维生素D与近视关联的研究进展
摘要
<正>近视是重要的全球性公共卫生问题,特别是在中国、新加坡等东亚国家。预计到2050年近视患病率会显著增加,影响全球近50亿人的健康~[1]。在20世纪以前,人们普遍认为教室里的高水平光照能够预防近视,教育部门通过扩大教室窗户来预防儿童近视,该种做法一直持续到20世纪60年代,这一时期近视被认为是一种由遗传条件导致的疾病,随后几年近视不再是重点研究领域~[2-3]。最近的研究结果恢复了19
引文
[1]HOLDEN B A,FRICKE T R,WILSON D A,et al.Global prevalence of myopia and high myopia and temporal trends from 2000 through2050[J].Ophthalmology,2016,123(5):1036-1042.
[2]POLLING J R,VERHOEVENERJ V J,TIDEMAN J W.Duke-Elder's views on prognosis,prophylaxis,and treatment of myopia:way ahead of his time[J].Strabismus,2016,24(1):40-43.
[3]RICHARD H.Myopia and daylight in schools:a neglected aspect of public health?[J].Persp Pub Health,2016,136(1):150-155.
[4]ROSE K A,MORGAN I G,IP J,et al.Outdoor activity reduces the prevalence of myopia in children[J].Ophthalmology,2008,115(8):1279-1285.
[5]金菊香,伍晓艳,万宇辉,等.户外活动对中小学生视力的保护效果评价[J].中国学校卫生,2014,35(12):1776-1779.
[6]翟露露,伍晓艳,许韶君,等.接触阳光与儿童近视关联的研究进展[J].中华流行病学杂志,2016,37(11):1555-1560.
[7]GUGGENHEIM J A,NORTHSTONE K,MCMAHON G,et al.Time outdoors and physical activity as predictors of incident myopia in childhood:a prospective cohort study[J].Invest Ophthalmol Vis Sci,2012,53(6):2856-2865.
[8]READ S A,COLLINS M J,VINCENT S J.Light exposure and physical activity in myopia and emmetropic children[J].Optom Vis Sci,2014,91(3):330-341.
[9]COHEN Y,PELEG E,BELKIN M,et al.Ambient illuminance,retinal dopamine release and refractive development in chicks[J].Exp Eye Res,2012,103(4):33-40.
[10]ASHBY R,OHLENDORF A,SCHAEFFEL F.The effect of ambient illuminance on the development of derivation myopia in chicks[J].Invest Ophthalmol Vis Sci,2009,50(11):5348-5354.
[11]MEHDIZADEH M,NOWROOZZADEH M H.Outdoor activity and myopia[J].Ophthalmology,2009,116(6):1229-1230.
[12]RUCKER F,BRITTON S,SPATCHER M,et al.Blue light protects against temporal frequency sensitive refractive changes[J].Invest Ophthalmol Vis Sci,2015,56(10):6121-6131.
[13]FRENCH A N,ASHBY R S,MORGAN I G.Time outdoors and the prevention of myopia[J].Exp Eye Res,2013,114(9):58-68.
[14]MORGAN I G.ALSPAC study does not support a role for vitamin D in the prevention of myopia[J].Invest Ophthalmol Vis Sci,2014,55(12):8559.
[15]RAMANURTHY D,LIN CHUA S Y.A review of environmental risk factors for myopia during early life,childhood and adolescence[J].Clin Exp Optom,2015,98(6):497-506.
[16]SHERWIN J C,REACHER M H,KEOGH R H,et al.The association between time spent outdoors and myopia in children and adolescents:a systematic review and Mate-analysis[J].Ophthalmology,2012,119(10):2141-2151.
[17]LAVAL J.Vatamin D and myopia[J].Arch Ophthalmol,1938,19(4):612.
[18]MUTTI D O.Blood levels of vitamin D in teens and young adults with myopia[J].Optom Vis Sci,2011,88(3):377-382.
[19]CHOI J A,HAN K,PARK Y M.Low serum 25-hydroxyvitamin D is associated with myopia in korean adolescents[J].Invest Ophthalmol Vis Sci,2014,55(4):2041-2047.
