应用Keratograph眼表综合分析仪观察2型糖尿病患者泪膜功能的改变
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摘要
目的应用Keratograph 5M眼表综合分析仪观察2型糖尿病患者泪膜功能的改变。方法选择我院内分泌科确诊的100例(200眼)糖尿病患者作为观察组,同期到我院眼科中心门诊就诊的50例(100眼)无糖尿病者作为对照组。采用Keratograph 5M眼表综合分析仪测定两组的首次泪膜破裂时间(BUTf)、平均泪膜破裂时间(BUTav)及中央泪河高度(TMHm),并分析上、下睑板腺缺失状况。同时两组均进行基础分泌试验(SIt)检查。结果观察组的BUTf及BUTav均短于照组(P <0.05)。两组的TMHm、上下睑板腺缺失状况评分比较均无统计学差异(P>0.05)。BUTf及BUTav均与SIt值呈正相关(r=0.317、0.298, P均=0.000)。结论 Keratograph 5M眼表综合分析仪可以客观、准确地分析2型糖尿病患者泪膜功能的改变,而2型糖尿病患者更容易出现泪膜功能的改变。
Objective To observe the changes of tear film function in patients with type 2 diabetes mellitus by Keratograph 5M.Methods 100 cases of patients(200 eyes) diagnosed as type 2 diabetes mellitus in endocrinology department of our hospital were selected as the observation group, 50 out-petients(100 eyes) with non-diabetes were selected as the control group. The first tear film break-up time(BUTf) and average tear film break-up time(BUTav) and middle tear meniscus height(TMHm) were detected by Keratograph 5M. The deficiency of meibomian glands were analyzed. The Schirmer Ⅰ test(SIt) were performed for both groups. Results The BUTf and BUTav of the observation group were shorter than those of the control group(P <0.05). No statistical was found in the TMHm and meibomian gland deficiency scores between the two groups(P >0.05). The BUTf and BUTav were positively related with SIt(r = 0.317, 0.298, all P = 0.000).Conclusions Keratograph 5M can directly evaluate the changes of tear film function of patients with type 2 diabetes mellitus objectively and precisely, and the tear film function of patients with type 2 diabetes mellitus changes more easily.
Objective To observe the changes of tear film function in patients with type 2 diabetes mellitus by Keratograph 5M.Methods 100 cases of patients(200 eyes) diagnosed as type 2 diabetes mellitus in endocrinology department of our hospital were selected as the observation group, 50 out-petients(100 eyes) with non-diabetes were selected as the control group. The first tear film break-up time(BUTf) and average tear film break-up time(BUTav) and middle tear meniscus height(TMHm) were detected by Keratograph 5M. The deficiency of meibomian glands were analyzed. The Schirmer Ⅰ test(SIt) were performed for both groups. Results The BUTf and BUTav of the observation group were shorter than those of the control group(P <0.05). No statistical was found in the TMHm and meibomian gland deficiency scores between the two groups(P >0.05). The BUTf and BUTav were positively related with SIt(r = 0.317, 0.298, all P = 0.000).Conclusions Keratograph 5M can directly evaluate the changes of tear film function of patients with type 2 diabetes mellitus objectively and precisely, and the tear film function of patients with type 2 diabetes mellitus changes more easily.
引文
[1]李凤鸣.中华眼科学[M].北京:人民卫生出版社, 2005:1153-1160.
[2] Best N, Drury L, Wolffsohn JS. Clinical evaluation of the Oculus Ker atography[J]. Cont Lens Anterior Eye, 2012, 35(4):171-174.
[3]吴雅冰,王玉斌,周真宝. Keratograph眼表综合分析仪观察2型糖尿病患者泪膜功能变化的研究[J].临床眼科杂志, 2016, 24(6):492-495.
[4]诸科璇,谢文加,应靖璐,等.运用Keratograph 5M眼表综合分析仪评价干眼患者的泪膜及睑板腺功能[J].浙江大学学报(医学版),2016, 45(4):422-428.
[5]田磊,宋文秀,王智群,等. Keratograph 5M眼表综合分析仪在干眼诊断中的应用研究[J].首都医科大学学报, 2017, 38(1):11-16.
[6]赖钟祺,李维娜,李惠娜. Keratograph 5M眼表综合分析仪观察小梁切除术后泪膜的早期变化[J].国际眼科杂志, 2015, 15(7):1282-1284.
[7]高妍,李冰,宁晓玲,等. 2型糖尿病患者眼表改变的临床分析[J].中华眼视光学与视觉科学杂志, 2011, 13(4):304-308.
[8]金姬,陈丽红,刘秀伦,等.糖尿病患者泪膜功能的研究[J].中华眼科杂志, 2003, 39(1):10-13.
[9]余玲,谢汉平,孟晓红,等. 2型糖尿病患者泪液分泌及泪膜功能的初步研究[J].眼科研究, 2004, 22(5):533-535.
[10] Shamsheer RP, Arunachalam C. A clinical study of meibomian gland dysfunction in patients with diabetes[J]. Middle East Afr J Ophthalmol, 2015, 22(4):462-466.
[2] Best N, Drury L, Wolffsohn JS. Clinical evaluation of the Oculus Ker atography[J]. Cont Lens Anterior Eye, 2012, 35(4):171-174.
[3]吴雅冰,王玉斌,周真宝. Keratograph眼表综合分析仪观察2型糖尿病患者泪膜功能变化的研究[J].临床眼科杂志, 2016, 24(6):492-495.
[4]诸科璇,谢文加,应靖璐,等.运用Keratograph 5M眼表综合分析仪评价干眼患者的泪膜及睑板腺功能[J].浙江大学学报(医学版),2016, 45(4):422-428.
[5]田磊,宋文秀,王智群,等. Keratograph 5M眼表综合分析仪在干眼诊断中的应用研究[J].首都医科大学学报, 2017, 38(1):11-16.
[6]赖钟祺,李维娜,李惠娜. Keratograph 5M眼表综合分析仪观察小梁切除术后泪膜的早期变化[J].国际眼科杂志, 2015, 15(7):1282-1284.
[7]高妍,李冰,宁晓玲,等. 2型糖尿病患者眼表改变的临床分析[J].中华眼视光学与视觉科学杂志, 2011, 13(4):304-308.
[8]金姬,陈丽红,刘秀伦,等.糖尿病患者泪膜功能的研究[J].中华眼科杂志, 2003, 39(1):10-13.
[9]余玲,谢汉平,孟晓红,等. 2型糖尿病患者泪液分泌及泪膜功能的初步研究[J].眼科研究, 2004, 22(5):533-535.
[10] Shamsheer RP, Arunachalam C. A clinical study of meibomian gland dysfunction in patients with diabetes[J]. Middle East Afr J Ophthalmol, 2015, 22(4):462-466.