微血管周细胞与糖尿病视网膜病变中西医研究进展
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摘要
大量的实验研究已经证实,微血管周细胞在糖尿病视网膜病变早期防治中扮演重要角色。为了观察和研究糖尿病视网膜病变早期微血管周细胞结构和功能变化,本文对近些年微血管周细胞的起源、形态分布、生理功能、细胞培养与鉴定、周细胞凋亡与糖尿病视网膜病变关系以及中医药防治糖尿病视网膜病变的研究进展进行综述,以期为糖尿病视网膜病变的周细胞研究及早期防治提供一种新思路。
A large number of experimental studies have demonstrated that microvascular pericytes play a major role in the early prevention and treatment of diabetic retinopathy. To observe and study the structural and functional changes of microvascular pericytes in early diabetic retinopathy, we review the literature on the origin, morphological distribution, physiological function, and cell culture and identification of microvascular pericytes, the relationship between pericyte apoptosis and diabetic retinopathy, and the traditional Chinese medicine prevention and treatment of diabetic retinopathy, so as to provide new insights into the pericyte studies and the early prevention and treatment of diabetic retinopathy.
A large number of experimental studies have demonstrated that microvascular pericytes play a major role in the early prevention and treatment of diabetic retinopathy. To observe and study the structural and functional changes of microvascular pericytes in early diabetic retinopathy, we review the literature on the origin, morphological distribution, physiological function, and cell culture and identification of microvascular pericytes, the relationship between pericyte apoptosis and diabetic retinopathy, and the traditional Chinese medicine prevention and treatment of diabetic retinopathy, so as to provide new insights into the pericyte studies and the early prevention and treatment of diabetic retinopathy.
引文
[1]彭清华.中医眼科学[M].4版.北京:中国中医药出版社,2016:175.
[2] CAI X, MCGINNIS J F. Diabetic retinopathy:animal models,therapies, and perspectives[J]. Journal of Diabetes Research, 2016,2016:3789217.
[3] HAMMES H P, FENG Y X, PFISTER F, et al. Diabetic retinopa-thy:targeting vasoregression[J]. Diabetes, 2011,60(1):9-16.
[4] DERUITER M C, POELMANN R E, VANMUNSTEREN J C, etal. Embryonic endothelial cells transdifferentiate into mesenchymalcells expressing smooth muscle actins in vivo and in vitro[J].Circulation Research, 1997,80(4):444-451.
[5] HUNGERFORD J E, LITTLE C D. Developmental biology of thevascular smooth muscle cell:building a multilayered vessel wall[J].Journal of Vascular Research, 1999, 36(1):2-27.
[6] ETCHEVERS H C, VINCENT C, LE DOUARIN N M, et al.The cephalic neural crest provides pericytes and smooth musclecells to all blood vessels of the face and forebrain[J]. Development,2001,128(7):1059-1068.
[7] VRANCKEN PEETERS M P, GITTENBERGER-DE GROOT AC,MENTINK M M,et al.Smooth muscle cells and fibroblasts ofthe coronary arteries derive from epithelial-mesenchymal trans-formation of the epicardium[J]. Anatomy and Embryology, 1999,199(4):367-378.
[8] RAJANTIE I, ILM ONEN M, ALMINAITE A, et al. Adultbone marrow-derived cells recruited during angiogenesis com-prise precursors for periendothelial vascular mural cells[J].Blood,2004,104(7):2084-2086.
[9] WONG S P, ROWLEY J E, REDPATH A N, et al. Pericytes, mes-enchymal stem cells and their contributions to tissue repair[J].Pharmacology&Therapeutics, 2015,151:107-120.
[10] DE SOUZA L E B, MALTA T M, KASHIMA HADDAD S, etal. Mesenchymal stem cells and pericytes:to what extent arethey related[J]. Stem Cells and Development, 2016, 25(24):1843-1852.
[11] FOSTER K, SHERIDAN J, VEIGA-FERNANDES H, et al.Contribution of neural crest-derived cells in the embryonic andadult thymus[J]. J Immunol, 2008,180(5):3183-3189.
[12] FORBES M S, RENNELS M L, NELSON E. Ultrastructure ofpericytes in mouse heart[J]. Am J Anat, 1977,149(1):47-69.
[13] ARMULIK A, ABRAMSSON A, BETSHOLTZ C. Endothelial/Peri-cyte interactions[J]. Circulation Research, 2005,97(6):512-523.
