呼出气冷凝液检测概述及其在呼吸系统疾病的应用
摘要
<正>气道炎症在多种呼吸道疾病中扮演着重要角色,可用多种非侵入性方法检测,如呼出气一氧化氮检测(fractional exhaled nitric oxide,FeNO)~([1]),方法快速简便、重复性好、可量化气道炎症等,缺点是价格昂贵,难以在基层医院开展。另外,如诱导痰检测技术~([2]),痰液的诱导和处理过程手工步骤多、耗时耗力,且诱导痰
引文
[1]各廷秋,张念志,王陶,等.呼出气一氧化氮(FeNO)检测在慢性阻塞性肺疾病中的应用进展[J].临床肺科杂志,2017,22(1):148-151
[2]肖伟,刘跃建,龙怀聪,等.诱导痰技术及在支气管哮喘中的应用[J].实用医院临床杂志,2016,13(3):159-161
[3]Davis MD,Montpetit A,Hunt J.Exhaled breath condensate:an overview[J].Immunol Allergy Clin North Am,2012,32(3):363-675
[4]许静.呼出气冷凝液检测在OSAHS中的研究进展[D].蚌埠:蚌埠医学院,2014
[5]Pauling L,Robinson AB,Teranishi R,et al.Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography[J].Proc Natl Acad Sci U S A,1972,69(4):1008-1008
[6]Sidorenko GI,ZborovskiǐEI,Levina DI.[Surface-active properties of the exhaled air condensate(a new method of studying lung function)][J].Ter Arkh,1980,52(3):65-68
[7]Wilson WC,Swetland JF,Benumof JL,et al.General anesthesia and exhaled breath hydrogen peroxide[J].Anesthesiology,1992,76(5):703-710
[8]Rosias P.Methodological aspects of exhaled breath condensate collection and analysis[J].J Breath Res,2012,6(2):027102
[9]KubáňP,Foret F.Exhaled breath condensate:determination of non-volatile compounds and their potential for clinical diagnosis and monitoring.A review[J].Anal Chim Acta,2013,805:1-18
[10]Konstantinidi EM,Lappas AS,Tzortzi AS,et al.Exhaled Breath Condensate:Technical and Diagnostic Aspects[J].Scientific World J,2015:435160
[11]Wallace MAG,Pleil JD.Evolution of clinical and environmental health applications of exhaled breath research:Review of methods and instrumentation for gas-phase,condensate,and aerosols[J].Anal Chim Acta,2018,1024:18-38
[12]Nagaraja C,Shashibhushan BL,Sagar,et al.Hydrogen peroxide in exhaled breath condensate:A clinical study[J].Lung India,2012,29(2):123-127
[13]Sood A,Qualls C,Seagrave J,et al.Effect of allergen inhalation on airway oxidant stress,using exhaled breath condensate 8-isoprostane,in mild asthma[J].J Asthma,2013,50(5):449-456
[14]Fila L,GrandcourtováA,Chládek J,et al.Oxidative stress in cystic fibrosis patients with Burkholderia cenocepacia,airway colonization:relation of 8-isoprostane concentration in exhaled breath condensate to lung function decline[J].Folia Microbiol(Praha),2014,59(3):217-222
[15]Chhabra SK,Gupta M.Exhaled breath condensate analysis in chronic obstructive pulmonary disease[J].Indian J Chest Dis Allied Sci,2012,54(1):27-37
[16]van der Zee P,Somhorst P,Molinger J,et al.A feasibility study into adenosine triphosphate measurement in exhaled breath condensate:apotential bedside method to monitor alveolar deformation[J].Purinergic Signal,2018(3):1-7
[17]Gregu2M,Foret F,KindlováD,et al.Monitoring the ionic content of exhaled breath condensate in various respiratory diseases by capillary electrophoresis with contactless conductivity detection.[J].J Breath Res,2015,9(2):027107
[18]Chérot-Kornobis N,Hulo S,Giovannelli J,et al.Exhaled breath NOx levels in a middle-aged adults population-based study:reference values and association with the smoking status[J].Respir Med,2018,137:134-140
[19]Lacombe M,Marie-Desvergne C,Combes F,et al.Proteomic characterization of human exhaled breath condensate[J].J Breath Res,2018,12(2):021001
[20]Horváth I,Barnes P J,Loukides S,et al.A European Respiratory Society technical standard:exhaled biomarkers in lung disease[J].Eur Respir J,2017,49(4):1600965