[20]KWON J W,CHOI J A,LA T Y.Serum 25-hydroxyvitamin D level is associated with myopia in the korea national health and nutrition examination survey[J].Medicine,2016,95(46):e5012.
[21]YAZAR S,HEWITT A W,BLACK L J,et al.Myopia is associated with lower vitamin D status in young adults[J].Invest Ophthalmol Vis Sci,2014,55(7):4552-4559.
[22]GUGGENHEIM J A,WILLIAMS C,NORTHSTONE K,et al.Dose vitamin D mediate the protective effects of time outdoors on myopia?Findings from a prospective birth cohort[J].Invest Ophthalmol Vis Sci,2014,55(12):8550-8558.
[23]MENG W,BUTTERWORTH J,MALECAZE F,et al.Axial length:an underestimated endophenotype of myopia[J].Med Hypoth,2010,74(2):252-253.
[24]TIDEMAN J W,POLLING J R,VOORTMAN T,et al.Low serum vitamin D is associated with axial length and risk of myopia in young children[J].Eur J Epidemiol,2016,31(5):491-499.
[25]ANNAMANENI S,BINDU C H,REDDY K P.Association of vitamin D receptor genestart codon(Fok1)polymorphism with high myopia[J].Oman J Ophthalmol,2011,4(2):57-62.
[26]MUTTI D O,COOPER M E,DRAGAN E,et al.Vitamin D receptor(VDR)and group-specific component(GC,vitamin D-blinding protein)polymorphisms in myopia[J].Invest Ophthalmol Vis Sci,2011,52(6):3818-3824.
[27]LIN R,WHITE J H.The pleiotropic actions of vitamin D[J].Bio Essays,2004,26(1):21-28.
[28]MCBRIEN N A.Role of the sclera in the development and pathological complications of myopia[J].Prog Retin Eye Res,2003,22(3):307-338.
[29]KIM R Y,STERN W H.Retinoids and butyrate modulate fibroblast growth and contraction of collagen matrices[J].Invest Ophthalmol Vis Sci,1990,31(6):1183-1186.
[30]SEKO Y,SHIMOKAWA H.In vivo and in vitro association of retinoic acid with form-deprivation myopia in the chick[J].Exp Eye Res,1996,63(4):443-452.
[31]MCFADDEN S A,HOWLETT M H.Vision res[J].Vis Res,2004,44(7):643-653.
[32]TAVERA-MENDOZA L,WANG T T,LALLEMANT B,et al.Convergence of vitamin D and retinoic acid signalling at a common hormone response element[J].Embo Rep,2006,7(2):180-185.
[33]KORBMACHER C,HELBIG H,HALLER H,et al.Endothelin depolarizes membrane voltage and increases intracellular calcium concentration in human ciliary muscle cells[J].Biochem Biophys Res Commun,1989,164(3):1031-1039.
[34]DUAN X,LU Q,XUE P,et al.Proteomic analysis of aqueous humor from patients with myopia[J].Mol Vis,2008,14(45):370-377.
[35]BAILEY M D,SINNOTT L T.Ciliary body thickness and refractive error in children[J].Invest Ophthalmol Vis Sci,2008,49(10):4353-4360.
[36]CARROLL W F,FABRES J,NAGY T R,et al.Results of extremelylow-birth-weight infants randomized to receive extra enteral calcium supply[J].J Pediatr Gastroenterol Nutr,2011,53(3):339-345.
[37]DALLOSSO H M,MCGROTHER C W,MATTHEWS R J,et al.Nutrient composition of the diet and the development of overactive bladder:a longitudinal study in women[J].Neurourol Urodyn,2004,23(3):204-210.
[38]HE M,XIANG F,ZENG Y,et al.Effect of time spent outdoors at school on the development of myopia among children in china:a randomized clinical trial[J].JAMA,2015,314(11):1142-1148.
[39]WU P C,TSAI C L,WU H L,et al.Outdoor activity during class recess reduces myopia onset and progression in school children[J].Ophthalmology,2013,120(5):1080-1085.
