甲泼尼松龙辅助治疗支原体肺炎的效果及其免疫影响
|
摘要
目的:研究甲泼尼松龙辅助治疗肺炎支原体肺炎的效果及其免疫影响。方法:2008年1月～2012年12月唐山市妇幼保健院支原体肺炎患儿,采用随机数字法均分为两组,根据是否接受甲泼尼松龙辅助治疗分为观察组与对照组。对两组患儿治疗的临床效果,及治疗前后血清CRP、IL-2、IL-8、TNF-α水平进行比较。结果:观察组治疗显效率明显高于对照组(57.0%vs.28.0%,P<0.05);其无效率则低于对照组(5.4%vs.19.4%,P<0.05)。甲泼尼松龙辅助治疗支原体肺炎前后,血清CRP、IL-8、TNF-α水平降低,IL-2水平升高(P<0.05);甲泼尼松龙辅助治疗支原体肺炎后,血清CRP、IL-8、TNF-α水平降低,IL-2水平升高,与对照组治疗后相比较,差异均有统计学意义(P<0.05)。结论:甲泼尼松龙辅助治疗支原体肺炎能够较快的减轻肺部炎症反应,缓解临床症状,缩短治疗时间,但远期效果尚待进一步随访。
Objective:To study the effect of methylprednisolone for adjunctive therapy of mycoplasma pneumonia and its immune effect.Methods:The children with mycoplasma pneumonia were selected from the hospital from January 2008 to December 2012,then they were divided into observation group and control group according to receiving adjunctive therapy with methylprednisolone or not by random number method;the clinical curative effects,serum levels of C-reactive protein(CRP),IL-2,IL-8,and tumor necrosis factor-α(TNF-α) before and after treatment in the two groups were compared.Results:The obvious effective rate in observation group(57.0%) was statistically significantly higher than that in control group(28.0%)(P<0.05);the ineffective rate in observation group(5.4%) was statistically significantly lower than that in control group(19.4%)(P<0.05).After treatment,the serum levels of CRP,IL-8,and TNF-α decreased,the serum level of IL-2 increased(P<0.05),compared with control group,there was statistically significant difference(P<0.05).Conclusion:Methylprednisolone used for adjuvant therapy of mycoplasma pneumonia can relieve pulmonary inflammatory response rapidly,alleviate the clinical symptoms,and shorten the treatment time,but the long-term effect need further follow-up.
Objective:To study the effect of methylprednisolone for adjunctive therapy of mycoplasma pneumonia and its immune effect.Methods:The children with mycoplasma pneumonia were selected from the hospital from January 2008 to December 2012,then they were divided into observation group and control group according to receiving adjunctive therapy with methylprednisolone or not by random number method;the clinical curative effects,serum levels of C-reactive protein(CRP),IL-2,IL-8,and tumor necrosis factor-α(TNF-α) before and after treatment in the two groups were compared.Results:The obvious effective rate in observation group(57.0%) was statistically significantly higher than that in control group(28.0%)(P<0.05);the ineffective rate in observation group(5.4%) was statistically significantly lower than that in control group(19.4%)(P<0.05).After treatment,the serum levels of CRP,IL-8,and TNF-α decreased,the serum level of IL-2 increased(P<0.05),compared with control group,there was statistically significant difference(P<0.05).Conclusion:Methylprednisolone used for adjuvant therapy of mycoplasma pneumonia can relieve pulmonary inflammatory response rapidly,alleviate the clinical symptoms,and shorten the treatment time,but the long-term effect need further follow-up.