[21]中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.支气管哮喘基层诊疗指南(2018年)[J].中国全科医师杂志,2018,17(10):751-762
[22]Keskin O,Balaban S,Keskin M,et al.Relationship between exhaled leukotriene and 8-isoprostane levels and asthma severity,asthma control level,and asthma control test score.[J].Allergol Immunopathol(Madr),2014,42(3):191-197
[23]Aldakheel FM,Thomas PS,Bourke JE,et al.Relationships between adult asthma and oxidative stress markers and pH in exhaled breath condensate:a systematic review[J].Allergy,2016,71(6):741-757
[24]Tomasiak-Lozowska MM,Zietkowski Z,Przeslaw K,et al.Inflammatory markers and acid-base equilibrium in exhaled breath condensate of stable and unstable asthma patients[J].Int Arch Allergy Immunol,2012,159(2):121-129
[25]姜茗宸,汪受传,徐珊,等.小儿哮喘患者呼出气冷凝液代谢组学研究[J].分析化学,2018,46(6):969-974
[26]Vogelmeier CF,Criner GJ,Martinez FJ,et al.Global Strategy for the Diagnosis,Management,and Prevention of Chronic Obstructive Lung Disease 2017 Report.GOLD Executive Summary[J].Am J Respir Crit Care Med,2017,195(5):557-582
[27]Maniscalco M,Paris D,Melck DJ,et al.Differential diagnosis between newly diagnosed asthma and COPD using exhaled breath condensate metabolomics:apilot study[J].Eur Respir J,2018,51(3):1701825
[28]Traphagen N,Tian Z,Allen-Gipson D.Chronic Ethanol Exposure:Pathogenesis of Pulmonary Disease and Dysfunction[J].Biomolecules,2015,5(4):2840-2853
[29]Antczak A,Ciebiada M,Pietras T,et al.Exhaled eicosanoids and biomarkers of oxidative stress in exacerbation of chronic obstructive pulmonary disease[J].Arch Med Sci,2012,8(2):277-285
[30]成人支气管扩张症诊治专家共识编写组.成人支气管扩张症诊治专家共识[J].中华结核和呼吸杂志,2012,35(7):485-492
[31]Lee AL,Button BM,Denehy L,et al.Exhaled Breath Condensate Pepsin:Potential Noninvasive Test for Gastroesophageal Reflux in COPD and Bronchiectasis[J].Respir Care,2015,60(2):244-250
[32]范晓丽,罗英男,闫永建.血清SP-A、SP-D和KL-6在间质性肺疾病中的检测及其意义[J].预防医学论坛,2018(1):78-80
[33]黄立霞,李小莉,黄晓星,等.间质性肺疾病患者呼出气冷凝液及支气管肺泡灌洗液中8-iso-PG、LTB4的对比研究[J].实用临床医学,2018,19(3):4-7
[34]Guillen-Del Castillo A,Sánchez-Vidaurre S,Simeón-Aznar CP,et al.Prognostic Role of Exhaled Breath Condensate pH and Fraction Exhaled Nitric Oxide in Systemic Sclerosis Related Interstitial Lung Disease[J].Arch Bronconeumol,2017,53(3):120-127
[35]Maniscalco M,Motta A.Metabolomics of exhaled breath condensate:a means for phenotyping respiratory diseases?[J].Biomark Med,2017,11(6):405-407
[36]Montuschi P,Paris D,Melck D,et al.NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis[J].Thorax,2012,67(3):222-228
[37]Neerincx AH,Geurts BP,Van Loon J,et al.Detection of Staphylococcus aureus in cystic fibrosis patients using breath VOC profiles[J].J Breath Res,2016,10(4):046014
[38]中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(2015)[J].中华结核和呼吸杂志,2016,39(5):323-354
[39]李志莹,徐健,陈济明,等.呼出气冷凝液中8-异前列腺素水平检测对咳嗽变异性哮喘的临床意义[J].临床肺科杂志,2015,20(9):1633-1635
[40]Heffler E,Crimi C,Brussino L,et al.Exhaled breath condensate pH and cysteinyl leukotriens in patients with chronic cough secondary to acid gastroesophageal reflux[J].J Breath Res,2016,11(1):016002
[41]Krawczyk A,Nowak D,Nowak PJ,et al.Elevated exhalation of hydrogen peroxide in patients with non-small cell lung cancer is not affected by chemotherapy[J].Redox Report,2017,22(6):308-314
[42]López-Lázaro M.Dual role of hydrogen peroxide in cancer:Possible relevance to cancer chemoprevention and therapy[J].Cancer Lett,2007,252(1):1-8
