桂枝茯苓胶囊对前列腺增生患者临床症状、睡眠质量及生活质量的影响
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摘要
目的分析桂枝茯苓胶囊联合坦索罗辛及非那雄胺治疗对前列腺增生(BPH)患者临床症状、睡眠质量及生活质量的影响。方法选取我院2016年4月—2018年5月收治的BPH患者112例,根据治疗药物的不同分为对照组和观察组,每组56例。对照组给予坦索罗辛联合非那雄胺治疗;观察组在对照组的基础上联合桂枝茯苓胶囊治疗。观察并记录2组治疗前后的临床症状、睡眠质量与生活质量变化情况,治疗后临床效果和治疗期间不良反应发生情况。结果观察组治疗后临床总有率高于对照组(P<0.05)。2组治疗后国际前列腺症状(IPSS)评分低于治疗前,且观察组低于对照组;最大尿流率(Qmax)评分高于治疗前,且观察组高于对照组(P<0.05)。2组治疗后阿斯森失眠量表(AIS)、生活质量(QOLS)评分显著低于治疗前,且观察组低于对照组(P<0.05)。观察组不良反应总发生率低于对照组(P<0.05)。结论在BPH治疗中,与坦索罗辛联合非那雄胺相比,桂枝茯苓胶囊联合坦索罗辛、非那雄胺治疗后可提高临床有效率,可通过降低前列腺平滑肌与尿道内张力、活血化瘀等作用改善BPH各症状,同时促进患者睡眠,提高其生活质量。
Objective To analyze effects of Rumulus Ginnamomi Tuckahoe capsule combined with Tamsulosin and Finasteride on clinical symptoms, sleep quality and life quality in treatment of patients with prostatic hyperplasia(PH). Methods A total of 112 PH patients admitted during April 2016 and May 2018 were divided into control group and observation group(n=56 in each group) according to different medications. Control group was treated with Tamsulosin combined with Finasteride, while observation group was added with Rumulus Ginnamomi Tuckahoe capsule on the basis of treatment for control group. Clinical symptoms, changes of sleep quality and life quality, clinical efficacy and incidence rate of adverse reactions during treatment were observed and recorded before and after treatment. Results After treatment, the total effective rate in observation group was significantly higher than that in control group(P<0.05). After treatment, International Pilot Study of Schizophrenia(IPSS) scores were significantly lower than those before treatment in two groups, and the score in observation group was significantly lower than that in control group; maximum urinary flow rate(Qmax) scores were significantly higher than those before treatment in two groups, and the score in observation group was significantly higher than that in control group(P<0.05). After treatment, Athens insomnia scale(AIS) and quality of life scale(QOLS) scores were significantly lower than those before treatment in two groups, and the scores in observation group were significantly lower than those in control group(P<0.05). The total incidence rate of adverse reactions in observation group was significantly lower than that in control group(P<0.05). Conclusion Compared with those by Tamsulosin combined with Finasteride, Tamsulosin and Finasteride combined with Rumulus Ginnamomi Tuckahoe capsule may improve clinical effective rate in BPH treatment, and it may improve BPH symptoms by reducing tension of prostatic smooth muscle and urethra, promoting blood circulation and removing blood stasis, and patient's sleep and quality of life may be improved simultaneously.