[14] AVOLIO E, RODRIGUEZ-ARABAOLAZA I, SPENCER H L,et al. Expansion and characterization of neonatal cardiac peri-cytes provides a novel cellular option for tissue engineering incongenital heart disease[J]. Journal of the American Heart As-sociation, 2015,4(6):e002043.
[15] OREKHOV A N, BOBRYSHEV Y V, CHISTIAKOV D A. The com-plexity of cell composition of the intima of large arteries:focuson pericyte-like cells[J]. Cardiovascular Research, 2014,103(4):438-451.
[16] SIMS D E. The pericyte:a review[J]. Tissue Cell,1986,18(2):153-174.
[17] ARMULIK A, GENOVéG, BETSHOLTZ C. Pericytes:developmental,physiological, and pathological perspectives, problems, andpromises[J]. Developmental Cell, 2011,21(2):193-215.
[18] DORE-DUFFY P, CLEARY K. Morphology and properties ofpericytes[J]. Methods Mol Biol,2011,686:49-68.
[19] WONG S P, ROWLEY J E, REDPATH A N, et al. Pericytes, mesenchymalstem cells and their contributions to tissue repair[J]. PharmacolTher, 2015,151:107-120.
[20] LEVESQUE J P. A niche in a dish:pericytes support HSC[J].Blood, 2013,121(15):2816-2818.
[21] CANFIELD A E, ALLEN T D, GRANT M E, et al. Modula-tion of extracellular matrix biosynthesis by bovine retinal peri-cytes in vitro:effects of the substratum and cell density[J].Journal of Cell Science, 1990,96(Pt1):159-169.
[22] RAMSAUER M, D'AMORE P A. Getting Tie(2)d up in angio-genesis[J]. Journal of Clinical Investigation, 2002, 110(11):1615-1617.
[23] MARTIN A R, BAILIE J R, ROBSON T, et al. Retinal peri-cytes control expression of nitric oxide synthase and endothe-lin-1 in microvascular endothelial cells[J]. Microvascular Research,2000, 59(1):131-139.
[24] BIRBRAIR A, ZHANG T, WANG Z M, et al. Pericytes at theintersection between tissue regeneration and pathology[J]. Clini-cal Science, 2015,128(2):81-93.
[25] O'FARRELL F M, ATTWELL D. A role for pericytes in coro-nary no-reflow[J]. Nature Reviews Cardiology, 2014, 11(7):427-432.
[26] MURRAY I R, BAILY J E, CHEN W C W, et al. Skeletaland cardiac muscle pericytes:Functions and therapeutic poten-tial[J]. Pharmacology&Therapeutics, 2017, 171(3):65-74.
[27] AVOLIO E, MADEDDU P. Discovering cardiac pericyte biology:From physiopathological mechanisms to potential therapeuticapplications in ischemic heart disease[J]. Vascul Pharmacol, 2016,86(11):53-63.
[28] GERHARDT H, BETSHOLTZ C. Endothelial-pericyte inerac-tions in angiogenesis[J]. Cell&Tissue Research, 2003, 314(1):15-23.
[29] HELLSTR魻M M, KALéN M, LINDAHL P, et al. Role of PDGF-band PDGFR-beta in recruitment of vascular smooth muscle cellsand pericytes during embryonic blood vessel formation inthe mouse[J]. Development, 1999, 126(14):3047-3055.
[30] HUGHES S, CHAN-LING T. Characterization of smooth musclecell and pericyte differentiation in the rat retina in vivo[J]. In-vest Ophthalmol Vis Sci, 2004, 45(8):2795-2806.
[31] CHAN-LING T, PAGE M P, GARDINER T, et al. Desminensheathment ratio as an indicator of vessel stability:evidencein normal development and in retinopathy of prematurity[J].American Journal of Pathology, 2004, 165(4):1301-1313.
[32] MORIKAWA S, BALUK P, KAIDOH T, et al. Abnormalities inpericytes on blood vessels and endothelial sprouts in tumors[J].American Journal of Pathology, 2002, 160(3):985-1000.
[33] BJARNEG魧RD M, ENGE M, NORLIN J, et al. Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular,cardiac and placental abnormalities[J]. Development, 2004, 131(8):1847-1857.
