生长抑素联合泮托拉唑治疗肝硬化合并上消化道出血的疗效观察
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摘要
目的观察生长抑素联合泮托拉唑治疗肝硬化合并上消化道出血的临床疗效。方法选择医院2015年1月-2018年7月收治的肝硬化合并上消化道出血患者42例,按照随机数字表法分为观察组和对照组各21例。对照组患者采用生长抑素治疗,观察组采用生长抑素联合泮托拉唑治疗。比较2组患者的临床疗效、止血时间、输血量、住院时间及不良反应发生情况。结果治疗后观察组患者临床总有效率明显高于对照组,止血时间、住院时间均明显短于对照组,输血量明显少于对照组,差异均有统计学意义(P<0.05)。2组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论生长抑素联合泮托拉唑治疗肝硬化合并上消化道出血能更有效地缩短患者止血时间及住院时间、降低患者输血量,且安全性高,疗效较好,临床应用价值高。
Objective To observe the efficacy of somatostatin combined with pantoprazole in treatment of cirrhosis with upper gastrointestinal hemorrhage.Methods Selected 42 patients with cirrhosis and upper gastrointestinal bleeding,admitted to the hospital from January 2015 to July 2018.According to the random number table method,they were divided into observation group and control group,each of 21 cases.Control group was treated with somatostatin,and observation group was treated with somatostatin and pantoprazole.The clinical efficacy,hemostasis time,blood transfusion,hospitalization time and adverse reactions were compared between two groups.Results After treatment,the total clinical effective rate of observation group was significantly higher than that of control group,the hemostasis time and hospitalization time were significantly shorter than control group,and the blood transfusion volume was significantly lower than that of control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion The combination of somatostatin and pantoprazole is effective in treatment of cirrhosis with upper gastrointestinal bleeding,and has high clinical value.
Objective To observe the efficacy of somatostatin combined with pantoprazole in treatment of cirrhosis with upper gastrointestinal hemorrhage.Methods Selected 42 patients with cirrhosis and upper gastrointestinal bleeding,admitted to the hospital from January 2015 to July 2018.According to the random number table method,they were divided into observation group and control group,each of 21 cases.Control group was treated with somatostatin,and observation group was treated with somatostatin and pantoprazole.The clinical efficacy,hemostasis time,blood transfusion,hospitalization time and adverse reactions were compared between two groups.Results After treatment,the total clinical effective rate of observation group was significantly higher than that of control group,the hemostasis time and hospitalization time were significantly shorter than control group,and the blood transfusion volume was significantly lower than that of control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion The combination of somatostatin and pantoprazole is effective in treatment of cirrhosis with upper gastrointestinal bleeding,and has high clinical value.
引文
[1] 杨绍广.奥曲肽联合普萘洛尔治疗肝硬化上消化道出血临床分析[J].吉林医学,2015,36(6):1107-1108.DOI:10.3969/j.issn.1004-0412.2015.06.045.
[2] 周德江,曾维政.生长抑素用于治疗肝硬化上消化道出血的临床价值分析[J].现代消化及介入诊疗,2015,20(2):153-154.DOI:10.3969/j.issn.1672-2159.2015.02.028.
[3] 吴会玲,娄侠,段立志,等.糖尿病胃轻瘫患者血胃泌素、胃动素水平的观察[J].临床荟萃,2014,29(7):800-801.DOI:10.3969/j.issn.1004-583X.2014.07.027.
[4] 李建生,张明礼.2007年美国肝硬化胃食管静脉曲张及出血的防治指南[J].胃肠病学和肝病学杂志,2008,17(2):85-92.DOI:10.3969/j.issn.1006-5709.2008.02.001.
[5] 高成广,谢峰,冯亚东.生长抑素联合泮托拉唑治疗肝硬化合并上消化道出血的效果观察[J].临床肝胆病杂志,2016,32(2):284-287.DOI:10.3969/j.issn.1001-5256.2016.02.017.
[6] 盛超,张承顺,何旭,等.非肝硬化食管胃底静脉曲张性上消化道出血患者内镜检查时长的相关影响因素[J].海南医学,2017,28(16):2685-2687.DOI:10.3969/j.issn.1003-6350.2017.16.034.
[7] 于然钦.奥曲肽联合普萘洛尔治疗肝硬化上消化道出血临床疗效观察[J].大家健康(中旬版),2018,12(5):48-49.DOI:10.3969/j.issn.1009-6019(z).2018.05.049.
[8] 罗金键.泮托拉唑治疗消化性溃疡合并上消化道出血的临床观察[J].中国医院用药评价与分析,2015,15(3):301-304.DOI:10.14009/j.issn.1672-2124.2015.03.005.
[9] 付岩.普萘洛尔联合奥曲肽治疗肝硬化上消化道出血患者的疗效[J].糖尿病天地,2018,15(5):69.
[10] 樊丽珍.奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的可行性分析[J].医学理论与实践,2018,31(6):836-838.DOI:10.19381/j.issn.1001-7585.2018.06.027.
[2] 周德江,曾维政.生长抑素用于治疗肝硬化上消化道出血的临床价值分析[J].现代消化及介入诊疗,2015,20(2):153-154.DOI:10.3969/j.issn.1672-2159.2015.02.028.
[3] 吴会玲,娄侠,段立志,等.糖尿病胃轻瘫患者血胃泌素、胃动素水平的观察[J].临床荟萃,2014,29(7):800-801.DOI:10.3969/j.issn.1004-583X.2014.07.027.
[4] 李建生,张明礼.2007年美国肝硬化胃食管静脉曲张及出血的防治指南[J].胃肠病学和肝病学杂志,2008,17(2):85-92.DOI:10.3969/j.issn.1006-5709.2008.02.001.
[5] 高成广,谢峰,冯亚东.生长抑素联合泮托拉唑治疗肝硬化合并上消化道出血的效果观察[J].临床肝胆病杂志,2016,32(2):284-287.DOI:10.3969/j.issn.1001-5256.2016.02.017.
[6] 盛超,张承顺,何旭,等.非肝硬化食管胃底静脉曲张性上消化道出血患者内镜检查时长的相关影响因素[J].海南医学,2017,28(16):2685-2687.DOI:10.3969/j.issn.1003-6350.2017.16.034.
[7] 于然钦.奥曲肽联合普萘洛尔治疗肝硬化上消化道出血临床疗效观察[J].大家健康(中旬版),2018,12(5):48-49.DOI:10.3969/j.issn.1009-6019(z).2018.05.049.
[8] 罗金键.泮托拉唑治疗消化性溃疡合并上消化道出血的临床观察[J].中国医院用药评价与分析,2015,15(3):301-304.DOI:10.14009/j.issn.1672-2124.2015.03.005.
[9] 付岩.普萘洛尔联合奥曲肽治疗肝硬化上消化道出血患者的疗效[J].糖尿病天地,2018,15(5):69.
[10] 樊丽珍.奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的可行性分析[J].医学理论与实践,2018,31(6):836-838.DOI:10.19381/j.issn.1001-7585.2018.06.027.