Objective To analyze effects of Rumulus Ginnamomi Tuckahoe capsule combined with Tamsulosin and Finasteride on clinical symptoms, sleep quality and life quality in treatment of patients with prostatic hyperplasia(PH). Methods A total of 112 PH patients admitted during April 2016 and May 2018 were divided into control group and observation group(n=56 in each group) according to different medications. Control group was treated with Tamsulosin combined with Finasteride, while observation group was added with Rumulus Ginnamomi Tuckahoe capsule on the basis of treatment for control group. Clinical symptoms, changes of sleep quality and life quality, clinical efficacy and incidence rate of adverse reactions during treatment were observed and recorded before and after treatment. Results After treatment, the total effective rate in observation group was significantly higher than that in control group(P<0.05). After treatment, International Pilot Study of Schizophrenia(IPSS) scores were significantly lower than those before treatment in two groups, and the score in observation group was significantly lower than that in control group; maximum urinary flow rate(Qmax) scores were significantly higher than those before treatment in two groups, and the score in observation group was significantly higher than that in control group(P<0.05). After treatment, Athens insomnia scale(AIS) and quality of life scale(QOLS) scores were significantly lower than those before treatment in two groups, and the scores in observation group were significantly lower than those in control group(P<0.05). The total incidence rate of adverse reactions in observation group was significantly lower than that in control group(P<0.05). Conclusion Compared with those by Tamsulosin combined with Finasteride, Tamsulosin and Finasteride combined with Rumulus Ginnamomi Tuckahoe capsule may improve clinical effective rate in BPH treatment, and it may improve BPH symptoms by reducing tension of prostatic smooth muscle and urethra, promoting blood circulation and removing blood stasis, and patient's sleep and quality of life may be improved simultaneously.
引文
[1] 廖洪秀,蒲玉红,李春霞,等.攀枝花市外来过冬人群生活质量变化及影响因素分析[J].预防医学情报杂志,2018,32(5):214-215.
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[5] 姚宏涛,薛晓玲.盐酸坦洛新缓释胶囊联合体外冲击波碎石术治疗输尿管下段结石合并前列腺增生效果观察[J].解放军医药杂志,2017,29(8):60-62,71.
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[8] 郑影,张鹤云,史云强.良性前列腺增生103例的临床诊治分析[J].云南医药,2017,38(1):27-28.
[9] 杨烁.健脾益肾汤联合坦索罗辛治疗良性前列腺增生疗效及对炎性细胞因子、PSA水平的影响[J].热带医学杂志,2017,17(10):1381-1384.
[10] 陈化磊,卓小岸,车宪平,等.活血化瘀方联合西医治疗前列腺增生症疗效及对血浆内皮素的影响[J].现代中西医结合杂志,2017,26(21):2287-2289,2292.
[11] 万涛.前列舒通胶囊联合坦索罗辛治疗良性前列腺增生疗效及对血清睾酮和雌二醇水平的影响[J].现代中西医结合杂志,2017,26(21):274-276.
[12] 胡文豪,陈光耀,沈立亮,等.坦索罗辛胶囊与多沙唑嗪片治疗良性前列腺增生伴下尿路症状的临床研究[J].中国临床药理学杂志,2017,33(24):2562-2565.
[13] 明成清,江涛,陶晓枫,等.术前应用非那雄胺对经尿道前列腺电切除术术中出血的预防作用[J].中国综合临床,2016,32(1):72-73.
[14] 薛萍,任斌,张小燕,等.癃闭舒联合盐酸坦索罗辛缓释胶囊治疗老年前列腺增生的效果以及安全性分析[J].中国性科学,2017,26(5):30-32.
[15] 于生龙,马德爽胡春欢.索利那新联合坦索罗辛治疗经尿道前列腺电切术后膀胱过度活动症临床评价[J].中国药业,2017,26(8):260-262.
[16] 田子阳,冯伟,朱元全,等.前列舒通胶囊联合非那雄胺对良性前列腺增生症的疗效观察[J].西部医学,2018,30(2):224-227.
[17] 袁琛,桂定文,王小英,等.索利那新联合坦索罗辛治疗前列腺增生伴下尿路症状患者的疗效观察[J].中国性科学,2017,26(6):10-12.
[18] Li F,Pascal L E,Zhou J,et al.BCL-2 and BCL-XL expression are down-regulated in benign prostate hyperplasia nodules and not affected by finasteride and/or celecoxib[J].American Journal of Clinical & Experimental Urology,2018,24(1):124-125.
[19] 陈晓松,欧彤文,张建.癃闭舒胶囊联合西医治疗良性前列腺增生的疗效及对中医证候积分、QOL积分的影响[J].现代中西医结合杂志,2017,26(36):4072-4074.