[34] LINDBLOM P, GERHARDT H, LIEBNER S, et al. EndothelialPDGF-b retention is required for proper investment of peri-cytes in the microvessel wall[J]. Genes&Development, 2003,17(15):1835-1840.
[35] ABRAMSSON A, BERLIN O, PAPAYAN H, et al. Analysis of muralcell recruitment to tumor vessels[J]. Circulation, 2002, 105(1):112-117.
[36] MARIN F, NIETO M A. Expression of chicken slug and snailin mesenchymal components of the developing central nervoussystem[J]. Developmental Dynamics, 2004, 230(1):144-148.
[37] AVOLIO E, MADEDDU P. Discovering cardiac pericyte biology:From physiopathological mechanisms to potential therapeuticapplications in ischemic heart disease[J]. Vascular Pharmacolo-gy, 2016, 86(11):53-63.
[38] DAR A, DOMEV H, BEN-YOSEF O, et al. Multipotent vas-culogenic pericytes from human pluripotent stem cells promoterecovery of murine ischemic limb[J]. Circulation, 2012, 125(1):87-99.
[39] BLOCKI A, WANG Y T, KOCH M, et al. Not all MSCs canact as pericytes:functional in vitro assays to distinguish peri-cytes from other mesenchymal stem cells in angiogenesis[J].Stem Cells&Development, 2013, 22(17):2347-2355.
[40]赵平,于华军.基质金属蛋白酶及其组织抑制剂在糖尿病小鼠视网膜组织中的表达[J].国际眼科杂志,2004,4(4):610-614.
[41]杨建华,段俊国,周春阳.牛视网膜毛细血管周细胞的选择性培养[J].国际眼科杂志,2007,7(2):389-391.
[42] SHIN E S, HUANG Q, GUREL Z, et al. STAT1-mediated Bim ex-pression promotes the apoptosis of retinal pericytes underhigh glucose conditions[J]. Cell Death and Disease, 2014, 5:e986.
[43] BARTHSON J, GERMANO C M, MOORE F, et al. Cytokinestumor necrosis factor-αand interferon-γinduce pancreaticβ-cell apoptosis through STAT1-mediated bim protein activation[J].Journal of Biological Chemistry, 2011, 286(45):39632-39643.
[44] FAID I, AL-HUSSAINI H, KILARKAJE N. Resveratrol allevi-ates diabetes-induced testicular dysfunction by inhibiting ox-idative stress and c-Jun N-terminal kinase signaling in rats[J].Toxicology and Applied Pharmacology, 2015, 289(3):482-494.
[45] SCHERZ-SHOUVAL R, ELAZAR Z. Regulation of autophagyby ROS:physiology and pathology[J]. Trends in Biochemical Sci-ences, 2011, 36(1):30-38.
[46] MIWA K, NAKAMURA J, HAMADA Y, et al. The role ofpolyol pathway in glucose-induced apoptosis of cultured retinalpericytes[J]. Diabetes Research and Clinical Practice, 2003, 60(1):1-9.
[47] SINGH L P. Thioredoxin interacting protein(TXNIP)and patho-genesis of diabetic retinopathy[J]. Journal of Clinical&Experi-mental Ophthalmology, 2013, 4(1):30-42.
[48] DEVI T S, HOSOYA K, TERASAKI T, et al. Critical role ofTXNIP in oxidative stress, DNA damage and retinal pericyteapoptosis under high glucose:implications for diabetic retinopa-thy[J]. Experimental Cell Research, 2013, 319(7):1001-1012.
[49] MANI A, SAYON R, GRAVES D T. FOXOI plays an essentialrole in apoptosis of retinal pericytes[J]. Molecular Vision, 2010,16:408-415.
[50]杨建华,段俊国.黄芪提取物对体外高糖培养牛视网膜毛细血管周细胞的影响[J].国际眼科杂志,2007,7(3):685-687.
[51]康英英,匡洪宇,马丽丽,等.不同浓度的黄芪总黄酮对高糖培养下牛视网膜血管周细胞凋亡的影响[J].哈尔滨医科大学学报,2008,42(2):135-137.
[52]张翔,耿燕,薛丽丽.槲皮素对高糖培养牛视网膜周细胞增殖和凋亡的影响[J].国际眼科杂志,2009,9(11):2078-2080.
[53]周水平,仝小林,潘琳,等.络通对不同病程糖尿病大鼠视网膜微血管细胞凋亡的影响[J].中华中医药杂志,2006,21(5):273-275.
