头孢克肟颗粒联合氨溴特罗口服液治疗门诊小儿肺炎的疗效观察
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摘要
目的:探讨头孢克肟颗粒联合氨溴特罗口服液治疗门诊小儿肺炎的疗效。方法:选取2015年5月至2018年4月广州市花都区妇幼保健院(胡忠医院)门诊收治的小儿肺炎患者98例,随机分为对照组和观察组,每组49例。对照组患儿给予氨溴特罗口服液治疗,观察组患儿给予头孢克肟颗粒、氨溴特罗口服液联合治疗。观察两组患儿的临床疗效、不良反应发生情况及临床症状改善情况。结果:治疗后,观察组患儿的总有效率为95.9%(47/49),明显优于对照组的71.4%(35/49),差异有统计学意义(P<0.05);观察组、对照组患儿不良反应发生率分别为8.2%(4/49)、10.2%(5/49),差异无统计学意义(P>0.05);治疗后,观察组患儿发热、气促、咳嗽及肺部啰音消失时间明显短于对照组,差异均有统计学意义(P<0.05)。结论:头孢克肟颗粒联合氨溴特罗口服液治疗门诊小儿肺炎的疗效显著,能够在较短的时间内改善患儿多项症状,且不良反应少。
OBJECTIVE: To probe into the efficacy of Cefixime granules combined with ambroxol oral liquid in treatment of outpatient pediatric pneumonia. METHODS: 98 children with pneumonia admitted into outpatients of Guangzhou Huadu District Maternal and Child Health Hospital(Huzhong Hospital) from May 2015 to Apr. 2018 were extracted to be randomly divided into control group and observation group, with 49 cases in each group. Patients in the control group were treated with ambroxol oral liquid, while the observation group received Cefixime granules combined with ambroxol oral liquid. The clinical efficacy, adverse drug reactions and improvement of clinical symptoms of two groups were observed. RESULTS: After treatment, the total effective rate of the observation group was 95.9%(47/49), significantly better than that of the control group 71.4%(35/49), with statistically significant difference(P<0.05). The incidence of adverse drug reactions in the observation group and the control group was 8.2%(4/49) and 10.2%(5/49), respectively, and the difference was not statistically significant(P>0.05). After treatment, the disappearance time of fever, anhelation, cough and lung voice of the observation group was significantly shorter than that of the control group, and the difference was statistically significant(P<0.05). CONCLUSIONS: The efficacy of Cefixime granules combined with ambroxol oral liquid in treatment of outpatient pediatric pneumonia is significant, which can improve a variety of symptoms in a short period of time, with fewer adverse drug reactions.
OBJECTIVE: To probe into the efficacy of Cefixime granules combined with ambroxol oral liquid in treatment of outpatient pediatric pneumonia. METHODS: 98 children with pneumonia admitted into outpatients of Guangzhou Huadu District Maternal and Child Health Hospital(Huzhong Hospital) from May 2015 to Apr. 2018 were extracted to be randomly divided into control group and observation group, with 49 cases in each group. Patients in the control group were treated with ambroxol oral liquid, while the observation group received Cefixime granules combined with ambroxol oral liquid. The clinical efficacy, adverse drug reactions and improvement of clinical symptoms of two groups were observed. RESULTS: After treatment, the total effective rate of the observation group was 95.9%(47/49), significantly better than that of the control group 71.4%(35/49), with statistically significant difference(P<0.05). The incidence of adverse drug reactions in the observation group and the control group was 8.2%(4/49) and 10.2%(5/49), respectively, and the difference was not statistically significant(P>0.05). After treatment, the disappearance time of fever, anhelation, cough and lung voice of the observation group was significantly shorter than that of the control group, and the difference was statistically significant(P<0.05). CONCLUSIONS: The efficacy of Cefixime granules combined with ambroxol oral liquid in treatment of outpatient pediatric pneumonia is significant, which can improve a variety of symptoms in a short period of time, with fewer adverse drug reactions.
引文
[1] 余超.布地奈德联合盐酸氨溴索雾化吸入治疗小儿支气管肺炎的疗效观察[J].中国医院用药评价与分析,2016,16(3):336-338.
[2] 马宝良,陈思,卢建中.头孢克肟颗粒治疗小儿急性淋球菌性尿道炎疗效观察[J].中国妇幼健康研究,2016,27(8):1004-1006.
[3] 胡利敏,杨丽.头孢克肟颗粒溶出曲线方法学验证[J].中国抗生素杂志,2017,42(5):373-376.
[4] 潘娜,陈乾华,高华英.桉柠蒎肠溶软胶囊联合头孢克肟治疗老年肺炎的临床研究[J].现代药物与临床,2018,33(4):805-808.
