血液透析和腹膜透析对慢性肾衰竭患者平均血小板体积和炎症相关因子的影响
摘要
目的:探讨血液透析和腹膜透析对慢性肾衰竭(CRF)患者平均血小板体积(MPV)和炎症相关因子的影响。方法:回顾性分析2017年03月～2018年03月我院住院期间行血液或腹膜透析的120例CRF患者,按透析方式不同随机均分为血液透析组与腹膜透析组,另选取体60例体检正常者作为健康对照组。分析比较3组MPV、CRP和hs-CRP水平,并比较两组透析患者在有无高血压、糖尿病或冠心病并发症情况下MPV、CRP和hs-CRP水平。分析MPV与CRP、hs-CRP水平相关性。结果:血液透析组与腹膜透析组的CRP和hs-CRP水平与健康对照组比较均显著升高,且血液透析组高于腹膜透析组,差异有统计学意义(P <0. 05)。3组MPV水平比较差异无统计学意义(P> 0. 05)。但血液透析组与腹膜透析组中有并发症患者的MPV、CRP和hs-CRP水平均显著高于无并发症患者(P <0. 05),且在有并发症情况下MPV与CRP、hs-CRP均呈正相关性(P <0. 05)。结论:与血液透析相比,腹膜透析方式产生的慢性微炎症反应相对较轻,在CRF伴并发症情况下MPV水平与增高的炎症相关因子水平相关。
引文
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8 .林建,叶晴,詹林达,等.腹膜透析对慢性肾脏病患者脂联素水平、微炎症及营养状态的影响.浙江医学,2017,39(13):1084-1087.
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10 .赵俊丽,朱君君,邵霞,等.血液透析患者颈动脉内中膜厚度与血栓调节蛋白、炎症因子及心血管疾病的关联.肾脏病与透析肾移植杂志,2018,27(1):24-28.
11 .束金莲,李贺,叶岚,等.高通量血液透析对糖尿病肾病维持性血液透析患者氧化应激和颈动脉内膜厚度影响.中国中西医结合肾病杂志,2017,18(12):1083-1085.
12 .廖靖华.平均血小板体积与血小板分布宽度联合检测在成人急性肾损伤早期诊断中的价值.中国医药科学,2017,7(13):215-218.
2 . Shah B,Valdes V,Nardi MA,et al. Mean platelet volume reproducibility and association with platelet activity and anti-platelet therapy. Platelets,2014,25(3):188-192.
3 . Trivedi H,Yang J,Szabo A. Gastrointestinal bleeding in patients on long-term dialysis. J Nephrol,2015,28(2):235-243.
4 . Altun E,Paydas S,Kaya B,et al. The relationship between inflammation,blood pressure,and mean platelet volume in chronic kidney disease. Saudi J Kidney Dis Transpl,2016,27(4):836-838.
5 . Sansanayudh N,Muntham D,Yamwong S,et al. The association between mean platelet volume and cardiovascular risk factors.Eur J Intern Med,2016,30(1):37-42.
6 . Bilen Y,Cankaya E,Keles M,et al. Does decreased mean platelet volume predict inflammation in chronic renal failure,dialysis,and transplanted patients. Ren Fail,2014,36(1):69-72.
7 .宋国巍,王磊.现有透析疗法对慢性肾衰竭尿毒症患者微炎症状态的影响.中国实验诊断学,2015,19(7):1199-1200.
8 .林建,叶晴,詹林达,等.腹膜透析对慢性肾脏病患者脂联素水平、微炎症及营养状态的影响.浙江医学,2017,39(13):1084-1087.
9 . Golia E,Limongelli G,Natale F,et al. Inflammation and cardiovascular disease:from pathogenesis to therapeutic target. Curr Atheroscler Rep,2014,16(9):435.
10 .赵俊丽,朱君君,邵霞,等.血液透析患者颈动脉内中膜厚度与血栓调节蛋白、炎症因子及心血管疾病的关联.肾脏病与透析肾移植杂志,2018,27(1):24-28.
11 .束金莲,李贺,叶岚,等.高通量血液透析对糖尿病肾病维持性血液透析患者氧化应激和颈动脉内膜厚度影响.中国中西医结合肾病杂志,2017,18(12):1083-1085.
12 .廖靖华.平均血小板体积与血小板分布宽度联合检测在成人急性肾损伤早期诊断中的价值.中国医药科学,2017,7(13):215-218.