东方栓菌化学成分研究
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摘要
目的:研究东方栓菌的化学成分。方法:通过凝胶、硅胶等多种柱层析方法分离纯化东方栓菌中的主要单体化合物,利用现代波谱分析方法及化学方法鉴定其化学结构。结果:从东方栓菌乙酸乙酯提取物中分离鉴定了12个化合物,分别鉴定为:多孔菌酸C(1)、齿孔酸(2)、茯苓酸(3)、硫磺菌酸(4)、齿孔醇(5)、麦角甾醇(6)、3β-羟基-5α,8α-过氧麦角甾醇-6,22-双烯(7)、3β-羟基-5α,8α-过氧麦角甾醇-6,9,22-三烯(8)、麦角甾-7,22-二烯-3β,5α,6β-三醇(9)、麦角甾-7,22-二烯-6β-甲氧基-3β,5α-二醇(10)、麦角甾-7,22-二烯-3β-醇(11)、亚油酸(12)。结论:其中,化合物1～5为首次从东方栓菌中分离得到。
Objective:To investigate the chemical constituents of Trametes orientalis.Methods:The major monomer compounds were isolated and purified by Sephadex LH-20,silica gel column chromatography,modern spectral analysis and chemical methods were used to identify the chemical structures.Results:Twelve compounds from the ethyl acetate extracts of Trametes orientalis were isolated and identified as polyporenic acid C(1),eburicoic acid(2),pachymic acid(3),sulfur bacteria acid(4),eburicol(5),ergosterol(6),3β-hydroxy-5α,8α-epidioxyergosta-6,22-diene(7),3β-hydroxy-5α,8α-epidioxyergosta-6,9,22-triene(8),ergosta-7,22-diene-3β,5α,6β-triol(9),ergosta-7,22-diene-6β-methoxyl-3β,5α-diol(10),ergosta-7,22-diene-3β-ol(11),linoleic acid(12).Conclusion:Compounds 1 to 5 are isolated from Trametes orientalis for the first time.
Objective:To investigate the chemical constituents of Trametes orientalis.Methods:The major monomer compounds were isolated and purified by Sephadex LH-20,silica gel column chromatography,modern spectral analysis and chemical methods were used to identify the chemical structures.Results:Twelve compounds from the ethyl acetate extracts of Trametes orientalis were isolated and identified as polyporenic acid C(1),eburicoic acid(2),pachymic acid(3),sulfur bacteria acid(4),eburicol(5),ergosterol(6),3β-hydroxy-5α,8α-epidioxyergosta-6,22-diene(7),3β-hydroxy-5α,8α-epidioxyergosta-6,9,22-triene(8),ergosta-7,22-diene-3β,5α,6β-triol(9),ergosta-7,22-diene-6β-methoxyl-3β,5α-diol(10),ergosta-7,22-diene-3β-ol(11),linoleic acid(12).Conclusion:Compounds 1 to 5 are isolated from Trametes orientalis for the first time.
引文
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[14] 李冬得,李晓明,崔传明,等.鸭毛藻内生真菌Hypocreales sp.的化学成分研究[J].海洋科学,2008,32(11):51-55.
[15] Vazirian M,Faramarzi MA,Sadat Ebrahimi SE,et al.Antimicrobial effect of the Lingzhi or Reishi medicinal mushroom,Ganoderma lucidum(Higher basidiomicetes)and its main compounds[J].International Journal of Medicinal Mushrooms,2014,16(1):77-84.
[16] 魏涵,吴光华,杨娴,等.华南毛蕨叶的化学成分研究[J].中草药,2013,44(17):2354-2357.
[2] 赵维鼎.中国真菌志[M].第三卷.北京:科学出版社,1998:372.
[3] Chen HL,Chiang HC.Constituents of fruit bodies of Tramete orientalis[J].Journal of the Chinese Chemical Society,1995,42(1):97-100.
[4] Chen HL,Chiang HC.Chemical compounds of Tramete orientalis[J].Formosan Science,1994,47(2):45-48.
[5] 赵吉福,何爱民,陈英杰,等.茯苓抗肿瘤成分研究(Ⅰ)[J].中国药物化学杂志,1993,3(2):128-129,131.
[6] Kamalov LS,Agzamova MA,Aripova SF,et al.Low-molecular weight mushroom metabolites V.Eburicoic acid from Polyporus ailanthus[J].Chemistry of Natural Compounds,2000,36(1):72-75.
[7] Kamo T,Asanoma M,Shibata H,et al.Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus[J].Journal of Natural Products,2003,66(8):1104-1106.
[8] Yoshikawa K,Matsumoto K,Mine C,et al.Five lanostane triterpenoids and three saponins from the fruit body of Laetiporus versisporus[J].Chemical & Pharmaceutical Bulletin,2000,48(10):1418-1421.
[9] Wu DP,Chiang HC.Constituents of Antrodia cinnamonea[J].Journal of the Chinese Chemical Society,1995,42(5):797-800.
[10] 张海娟,欧扬,娄红祥.光肺衣的化学成分研究[J].中药材,2007,30(6):651-655.
[11] 潘娟,杨炳友,王欣,等.洋金花甾体类化学成分研究[J].中医药信息,2015,32(4):23-25.
[12] Niramai F,Bungorn S,Kaoru U,et al.Bioactive ergostanoids and a new olyhydroxyoctane from Lentinus polychrous mycelia and their inhibitory effects on E2-enhanced cell proliferation of T47D cells[J].Natural Product Research,2013,27(18):1611-1619.
[13] Gao JM,Hu L,Liu JK.A novel sterol from Chinese truffles Tuber indicum[J].Steroids,2001,66(10):771-775.
[14] 李冬得,李晓明,崔传明,等.鸭毛藻内生真菌Hypocreales sp.的化学成分研究[J].海洋科学,2008,32(11):51-55.
[15] Vazirian M,Faramarzi MA,Sadat Ebrahimi SE,et al.Antimicrobial effect of the Lingzhi or Reishi medicinal mushroom,Ganoderma lucidum(Higher basidiomicetes)and its main compounds[J].International Journal of Medicinal Mushrooms,2014,16(1):77-84.
[16] 魏涵,吴光华,杨娴,等.华南毛蕨叶的化学成分研究[J].中草药,2013,44(17):2354-2357.