[5] 郭莉娟.氨溴特罗口服液佐治小儿肺炎支原体肺炎疗效分析[J].医药前沿,2016,6(13):117-118.
[6] 黄文娴,王燕红,罗光亮,等.氨溴特罗口服液与盐酸氨溴索颗粒治疗小儿支气管肺炎的效果[J].牡丹江医学院学报,2017,38(2):108-109.
[7] 魏国烨.氨溴特罗口服液与盐酸氨溴索颗粒治疗小儿支气管肺炎的效果比较[J].临床医药文献电子杂志,2017,4(16):3131-3131.
[8] 迪力那尔·阿西木.氨溴特罗口服液治疗婴幼儿支气管肺炎138例疗效观察[J].中国社区医师,2016,32(13):82.
[9] 侯珩.氨溴特罗口服液治疗婴幼儿支气管肺炎110例疗效观察[J].中国社区医师,2016,32(10):73.
[10] 刘向婕.氨溴特罗口服液应用于小儿支气管炎治疗中的疗效探究[J].临床医学研究与实践,2017,2(1):74-75.
[11] 谭永龙.氨溴特罗口服液治疗支气管炎患儿的临床效果研究[J].大家健康旬刊,2016,10(5):153.
[12] 王明明,邢吴敏,张蕾,等.清肺口服液联合喜炎平注射液治疗小儿博卡病毒肺炎的临床研究[J].中草药,2017,48(18):3802-3806.
[13] 马敬斌,盛方红,王道方.氨溴特罗口服液佐治儿童支气管肺炎临床分析[J].中国处方药,2017,15(2):107-108.
[14] 罗明鑫,华山,魏文.克洛己新治疗婴幼儿轻度社区获得性肺炎疗效观察[J].安徽卫生职业技术学院学报,2017,16(5):139-140,142.
[15] Kataoka H,Kasahara H,Sasagawa Y,et al.Evaluation of safety and efficacy of tebipenem pivoxil granules for pediatric in pneumonia, otitis media and sinusitis[J].Jpn J Antibiot,2016,69(1):53-76.
[2] 马宝良,陈思,卢建中.头孢克肟颗粒治疗小儿急性淋球菌性尿道炎疗效观察[J].中国妇幼健康研究,2016,27(8):1004-1006.
[3] 胡利敏,杨丽.头孢克肟颗粒溶出曲线方法学验证[J].中国抗生素杂志,2017,42(5):373-376.
[4] 潘娜,陈乾华,高华英.桉柠蒎肠溶软胶囊联合头孢克肟治疗老年肺炎的临床研究[J].现代药物与临床,2018,33(4):805-808.
[5] 郭莉娟.氨溴特罗口服液佐治小儿肺炎支原体肺炎疗效分析[J].医药前沿,2016,6(13):117-118.
[6] 黄文娴,王燕红,罗光亮,等.氨溴特罗口服液与盐酸氨溴索颗粒治疗小儿支气管肺炎的效果[J].牡丹江医学院学报,2017,38(2):108-109.
[7] 魏国烨.氨溴特罗口服液与盐酸氨溴索颗粒治疗小儿支气管肺炎的效果比较[J].临床医药文献电子杂志,2017,4(16):3131-3131.
[8] 迪力那尔·阿西木.氨溴特罗口服液治疗婴幼儿支气管肺炎138例疗效观察[J].中国社区医师,2016,32(13):82.
[9] 侯珩.氨溴特罗口服液治疗婴幼儿支气管肺炎110例疗效观察[J].中国社区医师,2016,32(10):73.
[10] 刘向婕.氨溴特罗口服液应用于小儿支气管炎治疗中的疗效探究[J].临床医学研究与实践,2017,2(1):74-75.
[11] 谭永龙.氨溴特罗口服液治疗支气管炎患儿的临床效果研究[J].大家健康旬刊,2016,10(5):153.
[12] 王明明,邢吴敏,张蕾,等.清肺口服液联合喜炎平注射液治疗小儿博卡病毒肺炎的临床研究[J].中草药,2017,48(18):3802-3806.
[13] 马敬斌,盛方红,王道方.氨溴特罗口服液佐治儿童支气管肺炎临床分析[J].中国处方药,2017,15(2):107-108.
[14] 罗明鑫,华山,魏文.克洛己新治疗婴幼儿轻度社区获得性肺炎疗效观察[J].安徽卫生职业技术学院学报,2017,16(5):139-140,142.
[15] Kataoka H,Kasahara H,Sasagawa Y,et al.Evaluation of safety and efficacy of tebipenem pivoxil granules for pediatric in pneumonia, otitis media and sinusitis[J].Jpn J Antibiot,2016,69(1):53-76.