联合应用消痈散结汤与盐酸左氧氟沙星注射液治疗附睾炎患者效果及对精浆中性α-葡糖苷酶和精液质量的影响
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摘要
目的观察联合应用消痈散结汤与盐酸左氧氟沙星注射液治疗附睾炎患者的效果及对精浆中性α-葡糖苷酶和精液质量的影响。方法选取航天中心医院诊治的130例附睾炎患者为研究对象,按照随机数字表法将其平均分为治疗组和对照组,每组65例患者。两组患者均给予基础干预,其后,对照组患者采用盐酸左氧氟沙星注射液治疗,治疗组患者在对照组基础上联合消痈散结汤治疗。观察两组患者临床症状评分、附睾形态、临床疗效,检测精浆中性α-葡糖苷酶和精液质量。结果治疗后,两组患者疼痛评分、生活质量评分均显著低于治疗前(均P<0.05),且治疗组患者显著低于对照组患者(P<0.05);治疗后,两组患者尾厚、头厚、体厚显著低于治疗前患者(P<0.05),且治疗组患者显著低于对照组患者(P<0.05);治疗组患者总有效率(93.9%)显著高于对照组患者(81.5%)(P<0.05)。治疗后,两组患者a级精子、精子活动率、精子密度、a+b级精子均显著高于治疗前(均P<0.05),且治疗组患者显著高于对照组患者(P<0.05)。治疗后,两组患者精浆中性α-葡糖苷酶水平显著高于治疗前患者(P<0.05),且治疗组患者显著高于对照组患者(P<0.05)。结论采用消痈散结汤联合盐酸左氧氟沙星注射液可以有效减轻附睾炎患者疼痛,提高生活质量,同时可以有效提高附睾炎患者精浆中性α-葡糖苷酶和精液质量。
Objective To observe the curative effect of combined application of Xiaoyong Sanjie decoction and levofloxacine hydrochloride injection in epididymitis patients and its influence on the seminal neutral α-glucosidase and semen quality. Methods 130 epididymitis patients in Aerospace Center Hospital were selected and, according to the random number table method, were divided into treatment group and control group, 65 cases in each group. All the patients in the two groups were given basic intervention. Besides, the control group was treated with levofloxacine hydrochloride injection and on the basis of the control group the treatment group was given Xiaoyong Sanjie decoction. The clinical symptom score, epididymal morphology and clinical efficacy of the two groups were observed, and the levels of seminal neutral α-glucosidase and semen quality were detected. Results After treatment, the pain scores and quality of life scores of the two groups were significantly lower than those before treatment(all P<0.05), and those of the treatment group was significantly lower than those of the control group(P<0.05). After treatment, the tail thickness, head thickness, body thickness were significantly lower than those before treatment in the two groups(P<0.05), and those of the treatment group were significantly lower than those of the control group(P<0.05). The total effective rate of the treatment group(93.9%) was significantly higher than that of the control group(81.5%)(P<0.05). After treatment, proportion of grade A sperm, sperm motility, sperm density, and proportion of grade A+B sperm were significantly higher than those before treatment(all P<0.05), and those of the treatment group was significantly higher than those of the control group(P<0.05). After treatment, the levels of neutral α-glucosidase in seminal plasma were significantly higher than those before treatment in the two groups(P<0.05), and the those of the treatment group were significantly higher than those of the control group(P<0.05). Conclusions The Xiaoyong Sanjie decoction combined with levofloxacine hydrochloride injection can effectively reduce the pain of epididymal patients, improve the quality of life, and at the same time effectively improve the seminal neutral α-glucosidase and semen quality of patients.
Objective To observe the curative effect of combined application of Xiaoyong Sanjie decoction and levofloxacine hydrochloride injection in epididymitis patients and its influence on the seminal neutral α-glucosidase and semen quality. Methods 130 epididymitis patients in Aerospace Center Hospital were selected and, according to the random number table method, were divided into treatment group and control group, 65 cases in each group. All the patients in the two groups were given basic intervention. Besides, the control group was treated with levofloxacine hydrochloride injection and on the basis of the control group the treatment group was given Xiaoyong Sanjie decoction. The clinical symptom score, epididymal morphology and clinical efficacy of the two groups were observed, and the levels of seminal neutral α-glucosidase and semen quality were detected. Results After treatment, the pain scores and quality of life scores of the two groups were significantly lower than those before treatment(all P<0.05), and those of the treatment group was significantly lower than those of the control group(P<0.05). After treatment, the tail thickness, head thickness, body thickness were significantly lower than those before treatment in the two groups(P<0.05), and those of the treatment group were significantly lower than those of the control group(P<0.05). The total effective rate of the treatment group(93.9%) was significantly higher than that of the control group(81.5%)(P<0.05). After treatment, proportion of grade A sperm, sperm motility, sperm density, and proportion of grade A+B sperm were significantly higher than those before treatment(all P<0.05), and those of the treatment group was significantly higher than those of the control group(P<0.05). After treatment, the levels of neutral α-glucosidase in seminal plasma were significantly higher than those before treatment in the two groups(P<0.05), and the those of the treatment group were significantly higher than those of the control group(P<0.05). Conclusions The Xiaoyong Sanjie decoction combined with levofloxacine hydrochloride injection can effectively reduce the pain of epididymal patients, improve the quality of life, and at the same time effectively improve the seminal neutral α-glucosidase and semen quality of patients.
引文
[1] 周玉春,夏国守,薛宇阳,等.补肾祛湿中药联合多沙唑嗪治疗慢性附睾炎的临床研究[J].中华男科学杂志,2010,16(12):1143-1146.
