长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的效果评价
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摘要
目的观察长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的疗效并对其进行探究。方法选取2016年12月—2018年1月期间该院的90例复发性鼻窦炎患者作为观察对象,将其分为常规组与联合组,两组人数均为45例。常规组的患者使用综合治疗(鼻用激素及鼻腔冲洗),联合组的患者在常规组的治疗基础上增加长期低剂量克拉霉素进行治疗。观察两组治疗后的治愈总有效率及鼻内镜评分(Modified Lund-Kennedy),以此评估疗效。结果治愈总有效率:常规组73.33%,联合组93.33%,差异有统计学意义(χ~2=6.48,P<0.05);鼻内镜平均分:常规组(3.77±0.36)分、联合组(2.03±0.53)分,且鼻内镜平均分明显低于常规组,差异有统计学意义(P<0.05)。结论在复发性鼻窦炎的治疗方面,长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗的治疗方法更具有效性,具备临床推广意义。
Objective To observe the curative effect of long-term low-dose clarithromycin combined with nasal hormone and nasal irrigation in the treatment of recurrent sinusitis. Methods 90 patients with recurrent sinusitis in our hospital from December 2016 to January 2018 were enrolled in the study. They were divided into the conventional group and the combined group. The number of the two groups was 45. Patients in the conventional group received comprehensive treatment(nasal hormones and nasal irrigation), and patients in the combined group were treated with conventional long-term low-dose clarithromycin. Efficacy was assessed by observing the total effective rate of cure and the endoscopic score(Modified Lund-Kennedy) after treatment. Results The total effective rate of cure was 73.33% in the conventional group and 93.33% in the combined group. the difference was statistically significant(χ~2=6.48,P<0.05).The average scores of nasal endoscopy were: the normal group(3.77±0.36)points and the combined group(2.03±0.53)points. the mean endoscopic score was significantly lower than the conventional group, the difference was statistically significant(P<0.05). Conclusion In the treatment of recurrent sinusitis, the long-term low-dose clarithromycin combined with nasal hormone and nasal irrigation is more effective and has clinical significance.
Objective To observe the curative effect of long-term low-dose clarithromycin combined with nasal hormone and nasal irrigation in the treatment of recurrent sinusitis. Methods 90 patients with recurrent sinusitis in our hospital from December 2016 to January 2018 were enrolled in the study. They were divided into the conventional group and the combined group. The number of the two groups was 45. Patients in the conventional group received comprehensive treatment(nasal hormones and nasal irrigation), and patients in the combined group were treated with conventional long-term low-dose clarithromycin. Efficacy was assessed by observing the total effective rate of cure and the endoscopic score(Modified Lund-Kennedy) after treatment. Results The total effective rate of cure was 73.33% in the conventional group and 93.33% in the combined group. the difference was statistically significant(χ~2=6.48,P<0.05).The average scores of nasal endoscopy were: the normal group(3.77±0.36)points and the combined group(2.03±0.53)points. the mean endoscopic score was significantly lower than the conventional group, the difference was statistically significant(P<0.05). Conclusion In the treatment of recurrent sinusitis, the long-term low-dose clarithromycin combined with nasal hormone and nasal irrigation is more effective and has clinical significance.
引文
[1]郭国平,介华,付利静.长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的疗效[J].北方药学,2018,15(10):75-76.
[2]于中君.长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的临床疗效[J].中国药物经济学,2017,12(7):57-59.
[3]钱芝卫.长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的效果评价[J].系统医学,2017,2(3):14-16.
[4]司江勇,司松环,杨浩,等.长期小剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的疗效[J].临床医药文献电子杂志,2016,3(14):2859-2860.
[5]周琴.长期使用低剂量克拉霉素联合鼻用激素和鼻腔冲洗疗法治疗复发性鼻窦炎的效果探讨[J].当代医药论丛,2016,14(5):164-165.
[6]朱金亮.布地奈德联合克拉霉素治疗慢性鼻–鼻窦炎98例[J].北方药学,2018,15(7):103-104.
[7]张奕芝.克拉霉素治疗鼻窦炎的临床效果及安全性研究[J].当代医药论丛,2017,15(19):131-132.
[8]肖立东.长期低剂量克拉霉素联合激素治疗慢性鼻窦炎的效果[J].中国继续医学教育,2018,10(29):141-143.
[9]段飞,倪宝良,罗晖晖,等.采用低剂量克拉霉素治疗慢性鼻窦炎的疗效探讨[J].天津药学,2018,30(4):45-46,72.
[2]于中君.长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的临床疗效[J].中国药物经济学,2017,12(7):57-59.
[3]钱芝卫.长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的效果评价[J].系统医学,2017,2(3):14-16.
[4]司江勇,司松环,杨浩,等.长期小剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的疗效[J].临床医药文献电子杂志,2016,3(14):2859-2860.
[5]周琴.长期使用低剂量克拉霉素联合鼻用激素和鼻腔冲洗疗法治疗复发性鼻窦炎的效果探讨[J].当代医药论丛,2016,14(5):164-165.
[6]朱金亮.布地奈德联合克拉霉素治疗慢性鼻–鼻窦炎98例[J].北方药学,2018,15(7):103-104.
[7]张奕芝.克拉霉素治疗鼻窦炎的临床效果及安全性研究[J].当代医药论丛,2017,15(19):131-132.
[8]肖立东.长期低剂量克拉霉素联合激素治疗慢性鼻窦炎的效果[J].中国继续医学教育,2018,10(29):141-143.
[9]段飞,倪宝良,罗晖晖,等.采用低剂量克拉霉素治疗慢性鼻窦炎的疗效探讨[J].天津药学,2018,30(4):45-46,72.