血小板源生长因子在肿瘤侵袭、转移和上皮间质转化中作用的研究进展
摘要
<正>血小板源生长因子(platelet-derived growth factors,PDGFs)是一种重要的结缔组织促有丝分裂因子。PDGFs及其受体可调控多种细胞过程,包括细胞增殖、凋亡、转化、血管生成、迁移、侵袭和转移等,在调节肿瘤生长、转移和肿瘤微环境等方面具有多种功能,可能代表人类肿瘤一个新的治疗靶。本文作者对PDGFs及其受体在肿瘤侵袭、转移和EMT过程中的作用和可能机制进行简要综述。1 PDGFs及其受体PDGFs最初从血小板中被发现,在组织损伤早期从血小板α颗粒释放出来,启动并加速组织创伤
引文
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[34]Wang W,Wang L,Mizokami A,et al.Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling[J].Chin J Cancer,2017,36(1):35.
[35]Turini S,Bergandi L,Gazzano E,et al.Epithelial to mesenchymal transition in human mesothelial cells exposed to asbestos fibers:Role of TGF-βas mediator of malignant mesothelioma development or metastasis via EMT event[J].Int J Mol Sci,2019,20(1):150.
[36]Lunardi A,Webster KA,Papa A,et al.Role of aberrant PI3Kpathway activation in gallbladder tumorigenesis[J].Oncotarget,2014,5(4):894.
[37]Ye B,Jiang LL,Xu HT,et al.Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis[J].Int J Immunopathol Pharmacol,2012,25(3):627.
[38]Dong P,Konno Y,Watari H,et al.The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer[J].J Transl Med,2014,12:231.
[39]Fu Z,Yu W,Wang H,et al.Overexpression of RNF187induces cell EMT and apoptosis resistance in NSCLC[J].J Cell Physiol,2019,[Epub ahead of print].
[40]Qiao X,Lv SX,Qiao Y,et al.Long noncoding RNA ABHD11-AS1predicts the prognosis of pancreatic cancer patients and serves as a promoter by activating the PI3K-AKT pathway[J].Eur Rev Med Pharmacol Sci,2018,22(24):8630.
[41]Na W,Li Y,Wei J,et al.TBX1functions as a tumor suppressor in thyroid cancer through inhibiting the activities of PI3K/AKTand MAPK/ERK pathways[J].Thyroid,2019,29(3):378.
[42]Li QL,Gu FM,Wang Z,et al.Activation of PI3K/AKT and MAPK pathway through a PDGFRβ-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma[J].PLoS One,2012,7(3):e33379.
[43]Lu C,Sun X,Sun L,et al.Snail mediates PDGF-BB-induced invasion of rat bone marrow mesenchymal stem cells in 3Dcollagen and chick chorioallantoic membrane[J].J Cell Physiol,2013,228(9):1827.
[44]Su A,He S,Tian B,et al.MicroRNA-221mediates the effects of PDGF-BB on migration,proliferation,and the epithelial-mesenchymal transition in pancreatic cancer cells[J].PLoS One,2013,8(8):e71309.
[45]Neri S,Miyashita T,Hashimoto H,et al.Fibroblast-led cancer cell invasion is activated by epithelial-mesenchymal transition through platelet-derived growth factor BB secretion of lung adenocarcinoma[J].Cancer Lett,2017,395:20.
[46]Guo Y,Yin J,Zha L,et al.Clinicopathological significance of platelet-derived growth factor B,platelet-derived growth factor receptor-β,and E-cadherin expression in gastric carcinoma[J].Contemp Oncol(Pozn),2013,17(2):150.
[47]Petz M,Them NC,Huber H,et al.PDGF enhances IRES-mediated translation of Laminin B1by cytoplasmic accumulation of La during epithelial to mesenchymal transition[J].Nucleic Acids Res,2012,40(19):9738.
[2]Board R,Jayson GC.Platelet-derived growth factor receptor(PDGFR):a target for anticancer therapeutics[J].Drug Resist Updat,2005,8(1-2):75.
[3]Lindahl P,Hellstr9m M,Kalén M,et al.Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli[J].Development,1998,125(17):3313.
[4]Uutela M,Laurén J,Bergsten E,et al.Chromosomal location,exon structure,and vascular expression patterns of the human PDGFC and PDGFD genes[J].Circulation,2001,103(18):2242.
[5]Zhao T,Zhao W,Chen Y,et al.Platelet-derived growth factor-Dpromotes fibrogenesis of cardiac fibroblasts[J].Am J Physiol Heart Circ Physiol,2013,304(12):H1719.