[54]罗旭昇,高健生,潘琳,等.交泰丸对实验性糖尿病大鼠视网膜及视网膜血管NF-KB表达的影响[J].成都中医药大学学报,2008,30(4):52-57.
[55]江红,匡洪宇,马丽丽,等.不同质量浓度的黄芪总黄酮对高糖培养下牛视网膜血管周细胞氧化应激的影响[J].中国中医急症,2011,20(7):1105,1133.
[56]倪劲松,王越晖,陈兰悦,等.银杏叶注射液对牛视网膜毛细血管周细胞的保护作用[J].吉林大学学报(医学版),2005,31(3):368-371.
[57] KIM O S, KIM J, KIM C S, et al. KIOM-79 prevents methyglyox-al-induced retinal pericyte apoptosis in vitro and in vivo[J].Journal of Ethnopharmacology, 2010, 129(3):285-292.
[2] CAI X, MCGINNIS J F. Diabetic retinopathy:animal models,therapies, and perspectives[J]. Journal of Diabetes Research, 2016,2016:3789217.
[3] HAMMES H P, FENG Y X, PFISTER F, et al. Diabetic retinopa-thy:targeting vasoregression[J]. Diabetes, 2011,60(1):9-16.
[4] DERUITER M C, POELMANN R E, VANMUNSTEREN J C, etal. Embryonic endothelial cells transdifferentiate into mesenchymalcells expressing smooth muscle actins in vivo and in vitro[J].Circulation Research, 1997,80(4):444-451.
[5] HUNGERFORD J E, LITTLE C D. Developmental biology of thevascular smooth muscle cell:building a multilayered vessel wall[J].Journal of Vascular Research, 1999, 36(1):2-27.
[6] ETCHEVERS H C, VINCENT C, LE DOUARIN N M, et al.The cephalic neural crest provides pericytes and smooth musclecells to all blood vessels of the face and forebrain[J]. Development,2001,128(7):1059-1068.
[7] VRANCKEN PEETERS M P, GITTENBERGER-DE GROOT AC,MENTINK M M,et al.Smooth muscle cells and fibroblasts ofthe coronary arteries derive from epithelial-mesenchymal trans-formation of the epicardium[J]. Anatomy and Embryology, 1999,199(4):367-378.
[8] RAJANTIE I, ILM ONEN M, ALMINAITE A, et al. Adultbone marrow-derived cells recruited during angiogenesis com-prise precursors for periendothelial vascular mural cells[J].Blood,2004,104(7):2084-2086.
[9] WONG S P, ROWLEY J E, REDPATH A N, et al. Pericytes, mes-enchymal stem cells and their contributions to tissue repair[J].Pharmacology&Therapeutics, 2015,151:107-120.
[10] DE SOUZA L E B, MALTA T M, KASHIMA HADDAD S, etal. Mesenchymal stem cells and pericytes:to what extent arethey related[J]. Stem Cells and Development, 2016, 25(24):1843-1852.
[11] FOSTER K, SHERIDAN J, VEIGA-FERNANDES H, et al.Contribution of neural crest-derived cells in the embryonic andadult thymus[J]. J Immunol, 2008,180(5):3183-3189.
[12] FORBES M S, RENNELS M L, NELSON E. Ultrastructure ofpericytes in mouse heart[J]. Am J Anat, 1977,149(1):47-69.
[13] ARMULIK A, ABRAMSSON A, BETSHOLTZ C. Endothelial/Peri-cyte interactions[J]. Circulation Research, 2005,97(6):512-523.
[14] AVOLIO E, RODRIGUEZ-ARABAOLAZA I, SPENCER H L,et al. Expansion and characterization of neonatal cardiac peri-cytes provides a novel cellular option for tissue engineering incongenital heart disease[J]. Journal of the American Heart As-sociation, 2015,4(6):e002043.
[15] OREKHOV A N, BOBRYSHEV Y V, CHISTIAKOV D A. The com-plexity of cell composition of the intima of large arteries:focuson pericyte-like cells[J]. Cardiovascular Research, 2014,103(4):438-451.
[16] SIMS D E. The pericyte:a review[J]. Tissue Cell,1986,18(2):153-174.
[17] ARMULIK A, GENOVéG, BETSHOLTZ C. Pericytes:developmental,physiological, and pathological perspectives, problems, andpromises[J]. Developmental Cell, 2011,21(2):193-215.
