,林辉,胡代玉,等.SP110和VDR基因多态性与结核病的关联及其与环境因素的交互作用[J].局解手术学杂志,2013,22(4):377-379.
[12]李春柱.NRAMPl基因、VDR基因多态性与新疆哈萨克族结核病的相关性研究[D].石河子:石河子大学,2009.
[13]陈丹丹,朱圭娜,关光玉,等.VDR-TaqⅠ、FokⅠ位点多态性与宁夏人群结核易感性研究[J].中国防痨杂志,2013,35(8):566-572.
[14]刘一典.新发和复发肺结核维生素D受体基因多态性分布及其意义[D].苏州:苏州大学,2008.
[15]高玉婧,裴秀英,杨华,等.维生素D受体基因多态性与宁夏结核病遗传易感性的关联性研究[J].宁夏医学杂志,2008,30(8):673-675.
[16]冯福民,郭梅,郝金奇,等.维生素D受体基因多态性与汉族人肺结核发病的关系[J].山东医药,2009,49(45):4-6.
[17]戴垚垚.维生素D及其代谢通路遗传多态与结核病发病风险和预后的关联研究[D].南京:南京医科大学,2013.
[18]苏倩,向颖,胡代玉,等.VDR基因多态性、环境因素与重庆地区肺结核病的联系及交互作用研究[J].局解手术学杂志,2012,21(4):361-364.
[19]Wilkinson RJ,Llewelyn M,Toossi Z,et al.Influence of vitamin D deficiency and vitamin D receptor polymorphismson tuberculosis among Gujarati Asians in West London:a case-control study[J].Lancet,2000,355(9204):618-621.
[20]Selvaraj P,Chandra G,Kurian SM,et al.Association of vitamin D receptor gene variants of BsmIⅠ,ApaⅠand FokⅠpolymorphisms with susceptibility to pulmonary tuberculosis[J].Curr Sci,2003,84:1.
[21]Bornman L,Campbell SJ,Fielding K,et al.Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa:a case-control and family study[J].J Infect Dis,2004,190(9):1631-1641.
[22]Roth DE,Soto G,Arenas F,et al.Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis[J].J Infect Dis,2004,190(5):920-927.
[23]杨本付,韩长磊.维生素D受体基因多态性与肺结核关系的Meta分析[J].中国热带医学,2006,6(8):1347-1349.
[24]Lewis SJ,Baker I,Davey Smith G.Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk[J].Int J Tuberc Lung Dis,9(10):1174-1177.