[6]Shin SS,Ko MC,Noh DH,et al.Morin inhibits PDGF-induced proliferation,migration,and invasion of vascular smooth muscle cells via modulating p27KIP1,AKT,and MMP-9activities[J].Gen Physiol Biophys,2018,37(6):633.
[7]He L,Wang X,Liu K,et al.Integrative PDGF/PDGFR and focal adhesion pathways are downregulated in ERCC1-defective nonsmall cell lung cancer undergoing sodium glycididazole-sensitized cisplatin treatment[J].Gene,2018,691:70.
[8]Yang C,Zhang M,Cai Y,et al.Platelet-derived growth factor-Dexpression mediates the effect of differentiated degree on prognosis in epithelial ovarian cancer[J].J Cell Biochem,2019,120(5):6920.
[9]Kilvaer TK,Smeland E,Valkov A,et al.The VEGF-and PDGF-family of angiogenic markers have prognostic impact in soft tissue sarcomas arising in the extremities and trunk[J].BMC ClinPathol,2014,14(1):5.
[10]Neri S,Miyashita T,Hashimoto H,et al.Fibroblast-led cancer cell invasion is activated by epithelial mesenchymal transition through platelet-derived growth factor BB secretion of lung adenocarcinoma[J].Cancer Lett,2017,395:20.
[11]Ding J,Li XM,Liu SL,et al.Overexpression of platelet-derived growth factor-D as a poor prognosticator in endometrial cancer[J].Asian Pac J Cancer Prev,2014,15(8):3741.
[12]Nordby Y,Richardsen E,Rakaee M,et al.High expression of PDGFR-βin prostate cancer stroma is independently associated with clinical and biochemical prostate cancer recurrence[J].Sci Rep,2017,7:43378.
[13]Kalluri R,Weinberg RA.The basics of epithelial-mesenchymaltransition[J].J Clin Invest,2009,119(6):1420.
[14]Tania M,Khan MA,Fu J.Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer[J].Tumour Biol,2014,35(8):7335.
[15]Katsuno Y,Lamouille S,Derynck R.TGF-beta signaling and epithelial mesenchymal transition in cancer progression[J].Curr Opin Oncol,2013,25(1):76.
[16]Hsu YL,YenMC,Chang WA,et al.CXCL17-derived CD11b+Gr-1+myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factorBB[J].Breast Cancer Res,2019,12,21(1):23.
[17]Ding M,He SJ,Yang J.MCP-1/CCL2 mediated by autocrine loop of PDGF-BB promotes invasion of lung cancer cell by recruitment of macrophages via CCL2-CCR2axis[J].J Interferon Cytokine Res,2019,[Epub ahead of print].
[18]Wu Q,Hou X,Xia J,et al.Emerging roles of PDGF-D in EMTprogression during tumorigenesis[J].Cancer Treat Rev,2013,39(6):640.
[19]Wang Y,Qiu H,Hu W,et al.Over-expression of platelet-derived growth factor-D promotes tumor growth and invasion in endometrial cancer[J].Int J Mol Sci,2014,15(3):4780.
[20]Zhang H,Sun JD,Yan LJ,et al.PDGF-D/PDGFRβpromotes tongue squamous carcinoma cell(TSCC)progression via activating p38/AKT/ERK/EMT signal pathway[J].Biochem Biophys Res Commun,2016,478(2):845.
[21]Kong D,Wang Z,Sarkar SH,et al.Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3prostate cancer cells[J].Stem Cells,2008,26(6):1425.
[22]Devarajan E,Song YH,Krishnappa S,et al.Epithelial-mesenchymal transition in breast cancer lines is mediated through PDGF-D released by tissue-resident stem cells[J].Int J Cancer,2012,131(5):1023.
[23]Chang KK,Yoon C,Yi BC,et al.Platelet-derived growth factor receptor-αand-βpromote cancer stem cell phenotypes in sarcomas[J].Oncogenesis,2018,7(6):47.
[24]Li J,Li Q,Lin L,et al.Targeting the Notch1oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition(EMT)[J].BMC Neurol,2018,18(1):133.
[25]Wang X,Zhang G,Cheng Z,et al.Knockdown of LncRNA-XISTSuppresses Proliferation and TGF-β1-Induced EMT in NSCLCThrough the Notch-1Pathway by Regulation of miR-137[J].Genet Test Mol Biomarkers,2018,22(6):333.
[26]Chen J,Zhang H,Chen Y,et al.MiR-598inhibits metastasis in colorectal cancer by suppressing JAG1/Notch2pathway stimulating EMT[J].Exp Cell Res,2017,352(1):104.