[18] DORE-DUFFY P, CLEARY K. Morphology and properties ofpericytes[J]. Methods Mol Biol,2011,686:49-68.
[19] WONG S P, ROWLEY J E, REDPATH A N, et al. Pericytes, mesenchymalstem cells and their contributions to tissue repair[J]. PharmacolTher, 2015,151:107-120.
[20] LEVESQUE J P. A niche in a dish:pericytes support HSC[J].Blood, 2013,121(15):2816-2818.
[21] CANFIELD A E, ALLEN T D, GRANT M E, et al. Modula-tion of extracellular matrix biosynthesis by bovine retinal peri-cytes in vitro:effects of the substratum and cell density[J].Journal of Cell Science, 1990,96(Pt1):159-169.
[22] RAMSAUER M, D'AMORE P A. Getting Tie(2)d up in angio-genesis[J]. Journal of Clinical Investigation, 2002, 110(11):1615-1617.
[23] MARTIN A R, BAILIE J R, ROBSON T, et al. Retinal peri-cytes control expression of nitric oxide synthase and endothe-lin-1 in microvascular endothelial cells[J]. Microvascular Research,2000, 59(1):131-139.
[24] BIRBRAIR A, ZHANG T, WANG Z M, et al. Pericytes at theintersection between tissue regeneration and pathology[J]. Clini-cal Science, 2015,128(2):81-93.
[25] O'FARRELL F M, ATTWELL D. A role for pericytes in coro-nary no-reflow[J]. Nature Reviews Cardiology, 2014, 11(7):427-432.
[26] MURRAY I R, BAILY J E, CHEN W C W, et al. Skeletaland cardiac muscle pericytes:Functions and therapeutic poten-tial[J]. Pharmacology&Therapeutics, 2017, 171(3):65-74.
[27] AVOLIO E, MADEDDU P. Discovering cardiac pericyte biology:From physiopathological mechanisms to potential therapeuticapplications in ischemic heart disease[J]. Vascul Pharmacol, 2016,86(11):53-63.
[28] GERHARDT H, BETSHOLTZ C. Endothelial-pericyte inerac-tions in angiogenesis[J]. Cell&Tissue Research, 2003, 314(1):15-23.
[29] HELLSTR魻M M, KALéN M, LINDAHL P, et al. Role of PDGF-band PDGFR-beta in recruitment of vascular smooth muscle cellsand pericytes during embryonic blood vessel formation inthe mouse[J]. Development, 1999, 126(14):3047-3055.
[30] HUGHES S, CHAN-LING T. Characterization of smooth musclecell and pericyte differentiation in the rat retina in vivo[J]. In-vest Ophthalmol Vis Sci, 2004, 45(8):2795-2806.
[31] CHAN-LING T, PAGE M P, GARDINER T, et al. Desminensheathment ratio as an indicator of vessel stability:evidencein normal development and in retinopathy of prematurity[J].American Journal of Pathology, 2004, 165(4):1301-1313.
[32] MORIKAWA S, BALUK P, KAIDOH T, et al. Abnormalities inpericytes on blood vessels and endothelial sprouts in tumors[J].American Journal of Pathology, 2002, 160(3):985-1000.
[33] BJARNEG魧RD M, ENGE M, NORLIN J, et al. Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular,cardiac and placental abnormalities[J]. Development, 2004, 131(8):1847-1857.
[34] LINDBLOM P, GERHARDT H, LIEBNER S, et al. EndothelialPDGF-b retention is required for proper investment of peri-cytes in the microvessel wall[J]. Genes&Development, 2003,17(15):1835-1840.
[35] ABRAMSSON A, BERLIN O, PAPAYAN H, et al. Analysis of muralcell recruitment to tumor vessels[J]. Circulation, 2002, 105(1):112-117.
[36] MARIN F, NIETO M A. Expression of chicken slug and snailin mesenchymal components of the developing central nervoussystem[J]. Developmental Dynamics, 2004, 230(1):144-148.
[37] AVOLIO E, MADEDDU P. Discovering cardiac pericyte biology:From physiopathological mechanisms to potential therapeuticapplications in ischemic heart disease[J]. Vascular Pharmacolo-gy, 2016, 86(11):53-63.
[38] DAR A, DOMEV H, BEN-YOSEF O, et al. Multipotent vas-culogenic pericytes from human pluripotent stem cells promoterecovery of murine ischemic limb[J]. Circulation, 2012, 125(1):87-99.
