摘要
<正>1概况湿疹(eczema)是由多种内、外因素引起的真皮浅层及表皮炎症。根据病程和临床特点可分为急性、亚急性和慢性湿疹。急性期皮损以丘疱疹为主,有渗出倾向,慢性期以苔藓样变为主,易反复发作[1]。湿疹发生在婴儿阶段,称为婴儿湿疹(infan-tile eczema)。湿疹的发病机制尚不明确,目前多认为是多种内外因素综合作用的结果。免疫性机制
引文
[1]张学军.皮肤性病学[M]. 8版.北京:人民卫生出版社,2017:109.
[2]中华医学会皮肤性病学分会免疫学组.湿疹诊疗指南(2011年)[J].中华皮肤科杂志,2011,44(1):5-6.
[3]路雪艳,李邻峰,尤艳明.丽水市社区人群皮肤病流行病学调查及风险因素分析[J].中国麻风皮肤病杂志,2008,24(9):692-694.
[4]冯梅,肖异珠,罗晓艳,等.不同遗传背景婴儿湿疹发病的环境影响因素分析[J].中国儿童保健杂志,2015,23(10):1070-1073.
[5] Hanifin JM,Reed ML. A population-based survey of eczema prevalence in the United States[J]. Dermatitis Contact Atopic Occupational Drug,2007,18(2):82-91.
[6] Brown S,Reynolds NJ. Atopic and non-atopic eczema[J]. BMJ,2006,332(7541):584-588.
[7] Spergel JM,Paller AS. Atopic dermatitis and the atopic march[J].J Allergy Clin Immunol,2003,112(6):118-127.
[8] Kummeling I,Thijs C,Stelma F,et al. Diphtheria,pertussis,poliomyelitis,tetanus,and Haemophilus influenzae type b vaccinations and risk of eczema and recurrent wheeze in the first year of life:the KOALA Birth Cohort Study[J]. Pediatrics,2007,119(2):367-373.
[9] Frydenberg AR,Buttery JP,Royle J. Determining the rate of varicella vaccine rash in children with moderate-severe eczema[J].J Paediatr Child Health,2005,41(11):561-563.
[10] M?hrenschlager M,Haberl VM,Kr?mer U,et al. Early BCG and pertussis vaccination and atopic diseases in 5-to 7-year-old preschool children from Augsburg, Germany:results from the MIRIAM study[J]. Pediatr Allergy Immunol,2007,18(1):5-9.
[11] World Health Organization. Expanded programme on immunization:Contraindications for vaccines used in EPI[J]. Wkly Epidemiol Rec,1988,63:279-281.