[40]DIRANI M,TONG L,GAZZARD G,et al.Outdoor activity and myopia in Singapore teenage children[J].Br J Ophthalmol,2009,93(8):997-1000.
[41]郭寅,刘丽娟,徐亮,等.北京市城乡681名小学生户外活动时间及与近视的关系[J].中华医学杂志,2014,94(3):191-194.
[2]POLLING J R,VERHOEVENERJ V J,TIDEMAN J W.Duke-Elder's views on prognosis,prophylaxis,and treatment of myopia:way ahead of his time[J].Strabismus,2016,24(1):40-43.
[3]RICHARD H.Myopia and daylight in schools:a neglected aspect of public health?[J].Persp Pub Health,2016,136(1):150-155.
[4]ROSE K A,MORGAN I G,IP J,et al.Outdoor activity reduces the prevalence of myopia in children[J].Ophthalmology,2008,115(8):1279-1285.
[5]金菊香,伍晓艳,万宇辉,等.户外活动对中小学生视力的保护效果评价[J].中国学校卫生,2014,35(12):1776-1779.
[6]翟露露,伍晓艳,许韶君,等.接触阳光与儿童近视关联的研究进展[J].中华流行病学杂志,2016,37(11):1555-1560.
[7]GUGGENHEIM J A,NORTHSTONE K,MCMAHON G,et al.Time outdoors and physical activity as predictors of incident myopia in childhood:a prospective cohort study[J].Invest Ophthalmol Vis Sci,2012,53(6):2856-2865.
[8]READ S A,COLLINS M J,VINCENT S J.Light exposure and physical activity in myopia and emmetropic children[J].Optom Vis Sci,2014,91(3):330-341.
[9]COHEN Y,PELEG E,BELKIN M,et al.Ambient illuminance,retinal dopamine release and refractive development in chicks[J].Exp Eye Res,2012,103(4):33-40.
[10]ASHBY R,OHLENDORF A,SCHAEFFEL F.The effect of ambient illuminance on the development of derivation myopia in chicks[J].Invest Ophthalmol Vis Sci,2009,50(11):5348-5354.
[11]MEHDIZADEH M,NOWROOZZADEH M H.Outdoor activity and myopia[J].Ophthalmology,2009,116(6):1229-1230.
[12]RUCKER F,BRITTON S,SPATCHER M,et al.Blue light protects against temporal frequency sensitive refractive changes[J].Invest Ophthalmol Vis Sci,2015,56(10):6121-6131.
[13]FRENCH A N,ASHBY R S,MORGAN I G.Time outdoors and the prevention of myopia[J].Exp Eye Res,2013,114(9):58-68.
[14]MORGAN I G.ALSPAC study does not support a role for vitamin D in the prevention of myopia[J].Invest Ophthalmol Vis Sci,2014,55(12):8559.
[15]RAMANURTHY D,LIN CHUA S Y.A review of environmental risk factors for myopia during early life,childhood and adolescence[J].Clin Exp Optom,2015,98(6):497-506.
[16]SHERWIN J C,REACHER M H,KEOGH R H,et al.The association between time spent outdoors and myopia in children and adolescents:a systematic review and Mate-analysis[J].Ophthalmology,2012,119(10):2141-2151.
[17]LAVAL J.Vatamin D and myopia[J].Arch Ophthalmol,1938,19(4):612.
[18]MUTTI D O.Blood levels of vitamin D in teens and young adults with myopia[J].Optom Vis Sci,2011,88(3):377-382.
[19]CHOI J A,HAN K,PARK Y M.Low serum 25-hydroxyvitamin D is associated with myopia in korean adolescents[J].Invest Ophthalmol Vis Sci,2014,55(4):2041-2047.
[20]KWON J W,CHOI J A,LA T Y.Serum 25-hydroxyvitamin D level is associated with myopia in the korea national health and nutrition examination survey[J].Medicine,2016,95(46):e5012.
[21]YAZAR S,HEWITT A W,BLACK L J,et al.Myopia is associated with lower vitamin D status in young adults[J].Invest Ophthalmol Vis Sci,2014,55(7):4552-4559.