[43]Barreiro E,Fermoselle C,Mateu-Jimenez M,et al.Oxidative stress and inflammation in the normal airways and blood of patients with lung cancer and COPD[J].Free Radic Biol Med,2013,65(6):859-871
[44]Quatromoni JG,Eruslanov E.Tumor-associated macrophages:function,phenotype,and link to prognosis in human lung cancer[J].Am J Transl Res,2012,4(4):376-389
[45]Durham AL,Adcock IM.The relationship between COPD and lung cancer[J].Lung Cancer,2015,90(2):121-127
[46]Okubo T,Suzuki T,Hosaka M,et al.Effects Induced by Organic Acids in a Human Lung Alveolar Carcinoma Cell Line A549[J].Yakugaku Zasshi-journal of the Pharmaceutical Society of Japan,2016,136(10):1433-1438
[47]Ahmed N,Bezabeh T,Ijare OB,et al.Metabolic Signatures of Lung Cancer in Sputum and Exhaled Breath Condensate Detected by1H Magnetic Resonance Spectroscopy:A Feasibility Study[J].Magn Reson Insights,2016,9:29-35
[48]Smyth RJ,Toomey SM,Sartori A,et al.Brief report on the detection of the EGFR-T790M mutation in exhaled breath condensate from lung cancer patients[J].J Thorac Oncol,2018,13(8):1213-1216
[49]Cherepanova A,Tamkovich S,Pyshnyi D,et al.Immunochemical assay for deoxyribonuclease activity in body fluids[J].J Immunol Methods,2007,325(1-2):96-103
[50]何权瀛,王莞尔.阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版)[J].中国呼吸与危重监护杂志,2015,14(4):398-405
[51]杨家盛,杜秀芳,王燕,等.阻塞性睡眠呼吸暂停低通气综合征患者呼出气冷凝液和血清SP-D、Leptin水平检测及其临床意义[J].中国处方药,2018,16(3):1-3
[52]赵鹏展,胡克,崔忠惠,等.阻塞性睡眠呼吸暂停低通气综合征患者呼出气冷凝液中TNF-α、IL-6的研究[J].临床肺科杂志,2011,16(4):620-622
[53]Barreto M,Montuschi P,Evangelisti M,et al.Comparison of two exhaled biomarkers in children with and without sleep disordered breathing[J].Sleep Med,2018,45:83-88
[54]Ghio AJ,Madden MC,Esther CR.Transition and post-transition metals in exhaled breath condensate[J].J Breath Res,2018,12(2):27-36
[2]肖伟,刘跃建,龙怀聪,等.诱导痰技术及在支气管哮喘中的应用[J].实用医院临床杂志,2016,13(3):159-161
[3]Davis MD,Montpetit A,Hunt J.Exhaled breath condensate:an overview[J].Immunol Allergy Clin North Am,2012,32(3):363-675
[4]许静.呼出气冷凝液检测在OSAHS中的研究进展[D].蚌埠:蚌埠医学院,2014
[5]Pauling L,Robinson AB,Teranishi R,et al.Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography[J].Proc Natl Acad Sci U S A,1972,69(4):1008-1008
[6]Sidorenko GI,ZborovskiǐEI,Levina DI.[Surface-active properties of the exhaled air condensate(a new method of studying lung function)][J].Ter Arkh,1980,52(3):65-68
[7]Wilson WC,Swetland JF,Benumof JL,et al.General anesthesia and exhaled breath hydrogen peroxide[J].Anesthesiology,1992,76(5):703-710
[8]Rosias P.Methodological aspects of exhaled breath condensate collection and analysis[J].J Breath Res,2012,6(2):027102
[9]KubáňP,Foret F.Exhaled breath condensate:determination of non-volatile compounds and their potential for clinical diagnosis and monitoring.A review[J].Anal Chim Acta,2013,805:1-18
[10]Konstantinidi EM,Lappas AS,Tzortzi AS,et al.Exhaled Breath Condensate:Technical and Diagnostic Aspects[J].Scientific World J,2015:435160
[11]Wallace MAG,Pleil JD.Evolution of clinical and environmental health applications of exhaled breath research:Review of methods and instrumentation for gas-phase,condensate,and aerosols[J].Anal Chim Acta,2018,1024:18-38
[12]Nagaraja C,Shashibhushan BL,Sagar,et al.Hydrogen peroxide in exhaled breath condensate:A clinical study[J].Lung India,2012,29(2):123-127