[39] BLOCKI A, WANG Y T, KOCH M, et al. Not all MSCs canact as pericytes:functional in vitro assays to distinguish peri-cytes from other mesenchymal stem cells in angiogenesis[J].Stem Cells&Development, 2013, 22(17):2347-2355.
[40]赵平,于华军.基质金属蛋白酶及其组织抑制剂在糖尿病小鼠视网膜组织中的表达[J].国际眼科杂志,2004,4(4):610-614.
[41]杨建华,段俊国,周春阳.牛视网膜毛细血管周细胞的选择性培养[J].国际眼科杂志,2007,7(2):389-391.
[42] SHIN E S, HUANG Q, GUREL Z, et al. STAT1-mediated Bim ex-pression promotes the apoptosis of retinal pericytes underhigh glucose conditions[J]. Cell Death and Disease, 2014, 5:e986.
[43] BARTHSON J, GERMANO C M, MOORE F, et al. Cytokinestumor necrosis factor-αand interferon-γinduce pancreaticβ-cell apoptosis through STAT1-mediated bim protein activation[J].Journal of Biological Chemistry, 2011, 286(45):39632-39643.
[44] FAID I, AL-HUSSAINI H, KILARKAJE N. Resveratrol allevi-ates diabetes-induced testicular dysfunction by inhibiting ox-idative stress and c-Jun N-terminal kinase signaling in rats[J].Toxicology and Applied Pharmacology, 2015, 289(3):482-494.
[45] SCHERZ-SHOUVAL R, ELAZAR Z. Regulation of autophagyby ROS:physiology and pathology[J]. Trends in Biochemical Sci-ences, 2011, 36(1):30-38.
[46] MIWA K, NAKAMURA J, HAMADA Y, et al. The role ofpolyol pathway in glucose-induced apoptosis of cultured retinalpericytes[J]. Diabetes Research and Clinical Practice, 2003, 60(1):1-9.
[47] SINGH L P. Thioredoxin interacting protein(TXNIP)and patho-genesis of diabetic retinopathy[J]. Journal of Clinical&Experi-mental Ophthalmology, 2013, 4(1):30-42.
[48] DEVI T S, HOSOYA K, TERASAKI T, et al. Critical role ofTXNIP in oxidative stress, DNA damage and retinal pericyteapoptosis under high glucose:implications for diabetic retinopa-thy[J]. Experimental Cell Research, 2013, 319(7):1001-1012.
[49] MANI A, SAYON R, GRAVES D T. FOXOI plays an essentialrole in apoptosis of retinal pericytes[J]. Molecular Vision, 2010,16:408-415.
[50]杨建华,段俊国.黄芪提取物对体外高糖培养牛视网膜毛细血管周细胞的影响[J].国际眼科杂志,2007,7(3):685-687.
[51]康英英,匡洪宇,马丽丽,等.不同浓度的黄芪总黄酮对高糖培养下牛视网膜血管周细胞凋亡的影响[J].哈尔滨医科大学学报,2008,42(2):135-137.
[52]张翔,耿燕,薛丽丽.槲皮素对高糖培养牛视网膜周细胞增殖和凋亡的影响[J].国际眼科杂志,2009,9(11):2078-2080.
[53]周水平,仝小林,潘琳,等.络通对不同病程糖尿病大鼠视网膜微血管细胞凋亡的影响[J].中华中医药杂志,2006,21(5):273-275.
[54]罗旭昇,高健生,潘琳,等.交泰丸对实验性糖尿病大鼠视网膜及视网膜血管NF-KB表达的影响[J].成都中医药大学学报,2008,30(4):52-57.
[55]江红,匡洪宇,马丽丽,等.不同质量浓度的黄芪总黄酮对高糖培养下牛视网膜血管周细胞氧化应激的影响[J].中国中医急症,2011,20(7):1105,1133.
[56]倪劲松,王越晖,陈兰悦,等.银杏叶注射液对牛视网膜毛细血管周细胞的保护作用[J].吉林大学学报(医学版),2005,31(3):368-371.
[57] KIM O S, KIM J, KIM C S, et al. KIOM-79 prevents methyglyox-al-induced retinal pericyte apoptosis in vitro and in vivo[J].Journal of Ethnopharmacology, 2010, 129(3):285-292.