[22]GUGGENHEIM J A,WILLIAMS C,NORTHSTONE K,et al.Dose vitamin D mediate the protective effects of time outdoors on myopia?Findings from a prospective birth cohort[J].Invest Ophthalmol Vis Sci,2014,55(12):8550-8558.
[23]MENG W,BUTTERWORTH J,MALECAZE F,et al.Axial length:an underestimated endophenotype of myopia[J].Med Hypoth,2010,74(2):252-253.
[24]TIDEMAN J W,POLLING J R,VOORTMAN T,et al.Low serum vitamin D is associated with axial length and risk of myopia in young children[J].Eur J Epidemiol,2016,31(5):491-499.
[25]ANNAMANENI S,BINDU C H,REDDY K P.Association of vitamin D receptor genestart codon(Fok1)polymorphism with high myopia[J].Oman J Ophthalmol,2011,4(2):57-62.
[26]MUTTI D O,COOPER M E,DRAGAN E,et al.Vitamin D receptor(VDR)and group-specific component(GC,vitamin D-blinding protein)polymorphisms in myopia[J].Invest Ophthalmol Vis Sci,2011,52(6):3818-3824.
[27]LIN R,WHITE J H.The pleiotropic actions of vitamin D[J].Bio Essays,2004,26(1):21-28.
[28]MCBRIEN N A.Role of the sclera in the development and pathological complications of myopia[J].Prog Retin Eye Res,2003,22(3):307-338.
[29]KIM R Y,STERN W H.Retinoids and butyrate modulate fibroblast growth and contraction of collagen matrices[J].Invest Ophthalmol Vis Sci,1990,31(6):1183-1186.
[30]SEKO Y,SHIMOKAWA H.In vivo and in vitro association of retinoic acid with form-deprivation myopia in the chick[J].Exp Eye Res,1996,63(4):443-452.
[31]MCFADDEN S A,HOWLETT M H.Vision res[J].Vis Res,2004,44(7):643-653.
[32]TAVERA-MENDOZA L,WANG T T,LALLEMANT B,et al.Convergence of vitamin D and retinoic acid signalling at a common hormone response element[J].Embo Rep,2006,7(2):180-185.
[33]KORBMACHER C,HELBIG H,HALLER H,et al.Endothelin depolarizes membrane voltage and increases intracellular calcium concentration in human ciliary muscle cells[J].Biochem Biophys Res Commun,1989,164(3):1031-1039.
[34]DUAN X,LU Q,XUE P,et al.Proteomic analysis of aqueous humor from patients with myopia[J].Mol Vis,2008,14(45):370-377.
[35]BAILEY M D,SINNOTT L T.Ciliary body thickness and refractive error in children[J].Invest Ophthalmol Vis Sci,2008,49(10):4353-4360.
[36]CARROLL W F,FABRES J,NAGY T R,et al.Results of extremelylow-birth-weight infants randomized to receive extra enteral calcium supply[J].J Pediatr Gastroenterol Nutr,2011,53(3):339-345.
[37]DALLOSSO H M,MCGROTHER C W,MATTHEWS R J,et al.Nutrient composition of the diet and the development of overactive bladder:a longitudinal study in women[J].Neurourol Urodyn,2004,23(3):204-210.
[38]HE M,XIANG F,ZENG Y,et al.Effect of time spent outdoors at school on the development of myopia among children in china:a randomized clinical trial[J].JAMA,2015,314(11):1142-1148.
[39]WU P C,TSAI C L,WU H L,et al.Outdoor activity during class recess reduces myopia onset and progression in school children[J].Ophthalmology,2013,120(5):1080-1085.
[40]DIRANI M,TONG L,GAZZARD G,et al.Outdoor activity and myopia in Singapore teenage children[J].Br J Ophthalmol,2009,93(8):997-1000.
[41]郭寅,刘丽娟,徐亮,等.北京市城乡681名小学生户外活动时间及与近视的关系[J].中华医学杂志,2014,94(3):191-194.