[13]Sood A,Qualls C,Seagrave J,et al.Effect of allergen inhalation on airway oxidant stress,using exhaled breath condensate 8-isoprostane,in mild asthma[J].J Asthma,2013,50(5):449-456
[14]Fila L,GrandcourtováA,Chládek J,et al.Oxidative stress in cystic fibrosis patients with Burkholderia cenocepacia,airway colonization:relation of 8-isoprostane concentration in exhaled breath condensate to lung function decline[J].Folia Microbiol(Praha),2014,59(3):217-222
[15]Chhabra SK,Gupta M.Exhaled breath condensate analysis in chronic obstructive pulmonary disease[J].Indian J Chest Dis Allied Sci,2012,54(1):27-37
[16]van der Zee P,Somhorst P,Molinger J,et al.A feasibility study into adenosine triphosphate measurement in exhaled breath condensate:apotential bedside method to monitor alveolar deformation[J].Purinergic Signal,2018(3):1-7
[17]Gregu2M,Foret F,KindlováD,et al.Monitoring the ionic content of exhaled breath condensate in various respiratory diseases by capillary electrophoresis with contactless conductivity detection.[J].J Breath Res,2015,9(2):027107
[18]Chérot-Kornobis N,Hulo S,Giovannelli J,et al.Exhaled breath NOx levels in a middle-aged adults population-based study:reference values and association with the smoking status[J].Respir Med,2018,137:134-140
[19]Lacombe M,Marie-Desvergne C,Combes F,et al.Proteomic characterization of human exhaled breath condensate[J].J Breath Res,2018,12(2):021001
[20]Horváth I,Barnes P J,Loukides S,et al.A European Respiratory Society technical standard:exhaled biomarkers in lung disease[J].Eur Respir J,2017,49(4):1600965
[21]中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.支气管哮喘基层诊疗指南(2018年)[J].中国全科医师杂志,2018,17(10):751-762
[22]Keskin O,Balaban S,Keskin M,et al.Relationship between exhaled leukotriene and 8-isoprostane levels and asthma severity,asthma control level,and asthma control test score.[J].Allergol Immunopathol(Madr),2014,42(3):191-197
[23]Aldakheel FM,Thomas PS,Bourke JE,et al.Relationships between adult asthma and oxidative stress markers and pH in exhaled breath condensate:a systematic review[J].Allergy,2016,71(6):741-757
[24]Tomasiak-Lozowska MM,Zietkowski Z,Przeslaw K,et al.Inflammatory markers and acid-base equilibrium in exhaled breath condensate of stable and unstable asthma patients[J].Int Arch Allergy Immunol,2012,159(2):121-129
[25]姜茗宸,汪受传,徐珊,等.小儿哮喘患者呼出气冷凝液代谢组学研究[J].分析化学,2018,46(6):969-974
[26]Vogelmeier CF,Criner GJ,Martinez FJ,et al.Global Strategy for the Diagnosis,Management,and Prevention of Chronic Obstructive Lung Disease 2017 Report.GOLD Executive Summary[J].Am J Respir Crit Care Med,2017,195(5):557-582
[27]Maniscalco M,Paris D,Melck DJ,et al.Differential diagnosis between newly diagnosed asthma and COPD using exhaled breath condensate metabolomics:apilot study[J].Eur Respir J,2018,51(3):1701825
[28]Traphagen N,Tian Z,Allen-Gipson D.Chronic Ethanol Exposure:Pathogenesis of Pulmonary Disease and Dysfunction[J].Biomolecules,2015,5(4):2840-2853
[29]Antczak A,Ciebiada M,Pietras T,et al.Exhaled eicosanoids and biomarkers of oxidative stress in exacerbation of chronic obstructive pulmonary disease[J].Arch Med Sci,2012,8(2):277-285
[30]成人支气管扩张症诊治专家共识编写组.成人支气管扩张症诊治专家共识[J].中华结核和呼吸杂志,2012,35(7):485-492
[31]Lee AL,Button BM,Denehy L,et al.Exhaled Breath Condensate Pepsin:Potential Noninvasive Test for Gastroesophageal Reflux in COPD and Bronchiectasis[J].Respir Care,2015,60(2):244-250