[20] 周益军,戴晓农,朱喜山,等.祛瘀散寒中药联合坦索罗辛治疗CABP/CPPS疗效及对白细胞计数的影响[J].现代中西医结合杂志,2018,23(12):231-232.
[21] 张朝晖,夏宇,杨安卿,等.前列腺癌与前列腺增生的差异基因比较[J].医学分子生物学杂志,2018,30(3):112-113.
[22] 王玉琳,阮振旭,李微,等.电针疏密波治疗良性前列腺增生22例临床观察[J].江苏中医药,2018,25(1):53-55.
[23] 张球勇,张敏建.疏肝益阳胶囊联合盐酸坦索罗辛治疗BPH/LUTS合并ED的临床观察[J].中国性科学,2017,26(4):19-22.
[24] 刘惠玲,廖冬梅.桂枝茯苓胶囊对慢性盆腔炎患者炎症因子及临床疗效的影响[J].中国性科学,2018,26(3):247-248.
[25] 张坤,田艺,左侠,等.桂枝茯苓胶囊对卵巢囊肿剥除术患者卵巢储备功能的影响[J].现代生物医学进展,2017,17(13):2502-2504.
[26] Odusanya B O,Tijani K H,Jeje E A,et al.Short-term Effect of Tamsulosin and Finasteride Monotherapy and their Combination on Nigerian Men with Benign Prostatic Hyperplasia[J].Nigerian Journal of Surgery Official Publication of the Nigerian Surgical Research Society,2017,23(1):5-10.
[27] 方霞,俞碧霞,顾海燕,等.克拉霉素结合桂枝茯苓胶囊对患者慢性盆腔炎的治疗疗效研究[J].中华医院感染学杂志,2018,28(5):761-763,767.
[28] 芦艳丽,李娟,韩璐.米非司酮联合桂枝茯苓胶囊对子宫内膜异位症患者血清CA125、CA199及性激素水平的影响[J].世界临床药物,2017,28(7):475-478.
[2] 王春仙,宫香宇,张素英,等.前列欣联合盐酸坦索罗辛和非那雄胺治疗老年良性前列腺增生的疗效观察[J].中国药房,2017,28(8):1108-1111.
[3] 高飞,刘华荣.ω-3脂肪酸联合非那雄胺及坦索罗辛治疗男性下尿路症状与良性前列腺增生的临床研究[J].现代泌尿外科杂志,2017,22(10):764-767.
[4] Zhang R H,Li C R,Yang H,et al.An UPLC-MS/MS method for simultaneous determination of multiple constituents in Guizhi Fuling capsule with ultrafast positive/negative ionization switching[J].Chinese Journal of Natural Medicines,2018,16(4):313.
[5] 姚宏涛,薛晓玲.盐酸坦洛新缓释胶囊联合体外冲击波碎石术治疗输尿管下段结石合并前列腺增生效果观察[J].解放军医药杂志,2017,29(8):60-62,71.
[6] 孙卫兵,蒋思雄.《中国泌尿外科疾病诊断和治疗指南》点评——前列腺增生症的诊断[J].医学与哲学,2007,28(4):54-55.
[7] 朱达明.中医辨证分型治疗前列腺肥大的临床观察及治疗方案的探讨[J].中外医学研究,2013(17):17-18.
[8] 郑影,张鹤云,史云强.良性前列腺增生103例的临床诊治分析[J].云南医药,2017,38(1):27-28.
[9] 杨烁.健脾益肾汤联合坦索罗辛治疗良性前列腺增生疗效及对炎性细胞因子、PSA水平的影响[J].热带医学杂志,2017,17(10):1381-1384.
[10] 陈化磊,卓小岸,车宪平,等.活血化瘀方联合西医治疗前列腺增生症疗效及对血浆内皮素的影响[J].现代中西医结合杂志,2017,26(21):2287-2289,2292.