[2] 南玉奎,田欣,胡晓刚,等.左氧氟沙星静点联合精索注药治疗急性附睾炎的临床疗效观察(附42例报告)[J].国际泌尿系统杂志,2014,34(4):542-545.
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[6] 李彪.新编中医外科学[M].北京:人民军医出版社,1999:196-197.
[7] 国家中医药管理局.中医病症诊断疗效标准[M].南京:南京大学出版社,1994:78-79.
[8] Johnston SD,Deif HH,Mckinnon A,et al.Orchitis and epididymitis in koalas (phascolarctos cinereus) infected with chlamydia pecorum[J].Veterinary Pathology,2015,52(6):1254-1257.
[9] 梁钰龙.复方丹参片治疗急性附睾炎的疗效及对生殖力的影响[J].中国中医急症,2013,22(4):661-662.
[10] Charles BT,Tracy M,Duke HS.Ectopic ureteral insertion into the seminal vesicle causing recurrent epididymitis in a 24-year-old[J].Journal of Endourology Case Reports,2015,1(1):14-16.
[11] 刘廷江,孙福振,尹香云,等.舒筋活血洗剂局部熏洗联合抗生素静滴治疗急性附睾炎效果观察[J].山东医药,2010,50(34):102-102.
[12] 赵俊.如意金黄散联合抗生素治疗急性附睾炎36例疗效观察[J].内蒙古中医药,2016(1):69-69.
[13] 袁少英,卢玉忠,覃湛,等.丹红通精方合针挑疗法对慢性附睾炎不育症精液质量、精浆中性α-葡糖苷酶的影响[J].南京中医药大学学报,2012,28(3):218-221.
[14] 李玉勤,徐少华,刘建,等.左氧氟沙星静滴联合精索注药治疗急性附睾炎的临床疗效观察[J].中国性科学,2015,24(7):10-12.
[15] 潘杰,梁健峰,范郁涛,等.龙胆泻肝汤结合外敷双柏散治疗急性附睾炎疗效观察[J].广西中医药,2016,39 (5):32-34.
[16] 江锋,吴鹏飞,刘之光.中西医结合治疗急性附睾炎43例[J].河南中医,2014,34(9):1804-1805.
[17] 蔡燕磊,孙自学.桂枝茯苓汤合五味消毒饮加减联合抗生素治疗急性附睾炎40例[J].中医学报,2014,29(1):88-89.
[18] 谢福贤.柴归汤佐治急性附睾炎35例疗效观察[J].国医论坛,2015,30(4):46-47.
[2] 南玉奎,田欣,胡晓刚,等.左氧氟沙星静点联合精索注药治疗急性附睾炎的临床疗效观察(附42例报告)[J].国际泌尿系统杂志,2014,34(4):542-545.
[3] 李德干.中西医结合治疗急性附睾炎疗效观察[J].现代中西医结合杂志,2010,19(30):3267-3268.
[4] 范曾,庄婷婵.消痈散结汤联合抗生素治疗急性附睾炎35例[J].现代中医药,2017,37(3):49-50.
[5] 葛宏发,李慎勤.泌尿外科疾病诊断和鉴别诊断[M].北京:人民卫生出版社,1988:214-215.
[6] 李彪.新编中医外科学[M].北京:人民军医出版社,1999:196-197.
[7] 国家中医药管理局.中医病症诊断疗效标准[M].南京:南京大学出版社,1994:78-79.
[8] Johnston SD,Deif HH,Mckinnon A,et al.Orchitis and epididymitis in koalas (phascolarctos cinereus) infected with chlamydia pecorum[J].Veterinary Pathology,2015,52(6):1254-1257.
[9] 梁钰龙.复方丹参片治疗急性附睾炎的疗效及对生殖力的影响[J].中国中医急症,2013,22(4):661-662.
[10] Charles BT,Tracy M,Duke HS.Ectopic ureteral insertion into the seminal vesicle causing recurrent epididymitis in a 24-year-old[J].Journal of Endourology Case Reports,2015,1(1):14-16.
[11] 刘廷江,孙福振,尹香云,等.舒筋活血洗剂局部熏洗联合抗生素静滴治疗急性附睾炎效果观察[J].山东医药,2010,50(34):102-102.
[12] 赵俊.如意金黄散联合抗生素治疗急性附睾炎36例疗效观察[J].内蒙古中医药,2016(1):69-69.
[13] 袁少英,卢玉忠,覃湛,等.丹红通精方合针挑疗法对慢性附睾炎不育症精液质量、精浆中性α-葡糖苷酶的影响[J].南京中医药大学学报,2012,28(3):218-221.
[14] 李玉勤,徐少华,刘建,等.左氧氟沙星静滴联合精索注药治疗急性附睾炎的临床疗效观察[J].中国性科学,2015,24(7):10-12.
[15] 潘杰,梁健峰,范郁涛,等.龙胆泻肝汤结合外敷双柏散治疗急性附睾炎疗效观察[J].广西中医药,2016,39 (5):32-34.
[16] 江锋,吴鹏飞,刘之光.中西医结合治疗急性附睾炎43例[J].河南中医,2014,34(9):1804-1805.
[17] 蔡燕磊,孙自学.桂枝茯苓汤合五味消毒饮加减联合抗生素治疗急性附睾炎40例[J].中医学报,2014,29(1):88-89.
[18] 谢福贤.柴归汤佐治急性附睾炎35例疗效观察[J].国医论坛,2015,30(4):46-47.