[27]Yuan X,Wu H,Han N,et al.Notch signaling and EMT in nonsmall cell lung cancer:biological significance and therapeutic application[J].J Hematol Oncol,2014,7:87.
[28]Liang T,Zhu L,Gao W,et al.Coculture of endothelial progenitor cells and mesenchymal stem cells enhanced their proliferation and angiogenesis through PDGF and Notch signaling[J].FEBS Open Bio,2017,7(11):1722.
[29]Jeon HM,Kim SH,Jin X,et al.Crosstalk between glioma-initiating cells and endothelial cells drives tumor progression[J].Cancer Res,2014,74(16):4482.
[30]Chen J,Yuan W,Wu L,et al.PDGF-D promotes cell growth,aggressiveness,angiogenesis and EMT transformation of colorectal cancer by activation of Notch1/Twist1pathway[J].Oncotarget,2017,8(6):9961.
[31]Liu T,Ma W,Xu H,et al.PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma[J].Nat Commun,2018,9(1):3439.
[32]Batlle E,Sancho E,FrancíC,et al.The transcription factor Snail is arepressor of E-cadherin gene expression in epithelial tumourcells[J].Nat Cell Biol,2000,2(2):84.
[33]Qiu Y,Liu Y,Li WH,et al.P2Y2receptor promotes the migration and invasion of breast cancer cells via EMT-related genes Snail and E-cadherin[J].Oncol Rep,2018,39(1):138.
[34]Wang W,Wang L,Mizokami A,et al.Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling[J].Chin J Cancer,2017,36(1):35.
[35]Turini S,Bergandi L,Gazzano E,et al.Epithelial to mesenchymal transition in human mesothelial cells exposed to asbestos fibers:Role of TGF-βas mediator of malignant mesothelioma development or metastasis via EMT event[J].Int J Mol Sci,2019,20(1):150.
[36]Lunardi A,Webster KA,Papa A,et al.Role of aberrant PI3Kpathway activation in gallbladder tumorigenesis[J].Oncotarget,2014,5(4):894.
[37]Ye B,Jiang LL,Xu HT,et al.Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis[J].Int J Immunopathol Pharmacol,2012,25(3):627.
[38]Dong P,Konno Y,Watari H,et al.The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer[J].J Transl Med,2014,12:231.
[39]Fu Z,Yu W,Wang H,et al.Overexpression of RNF187induces cell EMT and apoptosis resistance in NSCLC[J].J Cell Physiol,2019,[Epub ahead of print].
[40]Qiao X,Lv SX,Qiao Y,et al.Long noncoding RNA ABHD11-AS1predicts the prognosis of pancreatic cancer patients and serves as a promoter by activating the PI3K-AKT pathway[J].Eur Rev Med Pharmacol Sci,2018,22(24):8630.
[41]Na W,Li Y,Wei J,et al.TBX1functions as a tumor suppressor in thyroid cancer through inhibiting the activities of PI3K/AKTand MAPK/ERK pathways[J].Thyroid,2019,29(3):378.
[42]Li QL,Gu FM,Wang Z,et al.Activation of PI3K/AKT and MAPK pathway through a PDGFRβ-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma[J].PLoS One,2012,7(3):e33379.
[43]Lu C,Sun X,Sun L,et al.Snail mediates PDGF-BB-induced invasion of rat bone marrow mesenchymal stem cells in 3Dcollagen and chick chorioallantoic membrane[J].J Cell Physiol,2013,228(9):1827.
[44]Su A,He S,Tian B,et al.MicroRNA-221mediates the effects of PDGF-BB on migration,proliferation,and the epithelial-mesenchymal transition in pancreatic cancer cells[J].PLoS One,2013,8(8):e71309.
[45]Neri S,Miyashita T,Hashimoto H,et al.Fibroblast-led cancer cell invasion is activated by epithelial-mesenchymal transition through platelet-derived growth factor BB secretion of lung adenocarcinoma[J].Cancer Lett,2017,395:20.
[46]Guo Y,Yin J,Zha L,et al.Clinicopathological significance of platelet-derived growth factor B,platelet-derived growth factor receptor-β,and E-cadherin expression in gastric carcinoma[J].Contemp Oncol(Pozn),2013,17(2):150.
[47]Petz M,Them NC,Huber H,et al.PDGF enhances IRES-mediated translation of Laminin B1by cytoplasmic accumulation of La during epithelial to mesenchymal transition[J].Nucleic Acids Res,2012,40(19):9738.