[11] 万涛.前列舒通胶囊联合坦索罗辛治疗良性前列腺增生疗效及对血清睾酮和雌二醇水平的影响[J].现代中西医结合杂志,2017,26(21):274-276.
[12] 胡文豪,陈光耀,沈立亮,等.坦索罗辛胶囊与多沙唑嗪片治疗良性前列腺增生伴下尿路症状的临床研究[J].中国临床药理学杂志,2017,33(24):2562-2565.
[13] 明成清,江涛,陶晓枫,等.术前应用非那雄胺对经尿道前列腺电切除术术中出血的预防作用[J].中国综合临床,2016,32(1):72-73.
[14] 薛萍,任斌,张小燕,等.癃闭舒联合盐酸坦索罗辛缓释胶囊治疗老年前列腺增生的效果以及安全性分析[J].中国性科学,2017,26(5):30-32.
[15] 于生龙,马德爽胡春欢.索利那新联合坦索罗辛治疗经尿道前列腺电切术后膀胱过度活动症临床评价[J].中国药业,2017,26(8):260-262.
[16] 田子阳,冯伟,朱元全,等.前列舒通胶囊联合非那雄胺对良性前列腺增生症的疗效观察[J].西部医学,2018,30(2):224-227.
[17] 袁琛,桂定文,王小英,等.索利那新联合坦索罗辛治疗前列腺增生伴下尿路症状患者的疗效观察[J].中国性科学,2017,26(6):10-12.
[18] Li F,Pascal L E,Zhou J,et al.BCL-2 and BCL-XL expression are down-regulated in benign prostate hyperplasia nodules and not affected by finasteride and/or celecoxib[J].American Journal of Clinical & Experimental Urology,2018,24(1):124-125.
[19] 陈晓松,欧彤文,张建.癃闭舒胶囊联合西医治疗良性前列腺增生的疗效及对中医证候积分、QOL积分的影响[J].现代中西医结合杂志,2017,26(36):4072-4074.
[20] 周益军,戴晓农,朱喜山,等.祛瘀散寒中药联合坦索罗辛治疗CABP/CPPS疗效及对白细胞计数的影响[J].现代中西医结合杂志,2018,23(12):231-232.
[21] 张朝晖,夏宇,杨安卿,等.前列腺癌与前列腺增生的差异基因比较[J].医学分子生物学杂志,2018,30(3):112-113.
[22] 王玉琳,阮振旭,李微,等.电针疏密波治疗良性前列腺增生22例临床观察[J].江苏中医药,2018,25(1):53-55.
[23] 张球勇,张敏建.疏肝益阳胶囊联合盐酸坦索罗辛治疗BPH/LUTS合并ED的临床观察[J].中国性科学,2017,26(4):19-22.
[24] 刘惠玲,廖冬梅.桂枝茯苓胶囊对慢性盆腔炎患者炎症因子及临床疗效的影响[J].中国性科学,2018,26(3):247-248.
[25] 张坤,田艺,左侠,等.桂枝茯苓胶囊对卵巢囊肿剥除术患者卵巢储备功能的影响[J].现代生物医学进展,2017,17(13):2502-2504.
[26] Odusanya B O,Tijani K H,Jeje E A,et al.Short-term Effect of Tamsulosin and Finasteride Monotherapy and their Combination on Nigerian Men with Benign Prostatic Hyperplasia[J].Nigerian Journal of Surgery Official Publication of the Nigerian Surgical Research Society,2017,23(1):5-10.
[27] 方霞,俞碧霞,顾海燕,等.克拉霉素结合桂枝茯苓胶囊对患者慢性盆腔炎的治疗疗效研究[J].中华医院感染学杂志,2018,28(5):761-763,767.
[28] 芦艳丽,李娟,韩璐.米非司酮联合桂枝茯苓胶囊对子宫内膜异位症患者血清CA125、CA199及性激素水平的影响[J].世界临床药物,2017,28(7):475-478.