引文
1胡跃华,胡毅,闫宗荣et al.糖皮质激素治疗难治性支原体肺炎疗效观察(J).中国临床医生,2012,40(1):47
2刘旭辉,朱虹,陈德利et al.支原体肺炎病儿体液免疫功能的动态变化(J).齐鲁医学杂志,2010,25(6):518
3高大明,翟爱国,刘永红et al.小剂量激素短疗程辅助治疗支原体肺炎临床观察(J).安徽医药,2010,14(6):713
4钟伟.糖皮质激素辅助治疗小儿肺炎支原体肺炎的疗效探讨(J).医药前沿,2012,2(17):304
5万瑜,程宝金,薛梅et al.小儿支原体肺炎T细胞亚群和免疫球蛋白水平的变化与分析(J).实用临床医药杂志,2010,14(11):28
6陈真堂.短期小剂量糖皮质激素联合阿奇霉素治疗儿童支原体肺炎临床分析(J).内蒙古中医药,2010,29(20):114
7王丹霞.小剂量糖皮质激素在儿童支原体肺炎中应用疗效研究(J).中外医学研究,2011,9(29):30
8侯安存,卢炎,沙莉et al.支原体肺炎患儿辅助性T淋巴细胞亚群TH1、TH2细胞状况(J).中华儿科杂志,2003,41(9):652
9王娟,段全纪,张迎春et al.地塞米松对支原体肺炎肺外并发症患儿免疫指标的影响(J).贵阳医学院学报,2012,37(1):60
10孙占宇.支原体肺炎患儿血清IL-2、IL-8、TNF-α水平检测及意义(J).山东医药,2012,52(3):71
11陈波,张经.支原体肺炎患儿血清体液免疫检测的临床研究(J).临床肺科杂志,2012,17(6):1045
12郭云武.支原体肺炎患儿血清中体液免疫检测指标结果分析(J).浙江实用医学,2012,17(4):303
13安黎云,王缚鲲,冉向阳et al.肺炎支原体肺炎患儿总IgE、嗜酸性粒细胞变化及免疫机制研究(J).中国医师进修杂志,2011,34(27):35
14金燕.阿奇霉素与红霉素治疗小儿支原体肺炎的疗效观察及其肺炎支原体对免疫球蛋白、T淋巴细胞亚群细胞因子的影响(J).细胞与分子免疫学杂志,2010,26(6):593
2刘旭辉,朱虹,陈德利et al.支原体肺炎病儿体液免疫功能的动态变化(J).齐鲁医学杂志,2010,25(6):518
3高大明,翟爱国,刘永红et al.小剂量激素短疗程辅助治疗支原体肺炎临床观察(J).安徽医药,2010,14(6):713
4钟伟.糖皮质激素辅助治疗小儿肺炎支原体肺炎的疗效探讨(J).医药前沿,2012,2(17):304
5万瑜,程宝金,薛梅et al.小儿支原体肺炎T细胞亚群和免疫球蛋白水平的变化与分析(J).实用临床医药杂志,2010,14(11):28
6陈真堂.短期小剂量糖皮质激素联合阿奇霉素治疗儿童支原体肺炎临床分析(J).内蒙古中医药,2010,29(20):114
7王丹霞.小剂量糖皮质激素在儿童支原体肺炎中应用疗效研究(J).中外医学研究,2011,9(29):30
8侯安存,卢炎,沙莉et al.支原体肺炎患儿辅助性T淋巴细胞亚群TH1、TH2细胞状况(J).中华儿科杂志,2003,41(9):652
9王娟,段全纪,张迎春et al.地塞米松对支原体肺炎肺外并发症患儿免疫指标的影响(J).贵阳医学院学报,2012,37(1):60
10孙占宇.支原体肺炎患儿血清IL-2、IL-8、TNF-α水平检测及意义(J).山东医药,2012,52(3):71
11陈波,张经.支原体肺炎患儿血清体液免疫检测的临床研究(J).临床肺科杂志,2012,17(6):1045
12郭云武.支原体肺炎患儿血清中体液免疫检测指标结果分析(J).浙江实用医学,2012,17(4):303
13安黎云,王缚鲲,冉向阳et al.肺炎支原体肺炎患儿总IgE、嗜酸性粒细胞变化及免疫机制研究(J).中国医师进修杂志,2011,34(27):35
14金燕.阿奇霉素与红霉素治疗小儿支原体肺炎的疗效观察及其肺炎支原体对免疫球蛋白、T淋巴细胞亚群细胞因子的影响(J).细胞与分子免疫学杂志,2010,26(6):593