摘要
目的:探讨血液透析和腹膜透析对慢性肾衰竭(CRF)患者平均血小板体积(MPV)和炎症相关因子的影响。方法:回顾性分析2017年03月~2018年03月我院住院期间行血液或腹膜透析的120例CRF患者,按透析方式不同随机均分为血液透析组与腹膜透析组,另选取体60例体检正常者作为健康对照组。分析比较3组MPV、CRP和hs-CRP水平,并比较两组透析患者在有无高血压、糖尿病或冠心病并发症情况下MPV、CRP和hs-CRP水平。分析MPV与CRP、hs-CRP水平相关性。结果:血液透析组与腹膜透析组的CRP和hs-CRP水平与健康对照组比较均显著升高,且血液透析组高于腹膜透析组,差异有统计学意义(P <0. 05)。3组MPV水平比较差异无统计学意义(P> 0. 05)。但血液透析组与腹膜透析组中有并发症患者的MPV、CRP和hs-CRP水平均显著高于无并发症患者(P <0. 05),且在有并发症情况下MPV与CRP、hs-CRP均呈正相关性(P <0. 05)。结论:与血液透析相比,腹膜透析方式产生的慢性微炎症反应相对较轻,在CRF伴并发症情况下MPV水平与增高的炎症相关因子水平相关。
引文
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