[32]范晓丽,罗英男,闫永建.血清SP-A、SP-D和KL-6在间质性肺疾病中的检测及其意义[J].预防医学论坛,2018(1):78-80
[33]黄立霞,李小莉,黄晓星,等.间质性肺疾病患者呼出气冷凝液及支气管肺泡灌洗液中8-iso-PG、LTB4的对比研究[J].实用临床医学,2018,19(3):4-7
[34]Guillen-Del Castillo A,Sánchez-Vidaurre S,Simeón-Aznar CP,et al.Prognostic Role of Exhaled Breath Condensate pH and Fraction Exhaled Nitric Oxide in Systemic Sclerosis Related Interstitial Lung Disease[J].Arch Bronconeumol,2017,53(3):120-127
[35]Maniscalco M,Motta A.Metabolomics of exhaled breath condensate:a means for phenotyping respiratory diseases?[J].Biomark Med,2017,11(6):405-407
[36]Montuschi P,Paris D,Melck D,et al.NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis[J].Thorax,2012,67(3):222-228
[37]Neerincx AH,Geurts BP,Van Loon J,et al.Detection of Staphylococcus aureus in cystic fibrosis patients using breath VOC profiles[J].J Breath Res,2016,10(4):046014
[38]中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(2015)[J].中华结核和呼吸杂志,2016,39(5):323-354
[39]李志莹,徐健,陈济明,等.呼出气冷凝液中8-异前列腺素水平检测对咳嗽变异性哮喘的临床意义[J].临床肺科杂志,2015,20(9):1633-1635
[40]Heffler E,Crimi C,Brussino L,et al.Exhaled breath condensate pH and cysteinyl leukotriens in patients with chronic cough secondary to acid gastroesophageal reflux[J].J Breath Res,2016,11(1):016002
[41]Krawczyk A,Nowak D,Nowak PJ,et al.Elevated exhalation of hydrogen peroxide in patients with non-small cell lung cancer is not affected by chemotherapy[J].Redox Report,2017,22(6):308-314
[42]López-Lázaro M.Dual role of hydrogen peroxide in cancer:Possible relevance to cancer chemoprevention and therapy[J].Cancer Lett,2007,252(1):1-8
[43]Barreiro E,Fermoselle C,Mateu-Jimenez M,et al.Oxidative stress and inflammation in the normal airways and blood of patients with lung cancer and COPD[J].Free Radic Biol Med,2013,65(6):859-871
[44]Quatromoni JG,Eruslanov E.Tumor-associated macrophages:function,phenotype,and link to prognosis in human lung cancer[J].Am J Transl Res,2012,4(4):376-389
[45]Durham AL,Adcock IM.The relationship between COPD and lung cancer[J].Lung Cancer,2015,90(2):121-127
[46]Okubo T,Suzuki T,Hosaka M,et al.Effects Induced by Organic Acids in a Human Lung Alveolar Carcinoma Cell Line A549[J].Yakugaku Zasshi-journal of the Pharmaceutical Society of Japan,2016,136(10):1433-1438
[47]Ahmed N,Bezabeh T,Ijare OB,et al.Metabolic Signatures of Lung Cancer in Sputum and Exhaled Breath Condensate Detected by1H Magnetic Resonance Spectroscopy:A Feasibility Study[J].Magn Reson Insights,2016,9:29-35
[48]Smyth RJ,Toomey SM,Sartori A,et al.Brief report on the detection of the EGFR-T790M mutation in exhaled breath condensate from lung cancer patients[J].J Thorac Oncol,2018,13(8):1213-1216
[49]Cherepanova A,Tamkovich S,Pyshnyi D,et al.Immunochemical assay for deoxyribonuclease activity in body fluids[J].J Immunol Methods,2007,325(1-2):96-103
[50]何权瀛,王莞尔.阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版)[J].中国呼吸与危重监护杂志,2015,14(4):398-405
[51]杨家盛,杜秀芳,王燕,等.阻塞性睡眠呼吸暂停低通气综合征患者呼出气冷凝液和血清SP-D、Leptin水平检测及其临床意义[J].中国处方药,2018,16(3):1-3
[52]赵鹏展,胡克,崔忠惠,等.阻塞性睡眠呼吸暂停低通气综合征患者呼出气冷凝液中TNF-α、IL-6的研究[J].临床肺科杂志,2011,16(4):620-622
[53]Barreto M,Montuschi P,Evangelisti M,et al.Comparison of two exhaled biomarkers in children with and without sleep disordered breathing[J].Sleep Med,2018,45:83-88
[54]Ghio AJ,Madden MC,Esther CR.Transition and post-transition metals in exhaled breath condensate[J].J Breath Res,2018,12(2):27-36