基于专利数据分析的国内外缓控释微丸技术现状研究
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摘要
针对缓控释微丸制剂技术,在专利层面上,分别从全球专利申请趋势、申请国/地区、申请目标国/地区、IPC技术构成、申请人、重要申请人对比、国内各省市申请状况和缓控释微丸技术分类等维度进行详尽的定性与定量分析,阐明了缓控释微丸制剂的国内外研究进展,并为国内企业提出了发展建议。
In view of the technology of slow and controlled-release pellet preparation, at the patent level, a detailed qualitative and quantitative analysis was made from the global patent application trend, the applicant country/region, the target country/region, the IPC technology composition, the applicant, the important applicant contrast, the domestic and provincial application status and the slow controlled release pellets technology classification. The research progress of slow controlled release pellets preparation at home and abroad was explained, and suggestions for the development of domestic enterprises were put forward.
In view of the technology of slow and controlled-release pellet preparation, at the patent level, a detailed qualitative and quantitative analysis was made from the global patent application trend, the applicant country/region, the target country/region, the IPC technology composition, the applicant, the important applicant contrast, the domestic and provincial application status and the slow controlled release pellets technology classification. The research progress of slow controlled release pellets preparation at home and abroad was explained, and suggestions for the development of domestic enterprises were put forward.
引文
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[2]黄媛萍,赖春花.缓控释微丸的研究进展[J].江西中医学院学报,2010(2):88-91.
[3]任君刚,邹梅娟,王悦,等.硝苯地平骨架缓控释微丸的制备及在家犬体内的药物动力学[J].中国医药工业杂志,2007(2):70-73.
[4]施路,李三鸣,术红光,等.不同包衣条件下银杏缓释微丸体外释放考察[J].沈阳药科大学学报,2005(3):176.
[5]郑昕.通栓救心缓释微丸[D].沈阳:沈阳药科大学,2006.
[6] Mc Connell E,Short MD,Basit AW.An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man[J].J Control Release,2008(2):154-160.
[7] Youness Karrout,Christel Neut,Daniel Wils,et al.Novel polymeric film coatings for colon targeting:Drug release from coated Pellets[J].European Journal of Pharmaceutical Sciences,2009(37):427-433.
[8]张晓辉.盐酸地尔硫?缓释脉冲微丸的研制[D].石家庄:河北医科大学,2006.